Vegter, S., Perna, A., Hiddema, W., Ruggenenti, P., Remuzzi, G., Navis, G., ...
Introduction End-stage renal disease is associated with high health-care costs and low quality of life compared with chronic kidney disease. The renoprotective effectiveness of angiotensin-converting...
Karpman, D, Landau, D, Loirat, C, Remuzzi, G, ...
The diagnostic terms hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are based on historical and overlapping clinical descriptions. Advances in understanding some of the...
Dual Kidney Transplantation (2004)
I. Codreanu, P. Cravedi, G. Remuzzi, P. Ruggenenti
Organ availability still represents a major problem for renal transplantation programs. The number of patients awaiting transplantation greatly exceeds the available donor organs, and this...
Dual Kidney Transplantation (2004)
I. Codreanu, P. Cravedi, G. Remuzzi, P. Ruggenenti
Organ availability still represents a major problem for renal transplantation programs. The number of patients awaiting transplantation greatly exceeds the available donor organs, and this...
Molecular Basis of Familial Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome (2003)
Direct podocyte damage in the single nephron leads to albuminuria in vivo (1995)
Battaglia, C, Foglieni, C, Malanchini, B, Van Damme, B, ...
The hypothesis that detachment of podocytes leads to albuminuria was tested by studying the single nephron albuminuria in vivo after injecting a saponin solution (0.6 mg/ml) in Bowman's space of...
Direct podocyte damage leads to in-vivo single nephron albuminuria (1995)
Laurens, W, Battaglia, C, Foglieni, C, Malanchini, B, Vandamme, B, ...
C. Zoja, A. Benigni, G. Piccinini, M. Figliuzzi, L. Longaretti, G. Remuzzi
The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the...
Wang, J M, Bettoni, S, Sironi, M, Renzi, D, Chiaffarino, F, ...
The capacity of human cultured mesangial cells to produce soluble factors potentially relevant for mechanisms of inflammation and immunity at the glomerular site was analyzed. The nature of the...
Viganò, G., Gotti, E., Comberti, E., Giangrande, A., Trevisan, R., Remuzzi, G.
Patients with chronic renal failure suffer from secondary hyperparathyroidism and have greatly increased blood concentrations of intact parathyroid hormone (PTH) and PTH fragments. Thus PTH has been...
Remuzzi, A, Puntorieri, S, Battaglia, C, Bertani, T, Remuzzi, G
The effect of enalapril on glomerular hemodynamics and permselectivity and on subsequent sclerosis was studied in male MWF/Ztm rats which spontaneously develop proteinuria and glomerular structural...
Role of endothelium-derived nitric oxide in the bleeding tendency of uremia.
Remuzzi, G, Perico, N, Zoja, C, Corna, D, Macconi, D, Viganò, G
Endothelium-derived relaxing factor, now identified as nitric oxide (NO), is a labile humoral agent formed by vascular endothelial cells from L-arginine. NO mediates the action of substances that...
Remuzzi, G, Imberti, L, Rossini, M, Morelli, C, Carminati, C, Cattaneo, G M, ...
Altered glomerular metabolism of arachidonic acid (AA) has already been demonstrated in experimental nephrotoxic nephritis. The enhanced synthesis of thromboxane A2 (TxA2) in isolated glomeruli that...
Patrono, C, Ciabattoni, G, Remuzzi, G, Gotti, E, Bombardieri, S, Di Munno, O, ...
We have examined the urinary excretion of stable immunoreactive eicosanoids in 23 female patients with systemic lupus erythematosus (SLE), 16 patients with chronic glomerular disease (CGD), and 20...
Gaspari, F, Viganò, G, Orisio, S, Bonati, M, Livio, M, Remuzzi, G
We reported that aspirin (ASA) abnormally prolongs bleeding time (BT) in uremia. The present study was designed to investigate whether the abnormally prolonged post-ASA BT in uremia is due to...
Reduced Platelet Thromboxane Formation in Uremia. EVIDENCE FOR A FUNCTIONAL CYCLOOXYGENASE DEFECT
Remuzzi, G., Benigni, A., Dodesini, P., Schieppati, A., Livio, M., De Gaetano, G., ...
A qualitative platelet abnormality and a bleeding tendency are frequently associated with renal failure and uremia. We demonstrated previously that uremic patients display an abnormal platelet...
Morigi, M, Angioletti, S, Imberti, B, Donadelli, R, Micheletti, G, Figliuzzi, M, ...
We addressed the role of hyperglycemia in leukocyte-endothelium interaction under flow conditions by exposing human umbilical vein endothelial cells for 24 h to normal (5 mM), high concentration of...
Intermittent heparin treatment does not induce hypercoagulability in haemodialysed patients.
Pusineri, F, Bini, A, Mussoni, L, Remuzzi, G, Donati, M B
Antithrombin-III (AT-III) and factor VIII coagulant (F VIII:C) and antigenic (F VIII:RA) activities have been studied in nine conservatively treated and 26 dialysed uraemic patients. AT-III levels...
Haemolytic uraemic syndrome: therapeutic effect of plasma infusion.
Misiani, R, Appiani, A C, Edefonti, A, Gotti, E, Bettinelli, A, Giani, M, ...
The therapeutic effect of plasma infusion was evaluated in 10 children and seven adults with haemolytic uraemic syndrome. All but one patient responded to this treatment with rapid disappearance of...
Plasmatic regulation of vascular prostacyclin in pregnancy.
Remuzzi, G, Zoja, C, Marchesi, D, Schieppati, A, Mecca, G, Misiani, R, ...
Activity of prostacyclin-stimulating factor was measured in six normal, non-pregnant women, six women in early normal pregnancy, six in late normal pregnancy, and six in late pregnancy complicated by...
Remuzzi, G, Bertani, T, Mecca, G, Donati, M B, De Gaetano, G
To determine whether the prolonged bleeding time so common to chronic renal failure (CRF) was due to defective factor VIII-related activities, as in von Willebrand's disease, vascular-factor...
Bleeding in renal failure: is von Willebrand factor implicated?
Remuzzi, G, Livio, M, Roncaglioni, M C, Mecca, G, Donati, M B, De Gaetano, G
Normal or increased concentrations of factor VIII procoagulant activity (VIIIC), factor VIII-related antigen (VIIIRA), and factor VIII-von Willebrand activity (VIIIVWF) were found in the predialysis...
Remuzzi, A, Puntorieri, S, Battaglia, C, Bertani, T, Remuzzi, G
The effect of enalapril on glomerular hemodynamics and permselectivity and on subsequent sclerosis was studied in male MWF/Ztm rats which spontaneously develop proteinuria and glomerular structural...
Role of endothelium-derived nitric oxide in the bleeding tendency of uremia.
Remuzzi, G, Perico, N, Zoja, C, Corna, D, Macconi, D, Viganò, G
Endothelium-derived relaxing factor, now identified as nitric oxide (NO), is a labile humoral agent formed by vascular endothelial cells from L-arginine. NO mediates the action of substances that...
Remuzzi, G, Imberti, L, Rossini, M, Morelli, C, Carminati, C, Cattaneo, G M, ...
Altered glomerular metabolism of arachidonic acid (AA) has already been demonstrated in experimental nephrotoxic nephritis. The enhanced synthesis of thromboxane A2 (TxA2) in isolated glomeruli that...
Patrono, C, Ciabattoni, G, Remuzzi, G, Gotti, E, Bombardieri, S, Di Munno, O, ...
We have examined the urinary excretion of stable immunoreactive eicosanoids in 23 female patients with systemic lupus erythematosus (SLE), 16 patients with chronic glomerular disease (CGD), and 20...
Gaspari, F, Viganò, G, Orisio, S, Bonati, M, Livio, M, Remuzzi, G
We reported that aspirin (ASA) abnormally prolongs bleeding time (BT) in uremia. The present study was designed to investigate whether the abnormally prolonged post-ASA BT in uremia is due to...
Reduced Platelet Thromboxane Formation in Uremia. EVIDENCE FOR A FUNCTIONAL CYCLOOXYGENASE DEFECT
Remuzzi, G., Benigni, A., Dodesini, P., Schieppati, A., Livio, M., De Gaetano, G., ...
A qualitative platelet abnormality and a bleeding tendency are frequently associated with renal failure and uremia. We demonstrated previously that uremic patients display an abnormal platelet...
Morigi, M, Angioletti, S, Imberti, B, Donadelli, R, Micheletti, G, Figliuzzi, M, ...
We addressed the role of hyperglycemia in leukocyte-endothelium interaction under flow conditions by exposing human umbilical vein endothelial cells for 24 h to normal (5 mM), high concentration of...
Intermittent heparin treatment does not induce hypercoagulability in haemodialysed patients.
Pusineri, F, Bini, A, Mussoni, L, Remuzzi, G, Donati, M B
Antithrombin-III (AT-III) and factor VIII coagulant (F VIII:C) and antigenic (F VIII:RA) activities have been studied in nine conservatively treated and 26 dialysed uraemic patients. AT-III levels...
Haemolytic uraemic syndrome: therapeutic effect of plasma infusion.
Misiani, R, Appiani, A C, Edefonti, A, Gotti, E, Bettinelli, A, Giani, M, ...
The therapeutic effect of plasma infusion was evaluated in 10 children and seven adults with haemolytic uraemic syndrome. All but one patient responded to this treatment with rapid disappearance of...
Plasmatic regulation of vascular prostacyclin in pregnancy.
Remuzzi, G, Zoja, C, Marchesi, D, Schieppati, A, Mecca, G, Misiani, R, ...
Activity of prostacyclin-stimulating factor was measured in six normal, non-pregnant women, six women in early normal pregnancy, six in late normal pregnancy, and six in late pregnancy complicated by...
Remuzzi, G, Bertani, T, Mecca, G, Donati, M B, De Gaetano, G
To determine whether the prolonged bleeding time so common to chronic renal failure (CRF) was due to defective factor VIII-related activities, as in von Willebrand's disease, vascular-factor...
Bleeding in renal failure: is von Willebrand factor implicated?
Remuzzi, G, Livio, M, Roncaglioni, M C, Mecca, G, Donati, M B, De Gaetano, G
Normal or increased concentrations of factor VIII procoagulant activity (VIIIC), factor VIII-related antigen (VIIIRA), and factor VIII-von Willebrand activity (VIIIVWF) were found in the predialysis...
Bruzzi, I., Corna, D., Zoja, C., Orisio, S., Schiffrin, E. L., Cavallotti, D., ...
Experimental and human proteinuric glomerulopathies are associated with tubulo-interstitial injury that correlates with the decline of renal function even better than glomerular lesions do....
Tumor necrosis factor induces glomerular damage in the rabbit.
Bertani, T., Abbate, M., Zoja, C., Corna, D., Perico, N., Ghezzi, P., ...
Tumor necrosis factor (TNF) is a polypeptide hormone produced by activated macrophages detectable in the circulation of experimental animals given endotoxin. Recent evidence strongly suggests that...
Zoja, C., Benigni, A., Livio, M., Bergamelli, A., Orisio, S., Abbate, M., ...
Rats with extensive renal mass reduction develop hypertension, proteinuria and progressive glomerulosclerosis. Previous studies have demonstrated that these changes are associated with an increased...
Renal injury induced by long-term administration of cyclosporin A to rats.
Bertani, T., Perico, N., Abbate, M., Battaglia, C., Remuzzi, G.
Chronic administration of cyclosporin A (CyA) to animals and humans results in renal damage characterized by tubulointerstitial lesions and renal insufficiency. This nephrotoxicity limits the use of...
Severe glomerular epithelial cell damage does not prevent passive Heyman nephritis in rats.
Bertani, T, Remuzzi, G, Poggi, A, Delaini, F, Sacchi, G, Morassi, L, ...
Passive Heymann nephritis (PHN) is an experimental model of membranous glomerulopathy in the rat ascribed to in situ formation of immune complexes. Very recently the demonstration that the...
Zoja, C., Benigni, A., Piccinini, G., Figliuzzi, M., Longaretti, L., Remuzzi, G.
The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the...
Genetic and acquired abnormalities in complement factor H (CFH) have been associated with two different human renal diseases: haemolytic uraemic syndrome and membrano proliferative...
Ruggenenti, P., Gaspari, F., Perna, A., Remuzzi, G.
OBJECTIVE: To evaluate whether the protein:creatinine ratio in spot morning urine samples is a reliable indicator of 24 hour urinary protein excretion and predicts the rate of decline of glomerular...