Global Sensitivity Analysis of Biochemical Reaction Networks via Semidefinite Programming (2009)
Steffen Waldherr, Rolf Findeisen, Frank Allgöwer
Abstract: We study the problem of computing outer bounds for the region of steady states of biochemical reaction networks modelled by ordinary differential equations, with respect to parameters that...
Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach (2009)
Witt, Johannes, Barisic, Sandra, Schumann, Eva, Allgöwer, Frank, Sawodny, Oliver, Sauter, Thomas, ...
Abstract Background Biological effects of nuclear factor-κB (NFκB) can differ tremendously depending on the cellular context. For example, NFκB induced by interleukin-1 (IL-1) is converted from an...
Estimation of biochemical network parameter distributions in cell populations (2009)
Waldherr, Steffen, Hasenauer, Jan, Allgöwer, Frank
Populations of heterogeneous cells play an important role in many biological systems. In this paper we consider systems where each cell can be modelled by an ordinary differential equation. To...
Global Sensitivity Analysis of Biochemical Reaction Networks via Semidefinite Programming (2009)
Waldherr, Steffen, Findeisen, Rolf, Allgöwer, Frank
We study the problem of computing outer bounds for the region of steady states of biochemical reaction networks modelled by ordinary differential equations, with respect to parameters that are...
Sampled-Data Model Predictive Control for Constrained Continuous Time Systems (2008)
Rolf Findeisen, Tobias Raff, Frank Allgöwer
Summary. Typically one desires to control a nonlinear dynamical system in an optimal way taking constraints on the states and inputs directly into account. Classically this problem falls into the...
Waldherr, Steffen, Allgöwer, Frank
Bifurcations leading to complex dynamical behaviour of non-linear systems are often encountered when the characteristics of feedback circuits in the system are varied. In systems with many unknown or...
Michael Ederer, Thomas Sauter, Eric Bullinger, Ernst-dieter Gilles, Frank Allgöwer, Michael Ederer, ...
On behalf of:
Output Feedback Stabilization with Nonlinear Predictive Control: Asymptotic properties (2008)
Lars Imsl, Rolf Findeisen, Frank Allgöwer, Bjarne A. Foss
State space based nonlinear model predictive control (NMPC) needs the state for the prediction of the system behavior. Unfortunately, for most applications, not all states are directly measurable. To...
Lars Imsl, Frank Allgöwer, Bjarne A. Foss
Abstract: In recent years, nonlinear model predictive control schemes have been derived that guarantee stability of the closed loop under the assumption of full state information. However, only...
Eissing, Thomas, Waldherr, Steffen, Allgöwer, Frank, Scheurich, Peter, Bullinger, Eric
Recently, a mathematical model of the mitochondrial apoptotic pathway was proposed. In that study, the robustness of different simplified signaling models with respect to parameter changes was also...
Steady state and (bi-) stability evaluation of simple protease signalling networks (2007)
Eissing, Thomas, Waldherr, Steffen, Allgöwer, Frank, Scheurich, Peter, Bullinger, Eric
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper understanding requires a system analysis. Important aspects are the number, location and stability of...
Results towards identifiability properties of biochemical reaction networks (2006)
Farina, Marcello, Findeisen, Rolf, Bullinger, Eric, Bittanti, Sergio, Allgöwer, Frank, Wellstead, Peter
45th IEEE Conf. on Decision and Control
Eissing, Thomas, Waldherr, Steffen, Gondro, Cedric, Bullinger, Eric, Sawodny, Oliver, Allgöwer, Frank, ...
Proc. of the IEEE Conference on Control Applications
Bullinger, Eric, Ilchmann, Achim, Allgöwer, Frank
In this paper we present an adaptive high-gain observer-based controller for linear, minimum-phase systems with known relative degree larger than one and known sign of the high-frequency gain. The...
A simple adaptive observer for nonlinear systems (2005)
Bullinger, Eric, Ilchmann, Achim, Allgöwer, Frank
In this note we present a high-gain observer for nonlinear uniformly observable SISO systems for which the high-gain parameter is determined adaptively on-line. The adaptation scheme is simple and...
High-gain adaptive λ-[lambda]-tracking for nonlinear systems (2005)
Ilchmann, Achim, Allgöwer, Frank, Ashman, Jon
It is shown that a simple modification (introducing a dead zone in the adaptation law) of the known adaptive high-gain control strategy u(t) = -k(t)y(t), k(t) = ||y(t)||2 yields lambda-tracking in...
Adaptive lambda-tracking for nonlinear higher relative degree systems (2005)
Bullinger, Eric, Allgöwer, Frank
This paper proposes a relatively simple adaptive controller for nonlinear systems with higher relative degree. The controller achieves lambda-tracking for a large class of nonlinear systems, i.e. it...
Eißing, Thomas, Allgöwer, Frank, Bullinger, Eric
Analyses of different robustness aspects for models of the direct signal transduction pathway of receptor-induced apoptosis is presented. Apoptosis is a form of programmed cell death, removing...
Tilebein, Meike, Allgöwer, Frank, Fritsch, Dieter, Buhlmann, Bettina, Gilles, Ernst-Dieter, Banzhaf, Wolfgang, ...
Inhalt: Tilebein, Meike (Universität Stuttgart, Betriebswirtschaftliches Institut): Vorwort der Vorsitzenden des Vereins Alumni des Studiengangs Technische Kybernetik der Universität Stuttgart e....
Schneller sehen durch Regelungstechnik - Moderne Bildgebung in der Nanotechnologie (2004)
Rieber, Jochen M., Allgöwer, Frank, Stemmer, Andreas
Die Nanotechnologie, also die Wissenschaft von Untersuchungen und Manipulationen im Nanometermaßstab, wird als eine der Schlüsseltechnologien des 21. Jahrhunderts angesehen. Wichtige Komponenten...
Tilebein, Meike, Allgöwer, Frank, Fritsch, Dieter, Buhlmann, Bettina, Gilles, Ernst-Dieter, Banzhaf, Wolfgang, ...
Inhalt: Tilebein, Meike (Universität Stuttgart, Betriebswirtschaftliches Institut): Vorwort der Vorsitzenden des Vereins Alumni des Studiengangs Technische Kybernetik der Universität Stuttgart e....
Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Bullinger, Eric, Allgöwer, Frank, Gilles, Ernst Dieter
Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain...
Bistability analyses of a caspase activation model for receptor-induced apoptosis (2004)
Eissing, Thomas, Conzelmann, Holger, Gilles, Ernst Dieter, Allgöwer, Frank, Bullinger, Eric, Scheurich, Peter
Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed...
Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J, Sauter, Thomas, Bullinger, Eric, ...
A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...
Schumm, Peter, Bullinger, Eric, Schweickhardt, Tobias, Allgöwer, Frank
Since a few years high-schools are testing the use of notebooks for teaching purposes and already use them quite successfully. A new approach is to use them also for academic education. In the first...
Imsland, Lars, Findeisen, Rolf, Bullinger, Eric, Allgöwer, Frank, Foss, Bjarne A
In recent years. nonlinear model predictive control (NMPC) schemes have been derived that guarantee stability of the closed loop under the assumption of full state information. However, only limited...
An approach for dividing models of biological reaction networks into functional units (2003)
Ederer, Michael, Sauter, Thomas, Bullinger, Eric, Gilles, E. D., Allgöwer, Frank
Biological reaction networks consist of many substances and reactions between them. Like many other biological systems, they have a modular structure. Therefore, a division of a biological reaction...
Der Einsatz neuer Medien in der regelungstechnischen Ausbildung (2003)
Schumm, Peter, Bullinger, Eric, Schweickhardt, Tobias, Allgöwer, Frank
GMA-Kongress
Moritz Diehl, Ilknur Uslu, Rolf Findeisen, Stefan Schwarzkopf, Frank Allgöwer, H. Georg Bock, ...
The purpose of this paper is an experimental proof-of-concept of the application of NMPC for large scale systems using specialized dynamic optimization strategies. For this aim we investigate the...
Nonlinear Model Predictive Control (2000)
Frank Allgöwer, Rolf Findeisen, Zoltan Nagy, Moritz Diehl, Georg Bock, Johannes Schlöder
Abstract. In the past decade the field of nonlinear model predictive control (NMPC) has witnessed steadily increasing attention from control practitioners. Its popularity comes from the fact that...
Bullinger, Eric, Ilchmann, Chim, Allgöwer, Frank
Beijing
H_{infty} Control of Differential-Algebraic-Equation Systems (1998)
In this paper $H_{infty}$ control of high index and non-regularlinear differential-algebraic-equationsystems is addressed. Based on a generalization of the bounded real lemma (BRL)to index one...
H_{infty} Control of Differential-Algebraic-Equation Systems (1998)
In this paper $H_{infty}$ control of high index and non-regular linear differential-algebraic-equation systems is addressed. Based on a generalization of the bounded real lemma (BRL) to index one...
A simple adaptive observer for nonlinear systems (1998)
Bullinger, Eric, Ilchmann, Achim, Allgöwer, Frank
Proc. of the IFAC Nonlinear Control Systems Design, NOLCOS98
An adaptive high-gain observer for nonlinear systems (1997)
Bullinger, Eric, Allgöwer, Frank
Proc. of the 36th IEEE Conf. on Decision and Control
Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J., Sauter, Thomas, Bullinger, Eric, ...
A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...
Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J., Sauter, Thomas, Bullinger, Eric, ...
A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...