Functional Analysis of the Carboxy-Terminal Domain of Bacillus anthracis Protective Antigen
Brossier, Fabien, Sirard, Jean-Claude, Guidi-Rontani, Chantal, Duflot, Edith, Mock, Michele
Protective antigen (PA) is the common receptor-binding component of the two anthrax toxins. We investigated the involvement of the PA carboxy-terminal domain in the interaction of the protein with...
Role of Toxin Functional Domains in Anthrax Pathogenesis
Brossier, Fabien, Weber-Levy, Martine, Mock, Michele, Sirard, Jean-Claude
We investigated the role of the functional domains of anthrax toxins during infection. Three proteins produced by Bacillus anthracis, the protective antigen (PA), the lethal factor (LF), and the...
Brossier, Fabien, Weber-Levy, Martine, Mock, Michèle, Sirard, Jean-Claude
Bacillus anthracis secretes a lethal toxin composed of two proteins, the lethal factor (LF) and the protective antigen (PA), which interact within the host or in vitro at the surfaces of eukaryotic...
Anthrax Spores Make an Essential Contribution to Vaccine Efficacy
Brossier, Fabien, Levy, Martine, Mock, Michèle
Anthrax is caused by Bacillus anthracis, a gram-positive spore-forming bacterium. Septicemia and toxemia rapidly lead to death in infected mammal hosts. Currently used acellular vaccines against...
Brossier, Fabien, Lévy, Martine, Landier, Annie, Lafaye, Pierre, Mock, Michèle
Protective antigen (PA) is central to the action of the lethal and edema toxins produced by Bacillus anthracis. It is the common cell-binding component, mediating the translocation of the enzymatic...
Brossier, Fabien, Jewett, Travis J., Sibley, L. David, Urban, Sinisa
Apicomplexan parasites cause serious human and animal diseases, the treatment of which requires identification of new therapeutic targets. Host-cell invasion culminates in the essential cleavage of...
Functional Analysis of the Carboxy-Terminal Domain of Bacillus anthracis Protective Antigen
Brossier, Fabien, Sirard, Jean-Claude, Guidi-Rontani, Chantal, Duflot, Edith, Mock, Michele
Protective antigen (PA) is the common receptor-binding component of the two anthrax toxins. We investigated the involvement of the PA carboxy-terminal domain in the interaction of the protein with...
Role of Toxin Functional Domains in Anthrax Pathogenesis
Brossier, Fabien, Weber-Levy, Martine, Mock, Michele, Sirard, Jean-Claude
We investigated the role of the functional domains of anthrax toxins during infection. Three proteins produced by Bacillus anthracis, the protective antigen (PA), the lethal factor (LF), and the...
Brossier, Fabien, Weber-Levy, Martine, Mock, Michèle, Sirard, Jean-Claude
Bacillus anthracis secretes a lethal toxin composed of two proteins, the lethal factor (LF) and the protective antigen (PA), which interact within the host or in vitro at the surfaces of eukaryotic...
Anthrax Spores Make an Essential Contribution to Vaccine Efficacy
Brossier, Fabien, Levy, Martine, Mock, Michèle
Anthrax is caused by Bacillus anthracis, a gram-positive spore-forming bacterium. Septicemia and toxemia rapidly lead to death in infected mammal hosts. Currently used acellular vaccines against...
Brossier, Fabien, Lévy, Martine, Landier, Annie, Lafaye, Pierre, Mock, Michèle
Protective antigen (PA) is central to the action of the lethal and edema toxins produced by Bacillus anthracis. It is the common cell-binding component, mediating the translocation of the enzymatic...
Brossier, Fabien, Jewett, Travis J., Sibley, L. David, Urban, Sinisa
Apicomplexan parasites cause serious human and animal diseases, the treatment of which requires identification of new therapeutic targets. Host-cell invasion culminates in the essential cleavage of...
Brossier, Fabien, Starnes, G. Lucas, Beatty, Wandy L., Sibley, L. David
Rhomboids are serine proteases that cleave their substrates within the transmembrane domain. Toxoplasma gondii contains six rhomboids that are expressed in different life cycle stages and localized...