Gustavo Arrizabalaga

Ionophore-Resistant Mutants of Toxoplasma gondii Reveal Host Cell Permeabilization as an Early Event in Egress

Black, Michael W., Arrizabalaga, Gustavo, Boothroyd, John C.

Toxoplasma gondii is an obligate intracellular pathogen within the phylum Apicomplexa. Invasion and egress by this protozoan parasite are rapid events that are dependent upon parasite motility and...

Bioluminescence Imaging of Toxoplasma gondii Infection in Living Mice Reveals Dramatic Differences between Strains

Saeij, Jeroen P. J., Boyle, Jon P., Grigg, Michael E., Arrizabalaga, Gustavo, Boothroyd, John C.

We examined the in vivo growth, dissemination, and reactivation of strains of the protozoan parasite Toxoplasma gondii using a bioluminescence-based imaging system. Two T. gondii strains, one with a...

Ionophore-Resistant Mutants of Toxoplasma gondii Reveal Host Cell Permeabilization as an Early Event in Egress

Black, Michael W., Arrizabalaga, Gustavo, Boothroyd, John C.

Toxoplasma gondii is an obligate intracellular pathogen within the phylum Apicomplexa. Invasion and egress by this protozoan parasite are rapid events that are dependent upon parasite motility and...

Bioluminescence Imaging of Toxoplasma gondii Infection in Living Mice Reveals Dramatic Differences between Strains

Saeij, Jeroen P. J., Boyle, Jon P., Grigg, Michael E., Arrizabalaga, Gustavo, Boothroyd, John C.

We examined the in vivo growth, dissemination, and reactivation of strains of the protozoan parasite Toxoplasma gondii using a bioluminescence-based imaging system. Two T. gondii strains, one with a...

Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation

Arrizabalaga, Gustavo, Ruiz, Felix, Moreno, Silvia, Boothroyd, John C.

Calcium is a critical mediator of many intracellular processes in eukaryotic cells. In the obligate intracellular parasite Toxoplasma gondii, for example, a rise in [Ca2+] is associated with...

Exit from Host Cells by the Pathogenic Parasite Toxoplasma gondii Does Not Require Motility▿

Lavine, Mark D., Arrizabalaga, Gustavo

The process by which the intracellular parasite Toxoplasma gondii exits its host cell is central to its propagation and pathogenesis. Experimental induction of motility in intracellular parasites...

A Cluster of Four Surface Antigen Genes Specifically Expressed in Bradyzoites, SAG2CDXY, Plays an Important Role in Toxoplasma gondii Persistence▿

Saeij, Jeroen P. J., Arrizabalaga, Gustavo, Boothroyd, John C.

Toxoplasma gondii is one of the most successful protozoan parasites of warm-blooded animals. Stage-specific expression of its surface molecules is thought to be key to its ability to establish...