Françoise Jacob-Dubuisson

Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper

Bullitt, Esther, Jones, C. Hal, Striker, Robert, Soto, Gabriel, Jacob-Dubuisson, Françoise, Pinkner, Jerome, ...

The major subassemblies of virulence-associated P pili, the pilus rod (comprised of PapA) and tip fibrillum (comprised of PapE), were reconstituted from purified chaperone-subunit complexes in vitro....

New Virulence-Activated and Virulence-Repressed Genes Identified by Systematic Gene Inactivation and Generation of Transcriptional Fusions in Bordetella pertussis

Antoine, Rudy, Alonso, Sylvie, Raze, Dominique, Coutte, Loïc, Lesjean, Sarah, Willery, Eve, ...

An in silico scan of the partially completed genome sequence of Bordetella pertussis and analyses of transcriptional fusions generated with a new integrational vector were used to identify new...

Production of Neisseria meningitidis Transferrin-Binding Protein B by Recombinant Bordetella pertussis

Coppens, Isabelle, Alonso, Sylvie, Antoine, Rudy, Jacob-Dubuisson, Françoise, Renauld-Mongénie, Geneviève, Jacobs, Eric, ...

Neisseria meningitidis serogroup B infections are among the major causes of fulminant septicemia and meningitis, especially severe in young children, and no broad vaccine is available yet. Because of...

Subtilisin-like autotransporter serves as maturation protease in a bacterial secretion pathway

Coutte, Loic, Antoine, Rudy, Drobecq, Hervé, Locht, Camille, Jacob-Dubuisson, Françoise

Proteins of Gram-negative bacteria destined to the extracellular milieu must cross the two cellular membranes and then fold at the appropriate time and place. The synthesis of a precursor may be a...

Overrepresentation of a Gene Family Encoding Extracytoplasmic Solute Receptors in Bordetella

Antoine, Rudy, Jacob-Dubuisson, Françoise, Drobecq, Hervé, Willery, Eve, Lesjean, Sarah, Locht, Camille

A family of genes that are likely to encode extracytoplasmic solute receptors is strongly overrepresented in several β-proteobacteria, including Bordetella pertussis. This gene family, of which...

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway

Clantin, Bernard, Hodak, Hélène, Willery, Eve, Locht, Camille, Jacob-Dubuisson, Françoise, Villeret, Vincent

Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is...

Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper

Bullitt, Esther, Jones, C. Hal, Striker, Robert, Soto, Gabriel, Jacob-Dubuisson, Françoise, Pinkner, Jerome, ...

The major subassemblies of virulence-associated P pili, the pilus rod (comprised of PapA) and tip fibrillum (comprised of PapE), were reconstituted from purified chaperone-subunit complexes in vitro....

New Virulence-Activated and Virulence-Repressed Genes Identified by Systematic Gene Inactivation and Generation of Transcriptional Fusions in Bordetella pertussis

Antoine, Rudy, Alonso, Sylvie, Raze, Dominique, Coutte, Loïc, Lesjean, Sarah, Willery, Eve, ...

An in silico scan of the partially completed genome sequence of Bordetella pertussis and analyses of transcriptional fusions generated with a new integrational vector were used to identify new...

Production of Neisseria meningitidis Transferrin-Binding Protein B by Recombinant Bordetella pertussis

Coppens, Isabelle, Alonso, Sylvie, Antoine, Rudy, Jacob-Dubuisson, Françoise, Renauld-Mongénie, Geneviève, Jacobs, Eric, ...

Neisseria meningitidis serogroup B infections are among the major causes of fulminant septicemia and meningitis, especially severe in young children, and no broad vaccine is available yet. Because of...

Subtilisin-like autotransporter serves as maturation protease in a bacterial secretion pathway

Coutte, Loic, Antoine, Rudy, Drobecq, Hervé, Locht, Camille, Jacob-Dubuisson, Françoise

Proteins of Gram-negative bacteria destined to the extracellular milieu must cross the two cellular membranes and then fold at the appropriate time and place. The synthesis of a precursor may be a...

Overrepresentation of a Gene Family Encoding Extracytoplasmic Solute Receptors in Bordetella

Antoine, Rudy, Jacob-Dubuisson, Françoise, Drobecq, Hervé, Willery, Eve, Lesjean, Sarah, Locht, Camille

A family of genes that are likely to encode extracytoplasmic solute receptors is strongly overrepresented in several β-proteobacteria, including Bordetella pertussis. This gene family, of which...

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway

Clantin, Bernard, Hodak, Hélène, Willery, Eve, Locht, Camille, Jacob-Dubuisson, Françoise, Villeret, Vincent

Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is...

Role of Adhesin Release for Mucosal Colonization by a Bacterial Pathogen

Coutte, Loïc, Alonso, Sylvie, Reveneau, Nathalie, Willery, Eve, Quatannens, Brigitte, Locht, Camille, ...

Pathogen attachment is a crucial early step in mucosal infections. This step is mediated by important virulence factors called adhesins. To exert these functions, adhesins are typically...

Molecular Evolution of the Two-Component System BvgAS Involved in Virulence Regulation in Bordetella

Herrou, Julien, Debrie, Anne-Sophie, Willery, Eve, Renaud-Mongénie, Geneviève, Locht, Camille, Mooi, Frits, ...

The whooping cough agent Bordetella pertussis is closely related to Bordetella bronchiseptica, which is responsible for chronic respiratory infections in various mammals and is occasionally found in...