Secondary Outcomes of a Pilot Randomized Trial of Azithromycin Treatment for Asthma (2006)
David L. Hahn, Mary Beth Plane, Olaimatu S. Mahdi, Gerald I. Byrne
Objectives:The respiratory pathogen Chlamydia pneumoniae (C. pneumoniae) produces acute and chronic lung infections and is associated with asthma. Evidence for effectiveness of antichlamydial...
Chlamydial and Rickettsial Infections, (1998)
There is no more challenging dilemma than that presented to mammalian hosts by infection with chlamydiae and rickettsiae. These pathogens have adopted specialised mechanisms to assure satisfaction of...
Typescript.
Kane, Colleen D., Vena, Renee M., Ouellette, Scot P., Byrne, Gerald I.
Gamma interferon (IFN-γ) is an important factor in the modulating inhibition of intracellular chlamydial growth and persistence. In human epithelial cells and macrophages, this inhibition is the...
Ramsey, Kyle H., Cotter, Todd W., Salyer, Rena D., Miranpuri, Gurwattan S., Yanez, Michael A., Poulsen, Christoffer E., ...
We sought to assess the degree of cross-protective immunity in a mouse model of chlamydial genital tract infection. Following resolution of genital infection with the mouse pneumonitis (MoPn) biovar...
LaVerda, David, Albanese, Lisa N., Ruther, Paul E., Morrison, Sandra G., Morrison, Richard P., Ault, Kevin A., ...
We have identified the chlamydial heat shock protein Hsp10 as a potential correlate to the immunopathogenic process in women with tubal factor infertility (TFI). The human serologic response to...
Ramsey, Kyle H., Miranpuri, Gurwattan S., Sigar, Ira M., Ouellette, Scott, Byrne, Gerald I.
It was previously reported that female mice resolve a primary Chlamydia trachomatis urogenital infection independent of inducible nitric oxide synthase (iNOS). We now report that although...
Byrne, Gerald I., Ouellette, Scot P., Wang, Zhao, Rao, J. P., Lu, Lin, Beatty, Wandy L., ...
Chlamydia pneumoniae causes community-acquired pneumonia and is associated with several chronic diseases, including asthma and atherosclerosis. The intracellular growth rate of C. pneumoniae slows...
Ramsey, Kyle H., Miranpuri, Gurwattan S., Poulsen, Christoffer E., Marthakis, Nancy B., Braune, Laima M., Byrne, Gerald I.
Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma...
Kane, Colleen D., Byrne, Gerald I.
The effects of gamma interferon (IFN-γ) on Chlamydia trachomatis growth in polarized epithelial cells were examined. The range of IFN-γ concentrations causing aberrant chlamydial growth was wider...
Kalayoglu, Murat V., Byrne, Gerald I.
Chlamydia pneumoniae infection is associated with atherosclerotic heart and vessel disease, but a causal relationship between this pathogen and the disease process has not been established. Recently,...
Sakash, Jessica B., Byrne, Gerald I., Lichtman, Andrew, Libby, Peter
This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells....
Isolation of Chlamydia pneumoniae Clonal Variants by a Focus-Forming Assay
Gieffers, Jens, Belland, Robert J., Whitmire, William, Ouellette, Scot, Crane, Deborah, Maass, Matthias, ...
Chlamydia pneumoniae is an obligate intracellular prokaryotic human pathogen that causes community-acquired respiratory infection and has been associated with atherosclerosis and cardiovascular...
Differential Susceptibility of Chlamydiae to Exogenous Fibroblast Interferon
Byrne, Gerald I., Rothermel, Constance D.
Mouse fibroblasts (L cells) were incubated for 5 h with 1,000 U of murine fibroblast interferon (MuIFN α+ β) per ml and then were infected with either Chlamydia trachomatis (LGV 440), C. psittaci...
Ouellette, Scot P., AbdelRahman, Yasser M., Belland, Robert J., Byrne, Gerald I.
Two chlamydial homologues of the Yersinia lcrH chaperone for type III secretion system structural components are present within separate gene clusters. Quantitative transcriptional analyses...
Secondary Outcomes of a Pilot Randomized Trial of Azithromycin Treatment for Asthma
Hahn, David L, Plane, Mary Beth, Mahdi, Olaimatu S, Byrne, Gerald I
Kane, Colleen D., Vena, Renee M., Ouellette, Scot P., Byrne, Gerald I.
Gamma interferon (IFN-γ) is an important factor in the modulating inhibition of intracellular chlamydial growth and persistence. In human epithelial cells and macrophages, this inhibition is the...
Ramsey, Kyle H., Cotter, Todd W., Salyer, Rena D., Miranpuri, Gurwattan S., Yanez, Michael A., Poulsen, Christoffer E., ...
We sought to assess the degree of cross-protective immunity in a mouse model of chlamydial genital tract infection. Following resolution of genital infection with the mouse pneumonitis (MoPn) biovar...
LaVerda, David, Albanese, Lisa N., Ruther, Paul E., Morrison, Sandra G., Morrison, Richard P., Ault, Kevin A., ...
We have identified the chlamydial heat shock protein Hsp10 as a potential correlate to the immunopathogenic process in women with tubal factor infertility (TFI). The human serologic response to...
Ramsey, Kyle H., Miranpuri, Gurwattan S., Sigar, Ira M., Ouellette, Scott, Byrne, Gerald I.
It was previously reported that female mice resolve a primary Chlamydia trachomatis urogenital infection independent of inducible nitric oxide synthase (iNOS). We now report that although...
Byrne, Gerald I., Ouellette, Scot P., Wang, Zhao, Rao, J. P., Lu, Lin, Beatty, Wandy L., ...
Chlamydia pneumoniae causes community-acquired pneumonia and is associated with several chronic diseases, including asthma and atherosclerosis. The intracellular growth rate of C. pneumoniae slows...
Ramsey, Kyle H., Miranpuri, Gurwattan S., Poulsen, Christoffer E., Marthakis, Nancy B., Braune, Laima M., Byrne, Gerald I.
Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma...
Kane, Colleen D., Byrne, Gerald I.
The effects of gamma interferon (IFN-γ) on Chlamydia trachomatis growth in polarized epithelial cells were examined. The range of IFN-γ concentrations causing aberrant chlamydial growth was wider...
Kalayoglu, Murat V., Byrne, Gerald I.
Chlamydia pneumoniae infection is associated with atherosclerotic heart and vessel disease, but a causal relationship between this pathogen and the disease process has not been established. Recently,...
Sakash, Jessica B., Byrne, Gerald I., Lichtman, Andrew, Libby, Peter
This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells....
Isolation of Chlamydia pneumoniae Clonal Variants by a Focus-Forming Assay
Gieffers, Jens, Belland, Robert J., Whitmire, William, Ouellette, Scot, Crane, Deborah, Maass, Matthias, ...
Chlamydia pneumoniae is an obligate intracellular prokaryotic human pathogen that causes community-acquired respiratory infection and has been associated with atherosclerosis and cardiovascular...
Differential Susceptibility of Chlamydiae to Exogenous Fibroblast Interferon
Byrne, Gerald I., Rothermel, Constance D.
Mouse fibroblasts (L cells) were incubated for 5 h with 1,000 U of murine fibroblast interferon (MuIFN α+ β) per ml and then were infected with either Chlamydia trachomatis (LGV 440), C. psittaci...
Ouellette, Scot P., AbdelRahman, Yasser M., Belland, Robert J., Byrne, Gerald I.
Two chlamydial homologues of the Yersinia lcrH chaperone for type III secretion system structural components are present within separate gene clusters. Quantitative transcriptional analyses...
Secondary Outcomes of a Pilot Randomized Trial of Azithromycin Treatment for Asthma
Hahn, David L, Plane, Mary Beth, Mahdi, Olaimatu S, Byrne, Gerald I
Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2▿
Cao, Fei, Castrillo, Antonio, Tontonoz, Peter, Re, Fabio, Byrne, Gerald I.
Chlamydia pneumoniae induces macrophage foam cell formation, a hallmark of early atherosclerosis, in the presence of low-density lipoprotein (LDL). This study examined the role that Toll-like...