Guang Yang

Details der Publikationsliste

Zeitraum

1992 - 2010

Anzahl

130

Co-Autoren

Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity (2009)

Chen, Chuanwen, Yang, Guang, Buyske, Steven, Matise, Tara, Finch, Stephen J, Gordon, Derek

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and...

Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity (2009)

Chen, Chuanwen, Yang, Guang, Buyske, Steven, Matise, Tara, Finch, Stephen J, Gordon, Derek

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and...

Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity (2009)

Chen, Chuanwen, Yang, Guang, Buyske, Steven, Matise, Tara, Finch, Stephen J, Gordon, Derek

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and...

Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity (2009)

Chen, Chuanwen, Yang, Guang, Buyske, Steven, Matise, Tara, Finch, Stephen J, Gordon, Derek

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and...

Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity (2009)

Chen, Chuanwen, Yang, Guang, Buyske, Steven, Matise, Tara, Finch, Stephen J, Gordon, Derek

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and...

Social Proximity Networks on Cruise Ships (2009)

Guang Yang, Zhigang Liu, Karim Seada, Hawk-yin Pang, August Joki, Jun Yang, ...

Social interaction is an essential element of our daily lives. One could argue that such interaction is even more important while on vacation. To showcase certain technology enablers, we implement a...

A stochastic model for identifying differential gene pair co-expression patterns in prostate cancer progression (2009)

Mo, Wen, Fu, Xu, Han, Xiao, Yang, Guang, Zhang, Ji, Guo, Feng, ...

Abstract Background The identification of gene differential co-expression patterns between cancer stages is a newly developing method to reveal the underlying molecular mechanisms of carcinogenesis....

Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis (2009)

Chen, Yali, Honeychurch, Kady M, Yang, Guang, Byrd, Chelsea M, Harver, Chris, Hruby, Dennis E, ...

Abstract Background Proteins associated with the late endosome (LE) appear to play a central role in the envelopment of a number of taxonomically diverse viruses. How viral proteins interact with...

R9- 1 A Smart CMOS Imager with On-chip High-speed Windowed Centroiding Capability (2009)

Chao Sun, Guang Yang, Christopher Wrigley, Orly Yadid-pecht, Bedabrata Pain

Low-power, high-speed, accurate computation of centroid from a pre-defined window in the image plane is important for a number of space-based and commercial applications. These include object...

Seven new dolphin mitochondrial genomes and a time-calibrated phylogeny of whales (2009)

Xiong, Ye, Brandley, Matthew C, Xu, Shixia, Zhou, Kaiya, Yang, Guang

Abstract Background The phylogeny of Cetacea (whales) is not fully resolved with substantial support. The ambiguous and conflicting results of multiple phylogenetic studies may be the result of the...

Poly[[[μ-1,1′-(butane-1,4-diyl)diimidazole-κ2N3:N3′](μ-cyclohexane-1,4-dicarboxylato-κ4O1,O1′:O4,O4′)nickel(II)] 0.25-hydrate] (2009)

Chun-Hui Yang, Guang Yang, Zhen-Wu Du, Jun-Feng Lv, Wei-Tian Yin

In the title coordination polymer, {[Ni(C8H10O4)(C10H14N4)]·0.25H2O}n, the coordination of the NiII ion is distorted octahedral. The 1,1′-(butane-1,4-diyl)diimidazole ligand and the...

Bis(μ2-3,5-diisopropyl-4H-1,2,4-triazole-κ2N1:N2)bis[(nitrato-κO)silver(I)] (2009)

Zhao-Yang Wang, Ying-Li Wang, Guang Yang, Seik Weng Ng

The neutral N-heterocycle in the title centrosymmetric dinuclear compound, [Ag2(NO3)2(C8H15N3)2], bridges two metal atoms through its imino N atoms. The N—Ag—N skeleton is bent...

Bis[5-(2-naphthyl)-1H-pyrazole-κN2]silver(I) nitrate (2009)

Zhao-Yang Wang, Pei-Pei Zhang, Guang Yang, Seik Weng Ng

The Ag atom in the title compound, [Ag(C13H10N2)2]NO3, shows an approximately linear coordination [N–Ag–N 162.6 (4)°]. The coordination geometry is distorted towards...

In vitro selection of high-affinity DNA aptamers for streptavidin (2009)

Wang, Chenglong, Yang, Guang, Luo, Zhaofeng, Ding, Hongmei

In this study, we developed a systematic evolution of ligands by exponential enrichment (SELEX) method using a combination of magnetic beads immobilization and flow cytometric measurement. As an...

Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences (2009)

Zeng, Zhifeng, Li, Hongjian, Li, Yueqing, Cui, Yanwei, Zhou, Qi, Zou, Yi, ...

To investigate whether a 12 nucleotide DNA-based miniEGSs can silence the expression of human cytomegalovirus (HCMV) UL49 gene efficiently, A HeLa cell line stably expressing UL49 gene was...

BMC Evolutionary Biology BioMed Central (2009)

Ye Xiong, Matthew C Br, Shixia Xu, Kaiya Zhou, Guang Yang

Research article Seven new dolphin mitochondrial genomes and a time-calibrated phylogeny of whales

CMOS Digital Imager Design from a System-on-a-chip Perspective (2008)

Bedabrata Pain, Bruce Hancock, Thomas Cunningham, Guang Yang, Suresh Seshadri, Julie Heynssens, ...

Due to substantial mixed analog-digital circuit integration in one chips CMOS digital imager cannot be considered only as a photoelectric transducer. In this paper, we have identzjied timing and...

SenProbe: Path Capacity Estimation in Wireless Sensor Networks + (2008)

Tony Sun, Ling-jyh Chen, Guang Yang, M. Y. Sanadidi, Mario Gerla

Abstract + The infusion of mobile computing elements (e.g. data mules, mobile actuators/sinks and etc.) into Wireless Sensor Networks undoubtedly requires the knowledge of various wireless network...

Dynamically Reconfigurable Vision with High Performance CMOS Active Pixel Sensors (APS) (2008)

Bedabrata Pain, Chao Sun, Chris Wrigley, Guang Yang

A high-performance computational imager based on inte-gration of CMOS active pixel imager array with on-chip signal processing and control via a new column-parallel architecture is presented. Unlike...

The conservation pattern of short linear motifs is highly correlated with the function of interacting protein domains (2008)

Ren, Siyuan, Yang, Guang, He, Youyu, Wang, Yiguo, Li, Yixue, Chen, Zhengjun

Abstract Background Many well-represented domains recognize primary sequences usually less than 10 amino acids in length, called Short Linear Motifs (SLiMs). Accurate prediction of SLiMs has been...

Adaptive Video Streaming in Vertical Handoff: A Case Study (2008)

Ling-jyh Chen, Guang Yang, Tony Sun, M. Y. Sanadidi, Mario Gerla

Video streaming has become a popular form of transferring video over the Internet. With the emergence of mobile computing needs, a successful video streaming solution demands 1) uninterrupted...

A Next-Generation Design Framework for Platform-Based Design (2008)

Abhijit Davare, Douglas Densmore, Trevor Meyerowitz, Ro Pinto, Alberto Sangiovanni-vincentelli, Guang Yang, ...

Abstract — The platform-based design methodology [1] is based on the usage of formal modeling techniques, clearly defined abstraction levels and the separation of concerns to enable an effective...

Communication and Co-Simulation Infrastructure for Heterogeneous System Integration (2008)

Guang Yang, Felice Balarin, Harry Hsieh, Alberto Sangiovanni-vincentelli

With the increasing complexity and heterogeneity of embedded electronic systems, a unified design methodology at higher levels of abstraction becomes a necessity. Meanwhile, it is also important to...

Parallel Simulation in Metropolis (2008)

Guang Yang

Abstract. Electronic system design has been becoming more and more complex. It is very common to have dozens of IP modules in a single system. To quickly simulate the system is becoming a challenge....

Dealing (2008)

Mario Gerla, Ling-jyh Chen, Yeng-zhong Lee, Biao Zhou, Jiwei Chen, Guang Yang, ...

with node mobility in ad hoc wireless network

Monitoring Access Link Capacity Using TFRC Probe ∗ (2008)

Ling-jyh Chen, Tony Sun, Guang Yang, M. Y. Sanadidi, Mario Gerla

Accurate estimation of network characteristics based on end to end measurements is an important and challenging problem. With the increasing variety and sophistication of Internet access methods, the...

TCP Westwood with Bulk Repeat for heavy loss environments” UCLA CSD (2008)

Guang Yang, Ren Wang, Fei Wang, M. Y. Sanadidi, Mario Gerla

Abstract — TCP Westwood (TCPW), a recently introduced sender only variant of TCP, was shown to be particularly efficient in high bandwidth, large propagation paths, with light random loss. That is,...

PBProbe: A CapProbe based Scalable Capacity Estimation Tool (2008)

Ling-jyh Chen, Li Lao, Tony Sun, Guang Yang, M. Y. Sanadidi, Mario Gerla

We present a scalable capacity estimation technique, called PBProbe. PBProbe is based on CapProbe. Instead of solely relying on packet pairs, PBProbe employs a "packet bulk" technique and...

TCP Bulk Repeat for Heavy Random Losses: (2008)

Performance Analysis Guang, Guang Yang, Ren Wang, Mario Gerla, M. Y. Sanadidi

TCP Bulk Repeat (TCP BR) is a sender-side enhancement of TCP that greatly improves performance in wireless and satellite networks with very high packet error rates (above 1%), where conventional...

Ad-hoc Storage Overlay System (ASOS): A Delay-Tolerant Approach in MANETs (2008)

Guang Yang, Ling-Jyh Chen, Tony Sun, Biao Zhou, Mario Gerla

Mobile Ad-hoc NETworks (MANETs) are a type of infrastructure-less networks that are most useful in unprepared emergencies where critical applications must be launched quickly. However, they often...

AdHoc Probe: Path Capacity Probing in Wireless Ad Hoc Networks (2008)

Ling-Jyh Chen Tony, Tony Sun, Guang Yang, M. Y. Sanadidi, Mario Gerla

Abstract - Knowledge of end-to-end path capacity is useful for video/audio stream adaptation, rate control and overlay design. Capacity estimation in wired and last-hop wireless networks has been...

Adaptive Video Streaming in Vertical Handoff: A Case Study (2008)

Ling-Jyh Chen Guang, Guang Yang, Tony Sun, M. Y. Sanadidi, Mario Gerla

Video streaming has become a popular form of transferring video over the Internet. With the emergence of mobile computing needs, a successful video streaming solution demands 1) uninterrupted...

4-Amino-3-(4-hydroxyphenyl)-1H-1,2,4-triazol-5(4H)-one (2008)

Kai-Ge Shi, Guang Yang, Seik Weng Ng

The molecule of the title compound, C8H8N4O2, is nearly planar, with a dihedral angle between the rings of 1.1 (1)°. Adjacent molecules are linked into a layered structure by...

"Ju jian" de shi jie : lun dang dai Hua yi li san xie zuo (2008)

Yang, Guang (楊光)

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008

Transforming growth factor-{beta}-regulated miR-24 promotes skeletal muscle differentiation (2008)

Sun, Qiang, Zhang, Yan, Yang, Guang, Chen, Xiaoping, Zhang, Yingai, Cao, Guojun, ...

MicroRNAs (miRNAs) have recently been proposed as a versatile class of molecules involved in regulation of a variety of biological processes. However, the role of miRNAs in TGF-β-regulated...

Performance of TCPW BR in Next Generation Wireless and Satellite Networks (2007)

Guang Yang, Ren Wang, M. Y. Sanadidi, Mario Gerla

Abstract — Both ground radio and satellite links are error-prone. In the Next Generation Internet (NGI) link capacities and propagation delays will grow, leading to very large TCP pipes. It is well...

Constraints assisted modeling and validation in metropolis framework (2006)

Guang Yang, Harry Hsieh, Xi Chen, Felice Balarin, Alberto Sangiovanni-vincentelli

Abstract — This paper focuses on quantitative constraints specified with Logic of Constraints(LOC) and coordination constraints with Linear Temporal Logic (LTL) that are used in the specification,...

Smooth and Ecient Real-time Video Transport (2006)

In Presence Of, Guang Yang, Tony Sun, Mario Gerla, M. Y. Sanadidi

this paper we study a smooth and e#cient transport protocol for real-time video over wireless networks. The proposed scheme, named the Video Transport Protocol (VTP), has a new and unique end-to-end...

End-to-end asymmetric link capacity estimation (2005)

Chen, Ling-Jyh, Sun, Tony, Yang, Guang, Sanadidi, Medy Y, Gerla, Mario

Knowledge of link capacity is important for network design, management, and utilization. With the increasing popularity of asymmetric link technologies (such as DSL, 1xRTT, and satellite links), it...

A Measurement Study of Path Capacity in 802.11b Based Wireless Networks (2005)

Tony Sun, Guang Yang, Ling-jyh Chen, M. Y. Sanadidi, Mario Gerla

The rapid deployment of wireless networks in various environments necessitates the development of new end-to-end tools that monitor and measure the properties of wireless paths well. In this paper,...

Real-time Streaming over Wireless Links: A Comparative Study (2005)

Guang Yang Ling-Jyh, Guang Yang, Ling-jyh Chen, Tony Sun, Mario Gerla, M. Y. Sanadidi

Real-time streaming over wireless links is challenging. The streaming protocol must be efficient and robust to random wireless loss, fair to itself, and friendly to legacy TCP. Various solutions have...

Enhancing QoS Support for Vertical Handoffs Using Implicit/Explicit Handoff Notifications (2005)

Ling-Jyh Chen, Guang Yang, Tony Sun, M. Y. Sanadidi, Mario Gerla

Vertical handoffs between different wireless technologies usually lead to dramatic changes in the link capacity. A successful QoS solution for vertical handoffs must be able to fast track the...

End-to-End Asymmetric Link Capacity Estimation (2005)

Ling-Jyh Chen Tony, Tony Sun, Guang Yang, M. Y. Sanadidi, Mario Gerla

Knowledge of link capacity is important for network design, management, and utilization. With the increasing popularity of asymmetric link technologies (such as DSL, 1xRTT, and satellite links), it...

Monitoring Access Link Capacity Using TFRC Probe (2005)

Ling-Jyh Chen, Tony Sun, Guang Yang, M. Y. Sanadidi, Mario Gerla

this paper, we will discuss a passive link capacity estimation technique by embedding CapProbe techniques within TFRC protocol. The details of the design and protocol integration will be presented in...

A Measurement Study of Path Capacity in 802.11b Based Wireless Networks (2005)

Tony Sun, Guang Yang, Ling-jyh Chen, M. Y. Sanadidi, Mario Gerla

* Abstract – The rapid deployment of wireless networks in various environments necessitate the development of new end-to-end tools that monitor and measure the properties of wireless paths well. In...

Adaptive Video Streaming in Presence of Wireless Errors (2004)

Guang Yang, Mario Gerla, M. Y. Sanadidi

Real-time video streaming with rate adaptation to network load/congestion represents an e#cient solution to its coexistence with conventional TCP data services. Naturally, the streaming rate control...

Ubiquitous Video Streaming: A System Perspective (2004)

Mario Gerla, Ling-Jyh Chen, Tony Sun, Guang Yang

Video streaming has become a popular form of transferring video over the Internet. With the emergence of mobile computing needs, a successful video streaming solution demands 1) uninterrupted...

Defense against Low-rate TCP-targeted Denial-of-Service Attacks (2004)

Guang Yang, Mario Gerla, M. Y. Sanadidi

Low-rate TCP-targeted Denial-of-Service (DoS) attacks aim at the fact that most operating systems in use today have a common base TCP Retransmission Timeout (RTO) of 1 sec. An attacker injects...

Separation of concerns: Overhead in modeling and efficient simulation techniques (2004)

Guang Yang, Alberto Sangiovanni-vincentelli

Separating the description of important aspects of a design such as behavior and architecture, or computation and communication, may yield significant advantages in design time as well as in...

Separation of concerns: Overhead in modeling and efficient simulation techniques (2004)

Guang Yang, Alberto Sangiovanni-vincentelli

Separating the description of important aspects of a design such as behavior and architecture, or computation and communication, may yield significant advantages in design time as well as in...

TCPW with Bulk Repeat in Next Generation Wireless Networks (2003)

Guang Yang, Ren Wang, M. Y. Sanadidi, Mario Gerla

Wireless links are error-prone. In Next Generation wireless networks, link capacities will still grow. It is known that in such configurations the performance of current TCP variants degrades...

Empirical probability based QoS routing (2003)

Xin Yuan, Guang Yang

We study Quality-of-Service (QoS) routing schemes that make routing decisions based on empirical resource availability probability information. These empirical probability based routing schemes offer...

Empirical Probability Based QoS Routing (2003)

Xin Yuan, Guang Yang

We study Quality-of-Service (QoS) routing schemes that make routing decisions based on empirical resource availability probability information. These empirical probability based routing schemes offer...

Fuel optimal maneuvers for multiple spacecraft formation reconfiguration using multi-agent optimization (2002)

Yang, Guang, Yang, Qingsong, Kapila, Vikram, Palmer, Daniel, Vaidyanathan, Ravi

The Air Force Research Laboratory has identified multiple spacecraft formation flying as an enabling technology for several future space missions. A key benefit of formation flying is the ability to...

National parks legislation and the protection of Canadian biodiversity / (2002)

Yang, Guang.

A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree of Master of Laws, Faculty of Law, Edmonton, Alberta, Spring, 2002.

National parks legislation and the protection of Canadian biodiversity / (2002)

Yang, Guang.

A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree of Master of Laws, Faculty of Law, Edmonton, Alberta, Spring, 2002.

Performance enhancement for cellular CDMA with SMART antennas / (2002)

Yang, Guang.

Thesis (M. Sc. (Comm. Eng.))--Nanyang Technological University, School of Electrical and Electronic Engineering, 2002.

Concurrent execution semantics and sequential simulation algorithms for the metropolis meta-model (2002)

Felice Balarin, Luciano Lavagno, Claudio Passerone, Alberto Sangiovanni-vincentelli, Yosinori Watanabe, Guang Yang

This paper presents the simulation techniques that are available in Metropolis, an inter-disciplinary research project that develops a design methodology, supported by a comprehensive design...

Concurrent execution semantics and sequential simulation algorithms for the metropolis meta-model (2002)

Felice Balarin, Luciano Lavagno, Claudio Passerone, Alberto Sangiovanni-vincentelli, Yosinori Watanabe, Guang Yang

This paper presents the simulation techniques that are available in Metropolis, an inter-disciplinary research project that develops a design methodology, supported by a comprehensive design...

Multi-Agent Algorithms for Chemical Cloud Detection and Mapping Using Unmanned Air Vehicles (1998)

Kovacina, Michael A., Palmer, Daniel, Yang, Guang, Vaidyanathan, Ravi

Traditional control approaches fall well short of the necessary flexibility and efficiency needed to meet the commercial and military demands placed upon UAV swarms. Effective coordination of these...

Superplastic Deformation and Mechanisms of the Commercial Aluminium Alloy Al-4Cu-1.6Mg-0.8Mn. (1998)

Liu, Yuwen, Yang, Guang, Lian, Jianshe, Zeng, Xianwen

The superplastic deformation and mechanisms of commercial Al-4Cu-1.6Mg-0.8Mn have been studied, using tensile tests with microstructural observations being carried out by optical and transmission...

Simulating American bond options in HJM framework. Working paper (1998)

Peter Carr, Guang Yang

This paper develops a method called Markov Chain Approximation (MCA) to approximate the value of American bond options in a general multi-factor Heath-JarrowMorton (HJM) framework. Our approach is...

Simulating Bermudan interest rate derivatives. Working paper (1997)

Peter Carr, Guang Yang

We use simulation to develop a Markov chain approximation for the value of caplets and Bermudan interest rate derivatives in the Market Model developed by Brace, Gatarek, and Musiela (1995) and...

Detection and assay of oxygen free radicals /--by Guang Yang. (1992)

Yang, Guang.

Thesis (Ph. D.)--University of Newcastle upon Tyne, 1992.

Protection against Tetanus by Needle-Free Inoculation of Adenovirus-Vectored Nasal and Epicutaneous Vaccines

Shi, Zhongkai, Zeng, Mingtao, Yang, Guang, Siegel, Felix, Cain, Laura J., Van Kampen, Kent R., ...

The effectiveness of vaccination programs would be enhanced greatly through the availability of vaccines that can be administered simply and, preferably, painlessly without the need for timed booster...

Maturational differences in lung NF-κB activation and their role in tolerance to hyperoxia

Yang, Guang, Abate, Aida, George, Adia G., Weng, Yi-Hao, Dennery, Phyllis A.

Neonatal rodents are more tolerant to hyperoxia than adults. We determined whether maturational differences in lung NF-κB activation could account for the differences. After hyperoxic exposure (O2 >...

Newly Synthesized Hepatitis C Virus Replicon RNA Is Protected from Nuclease Activity by a Protease-Sensitive Factor(s)

Yang, Guang, Pevear, Daniel C., Collett, Marc S., Chunduru, Srinivas, Young, Dorothy C., Benetatos, Christopher, ...

Biochemical characterization of hepatitis C virus (HCV) replication using purified, membrane-associated replication complexes is hampered by the presence of endogenous nuclease activity that...

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec

Wang, Yue-Ying, Zhou, Guang-Biao, Yin, Tong, Chen, Bing, Shi, Jing-Yi, Liang, Wen-Xue, ...

To explore the genetic abnormalities that cooperate with AML1-ETO (AE) fusion gene to cause acute myeloid leukemia (AML) with t(8;21), we screened a number of candidate genes and identified 11 types...

An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge

Yang, Guang, Pevear, Daniel C., Davies, Marc H., Collett, Marc S., Bailey, Tom, Rippen, Susan, ...

ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that...

Transthyretin constitutes a functional component in pancreatic β-cell stimulus-secretion coupling

Refai, Essam, Dekki, Nancy, Yang, Shao-Nian, Imreh, Gabriela, Cabrera, Over, Yu, Lina, ...

Transthyretin (TTR) is a transport protein for thyroxine and, in association with retinol-binding protein, for retinol, mainly existing as a tetramer in vivo. We now demonstrate that TTR tetramer has...

Protection against Tetanus by Needle-Free Inoculation of Adenovirus-Vectored Nasal and Epicutaneous Vaccines

Shi, Zhongkai, Zeng, Mingtao, Yang, Guang, Siegel, Felix, Cain, Laura J., Van Kampen, Kent R., ...

The effectiveness of vaccination programs would be enhanced greatly through the availability of vaccines that can be administered simply and, preferably, painlessly without the need for timed booster...

Maturational differences in lung NF-κB activation and their role in tolerance to hyperoxia

Yang, Guang, Abate, Aida, George, Adia G., Weng, Yi-Hao, Dennery, Phyllis A.

Neonatal rodents are more tolerant to hyperoxia than adults. We determined whether maturational differences in lung NF-κB activation could account for the differences. After hyperoxic exposure (O2 >...

Newly Synthesized Hepatitis C Virus Replicon RNA Is Protected from Nuclease Activity by a Protease-Sensitive Factor(s)

Yang, Guang, Pevear, Daniel C., Collett, Marc S., Chunduru, Srinivas, Young, Dorothy C., Benetatos, Christopher, ...

Biochemical characterization of hepatitis C virus (HCV) replication using purified, membrane-associated replication complexes is hampered by the presence of endogenous nuclease activity that...

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec

Wang, Yue-Ying, Zhou, Guang-Biao, Yin, Tong, Chen, Bing, Shi, Jing-Yi, Liang, Wen-Xue, ...

To explore the genetic abnormalities that cooperate with AML1-ETO (AE) fusion gene to cause acute myeloid leukemia (AML) with t(8;21), we screened a number of candidate genes and identified 11 types...

An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge

Yang, Guang, Pevear, Daniel C., Davies, Marc H., Collett, Marc S., Bailey, Tom, Rippen, Susan, ...

ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that...

Transthyretin constitutes a functional component in pancreatic β-cell stimulus-secretion coupling

Refai, Essam, Dekki, Nancy, Yang, Shao-Nian, Imreh, Gabriela, Cabrera, Over, Yu, Lina, ...

Transthyretin (TTR) is a transport protein for thyroxine and, in association with retinol-binding protein, for retinol, mainly existing as a tetramer in vivo. We now demonstrate that TTR tetramer has...

Adenovirus Fiber Shaft Contains a Trimerization Element That Supports Peptide Fusion for Targeted Gene Delivery▿ †

Li, Jiali, Lad, Sonya, Yang, Guang, Luo, Yunping, Iacobelli-Martinez, Milena, Primus, F. James, ...

Adenoviral (Ad) vectors have been widely used in human gene therapy clinical trials. However, their application has frequently been restricted by the unfavorable expression of cell surface receptors...

Disruption of the Caveolin-1 Gene Impairs Renal Calcium Reabsorption and Leads to Hypercalciuria and Urolithiasis

Cao, Guangwen, Yang, Guang, Timme, Terry L., Saika, Takashi, Truong, Luan D., Satoh, Takefumi, ...

Using LoxP/Cre technology, we generated a knockout mouse homozygous for a null mutation in exon 2 of Cav1. In male Cav1−/− animals, we observed a dramatic increase in the incidence of urinary...

Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling

Wang, Yiguo, Du, Dan, Fang, Longhou, Yang, Guang, Zhang, Chenyi, Zeng, Rong, ...

The conserved polarity complex, comprising the partitioning-defective (Par) proteins Par3 and Par6, and the atypical protein kinase C, functions in various cell-polarization events and asymmetric...

The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus▿

Honeychurch, Kady M., Yang, Guang, Jordan, Robert, Hruby, Dennis E.

The Tyr-X-X-Leu (YxxL) motif of the vaccinia virus F13L protein was examined for late (L) domain activity. The ability of an F13L deletion virus to form plaques was restored by PCR products...

Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific Protease That Interferes with the NF-κB Pathway of Immune Response▿

Lad, Sonya P., Yang, Guang, Scott, David A., Wang, Guizhen, Nair, Priyanka, Mathison, John, ...

Chlamydia species are bacterial pathogens that affect over 140 million individuals worldwide. Ocular infection by Chlamydia trachomatis is the leading cause of preventable blindness, and urogenital...

Tension and trust in international business negotiations: American executives negotiating with Chinese executives

Kam-hon Lee, Guang Yang, John L Graham

The purpose of the study is to shed light on the antecedents and consequences of tension felt during international business negotiations. A total of 176 American and Chinese executives participated...

Transforming growth factor-β-regulated miR-24 promotes skeletal muscle differentiation

Sun, Qiang, Zhang, Yan, Yang, Guang, Chen, Xiaoping, Zhang, Yingai, Cao, Guojun, ...

MicroRNAs (miRNAs) have recently been proposed as a versatile class of molecules involved in regulation of a variety of biological processes. However, the role of miRNAs in TGF-β-regulated...

Arabidopsis Inositol Polyphosphate 6-/3-Kinase (AtIpk2β) Is Involved in Axillary Shoot Branching via Auxin Signaling1[W][OA]

Zhang, Zai-Bao, Yang, Guang, Arana, Fernando, Chen, Zhen, Li, Yan, Xia, Hui-Jun

The Arabidopsis (Arabidopsis thaliana) inositol polyphosphate 6-/3-kinase gene (AtIpk2β) is known to participate in inositol phosphate metabolism. However, little is known about its physiological...

Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation

Yang, Guang, Huang, Shu-Ching, Wu, Jane Y., Benz, Edward J.

A regulated splicing event in protein 4.1R pre-mRNA—the inclusion of exon 16–encoding peptides for spectrin-actin binding—occurs in late erythroid differentiation. We defined the functional...

Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1*

Shah, Charmi, Yang, Guang, Lee, Ian, Bielawski, Jacek, Hannun, Yusuf A., Samad, Fahumiya

Obesity increases the risk for metabolic and cardiovascular disease, and adipose tissue plays a central role in this process. Ceramide, the key intermediate of sphingolipid metabolism, also...

Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion

Yang, Guang, Huang, Chen, Cao, Jun, Huang, Ke-Jian, Jiang, Tao, Qiu, Zheng-Jun

AIM: To investigate RNA interference targeting signal transducer and activator of transcription-3 (STAT3) on invasion of human pancreatic cancer cells.

3′-Poly(A) tail enhances siRNA activity against exogenous reporter genes in MCF-7 cells

Li, Jie, Yang, Guang, Li, Shaohua, Cao, Guojun, Zhao, Qiang, Liu, Xuemei, ...

RNA interference (RNAi) is a powerful tool in the study of gene function. We added poly(A) tails to the 3′ ends of siRNA antisense strands by in vitro transcription, and investigated the silencing...

Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity

Chuanwen Chen, Guang Yang, Steven Buyske, Tara Matise, Stephen J. Finch, Derek Gordon

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and...

Local government expenditure, RBC model and regional business cycle in China-Take Tianjin for example

Guang Yang

local government expenditure, regional business cycle, RBC model, E32, E62, H41, 地方政府支出, 区域经济周期, RBC 模型,

The Protective Antibodies Induced by a Novel Epitope of Human TNF-α Could Suppress the Development of Collagen-Induced Arthritis

Dong, Jie, Gao, Yaping, Liu, Yu, Shi, Jinxia, Feng, Jiannan, Li, Zhanguo, ...

Tumor necrosis factor alpha (TNF-α) is a major inflammatory mediator that exhibits actions leading to tissue destruction and hampering recovery from damage. At present, two antibodies against human...

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations*

Zhu, Bo-feng, Yang, Guang, Shen, Chun-mei, Qin, Hai-xia, Liu, Shun-zhi, Deng, Ya-jun, ...

Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China....

Hyperoxia-induced NF-κB activation occurs via a maturationally sensitive atypical pathway

Wright, Clyde J., Zhuang, Tiangang, La, Ping, Yang, Guang, Dennery, Phyllis A.

NF-κB activation is exaggerated in neonatal organisms after oxidant and inflammatory insults, but the reason for this and the downstream effects are unclear. We hypothesized that specific...