Seddon, B.M., Payne, G.S., Simmons, L., Ruddle, R., Grimshaw, R., Tan, S., ...
A Phase I study of SR-4554, a fluorinated 2-nitroimidazole noninvasive probe of tumor hypoxia detected by 19F magnetic resonance spectroscopy (MRS). Eight patients underwent pharmacokinetic studies,...
Seddon, B.M., Payne, G.S., Simmons, L., Ruddle, R., Grimshaw, R., Tan, S., ...
A Phase I study of SR-4554, a fluorinated 2-nitroimidazole noninvasive probe of tumor hypoxia detected by 19F magnetic resonance spectroscopy (MRS). Eight patients underwent pharmacokinetic studies,...
Seddon, B.M., Payne, G.S., Simmons, L., Ruddle, R., Grimshaw, R., Tan, S., ...
A Phase I study of SR-4554, a fluorinated 2-nitroimidazole noninvasive probe of tumor hypoxia detected by 19F magnetic resonance spectroscopy (MRS). Eight patients underwent pharmacokinetic studies,...
Yeast Gga Coat Proteins Function with Clathrin in Golgi to Endosome Transport (2001)
G. Costaguta, C. J. Stefan, E. S. Bensen, S. D. Emr, G. S. Payne
Gga proteins represent a newly recognized, evolutionarily conserved protein family with homology to the “ear ” domain of the clathrin adaptor AP-1 � subunit. Yeast cells contain two Gga...
Findlay, M. P. N., Leach, M. O., Cunningham, D., Collins, D. J., Payne, G. S., Glaholm, J., ...
Background: 5-Fluorouracil (5-FU) is the most widely used cytotoxic drug in oncology and the only one useful in the management of colorectal cancer - a leading cause of cancer death worldwide. Recent...
Yeast Gga Coat Proteins Function with Clathrin in Golgi to Endosome Transport
Costaguta, G., Stefan, C. J., Bensen, E. S., Emr, S. D., Payne, G. S.
Gga proteins represent a newly recognized, evolutionarily conserved protein family with homology to the “ear” domain of the clathrin adaptor AP-1 γ subunit. Yeast cells contain two Gga proteins,...
Redding, K, Seeger, M, Payne, G S, Fuller, R S
Localization of Kex2 protease (Kex2p) to the yeast trans-Golgi network (TGN) requires a TGN localization signal (TLS) in the Kex2p C-terminal cytosolic tail. Mutation of the TLS accelerates transport...
Munn, A L, Silveira, L, Elgort, M, Payne, G S
The gene encoding clathrin heavy chain in Saccharomyces cerevisiae (CHC1) is not essential for growth in most laboratory strains tested. However, in certain genetic backgrounds, a deletion of CHC1...
Genetic and biochemical characterization of clathrin-deficient Saccharomyces cerevisiae.
Payne, G S, Hasson, T B, Hasson, M S, Schekman, R
Clathrin is important but not essential for yeast cell growth and protein secretion. Diploid Saccharomyces cerevisiae cells heterozygous for a clathrin heavy-chain gene (CHC1) disruption give rise to...
Phan, H L, Finlay, J A, Chu, D S, Tan, P K, Kirchhausen, T, Payne, G S
Clathrin-associated protein (AP) complexes have been implicated in the assembly of clathrin coats and the selectivity of clathrin-mediated protein transport processes. We have identified a yeast...
The KEX2-encoded endoprotease of Saccharomyces cerevisiae resides in the Golgi complex where it participates in the maturation of alpha-factor mating pheromone precursor. Clathrin heavy chain gene...
A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast.
We have investigated the role of clathrin in vacuolar protein sorting using yeast strains harboring a temperature-sensitive allele of clathrin heavy chain (chc1-ts). After a 5 min incubation at the...
A novel structural model for regulation of clathrin function.
Pishvaee, B, Munn, A, Payne, G S
The distinctive triskelion shape of clathrin allows assembly into polyhedral lattices during the process of clathrin-coated vesicle formation. We have used random and site-directed mutagenesis of the...
Transport of yeast alkaline phosphatase (ALP) to the vacuole depends on the clathrin adaptor-like complex AP-3, but does not depend on proteins necessary for transport through pre-vacuolar endosomes....
Bensen, E S, Costaguta, G, Payne, G S
Clathrin is involved in selective protein transport at the Golgi apparatus and the plasma membrane. To further understand the molecular mechanisms underlying clathrin-mediated protein transport...
Yeast Gga Coat Proteins Function with Clathrin in Golgi to Endosome Transport
Costaguta, G., Stefan, C. J., Bensen, E. S., Emr, S. D., Payne, G. S.
Gga proteins represent a newly recognized, evolutionarily conserved protein family with homology to the “ear” domain of the clathrin adaptor AP-1 γ subunit. Yeast cells contain two Gga proteins,...
Redding, K, Seeger, M, Payne, G S, Fuller, R S
Localization of Kex2 protease (Kex2p) to the yeast trans-Golgi network (TGN) requires a TGN localization signal (TLS) in the Kex2p C-terminal cytosolic tail. Mutation of the TLS accelerates transport...
Munn, A L, Silveira, L, Elgort, M, Payne, G S
The gene encoding clathrin heavy chain in Saccharomyces cerevisiae (CHC1) is not essential for growth in most laboratory strains tested. However, in certain genetic backgrounds, a deletion of CHC1...
Genetic and biochemical characterization of clathrin-deficient Saccharomyces cerevisiae.
Payne, G S, Hasson, T B, Hasson, M S, Schekman, R
Clathrin is important but not essential for yeast cell growth and protein secretion. Diploid Saccharomyces cerevisiae cells heterozygous for a clathrin heavy-chain gene (CHC1) disruption give rise to...
Phan, H L, Finlay, J A, Chu, D S, Tan, P K, Kirchhausen, T, Payne, G S
Clathrin-associated protein (AP) complexes have been implicated in the assembly of clathrin coats and the selectivity of clathrin-mediated protein transport processes. We have identified a yeast...
The KEX2-encoded endoprotease of Saccharomyces cerevisiae resides in the Golgi complex where it participates in the maturation of alpha-factor mating pheromone precursor. Clathrin heavy chain gene...
A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast.
We have investigated the role of clathrin in vacuolar protein sorting using yeast strains harboring a temperature-sensitive allele of clathrin heavy chain (chc1-ts). After a 5 min incubation at the...
A novel structural model for regulation of clathrin function.
Pishvaee, B, Munn, A, Payne, G S
The distinctive triskelion shape of clathrin allows assembly into polyhedral lattices during the process of clathrin-coated vesicle formation. We have used random and site-directed mutagenesis of the...
Transport of yeast alkaline phosphatase (ALP) to the vacuole depends on the clathrin adaptor-like complex AP-3, but does not depend on proteins necessary for transport through pre-vacuolar endosomes....
Bensen, E S, Costaguta, G, Payne, G S
Clathrin is involved in selective protein transport at the Golgi apparatus and the plasma membrane. To further understand the molecular mechanisms underlying clathrin-mediated protein transport...
Smith, T. A., Glaholm, J., Leach, M. O., Machin, L., Collins, D. J., Payne, G. S., ...
An in vivo 31P NMR spectrum was obtained from each of four human breast tumours. The phosphomonoester and phosphodiester region of each spectrum consisted of a broad peak. Chemical extracts from...