Lippert, E., Falk, W., Bataille, F., Kaehne, T., Naumann, M., Goeke, M., ...
BACKGROUND: Colonic lamina propria fibroblasts (CLPFs) play an important role in the pathogenesis of fibrosis and strictures in Crohn's disease. AIM: To identify colonic epithelial cell (CEC)-derived...
MR colonography in inflammatory bowel disease (2006)
Schreyer, A. G., Scheibl, K., Heiss, P., Feuerbach, S., Seitz, J., Herfarth, H.
Colonography based on magnetic resonance imaging (MRI) appears to be a promising technique for polyp assessment in the colon. Several studies have evaluated this method for colonic assessment in...
Rieder, F., Schneidewind, A., Bolder, U., Zorger, N., Schölmerich, J., Schäffler, A., ...
Detecting the source of obscure gastrointestinal bleeding can be difficult. Capsule endoscopy is a promising diagnostic tool for investigating patients with this condition, although identifying the...
Holtmann, M.H., Krummenauer, F., Claas, C., Kremeyer, K., Lorenz, D., Rainer, O., ...
In Crohn's disease the optimal duration of azathioprine treatment is still controversial and for ulcerative colitis only limited data are available to support its efficacy. Charts of 1176 patients...
The potential role of adiponectin in driving arthritis (2004)
Müller-Ladner, U, Ehling, A, Neumann, E, Tarner, IH, Herfarth, H, Grifka, J, ...
No abstract available.
Gelbmann, C M, Leeb, S N, Vogl, D, Maendel, M, Herfarth, H, Schölmerich, J, ...
Background: CD40 has been shown to be a functional activation antigen on a variety of cell types involved in immune responses. As intestinal fibroblasts and myofibroblasts may play a role during...
OBERMEIER, F, DUNGER, N, STRAUCH, U G, GRUNWALD, N, HERFARTH, H, SCHÖLMERICH, J, ...
Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The...
Cathepsin D is up-regulated in inflammatory bowel disease macrophages
HAUSMANN, M, OBERMEIER, F, SCHREITER, K, SPOTTL, T, FALK, W, SCHÖLMERICH, J, ...
Down-regulation of receptors involved in the recognition or transmission of inflammatory signals and a reduced responsiveness support the concept that macrophages are ‘desensitized’ during their...
Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis
Paul, G, Bataille, F, Obermeier, F, Bock, J, Klebl, F, Strauch, U, ...
Haem-oxygenase-1 (HO-1) has been shown to exert anti-inflammatory, anti-apoptotic and anti-proliferative effects. We investigated HO-1 expression in patients with inflammatory bowel disease (IBD) and...
Farkas, S, Hornung, M, Sattler, C, Anthuber, M, Gunthert, U, Herfarth, H, ...
Increased expression of CD44 variant isoforms have been shown on the inflammatory infiltrates in human and mouse colitis and blockade or deletion of CD44 isoforms inhibit experimental colitis. The...
Herfarth, H, Brand, K, Rath, H C, Rogler, G, Schölmerich, J, Falk, W
In acute DSS-induced colitis nuclear factor (NF)-κ B-dependent inflammatory cytokines including IL-1 and tumour necrosis factor-alpha (TNF-α) are up-regulated. Here we examined the effects of...
Hausmann, M, Spöttl, T, Andus, T, Rothe, G, Falk, W, Schölmerich, J, ...
Macrophages play a central role during the pathogenesis of inflammation. In normal intestinal mucosa surface expression of typical macrophage markers such as CD14, CD16, CD11b or T-cell...
Farkas, S, Herfarth, H, Rössle, M, Schroeder, J, Steinbauerauer, M, Guba, M, ...
Leucocyte recruitment to sites of intestinal inflammation is a crucial, multi-step process that leads ultimately to the accumulation of cells in the inflamed tissue. We established a new in vivo...
Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes
Spoettl, T, Hausmann, M, Herlyn, M, Gunckel, M, Dirmeier, A, Falk, W, ...
Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated...
Morphological characterisation of Crohn’s disease fistulae
Bataille, F, Klebl, F, Rümmele, P, Schroeder, J, Farkas, S, Wild, P-J, ...
Background: Fistulae are a common complication in up to 35% of all patients with Crohn’s disease. Their therapy is difficult and frequently unsatisfactory. To date, no histological comparison of...
Menzel, K, Hausmann, M, Obermeier, F, Schreiter, K, Dunger, N, Bataille, F, ...
The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shown...
Schreyer, A G, Rath, H C, Kikinis, R, Völk, M, Schölmerich, J, Feuerbach, S, ...
Aim: Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatory...
Hausmann, M, Obermeier, F, Paper, D H, Balan, K, Dunger, N, Menzel, K, ...
Recently we demonstrated that in inflammatory bowel disease (IBD) macrophage-oxidative burst activity is increased and NADPH oxidase mRNA is induced. The herbal phenylethanoid acteoside isolated from...
Schreiter, K, Hausmann, M, Spoettl, T, Strauch, U G, Bataille, F, Schoelmerich, J, ...
Background: The glycoprotein (gp) 96 links the adaptive with the innate immune system. It is a chaperone with a binding domain for peptides generated by proteasomal degradation. During cellular...
Obermeier, F, Strauch, U G, Dunger, N, Grunwald, N, Rath, H C, Herfarth, H, ...
Background and methods: Cytosin-guanosin dinucleotide (CpG) motifs of bacterial DNA are known to be potent activators of innate immunity. We have shown previously that administration of CpG...
Hausmann, M, Paul, G, Kellermeier, S, Frey, I, Schölmerich, J, Falk, W, ...
Haem oxygenase-1 (HO-1) up-regulation was suggested to reduce mucosal tissue damage in inflammatory bowel disease (IBD) and an up-regulation of HO-1 expression in patients with Crohn's disease (CD)...