Intense pulsed electron beams application of modified materials. (2009)
Weisenburger, A., An, W., Engelko, V., Heinzel, A., Jianu, A., Lang, F., ...
Acta Physica Polonica A, 115(2009) S.1053-55
Surface modification of alloys exposed to extreme environment. (2009)
Jianu, A., Müller, G., Weisenburger, A., An, W., Heinzel, A., Zimmermann, F., ...
Euromat 2009 : European Congress and Exhibition on Advanced Materials and Processes, Glasgow, GB, September 7-10, 2009
Rubinstein-Taybi Syndrome (2008)
GERVASINI, CRISTINA COSTANZA GIOVANNA, LARIZZA, LIDIA, F. Lang
Rubinstein-Taybi Syndrome / C. Gervasini, A. Bentivegna, L. Larizza. - (Encyclopedia of Molecular Mechanisms of Disease 2008). - In: Encyclopedia of molecular mechanisms of disease ; [a cura di] F....
Ultracold Molecules in the Ro-Vibrational Triplet Ground State (2008)
Lang, F., Winkler, K., Strauss, C., Grimm, R., Denschlag, J. Hecker
We report here on the production of an ultracold gas of tightly bound Rb2 molecules in the ro-vibrational triplet ground state, close to quantum degeneracy. This is achieved by optically transferring...
J. Armstrong, R. Virding, C. Wikström, M. Williams Concurrent, H. Garavel, F. Lang, ...
Erlang to µCRL.In Proceedings of the International Conference on Application
Bareiss, P.M., Metzger, M., Sohn, K., Rupp, S., Frick, J.S., Autenrieth, I.B., ...
Together with animal experiments, organotypical cell cultures are important models for analyzing cellular interactions of the mucosal epithelium and pathogenic mechanisms in the gastrointestinal...
Overview on applications of materials modified by intense pulsed electron beams. (2008)
An, W., Engelko, V., Heinzel, A., Jianu, A., Lang, F., Müller, G., ...
35th IEEE Internat.Conf.on Plasma Science (ICOPS), Karlsruhe, June 15-19, 2008
Intense pulsed electron beams - application of modified materials. (2008)
Weisenburger, A., An, W., Heinzel, A., Jianu, A., Lang, F., Müller, G., ...
2nd Euro-Asian Pulsed Power Conf., Vilnius, LT, September 22-26, 2008
Pulsed electron beams and their use for material modification. (2008)
Weisenburger, A., Engelko, V., An, W., Heinzel, A., Jianu, A., Lang, F., ...
1st ITG Internat.Vacuum Electronics Workshop, Bad Honnef, November 10-11, 2008
Cruising through molecular bound state manifolds with radio frequency (2007)
Lang, F., Straten, P. V. D., Brandstätter, B., Thalhammer, G., Winkler, K., Julienne, P. S., ...
The emerging field of ultracold molecules with their rich internal structure is currently attracting a lot of interest. Various methods have been developed to produce ultracold molecules in pre-set...
Coherent optical transfer of Feshbach molecules to a lower vibrational state (2006)
Winkler, K., Lang, F., Thalhammer, G., Straten, P. V. D., Grimm, R., Denschlag, J. Hecker
Using the technique of stimulated Raman adiabatic passage (STIRAP) we have coherently transferred ultracold 87Rb2 Feshbach molecules into a more deeply bound vibrational quantum level. Our...
Lang, F, Joubert, G, Prinsloo, EAM
In 2002, we conducted a cross-sectional study to determine the profile of women seeking termination of pregnancy (TOP) in the Free State and to find out whether TOP was being used as a family...
Repulsively bound atom pairs: Overview, Simulations and Links (2006)
Daley, A. J., Kantian, A., Büchler, H. P., Zoller, P., Winkler, K., Thalhammer, G., ...
We review the basic physics of repulsively bound atom pairs in an optical lattice, which were recently observed in the laboratory, including the theory and the experimental implementation. We also...
Repulsively bound atom pairs in an optical lattice (2006)
Winkler, K., Thalhammer, G., Lang, F., Grimm, R., Denschlag, J. Hecker, Daley, A. J., ...
Throughout physics, stable composite objects are usually formed via attractive forces, which allow the constituents to lower their energy by binding together. Repulsive forces separate particles in...
F Lang; Faculty Of Health Sciences, University Of The Free State, Bloemfontein, G Joubert; Faculty Of Health Sciences, University Of The Free State, Bloemfontein, EAM Prinsloo; Faculty Of Health Sciences, University Of The Free State, Bloemfontein
In 2002, we conducted a cross-sectional study to determine the profile of women seeking termination of pregnancy (TOP) in the Free State and to find out whether TOP was being used as a family...
Is pregnancy termination being used as a family planning method in the Free State? (2005)
F Lang; Department Of Family Medicine, University Of The Free State., G Joubert; Department Of Biostatistics, University Of The Free State., EAM Prinsloo; Department Of Family Medicine, University Of The Free State, Bloemfontein.
Background: This study determined the profile of women seeking termination of pregnancy (TOP) in the Free State and whether TOP was used as a family planning method. Methods: Seven hundred and fifty...
Palmada, M, Dieter, M, Speil, A, Böhmer, C, Mack, A F, Wagner, H J, ...
Serum and glucocorticoid-inducible kinase 1 (SGK1) is highly expressed in enterocytes. The significance of the kinase in regulation of intestinal function has, however, remained elusive. In Xenopus...
Influence of low power cm-/mm-microwaves on cardiovascular function (2004)
Müller,J., Hadeler,K. P., Müller,Viktor, Waldmann,J., Landstorfer,F. M., Wisniewski,R., ...
Influence of low power cm-/mm-microwaves on cardiovascular function (2004)
Müller, J., Hadeler, K. P., Müller, Viktor, Waldmann, J., Landstorfer, F. M., Wisniewski, R., ...
Kornek, G. V., Schuell, B., Laengle, F., Gruenberger, T., Penz, M., Karall, K., ...
Background: Patients with advanced biliary tract carcinoma face a particularly dismal prognosis, and no standard palliative chemotherapy has yet been defined. Among several different single agents,...
Multiplexed 3D imaging using wavelength encoded spectral interferometry: a proof of principle (2003)
Froehly, L., Martin, S. N., Lasser, T., Depeursinge, C., Lang, F.
Based on spectral interferometry and wavelength multiplexing, we demonstrate that a combination of these methods could lead to a 3D imaging system. This system has the advantage of a one-dimensional...
Scheithauer, W., Schüll, B., Ulrich-Pur, H., Schmid, K., Raderer, M., Haider, K., ...
Background: Gemcitabine is an active antitumor agent in the treatment of advanced pancreatic cancer, and has shown potential synergistic activity with the oral fluoropyrimidine capecitabine in...
Effect of NaPi-mediated phosphate transport on intracellular pH. (2001)
Moschèn, I, Setiawan, I, Bröer, S, Murer, H, Lang, F
Extracellular pH has been shown previously to influence transport via type-II Na+/phosphate (NaPi) transporters by modifying the affinity of the carrier for Na+ and by altering the availability of...
Jendrossek, V., Kugler, W., Erdlenbruch, B., Eibl, H., Lang, F., Lakomek, M.
Intrinsic chemoresistance constitutes a major problem in the therapy of malignant gliomas. In vitro experiments with four astrocytoma/glioblastoma (AC/GBM) cell lines revealed that the...
Ulrich-Pur, H., Kornek, G.V., Fiebiger, W., Gedlicka, C., Raderer, M., Lenauer, A., ...
Background A multicenter phase II trial was initiated to investigate the efficacy and tolerance of a dose-fractionated administration schedule of innotecan in patients with advanced colorectal cancer...
Scheithauer, W., Kornek, G. V., Schuell, B., Ulrich-Pur, H., Penz, M., Raderer, M., ...
Background. To evaluate the efficacy and tolerance of combined raltitrexed and oxaliplatin in patients with advanced colorectal cancer pretreated with fluoropyrimidine—leucovorin-based...
Waldegger, S, Steuer, S, Risler, T, Heidland, A, Capasso, G, Massry, S, ...
Forster, I C, Wagner, C A, Busch, A E, Lang, F, Biber, J, Hernando, N, ...
The two electrode voltage clamp technique was used to investigate the steady-state and presteady-state kinetic properties of the type II Na+/Pi cotransporter NaPi-5, cloned from the kidney of winter...
A hybrid concept for 3D building acquisition (1997)
A. Brunn, E. Gülch, F. Lang, W. Förstner
This paper presents a hybrid concept of interaction between scene and
Wagner, C A, Waldegger, S, Osswald, H, Biber, J, Murer, H, Busch, A E, ...
Heavy metal intoxication with Hg2+, Pb2+ and Cd2+ commonly leads to phosphaturia. In this study, we examined the effects of these heavy metals on Pi-induced currents (Ip) through NaPi-3, the human...
Busch, A E, Schuster, A, Waldegger, S, Wagner, C A, Zempel, G, Broer, S, ...
Two distinct molecular types (I and II) of renal proximal tubular brush border Na+/Pi cotransporters have been identified by expression cloning on the basis of their capacity to induce Na+-dependent...
Waldegger, S, Raber, G, Sussbrich, H, Ruppersberg, J P, Fakler, B, Murer, H, ...
Expression of the IsK protein in Xenopus oocytes induced the characteristically slow, voltage-dependent outward currents. Superfusion with the parathyroid hormone (PTH) peptide 1-34 had no effect on...
Function and dysfunction of renal transport molecules: lessons from electrophysiology. (1996)
Waldegger, S, Busch, A E, Kern, C, Capasso, G, Murer, H, Lang, F
The availability of cloned transport molecules achieved by efforts in expression cloning has allowed their electrophysiological analysis in the Xenopus oocyte expression system. We describe the...
Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
Lang, F., Klingel, K., Wagner, C. A., Stegen, C., Wärntges, S., Friedrich, B., ...
Transforming growth factor β (TGF-β) has been shown to participate in the pathophysiology of diabetic complications. As shown most recently, TGF-β stimulates the expression of a distinct...
l-Selectin activates the Ras pathway via the tyrosine kinase p56lck
Brenner, B., Gulbins, E., Schlottmann, K., Koppenhoefer, U., Busch, G. L., Walzog, B., ...
Selectins mediate rolling, the initial step of leukocyte adhesion to endothelial cells [Springer, T. A. (1995) Annu. Rev. Physiol. 57, 827–872 and Butcher, E. C. (1991) Cell 67, 1033–1036]. In...
Busch, A E, Schuster, A, Waldegger, S, Wagner, C A, Zempel, G, Broer, S, ...
Two distinct molecular types (I and II) of renal proximal tubular brush border Na+/Pi cotransporters have been identified by expression cloning on the basis of their capacity to induce Na+-dependent...
Van Kuijck, M A, Van Aubel, R A, Busch, A E, Lang, F, Russel, F G, Bindels, R J, ...
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-regulated, cAMP-activated chloride channel located in the apical membrane of many epithelial secretory cells. Here we report...
Busch, A, Waldegger, S, Herzer, T, Biber, J, Markovich, D, Hayes, G, ...
Phosphate (Pi) reabsorption in renal proximal tubules involves Na+/Pi cotransport across the brush border membrane; its transport rate is influenced by the Na(+)-coupled transport of other solutes as...
Busch, G L, Schreiber, R, Dartsch, P C, Völkl, H, Vom Dahl, S, Häussinger, D, ...
Cell swelling is shown to induce an increase in acridine orange fluorescence intensity, an effect pointing to the alkalinization of acidic vesicles. Since autophagic hepatic proteolysis is...
Neumeister, B., Reiff, G., Faigle, M., Dietz, K., Northoff, H., Lang, F.
Previous studies using a murine model of coinhalation of Legionella pneumophila and Hartmannella vermiformis have shown a significantly enhanced intrapulmonary growth of L. pneumophila in comparison...
Weyer, K. A., Lottspeich, F., Gruenberg, H., Lang, F., Oesterhelt, D., Michel, H.
The complete nucleotide sequence of the gene encoding the cytochrome subunit of the photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis, and the derived amino acid...
Regulation of cell volume in the perfused rat liver by hormones.
Vom Dahl, S, Hallbrucker, C, Lang, F, Häussinger, D
The effect of hormones on cell volume was studied in isolated perfused rat liver by assessing the intracellular water space as the difference between a [3H]inulin- and a [14C]urea-accessible space....
Hallbrucker, C, Lang, F, Gerok, W, Häussinger, D
The effects of aniso-osmotically and amino-acid-induced cell-volume changes on bile flow and biliary taurocholate excretion were studied in isolated perfused rat liver. With taurocholate (100 microM)...
Cell volume and bile acid excretion.
Häussinger, D, Hallbrucker, C, Saha, N, Lang, F, Gerok, W
The interaction between cell volume and taurocholate excretion into bile was studied in isolated perfused rat liver. Cell swelling due to hypo-osmotic exposure, addition of amino acids or insulin...
Häussinger, D, Saha, N, Hallbrucker, C, Lang, F, Gerok, W
An increase of the hepatocellular hydratation state, induced by hypotonic exposure, amino acids or tauroursodeoxycholate, was shown to increase within minutes the Vmax of transcellular taurocholate...
Liver cell volume and protein synthesis.
Stoll, B, Gerok, W, Lang, F, Häussinger, D
Protein synthesis in isolated rat hepatocytes was determined from the incorporation of [3H]leucine (4 mM) into acid-precipitable material in the presence of amino acids at twice their physiological...
Effect of cell volume on Acridine Orange fluorescence in hepatocytes.
Völkl, H, Friedrich, F, Häussinger, D, Lang, F
Hepatic proteolysis is inhibited by cell swelling following a variety of experimental manoeuvres, such as reduction of extracellular osmolarity, concentrative uptake of amino acids, or blockade of K+...
Schreiber, R, Stoll, B, Lang, F, Häussinger, D
Freshly isolated rat hepatocytes were plated for 4-6 h and either loaded with (2',7)-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) or allowed to endocytose fluorescein isothiocyanate...
Endogenous hydroperoxide formation, cell volume and cellular K+ balance in perfused rat liver.
Saha, N, Schreiber, R, Vom Dahl, S, Lang, F, Gerok, W, Häussinger, D
Addition of benzylamine (0.5 mM) to isolated perfused rat liver led to a net release of K+ of 10.5 +/- 0.3 mumol/g, which was accompanied by a decrease in liver mass by 9.3 +/- 0.4% and a decrease of...
Cell swelling inhibits proteolysis in perfused rat liver.
Häussinger, D, Hallbrucker, C, Vom Dahl, S, Lang, F, Gerok, W
Exposure of isolated single-pass-perfused rat liver to hypo-osmotic media resulted in liver cell swelling and an inhibition of release of branched-chain amino acids. Similarly, cell swelling...
Cellular mechanisms of adrenaline-induced hyperpolarization in renal epitheloid MDCK cells.
Pfeilschifter, J, Paulmichl, M, Wöll, E, Paulmichl, R, Lang, F
The effects of adrenaline on the potential difference across the cell membrane, on formation of inositol phosphates and on intracellular Ca2+ ([Ca2+]i) were analysed in cells without or with...
Hauck, C R, Meyer, T F, Lang, F, Gulbins, E
The interaction of Neisseria gonorrhoeae with human phagocytes is a hallmark of gonococcal infections. Recently, CD66 molecules have been characterized as receptors for Opa52-expressing gonococci on...
Bröer, A, Wagner, C, Lang, F, Bröer, S
The neutral amino acid transporter ASCT2 mediates electroneutral obligatory antiport but at the same time requires Na(+) for its function. To elucidate the mechanism, ASCT2 was expressed in Xenopus...
Bröer, A, Wagner, C A, Lang, F, Bröer, S
The cationic amino acid arginine, due to its positive charge, is usually accumulated in the cytosol. Nevertheless, arginine has to be released by a number of cell types, e.g. kidney cells, which...
Dimmer, K S, Friedrich, B, Lang, F, Deitmer, J W, Bröer, S
Transport of lactate and other monocarboxylates in mammalian cells is mediated by a family of transporters, designated monocarboxylate transporters (MCTs). The MCT4 member of this family has recently...
Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
Bröer, A, Friedrich, B, Wagner, C A, Fillon, S, Ganapathy, V, Lang, F, ...
Heterodimeric amino acid transporters are comprised of a type-II membrane protein named the heavy chain (4F2hc or rBAT) that may associate with a number of different polytopic membrane proteins,...
Regulation of liver cell volume and proteolysis by glucagon and insulin.
Vom Dahl, S, Hallbrucker, C, Lang, F, Gerok, W, Häussinger, D
The effects of insulin and glucagon on liver cell volume and proteolysis were studied in isolated perfused rat liver. The rate of proteolysis was assessed as [3H]leucine release from...
Busch, A E, Kopp, H G, Waldegger, S, Samarzija, I, Süssbrich, H, Raber, G, ...
1. The effects of isosorbiddinitrate (ISDN) were tested on membrane currents and resting potential in Xenopus laevis oocytes which were either uninjected or injected with cRNA encoding for K+...
1. Previous studies have shown that bradykinin, ATP and adrenaline hyperpolarize the cell membrane of Madin-Darby canine kidney (MDCK) cells by activation of calcium-sensitive K+ channels. The...
Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
Lang, F., Klingel, K., Wagner, C. A., Stegen, C., Wärntges, S., Friedrich, B., ...
Transforming growth factor β (TGF-β) has been shown to participate in the pathophysiology of diabetic complications. As shown most recently, TGF-β stimulates the expression of a distinct...
l-Selectin activates the Ras pathway via the tyrosine kinase p56lck
Brenner, B., Gulbins, E., Schlottmann, K., Koppenhoefer, U., Busch, G. L., Walzog, B., ...
Selectins mediate rolling, the initial step of leukocyte adhesion to endothelial cells [Springer, T. A. (1995) Annu. Rev. Physiol. 57, 827–872 and Butcher, E. C. (1991) Cell 67, 1033–1036]. In...
Busch, A E, Schuster, A, Waldegger, S, Wagner, C A, Zempel, G, Broer, S, ...
Two distinct molecular types (I and II) of renal proximal tubular brush border Na+/Pi cotransporters have been identified by expression cloning on the basis of their capacity to induce Na+-dependent...
Van Kuijck, M A, Van Aubel, R A, Busch, A E, Lang, F, Russel, F G, Bindels, R J, ...
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-regulated, cAMP-activated chloride channel located in the apical membrane of many epithelial secretory cells. Here we report...
Busch, A, Waldegger, S, Herzer, T, Biber, J, Markovich, D, Hayes, G, ...
Phosphate (Pi) reabsorption in renal proximal tubules involves Na+/Pi cotransport across the brush border membrane; its transport rate is influenced by the Na(+)-coupled transport of other solutes as...
Busch, G L, Schreiber, R, Dartsch, P C, Völkl, H, Vom Dahl, S, Häussinger, D, ...
Cell swelling is shown to induce an increase in acridine orange fluorescence intensity, an effect pointing to the alkalinization of acidic vesicles. Since autophagic hepatic proteolysis is...
Neumeister, B., Reiff, G., Faigle, M., Dietz, K., Northoff, H., Lang, F.
Previous studies using a murine model of coinhalation of Legionella pneumophila and Hartmannella vermiformis have shown a significantly enhanced intrapulmonary growth of L. pneumophila in comparison...
Weyer, K. A., Lottspeich, F., Gruenberg, H., Lang, F., Oesterhelt, D., Michel, H.
The complete nucleotide sequence of the gene encoding the cytochrome subunit of the photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis, and the derived amino acid...
Regulation of cell volume in the perfused rat liver by hormones.
Vom Dahl, S, Hallbrucker, C, Lang, F, Häussinger, D
The effect of hormones on cell volume was studied in isolated perfused rat liver by assessing the intracellular water space as the difference between a [3H]inulin- and a [14C]urea-accessible space....
Hallbrucker, C, Lang, F, Gerok, W, Häussinger, D
The effects of aniso-osmotically and amino-acid-induced cell-volume changes on bile flow and biliary taurocholate excretion were studied in isolated perfused rat liver. With taurocholate (100 microM)...
Cell volume and bile acid excretion.
Häussinger, D, Hallbrucker, C, Saha, N, Lang, F, Gerok, W
The interaction between cell volume and taurocholate excretion into bile was studied in isolated perfused rat liver. Cell swelling due to hypo-osmotic exposure, addition of amino acids or insulin...
Häussinger, D, Saha, N, Hallbrucker, C, Lang, F, Gerok, W
An increase of the hepatocellular hydratation state, induced by hypotonic exposure, amino acids or tauroursodeoxycholate, was shown to increase within minutes the Vmax of transcellular taurocholate...
Liver cell volume and protein synthesis.
Stoll, B, Gerok, W, Lang, F, Häussinger, D
Protein synthesis in isolated rat hepatocytes was determined from the incorporation of [3H]leucine (4 mM) into acid-precipitable material in the presence of amino acids at twice their physiological...
Effect of cell volume on Acridine Orange fluorescence in hepatocytes.
Völkl, H, Friedrich, F, Häussinger, D, Lang, F
Hepatic proteolysis is inhibited by cell swelling following a variety of experimental manoeuvres, such as reduction of extracellular osmolarity, concentrative uptake of amino acids, or blockade of K+...
Schreiber, R, Stoll, B, Lang, F, Häussinger, D
Freshly isolated rat hepatocytes were plated for 4-6 h and either loaded with (2',7)-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) or allowed to endocytose fluorescein isothiocyanate...
Endogenous hydroperoxide formation, cell volume and cellular K+ balance in perfused rat liver.
Saha, N, Schreiber, R, Vom Dahl, S, Lang, F, Gerok, W, Häussinger, D
Addition of benzylamine (0.5 mM) to isolated perfused rat liver led to a net release of K+ of 10.5 +/- 0.3 mumol/g, which was accompanied by a decrease in liver mass by 9.3 +/- 0.4% and a decrease of...
Cell swelling inhibits proteolysis in perfused rat liver.
Häussinger, D, Hallbrucker, C, Vom Dahl, S, Lang, F, Gerok, W
Exposure of isolated single-pass-perfused rat liver to hypo-osmotic media resulted in liver cell swelling and an inhibition of release of branched-chain amino acids. Similarly, cell swelling...
Cellular mechanisms of adrenaline-induced hyperpolarization in renal epitheloid MDCK cells.
Pfeilschifter, J, Paulmichl, M, Wöll, E, Paulmichl, R, Lang, F
The effects of adrenaline on the potential difference across the cell membrane, on formation of inositol phosphates and on intracellular Ca2+ ([Ca2+]i) were analysed in cells without or with...
Regulation of liver cell volume and proteolysis by glucagon and insulin.
Vom Dahl, S, Hallbrucker, C, Lang, F, Gerok, W, Häussinger, D
The effects of insulin and glucagon on liver cell volume and proteolysis were studied in isolated perfused rat liver. The rate of proteolysis was assessed as [3H]leucine release from...
Busch, A E, Kopp, H G, Waldegger, S, Samarzija, I, Süssbrich, H, Raber, G, ...
1. The effects of isosorbiddinitrate (ISDN) were tested on membrane currents and resting potential in Xenopus laevis oocytes which were either uninjected or injected with cRNA encoding for K+...
Hauck, C R, Meyer, T F, Lang, F, Gulbins, E
The interaction of Neisseria gonorrhoeae with human phagocytes is a hallmark of gonococcal infections. Recently, CD66 molecules have been characterized as receptors for Opa52-expressing gonococci on...
1. Previous studies have shown that bradykinin, ATP and adrenaline hyperpolarize the cell membrane of Madin-Darby canine kidney (MDCK) cells by activation of calcium-sensitive K+ channels. The...
Bröer, A, Wagner, C, Lang, F, Bröer, S
The neutral amino acid transporter ASCT2 mediates electroneutral obligatory antiport but at the same time requires Na(+) for its function. To elucidate the mechanism, ASCT2 was expressed in Xenopus...
Bröer, A, Wagner, C A, Lang, F, Bröer, S
The cationic amino acid arginine, due to its positive charge, is usually accumulated in the cytosol. Nevertheless, arginine has to be released by a number of cell types, e.g. kidney cells, which...
Dimmer, K S, Friedrich, B, Lang, F, Deitmer, J W, Bröer, S
Transport of lactate and other monocarboxylates in mammalian cells is mediated by a family of transporters, designated monocarboxylate transporters (MCTs). The MCT4 member of this family has recently...
Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
Bröer, A, Friedrich, B, Wagner, C A, Fillon, S, Ganapathy, V, Lang, F, ...
Heterodimeric amino acid transporters are comprised of a type-II membrane protein named the heavy chain (4F2hc or rBAT) that may associate with a number of different polytopic membrane proteins,...
L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac.
Brenner, B, Weinmann, S, Grassmé, H, Lang, F, Linderkamp, O, Gulbins, E
Selectin and alpha 4 beta 7-integrins have been shown to mediate transient leucocyte interactions with endothelial cells which is a crucial step in the initial immune response to pathogens. We have...
Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis.
Gulbins, E, Brenner, B, Schlottmann, K, Welsch, J, Heinle, H, Koppenhoefer, U, ...
Fas induces apoptosis in lymphocytes via a poorly defined intracellular signalling cascade. Previously, we have demonstrated the involvement and significance of a signalling cascade from the Fas...
Suessbrich, H, Schönherr, R, Heinemann, S H, Attali, B, Lang, F, Busch, A E
The antipsychotic drug haloperidol can induce a marked QT prolongation and polymorphic ventricular arrhythmias. In this study, we expressed several cloned cardiac K+ channels, including the human...
Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action
Busch, A E, Eigenberger, B, Jurkiewicz, N K, Salata, J J, Pica, A, Suessbrich, H, ...
The class III antiarrhythmic azimilide has previously been shown to inhibit IKs and IKr in guinea-pig cardiac myocytes and IKs (minK) channels expressed in Xenopus oocytes. Because HERG channels...
Ritter, M, Schratzberger, P, Rossmann, H, Wöll, E, Seiler, K, Seidler, U, ...
Stimulation of chemotaxis of human polymorphonuclear leucocytes (PMNs) with the chemoattractive peptide fMLP (N-formyl-Met-Leu-Phe) is paralleled by profound morphological and metabolic alterations...
Klaus, F, Palmada, M, Lindner, R, Laufer, J, Jeyaraj, S, Lang, F, ...
Mechanisms of regulatory cell volume increase following cell shrinkage include accumulation of organic osmolytes such as betaine, taurine, sorbitol, glycerophosphorylcholine (GPC) and myo-inositol....
Kornek, G. V., Haider, K., Kwasny, W., Lang, F., Krauss, G., Hejna, M., ...
A phase II trial was performed to investigate the efficacy and tolerance of vinorelbine (VNB), 5-fluorouracil (5-FU), l-leucovorin (LLV) and recombinant human granulocyte colony-stimulating factor...
Side effects during chemotherapy predict tumour response in advanced colorectal cancer
Schuell, B, Gruenberger, T, Kornek, G V, Dworan, N, Depisch, D, Lang, F, ...
To investigate whether a relationship between chemotherapy-associated adverse events and treatment efficacy exists, we have analysed the toxicity, objective response and survival data of 303 patients...
Kornek, G V, Raderer, M, Schüll, B, Fiebiger, W, Gedlicka, C, Lenauer, A, ...
A phase II trial was performed to determine the antitumour efficacy and tolerance of combined paclitaxel and cisplatin with or without hematopoetic growth factor support in patients with advanced...
Ulrich-Pur, H, Raderer, M, Verena Kornek, G, Schüll, B, Schmid, K, Haider, K, ...
There is no established second-line treatment for advanced pancreatic cancer after gemcitabine failure. In view of the urgent need for such therapy, and since preclinical and phase I clinical data...