The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle (2006)
Xian Tao Li,, Dyachenko, Vitaly, Zuzarte, Marylou, Putzke, Caroline, Preisig-Müller, Regina, Isenberg, Gerrit, ...
Objective: The biophysical properties and the regulation of the two-pore-domain potassium channel TREK-1 were studied in rat cardiomyocytes. Methods: RT-PCR, immunohistochemistry and patch-clamp...
Na+-Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury (2003)
Wagner, Stefan, Seidler, Tim, Picht, Eckard, Maier, Lars S, Kazanski, Victor, Teucher, Nils, ...
Objective: In heart failure (HF), the generation of reactive oxygen species (ROS) is enhanced. It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to...
Kamkin, Andre, Kiseleva, Irina, Isenberg, Gerrit
Objective: We describe mechanically induced non-selective cation currents in isolated rat atrial fibroblasts, which might play a role as a substrate for mechano-electrical feedback in the heart....
Ehrhardt, Anka G., Frankish, Neil, Isenberg, Gerrit
1. DDT1 MF-2 smooth muscle cells responded to the bath application of histamine or ATP with an increase in the cytosolic Ca2+ concentration ([Ca2+]c) and the whole-cell K+ current, IK(BA). 2. In...
Changes in mitochondrial calcium concentration during the cardiac contraction cycle (1993)
Isenberg, Gerrit, Han, Song, Schiefer, Alfred, Wendt-Gallitelli, Maria-Fiora
Objective: The aim was to examine whether mitochondrial Ca2+ fluxes are high enough to change mitochondrial and cytosolic calcium concentration during the contraction cycle. Methods: Isolated...
Organization of Ca2+ Release Units in Excitable Smooth Muscle of the Guinea-Pig Urinary Bladder
Moore, Edwin D., Voigt, Tilman, Kobayashi, Yvonne M., Isenberg, Gerrit, Fay, Fred S., Gallitelli, Maria F., ...
Ca2+ release from internal stores (sarcoplasmic reticulum or SR) in smooth muscles is initiated either via pharmaco-mechanical coupling due to the action of an agonist and involving IP3 receptors, or...
Contraction augments L-type Ca2+ currents in adherent guinea-pig cardiomyocytes
Rueckschloss, Uwe, Isenberg, Gerrit
As integrins are thought to function as mechanoreceptors, we studied whether they could mediate mechanical modulation of the L-type Ca2+ channel current (ICa) in guinea-pig cardiac ventricular...
Organization of Ca2+ Release Units in Excitable Smooth Muscle of the Guinea-Pig Urinary Bladder
Moore, Edwin D., Voigt, Tilman, Kobayashi, Yvonne M., Isenberg, Gerrit, Fay, Fred S., Gallitelli, Maria F., ...
Ca2+ release from internal stores (sarcoplasmic reticulum or SR) in smooth muscles is initiated either via pharmaco-mechanical coupling due to the action of an agonist and involving IP3 receptors, or...
Contraction augments L-type Ca2+ currents in adherent guinea-pig cardiomyocytes
Rueckschloss, Uwe, Isenberg, Gerrit
As integrins are thought to function as mechanoreceptors, we studied whether they could mediate mechanical modulation of the L-type Ca2+ channel current (ICa) in guinea-pig cardiac ventricular...
Ca2+ influx through carbachol-activated non-selective cation channels in guinea-pig gastric myocytes
Kim, Sung Joon, Koh, Eun-Mi, Kang, Tong Mook, Kim, Young Chul, So, Insuk, Isenberg, Gerrit, ...
Ca2+ microfluorometry (100 μm K5 fura-2) and the voltage-clamp technique were combined to study the effect of carbachol (CCh, 50 μm) in inducing currents (ICCh) through non-selective cation...
Gödecke, Axel, Heinicke, Thomas, Kamkin, Andreij, Kiseleva, Irina, Strasser, Ruth H, Decking, Ulrich K M, ...
The functional consequences of a lack of endothelial nitric oxide synthase (eNOS) on left ventricular force development and the anti-adrenergic effect of acetylcholine (ACh) were investigated in...