G. Leroux-Roels

Detection of Mumps Virus-specific Memory B cells by Transfer of Peripheral Blood Mononuclear Cells into Immune Deficient Mice (2010)

Vandermeulen, Corinne; U0008175 JFA; CORA, Verhoye, L, Vaidya, S, Clement, F, Brown, K, Hoppenbrouwers, Karel; U0012253 ;, ...

Lange termijnbescherming na bofvaccinatie: memory is not forever (2009)

Vandermeulen, Corinne; U0008175 JFA; CORA, Leroux-Roels, G, Van Damme, P, Hoppenbrouwers, Karel; U0012253 ;

Comparison of serum humoral responses induced by oral immunization with the hepatitis B virus core antigen and the cholera toxin B subunit (2008)

Broos, K., Janssens, M. E., De Goeyse, I., Vanlandschoot, P., Leroux-Roels, G., Geysen, D., ...

The hepatitis B virus core (HBc) virus-like particle (VLP) is known as one of the most immunogenic antigens and carrier vehicles in different immunization strategies. Recent findings are suggesting...

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients (2007)

Steyaert, S., Heyndrickx, L., Verhoye, L., Vermoesen, T., Donners, H., Fransen, K., ...

Although a limited number of HIV-infected patients have broadly neutralizing antibodies, it has not been examined whether these antibodies can protect against infection with primary virus in vivo....

The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection (2007)

Steyaert, S., Verhoye, L., Beirnaert, E., Donners, H., Fransen, K., Heyndrickx, L., ...

The intrasplenic injection of human peripheral blood mononuclear cells (PBMCs) into severely immune deficient NOD/SCID mice, causes a massive and transient dominant expansion of human B cells in the...

A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers (2004)

Leroux-Roels, G, Depla, E, Hulstaert, F, Tobback, L, Dincq, S, Desmet, J, ...

The tolerability and immunogenicity of the hepatitis C virus E1 protein as a candidate vaccine was examined in a Phase I, single-arm study. Twenty healthy male volunteers were injected in the deltoid...

The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level (2004)

Desombere, I ; JFA; CORA, Meuleman, P, Rigole, H, Willems, An; U0044012 ;, Irsch, J, Leroux-Roels, G

Different single-cell analyses for the detection of antigen-specific T cells based on antigen-triggered induction of cytokine production (elispot, intracellular cytokine staining, cytokine secretion...

Virological and morphological characterization of HBV and HCV infections in human liver-UPA-SCID mice (2004)

Meuleman, P, Libbrecht, Louis; U0004659, De Vos, Rita; U0012983, Roskams, Tania; U0007204, Leroux-Roels, G

Morphological and biochemical characterization of a human liver in uPA-scid mouse chimera (2004)

Meuleman, P, Libbecht, L, De Vos, Rita; U0012983, Roskams, Tania; U0007204, Leroux-Roels, G

Improvement in liver histology after 3 years of E1 therapeutic vaccination in 23 patients with chronic hepatitis C (2004)

Nevens, Frederik; U0014330 JFA; CORA, Roskams, Tania; U0007204, Van Vlierberghe, H, Horsmans, Y, Sprengers, D, Elewaut, A, ...

Daily induction combination treatment with alpha 2b interferon and ribavirin or standard combination treatment in naive chronic hepatitis C patients. A multicentre randomized controlled trial (2003)

Van Vlierberghe, H, Leroux-Roels, G, Adler, M, Bourgeois, N, Nevens, Frederik; U0014330 ;, Horsmans, Y, ...

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the...

The immunogenicity and reactogenicity profile of a candidate hepatitis B vaccine in an adult vaccine non-responder population (2002)

Jacques, P ; JFA; CORA, Moens, Guido; U0012035 ;, Desombere, I, Dewijngaert, J, Leroux-Roels, G, Wettendorff, M, ...

Approximately 5% of vaccinees display an inadequate response after the administration of the standard three dose hepatitis B vaccine. A new hepatitis B vaccine (HBsAg/AS04) formulated with the...

Human B cell growth and differentiation in the spleen of immunodeficient mice (2001)

Depraetere, S ; JFA; CORA, Verhoye, L, Leclercq, G, Leroux-Roels, G

Human mAbs (HumAbs) have therapeutic potential against infectious diseases and cancer, Heretofore, their production has been hampered by ethical constraints preventing the isolation of Ag-specific...

Long term response to interferon treatment in chronic hepatitis C patients is associated with a significant reduction in anti-E1 envelope antibody titers (2000)

Depraetere, S ; JFA; CORA, Van Kerschaever, E, Vlierberghe, HV, Elewaut, A, Brouwer, JT, Niesters, HGM, ...

Interferon (IFN) alfa has been used widely for the treatment of chronic hepatitis C virus (HCV) infections but only a small number of patients treated have shown a sustained biochemical and...

A hepatitis B vaccine with a novel adjuvant: immunogenicity and reactogenicity profile in adult vaccine nonresponders (1999)

Jacques, P, Moens, G, Desombere, I, Dewijngaert, J, Leroux-Roels, G, Thiriart, C, ...

MN blood group, a genetic marker for essential arterial hypertension in young adults (1995)

DELANGHE, J., DUPREZ, D., BUYZERE, M. DE, ROBBRECHT, D., BERGEZ, B., LEROUX-ROELS, G., ...

The MN blood group has been linked with blood pressure levels and sodium-lithium counter-transport in red blood cells of normotensives. The aim of the study was to compare the distribution of MN...

Fibrinolysis and coagulation in patients with infectious disease and sepsis (1991)

Philippé, J ; JFA; CORA, Offner, F, Declerck, Paul; U0003845 ;, Leroux-Roels, G, Vogelaers, D, Baele, G, ...

Sepsis is often associated with hemostatic dysfunction. This study aimed to relate changes in fibrinolysis and coagulation parameters to sepsis and sepsis outcome. Urokinase-type plasminogen...