3D COMPUTER MODEL OF HUMAN ATRIAL ANATOMY AND ELECTROPHYSIOLOGY (2009)
C. Höper, G. Seemann, F. B. Sachse, H. Zhang, O. Dössel
models of human atria are of interest in cardiology. The developed 3D anatomical model incorporates different atrial tissue, such as crista terminalis, pectinate muscles and Bachmann´s bundle, as...
Dl Weiss, G Seemann, Fb Sachse, O Doessel
Genetically engineered cardiac pacemakers are a proposed alternative or support to the state-of-the-art electronic devices. Down-regulation of the expression of Kir2.1 channels reduces the activity...
Towards the numerical simulation of electrocardiograms (2008)
Muriel Boulakia, Nejib Zemzemi, F. B. Sachse, G. Seemann
Abstract. We present preliminary results of the numerical simulation of electrocardiograms (ECG). We consider the bidomain equations to model the electrical activity of the heart and a Laplace...
Hassel, D, Scholz, E P, Trano, N, Friedrich, O, Just, S, Meder, B, ...
Simulating the Excitation Propagation in Mechano-Electrical Models of (2007)
Myocardial Cells, Fb Sachse, C Riedel, G Seemann, Cd Werner, O D Ossel
A three dimensional model of a myocardial area is presented, which allows the simulation of electrical excitation propagation under the influence of stretch. The model is based on a modified...
Stretch Activated ION Channels in Myocytes: Parameter Estimation, Simulations and Phenomena (2003)
Sachse, F. B., Riedel, C., Seemann, G., Werner, C. D.
Mechanosensitive ion channels influence the electrophysiological state of cardiac myocytes. An examination of the mechanisms of mechano-electrical coupling on cellular level by the mechanosensitive...
Grunicke, Hans, Stoeck, Michael, Elsner, J., Seemann, G., Pfeiffer, C., Wegmann, B., ...
Peer Reviewed
Characterisation of a humanised bispecific monoclonal antibody for cancer therapy.
Bruynck, A., Seemann, G., Bosslet, K.
A humanised bispecific monoclonal antibody (bsMAb) with binding specificity for carcinoembryonic antigen (CEA) on one arm and a radiolabelled chelate (DTPA-90Y) on the other arm was generated by...
Generation of bispecific monoclonal antibodies for two phase radioimmunotherapy.
Bosslet, K., Steinstraesser, A., Hermentin, P., Kuhlmann, L., Bruynck, A., Magerstaedt, M., ...
A two phase radioimmunotherapy based on bispecific MAbs in which one arm recognises a tumour antigen and the other a radiolabelled chelate, may prove more effective in the treatment of carcinomas...
Bosslet, K., Czech, J., Lorenz, P., Sedlacek, H. H., Schuermann, M., Seemann, G.
A fusion protein consisting of the humanised Fab fragment of the anti CEA MAb BW 431 and the human beta-glucuronidase was expressed in BHK cells. Functional testing revealed that the specificity and...