Lippert, E., Falk, W., Bataille, F., Kaehne, T., Naumann, M., Goeke, M., ...
BACKGROUND: Colonic lamina propria fibroblasts (CLPFs) play an important role in the pathogenesis of fibrosis and strictures in Crohn's disease. AIM: To identify colonic epithelial cell (CEC)-derived...
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.
Brand, K, Page, S, Rogler, G, Bartsch, A, Brandl, R, Knuechel, R, ...
Nuclear factor-kappa B (NF-kappaB)/Rel transcription factors play an important role in the inducible regulation of a variety of genes involved in the inflammatory and proliferative responses of...
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.
Brand, K, Page, S, Rogler, G, Bartsch, A, Brandl, R, Knuechel, R, ...
Nuclear factor-kappa B (NF-kappaB)/Rel transcription factors play an important role in the inducible regulation of a variety of genes involved in the inflammatory and proliferative responses of...
Daig, R, Rogler, G, Aschenbrenner, E, Vogl, D, Falk, W, Gross, V, ...
BACKGROUND—There is growing evidence that intestinal epithelial cells (IECs) are involved in the mucosal immune system. AIM—To assess the pattern of cytokines secreted by IECs and lamina...
Gelbmann, C M, Leeb, S N, Vogl, D, Maendel, M, Herfarth, H, Schölmerich, J, ...
Background: CD40 has been shown to be a functional activation antigen on a variety of cell types involved in immune responses. As intestinal fibroblasts and myofibroblasts may play a role during...
Cathepsin D is up-regulated in inflammatory bowel disease macrophages
HAUSMANN, M, OBERMEIER, F, SCHREITER, K, SPOTTL, T, FALK, W, SCHÖLMERICH, J, ...
Down-regulation of receptors involved in the recognition or transmission of inflammatory signals and a reduced responsiveness support the concept that macrophages are ‘desensitized’ during their...
Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis
Paul, G, Bataille, F, Obermeier, F, Bock, J, Klebl, F, Strauch, U, ...
Haem-oxygenase-1 (HO-1) has been shown to exert anti-inflammatory, anti-apoptotic and anti-proliferative effects. We investigated HO-1 expression in patients with inflammatory bowel disease (IBD) and...
Isolation and phenotypic characterization of colonic macrophages
Rogler, G, Hausmann, M, Vogl, D, Aschenbrenner, E, Andus, T, Falk, W, ...
Macrophages play an important role in the intestinal mucosal immune system. However, they are a poorly defined cell population. We therefore determined their phenotype in normal colonic mucosa....
Herfarth, H, Brand, K, Rath, H C, Rogler, G, Schölmerich, J, Falk, W
In acute DSS-induced colitis nuclear factor (NF)-κ B-dependent inflammatory cytokines including IL-1 and tumour necrosis factor-alpha (TNF-α) are up-regulated. Here we examined the effects of...
Hausmann, M, Spöttl, T, Andus, T, Rothe, G, Falk, W, Schölmerich, J, ...
Macrophages play a central role during the pathogenesis of inflammation. In normal intestinal mucosa surface expression of typical macrophage markers such as CD14, CD16, CD11b or T-cell...
Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes
Spoettl, T, Hausmann, M, Herlyn, M, Gunckel, M, Dirmeier, A, Falk, W, ...
Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated...
Morphological characterisation of Crohn’s disease fistulae
Bataille, F, Klebl, F, Rümmele, P, Schroeder, J, Farkas, S, Wild, P-J, ...
Background: Fistulae are a common complication in up to 35% of all patients with Crohn’s disease. Their therapy is difficult and frequently unsatisfactory. To date, no histological comparison of...
Menzel, K, Hausmann, M, Obermeier, F, Schreiter, K, Dunger, N, Bataille, F, ...
The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shown...
Schreyer, A G, Rath, H C, Kikinis, R, Völk, M, Schölmerich, J, Feuerbach, S, ...
Aim: Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatory...
Hausmann, M, Obermeier, F, Paper, D H, Balan, K, Dunger, N, Menzel, K, ...
Recently we demonstrated that in inflammatory bowel disease (IBD) macrophage-oxidative burst activity is increased and NADPH oxidase mRNA is induced. The herbal phenylethanoid acteoside isolated from...
Schreiter, K, Hausmann, M, Spoettl, T, Strauch, U G, Bataille, F, Schoelmerich, J, ...
Background: The glycoprotein (gp) 96 links the adaptive with the innate immune system. It is a chaperone with a binding domain for peptides generated by proteasomal degradation. During cellular...
Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammation
Lippert, E, Gunckel, M, Brenmoehl, J, Bataille, F, Falk, W, Scholmerich, J, ...
Recently we identified galectin-3 (gal-3), which is secreted by colonic epithelial cells (CEC), to be a strong activator of colonic lamina propria fibroblasts (CLPF). Modulation of CLPF function may...
Hausmann, M, Paul, G, Kellermeier, S, Frey, I, Schölmerich, J, Falk, W, ...
Haem oxygenase-1 (HO-1) up-regulation was suggested to reduce mucosal tissue damage in inflammatory bowel disease (IBD) and an up-regulation of HO-1 expression in patients with Crohn's disease (CD)...
Significance of anti‐inflammatory effects of PPARγ agonists?
Peroxisome proliferator activated receptor γ expression in mucosal epithelial cells seems to be crucial for its anti‐inflammatory effects with respect to experimental colitis, and for maintaining...