Single-molecule transition-state analysis of RNA folding
Bokinsky, Gregory, Rueda, David, Misra, Vinod K., Rhodes, Maria M., Gordus, Andrew, Babcock, Hazen P., ...
How RNA molecules fold into functional structures is a problem of great significance given the expanding list of essential cellular RNA enzymes and the increasing number of applications of RNA in...
Single-molecule enzymology of RNA: Essential functional groups impact catalysis from a distance
Rueda, David, Bokinsky, Gregory, Rhodes, Maria M., Rust, Michael J., Zhuang, Xiaowei, Walter, Nils G.
The hairpin ribozyme is a minimalist paradigm for studying RNA folding and function. In this enzyme, two domains dock by induced fit to form a catalytic core that mediates a specific backbone...
Single-molecule transition-state analysis of RNA folding
Bokinsky, Gregory, Rueda, David, Misra, Vinod K., Rhodes, Maria M., Gordus, Andrew, Babcock, Hazen P., ...
How RNA molecules fold into functional structures is a problem of great significance given the expanding list of essential cellular RNA enzymes and the increasing number of applications of RNA in...
Single-molecule enzymology of RNA: Essential functional groups impact catalysis from a distance
Rueda, David, Bokinsky, Gregory, Rhodes, Maria M., Rust, Michael J., Zhuang, Xiaowei, Walter, Nils G.
The hairpin ribozyme is a minimalist paradigm for studying RNA folding and function. In this enzyme, two domains dock by induced fit to form a catalytic core that mediates a specific backbone...
Liu, Shixin, Bokinsky, Gregory, Walter, Nils G., Zhuang, Xiaowei
Single-molecule FRET is a powerful tool for probing the kinetic mechanism of a complex enzymatic reaction. However, not every reaction intermediate can be identified via a distinct FRET value, making...