Scientific Commons: H. J. Rahmsdorf

6th Charles Heidelberger Conf.'Control of Cell Proliferation and Differentiation: Molecular Targets in Carcinogenesis and Cancer Therapy', Essen, July 9-13, 1995

Regulation of AP-1 activity and of AP-1-dependent target genes. (1995)

Iordanov, M., Wade, E., Knebel, A., Angel, P., Rahmsdorf, H.J., Wilhelm, D., ...

5th Internat.Congress: Hormones and Cancer, Quebec, CDN, September 16-20, 1995

Strahleninduzierte Genaktivierung: Ein zellmembranabhängiger Prozeß? (1995)

Rahmsdorf, H.J.

Nachrichten - Forschungszentrum Karlsruhe, 27(1995) S.87-98

Regulation of AP-1 transcription factor activity. (1995)

Herrlich, P., Angel, P., Wilhelm, D., Tuckermann, J., Knebel, A., Rahmsdorf, H.J., ...

Symp.on Cell Proliferation, Innsbruck, A, November 30 - December 1, 1995

UV signaling through the plasma membrane. (1995)

Sachsenmaier, C., Knebel, A., Rahmsdorf, H.J., Herrlich, P.

Symp.on Cell Proliferation, Innsbruck, A, November 30 - December 1, 1995

Damage to DNA by UV light and activation of transcription factors. (1994)

Sachsenmaier, C., Radler-Pohl, A., Müller, A., Herrlich, P., Rahmsdorf, H.J.

Biochemical Pharmacology, 47(1994) S.129-36

UV-induced c-fos/c-jun expression involves growth factor receptor dependent signalling. (1994)

Sachsenmaier, C., Radler-Pohl, A., Herrlich, P., Rahmsdorf, H.J.

Keystone Symp.on Molecular and Cellular Biology, Keystone, Colo., February 6-13, 1994

Ultraviolet light induced rapid signalling from plasma membrane to nucleus. (1994)

Sachsenmaier, C., Radler-Pohl, A., Knebel, A., Herrlich, P., Rahmsdorf, H.J.

Internat.Symp.'Ozone - Sun - Cancer, Molecular and Cellular Mechanisms, Prevention', Paris, F, May 17-20, 1994

Growth factor receptor activation is an obligatory step in UVC-induced gene transcription. (1994)

Sachsenmaier, C., Radler-Pohl, A., Herrlich, P., Rahmsdorf, H.J.

Internat.Symp.on Ozone-Sun-Cancer: Molecular and Cellular Mechanisms, Prevention, Paris, F, May 17-20, 1994

Transcriptional and posttranscriptional responses to DNA damaging agents. (1994)

Herrlich, P., Rahmsdorf, H.J.

Current Opinion in Cell Biology, 6(1994) S.425-31

Carcinogen-dependent regulation of Fos/Jun activity and Fos/Jun-dependent gene expression. (1994)

Sachsenmaier, C., Van Dam, H., Gack, S., Radler-Pohl, A., Herr, I., Rüther, U., ...

1st EMBL Meeting on Transcription, Heidelberg, August 28 - September 1, 1994

The mammalian UV response: mechanism of DNA damage induced gene expression. (1994)

Herrlich, P., Sachsenmaier, C., Radler-Pohl, A., Gebel, S., Blattner, Ch., Rahmsdorf, H.J.

Advances in Enzyme Regulation, 34(1994) S.381-95

Signal transduction following DNA damage. (1994)

Herrlich, P., Sachsenmaier, C., Radler-Pohl, A., Blattner, C., Rahmsdorf, H.J.

11th Internat.Symp.on ADP-Ribosylation, Strasbourg, F, September 17-21, 1994

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. (1994)

Heck, S., Kullmann, M., Gast, A., Ponta, H., Rahmsdorf, H.J., Herrlich, P., ...

The EMBO Journal, 13(1994) S.4087-95

DNA damaging agents and growth factors induce changes in the program of expressed gene products through common routes. (1994)

Blattner, Ch., Knebel, A., Radler-Pohl, A., Sachsenmaier, C., Herrlich, P., Rahmsdorf, H.J.

Environmental and Molecular Mutagenesis, 24(1994) S.3-10

Involvement of growth factor receptors in the mammalian UV response. (1994)

Sachsenmaier, C., Radler-Pohl, A., Zinck, R., Nordheim, A., Herrlich, P., Rahmsdorf, H.J.

Cell, 78(1994) S.963-72

Ultraviolet irradiation, although it activates the transcription factor AP-1 in F9 teratocarcinoma stem cells, does not induce the full complement of differentiation-associated genes. (1994)

Auer, H.P., König, H., Litfin, M., Stein, B., Rahmsdorf, H.J.

Experimental Cell Research, 214(1994) S.131-38

Modulation of Fos and Jun in response to adverse environmental agents. (1994)

Rahmsdorf, H.J.

Angel, P.E.; Herrlich, P.A. [Hrsg.]

Overexpression of c-fos increases recombination frequency in human osteosarcoma cells (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

We have shown previously that overexpression of c-Ha-ras, v-mos or c-fos increases the spontaneous level of chromosomal aberrations and gene mutations in NIH 3T3 cells, and that reduction of the Fos...

Involvement of oncogenes in mutagenesis. (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

The Molecular Basis of Chromosomal Aberrations, Castlemaine, AUS, February 17-20, 1993

Common routes in DNA damage and growth factor induced gene transcription. (1993)

Rahmsdorf, H.J., Radler-Pohl, A., Sachsenmaier, C., Herrlich, P.

Environmental Mutagen Society Annual Meeting, Norfolk, Va., April 17-22, 1993

Carcinogen induced regulation of immediate early genes. (1993)

Herrlich, P., Sachsenmaier, C., Gebel, S., Radler-Pohl, A., Auer, H.P., Kraemer, M., ...

2nd Biannual ISREC Conf.on Genetic Damage and Escape from Proliferation Control, Lausanne, CH, January 14-15, 1993

UV-C induced immediate activation of MAP-2 kinase and c-Jun phosphorylation. (1993)

Radler-Pohl, A., Sachsenmaier, C., Gebel, S., Herrlich, P., Rahmsdorf, H.J.

Keystone Symp.'Transcription Factors, Regulation and Differentiation', Keystone, Colo., January 17-24, 1993

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. (1993)

Radler-Pohl, A., Sachsenmaier, C., Gebel, S., Auer, H.P., Bruder, J.T., Rapp, U., ...

EMBO Journal, 12(1993) S.1005-12

UV-irradiation of mammalian cells induces a cascade of cytoplasmic events leading to AP-1 activation. (1993)

Radler-Pohl, A., Sachsenmaier, C., Herrlich, P., Rahmsdorf, H.J.

5th Congress on the Society for Photobiology, Marburg, September 19-26, 1993

UV-irradiation induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. (1993)

Kraemer, M., Sachsenmaier, C., Herrlich, P., Rahmsdorf, H.J.

Journal of Biological Chemistry, 268(1993) S.6734-41

Oncogene overexpression affects genomic instability. (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

23rd Annual Meeting of the European Environmental Mutagen Society, Barcelona, E, September 27 - October 2, 1993

Onkogene und Mutationen. (1993)

Rahmsdorf, H.J.

Fahrig, R. [Hrsg.]

Overexpression of c-fos increases recombination frequency in human osteosarcoma cells. (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

Carcinogenesis, 14(1993) S.925-28

The activation and activity control of AP-1 (Fos/Jun). (1993)

Radler-Pohl, A., Gebel, S., Sachsenmaier, C., Koenig, H., Kraemer, M., Oehler, T., ...

Sluyser, M. [Hrsg.]

UV-C induced signal transduction. (1993)

Sachsenmaier, C., Radler-Pohl, A., Blattner, C., Fritz, E., Rahmsdorf, H.J., Herrlich, P.

9th Internat.Symp.on Cellular Endocrinology 'Cell Signalling and the Molecular Stress Response' Lake Placid, N.Y., September 23-26, 1993

DNA damage induced gene expression involves a pathway of reverse signal transduction. (1993)

Sachsenmaier, C., Radler-Pohl, A., Angel, P., Rahmsdorf, H.J., Herrlich, P.

40th Harden Conf., Nethy Bridge, GB, August 29 - September 3, 1993

Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response. (1992)

Stein, B., Angel, P., Van Dam, H., Ponta, H., Herrlich, P., ...

Photochemistry and Photobiology, 55(1992) S.409-15

Phorbol ester tumor promoters and the anti-tumor-promoter dexamethasone share a molecular target: modulation of the transcription factor AP-1 by novel type of interaction. (1992)

Herrlich, P., Jonat, C., Ponta, H., Rahmsdorf, H.J.

Nygaard, O.F. [Hrsg.]

Involvement of fos in spontaneous and ultraviolet light-induced genetic changes. (1992)

Kaina, B., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Molecular Carcinogenesis, 4(1991) S.460-66

DNA damage inducible genetic responses in eukaryotes. (1992)

Herrlich, P., Gebel, S., Sachsenmaier, Ch., Rahmsdorf, H.J., Angel, P.

21st FEBS Meeting, Dublin, IRL, August 9-14, 1992

Transcriptional regulation of genes in response to photon absorption. (1992)

Herrlich, P., Kraemer, M., Gebel, S., Sachsenmaier, Ch., Stein, B., Rahmsdorf, H.J.

Symp.on Activation of Cellular and Viral Genes by Optical Photons, 20th Annual Meeting of the American Society for Photobiology, Marco Island, Fla., June 21-25, 1992

Tumor-Initiatoren und Tumor-Promotoren: Wirkungen auf das genetische Programm der Zelle. (1992)

Rahmsdorf, H.J.

KfK-Nachrichten, 24(1992) S.47-55

DNA damage-induced gene expression: signal transduction and relation to growth factor signaling. (1992)

Herrlich, P., Ponta, H., Rahmsdorf, H.J.

Reviews of Physiology, Biochemistry and Pharmacology, 119(1992) S.187-223

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. (1992)

Koenig, H., Ponta, H., Rahmsdorf, H.J., Herrlich, P.

EMBO Journal, 11(1992) S.2241-46

Positive and negative regulation of collagenase gene expression. (1992)

Jonat, C., Stein, B., Ponta, H., Herrlich, P., Rahmsdorf, H.J.

Birkedale-Hansen, H. [Hrsg.]

UV-irradiation induced collagenase gene transcription involves an IL-1#a and bFGF dependent signalling pathway. (1992)

Sachsenmaier, Ch., Kraemer, M., Rahmsdorf, H.J.

Gemeinsame Jahrestagung der Oesterreichischen Biochemischen Gesellschaft und der Oesterreichischen Gesellschaft fuer Genetik und Gentechnik, Innsbruck, A, September 21-23, 1992

Ultraviolet irradiation and phorbol esters induce gene transcription by different mechanisms. (1992)

Rahmsdorf, H.J., Gebel, S., Kraemer, M., Koenig, H., Luecke-Huhle, C., Radler-Pohl, A., ...

Rossman, T.G. [Hrsg.]

Cellular responses to carcinogens. (1992)

Herrlich, P., Radler-Pohl, A., Rahmsdorf, H.J., Sachsenmaier, Ch.

AACR Special Conf. Chemicals, Mutations and Cancer, Banff, CDN, December 7-12, 1992

On the road to Ataxia teleangiectasia complementation: the use of cDNA-libraries. (1991)

Fritz, E., Rahmsdorf, H.J., Herrlich, P.

Workshop on DNA Repair, Noordwijkerhout, NL, April 14-19, 1991

UV response in human cells: radiation induced synthesis of growth factors. (1991)

Kraemer, M., Rahmsdorf, H.J.

4.Symp.Molekulare und zellulaere Mechanismen der biologischen Strahlenwirkung, Essen, 27.Februar - 1.Maerz 1991

UV induced synthesis of growth factors in mammalian cells. (1991)

Kraemer, M., Herrlich, P., Rahmsdorf, H.J.

Workshop on DNA Repair, Noordwijkerhout, NL, April 14-19, 1991

Involvement of Fos in the control of genomic stability. (1991)

Kaina, B., Ponta, H., Herrlich, P., Rahmsdorf, H.J.

Workshop on DNA Repair, Noordwijkerhout, NL, April 14-19, 1991

Inducible effects of DNA damage. (1991)

Herrlich, P., Kraemer, M., Gebel, S., Luecke-Huhle, C., Mai, S., Fritz, G., ...

Workshop on DNA Repair, Noordwijkerhout, NL, April 14-19, 1991

c-fos activation and repression: interference with differentiation pathways. (1991)

Rahmsdorf, H.J.

EULEP Symp. 'Molekular Markers of Differentiation', Schloss Reisensburg, Guenzburg, 12.Maerz 1991

A new function for oncogenes: regulation of genomic stability. (1991)

Kaina, B., Ponta, H., Herrlich, P., Rahmsdorf, H.J.

7th Annual Meeting on Oncogenes, Frederick, Md., June 24-26, 1991

A new cAMP response element in the transcribed region of the human c-fos gene. (1991)

Haertig, E., Loncarevic, I.F., Buescher, M., Herrlich, P., Rahmsdorf, H.J.

Nucleic Acids Research, 19(1991) S.4153-59

Mechanism of interference between glucocorticoid hormone receptor and the transcription factor AP-1. (1991)

Koenig, H., Gebel, S., Hagmeyer, B., Van Dam, H., Angel, P., Ponta, H., ...

11th Biennial Meeting of the European Association for Cancer Research, Genova, I, November 3-6, 1991

Die Wirkung krebserregender Substanzen in der Tumorpromotion. (1991)

Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Umwelt und Krebs : Tagung der AGF, Bonn-Bad Godesberg, 13.-14.Dezember 1990 Berichtsband

The interference between pathway specific transcription factors. (1991)

Koenig, H., Cato, A.C.B., Ponta, H., Rahmsdorf, H.J., Herrlich, P.

4th Internat.Congress on Hormones and Cancer, Amsterdam, NL, September 15-19, 1991

Wie Viren auf die Umwelt reagieren. (1990)

Herrlich, P., Rahmsdorf, H.J., Ponta, H.

AGF-Forschungsthemen, 3(1989) S.21-22

Damage induced signal transduction in mammalian cells. (1990)

Mai, S., Stein, B., Rahmsdorf, H.J., Kaina, B., Luecke-Huhle, C., Herrlich, P.

Conf.on Ionizing Radiation Damage to DNA: Molecular Aspects, Lake Tahoe, Calif., January 13-28, 1990

Gentechnologie in der Erforschung der Auseinandersetzung zwischen Mensch und Umwelt. (1990)

Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Bio-Engineering, 5(1989) Nr. 6, S.91-92

Phorbol ester induced activation of transcription factors as mechanisms of tumor promotion. (1990)

Herrlich, P., Jonat, C., Rahmsdorf, H.J., Ponta, H., Stein, B., Offringa, R., ...

15th Internat.Cancer Congress, Hamburg, August 16-22, 1990

Stress-induced genetic changes in mammalian cells. (1990)

Kaina, B., Mai, S., Luecke-Huhle, C., Fritz, G., Rahmsdorf, H.J., ...

Fruehjahrstagung der Deutschen Gesellschaft fuer Zellbiologie, Bremen, 19.-22.Maerz

Primary interactions of adverse environmental agents are transduced into genetic consequences by cellular mechanisms: an analysis into the molecular components of the response. (1990)

Kraemer, M., Kaina, B., Herrlich, P., Rahmsdorf, H.J.

Jahrestagung der Gesellschaft fuer Umwelt- und Mutationsforschung, Die zukuenftige Nutzung der Molekularbiologie in der Mutagenitaetspruefung, Westerland, 3.-4.Mai 1990

Complementation of N-hydroxyethyl-N- chloroethylnitrosourea hypersensitivity of Mex`- cells by microinjection of mRNA from Mex`+ cells. (1990)

Fritz, G., Rahmsdorf, H.J., Kaina, B.

Mutation Research, 244(1990) S.49-53

Different proteins bind to the phorbol ester responsive sequences in collagenase and c-jun promoters. (1990)

Stein, B., Gebel, S., Rahmsdorf, H.J., Herrlich, P., Ponta, H.

Papas, T.S. [Hrsg.]

Machanisms of the ultraviolet light response in mammalian cells. (1990)

Mai, S., Stein, B., Kaina, B., Luecke-Huhle, C., Ponta, H., ...

Journal of Cell Science, 94(1989) S.609-15

The IFN-#g response of the murine invariant chain gene is mediated by a complex enhancer that includes several MHC class II consensus elements. (1990)

Eades, A.M., Litfin, M., Rahmsdorf, H.J.

The Journal of Immunology, 144(1990) S.4399-4409

Transcription factors in normal and malignant cells. (1990)

Herrlich, P., Ponta, H., Stein, B., Jonat, C., Gebel, S., Koenig, H., ...

Sluyser, M. [Hrsg.]

An update of the mammalian uv response: gene regulation and induction of a protective function. (1990)

Kaina, B., Stein, B., Schoenthal, A., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Lambert, M.W. [Hrsg.]

Radiation-induced activation of transcription factors in mammalian cells. (1990)

Kraemer, M., Stein, B., Mai, S., Kunz, E., Koenig, H., Loferer, H., ...

Radiation and Environmental Biophysics, 29(1990) S.303-13

A major decision: proliferation or differentiation. Interactions between pathway-specific transcription factors exemplify a molecular mechanism for the decision. (1990)

Herrlich, P., Jonat, C., Ponta, H., Rahmsdorf, H.J.

Bartram, C.R. [Hrsg.]

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. (1990)

Jonat, C., Rahmsdorf, H.J., Park, K.K., Cato, A.C.B., Gebel, S., Ponta, H., ...

Cell, 62(1990) S.1189-1204

Ionizing radiation induced formation of a replication origin binding complex involving the product of the cellular oncogene c-myc. (1990)

Mai, S., Luecke-Huhle, C., Kaina, B., Rahmsdorf, H.J., Stein, B., Ponta, H., ...

Wallace, S. [Hrsg.]

Regulation of gene expression by tumor promoters. (1990)

Rahmsdorf, H.J., Herrlich, P.

Pharmacology and Therapeutics, 48(1990) S.157-88

The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. (1989)

Schoenthal, A., Buescher, M., Angel, P., Rahmsdorf, H.J., Ponta, H., Hattori, K., ...

Oncogene, 4(1989) S.629-36

A promising genomic transfectant into Xeroderma pigmentosum group A with highly amplified mouse DNA and intermediate UV resistance turns revertant. (1989)

Blum, M., Baumann, I., Lohrer, H., Rahmsdorf, H.J., Herrlich, P.

Biochemical and Biophysical Research Communications, 160(1989) S.647-55

Nuclear oncoproteins determine the genetic program in response to external stimuli. (1989)

Schoenthal, A., Gebel, S., Stein, B., Ponta, H., Rahmsdorf, H.J., Herrlich, P.

Cold Spring Harbor Symposia on Quantitative Biology, 53(1989) S.779-87

Negative control of AP-1 activity by glucocorticoid hormone requires a novel function of the specific receptor molecule. (1989)

Jonat, C., Rahmsdorf, H.J., Ponta, H., Cato, A.C.B., Kraemer, M., Offringa, R., ...

8th Cold Spring Harbor Conf.on Cancer Cells 'Regulation of Eukaryotic mRNA Transcription', Cold Spring Harbor, N.Y., September 6-10, 1989

Negative regulation of collagenase gene transcription by glucocorticoids. (1989)

Jonat, C., Herrlich, P., Rahmsdorf, H.J.

Matrix Metalloproteinase Conf., Destin, Fla., September 11-15, 1989

The mammalian UV response. (1989)

Mai, S., Rahmsdorf, H.J., Ponta, H., Stein, B., Kaina, B., ...

NICHD Workshop on Genetic Response to Environmental Adversity, Airlie, USA, April 23-26, 1989

Mechanism of the UV response in mammalian cells. (1989)

Herrlich, P., Mai, S., Waldstein, E., Kaina, B., Lavi, S., ...

UKEMS/DNA Repair Network Meeting, Brighton, GB, April 3-7, 1989

Modulation of expression of stress-related genes. (1989)

Jonat, C., Gebel, S., Cato, A.C.B., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

3rd Internat.Conf.on Anticarcinogenesis and Radiation Protection, Dubrovnik, YU, October 15-21, 1989

Genotoxic agents and the control of gene expression and amplification. (1989)

Herrlich, P., Mai, S., Stein, B., Rahmsdorf, H.J., Luecke-Huhle, C., Ponta, H., ...

Falk Symp.No. 55 'Proteins in the Regulation of Hepatic Genes' Basel, CH, October 15-17, 1989

UV induced transcription of HIV-1 and collagenase: DNA damage as intermediate, involvement of NFkB and JUN/FOS, and intercellular transmission by an extracellular factor. (1989)

Stein, B., Rahmsdorf, H.J., Herrlich, P.

1st Internat.Conf.on Gene Regulation, Oncogenesis, Aids, Loutraki, GR, September 15-21, 1989

Genetische Reaktionen auf Einwirkungen der Umwelt. (1989)

Rahmsdorf, H.J., Luecke-Huhle, C., Kaina, B., Ponta, H., Herrlich, P.

KfK-Nachrichten, 21(1989) S.119-28

Autoregulation of fos: the dyad symmetry element as the major target of repression. (1989)

Koenig, H., Ponta, H., Rahmsdorf, U., Buescher, M., Schoenthal, A., Rahmsdorf, H.J., ...

The EMBO Journal, 8(1989) S.2559-66

Two nuclear oncogene products cooperate in the formation of the transcription factor AP-1. (1989)

Gebel, S., Stein, B., Koenig, H., Rahmsdorf, H.J., Ponta, H., Risse, G., ...

Lother, H. [Hrsg.]

UV-induced DNA damage is an intermediate step in UV induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. (1989)

Stein, B., Rahmsdorf, H.J., Steffen, A., Litfin, M., Herrlich, P.

Molecular and Cellular Biology, 9(1989) S.5169-81

UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells. (1989)

Stein, B., Kraemer, M., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Journal of Virology, 63(1989) S.4540-44

The role of fos in gene regulation. (1989)

Herrlich, P., Ponta, H., Stein, B., Gebel, S., Koenig, H., Schoenthal, A., ...

Alexis, M.N. [Hrsg.]

Signals and sequences involved in the ultraviolet- and 12-O-tetradecanoylphorbol- 13-acetate (TPA)-dependent induction of genes. (1988)

Herrlich, P., Jonat, C., Rahmsdorf, H.J., Angel, P., Haslinger, A., Imagawa, M., ...

Colburn, N.H. [Hrsg.]

The UV induced signal transduction pathway to specific genes. (1988)

Stein, B., Rahmsdorf, H.J., Schoenthal, A., Buescher, M., Ponta, H., Herrlich, P.

Friedberg, E. [Hrsg.]

Mechanisms of the mammalian UV response. (1988)

Herrlich, P., Stein, B., Schoenthal, A., Gebel, S., Buescher, M., Vanetti, M., ...

NATO-Advanced Workshop 'DNA Repair Mechanisms' Fontevraud, F, October 2-7, 1988

The ultraviolet light induced signal pathways to specific genes. (1988)

Rahmsdorf, H.J., Stein, B., Buescher, M., Vanetti, M., Schoenthal, A., Ponta, H., ...

10th Internat.Congress on Photobiology, Jerusalem, IL, October 30 - November 4, 1988

Nuclear oncogenes determine the genetic program and are subject to autoregulation. (1988)

Herrlich, P., Schoenthal, A., Buescher, M., Stein, B., Gebel, S., Koenig, H., ...

Herbsttagung der Universitaet Innsbruck, A, 12.-14.September 1988

Nuclear Oncogenes determine the genetic program and are subject to autoregulation. (1988)

Ponta, H., Schoenthal, A., Buescher, M., Stein, B., Gebel, S., Koenig, H., ...

EMBO-Meeting on Oncogenes and Growth Control, Heidelberg, September 19-22, 1988

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. (1988)

Buescher, M., Rahmsdorf, H.J., Litfin, M., Karin, M., Herrlich, P.

Oncogene, 3(1988) S.301-11

Evidence of inducible error-prone mechnisms in diploid human fibroblasts. (1988)

Maher, V.M., Sato, K., Kateley-Kohler, S., Thomas, H., Michaud, S., Mc Cormick, J.J., ...

Moses, R.E. [Hrsg.]

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. (1988)

Schoenthal, A., Herrlich, P., Rahmsdorf, H.J., Ponta, H.

Cell, 54(1988) S.325-34

Posttranscriptional regulation of c-fos mRNA expression. (1987)

Rahmsdorf, H.J., Schoenthal, A., Angel, P., Litfin, M., Ruether, U., Herrlich, P.

Nucleic Acids Research, 15(1987) S.1643-59

Cis-acting elements for UV and TPA induced c-fos expression. (1987)

Buescher, M., Rahmsdorf, H.J., Herrlich, P.

Tagung der Gesellschaft fuer Genetik, Martinsried, 28.-30.Mai 1987

Temporary correction of defective DNA repair processes after microinjection of fibroblasts with mRNA fractions. (1987)

Digweed, M., Guenthert, U., Rahmsdorf, H.J., Sperling, K.

Tagung der Gesellschaft fuer Genetik, Martinsried, 28.-30.Mai 1987

DNA damage inducible responses in mammalian cells. (1987)

Herrlich, P., Imagawa, M., Angel, P., Buescher, M., Karin, M., Rahmsdorf, H.J., ...

British Association for Cancer Research Annual General Meeting, Univ.of Newcastle upon Tyne, GB, April 5-8, 1987

Post-translational modulation of enhancer factors by phorbol esters and UV irradiation. (1987)

Herrlich, P., Angel, P., Buescher, M., Rahmsdorf, H.J., Stein, B., Imagawa, M., ...

EMBO-Meeting 'Oncogenesis and Growth Control', Heidelberg, April 26-30, 1987

Ultraviolet irradiation and phorbol esters activate the human c-fos gene through similar, but not identical pathways. (1987)

Schoenthal, A., Buescher, M., Ponta, H., Herrlich, P., Rahmsdorf, H.J.

3rd Annual Meeting on Oncogenes, Frederick, Md., July 7-11, 1987

TPA induction of the human collagenase gene is mediated by an 8bp inducible enhancer element. (1987)

Stein, B., Angel, P., Rahmsdorf, H.J., Imagawa, M., Chiu, R., Karin, M., ...

Tagung der Gesellschaft fuer Genetik, Martinsried, 28.-30.Mai 1987

Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1#b or phorbol ester. (1987)

Stephenson, M.L., Goldring, M.B., Birkhead, J.R., Krane, S.M., Rahmsdorf, H.J., Angel, P.

Biochemical and Biophysical Research Communications, 144(1987) S.583-90

Attempts to complement human repair deficient cells by microinjection of protein, RNA or DNA. (1987)

Zoeller, B., Angel, P., Herrlich, P., Rahmsdorf, H.J.

Workshop on Molecular Aspects of DNA Repair, Noordwijkerhout, NL, March 1-5, 1987

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. (1987)

Angel, P., Baumann, I., Stein, B., Delius, H., Rahmsdorf, H.J., Herrlich, P.

Molecular and Cellular Biology, 7(1987) S.2256-66

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. (1987)

Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R.J., Rahmsdorf, H.J., ...

Cell, 49(1987) S.729-39

Comparison of human stromelysin and collagenase by cloning and sequence analysis. (1987)

Whitham, S.E., Murphy, G., Angel, P., Rahmsdorf, H.J., Smith, B.J., Lyons, A., ...

Biochemical Journal, 240(1986) S.913-16

Preformed regulatory proteins as targets of carcinogen action. (1987)

Herrlich, P., Stein, B., Rahmsdorf, H.J., Buescher, M., Schoenthal, A., Angel, P., ...

Japanese-German Workshop on 'Molecular Aspects of Cacinogenesis', Essen, October 1-3, 1987

The molecular basis for the UV response: cis- and trans-acting elements responsible for gene induction. (1987)

Herrlich, P., Imagawa, M., Maher, V., Sato, K., Mc Cormick, J.J., Angel, P., ...

Accomplishments in Oncology, 2(1987) S.95-105

Interferron-#g, mitomycin C, and cycloheximide as regulatory agents of MHC class II -associated invariant chain expression. (1986)

Rahmsdorf, H.J., Harth, N., Eades, A.M., Litfin, M., Steinmetz, M., Forni, L., ...

The Journal of Immunology, 136(1986) S.2293-99

12-O-tetradecanoylphorbol-13-acetate (TPA)-induced gene sequences in human primary diploid fibroblasts and their expression in SV40-transformed fibroblasts. (1986)

Angel, P., Rahmsdorf, H.J., Poeting, A., Luecke-Huhle, C., Herrlich, P.

Journal of Cellular Biochemistry, 29(1985) S.351-60

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. (1986)

Angel, P., Poeting, A., Mallick, U., Rahmsdorf, H.J., Schorpp, M., Herrlich, P.

Molecular and Cellular Biology, 6(1986) S.1760-66

The mammalian genetic stress response. (1986)

Herrlich, P., Angel, P., Rahmsdorf, H.J., Mallick, U., Poeting, A., Hieber, L., ...

Advances in Enzyme Regulation, 25(1986) S.485-504

Genes and gene products identified as part of the mammalian genetic stress response. (1986)

Rahmsdorf, H.J., Angel, P., Schorpp, M., Luecke-Huhle, C., Herrlich, P.

UCLA-Symp.on Growth Factors, Tumor Promoters and Cancer Genes, Steamboat Springs, Colo., April 2-16, 1986

The stress response of human primary fibroblasts and its possible implications for carcinogenesis. (1985)

Herrlich, P., Angel, P., Rahmsdorf, H.J., Luecke-Huhle, C., Schorpp, M., Poeting, A.

Journal of Cellular Biochemistry, Suppl. 9C(1985), S.17

c-fos mRNA levels in primary human fibroblasts after arrest in various stages of the cell cycle. (1985)

Angel, P., Rahmsdorf, H.J., Poeting, A., Herrlich, P.

Cancer Cells, 3(1985) S.315-19

Differential expression of two TPA inducible proteins in primary and transformed human fibroblasts. (1985)

Angel, P., Poeting, A., Luecke-Huhle, C., Rahmsdorf, H.J., Herrlich, P.

4th Internat.Conf.on Differentiation of Normal and Neoplastic Cells, Heidelberg, May 1-4, 1985

Mutagenes and interferon regulate the synthesis of the MHC associated invariant chain in B cells and fibroblasts. (1985)

Harth, N., Eades, A., Herrlich, P., Rahmsdorf, H.J.

Fruehjahrstagung der Gesellschaft fuer Immunologie, Tuebingen, 6.-8.Maerz 1985

Increased transcription of the mouse and human fos oncogene in resting cells. (1985)

Herrlich, P., Harth, N., Angel, P., Poeting, A., Rahmsdorf, H.J.

1st Annual Meeting of Oncogenes, Frederick, Md., July 10-13, 1985

The metallothionein gene reveals a general stress sensing mechanism. (1985)

Herrlich, P., Karin, M., Rahmsdorf, H.J., Angel, P., Cato, A.C.B.

11th EMBO Annual Symp. 'Growth Factors, Receptors and Oncogenes', Heidelberg, September 16-19, 1985

The transmission and characteristics of the human genetic stress response. (1985)

Herrlich, P., Luecke-Huhle, C., Angel, P., Poeting, A., Rahmsdorf, H.J.

Tagung 'Transfer of Information', Hamburg, May 20-24, 1985

Mammalian stress response, its genetic components and possible function. (1985)

Herrlich, P., Angel, P., Luecke-Huhle, C., Harth, N., Eades, A., Rahmsdorf, H.J.

24th Internat.Symp., on Regulation of Enzyme Activity, Indianapolis, Ind., September 30 - October 1, 1985

Proliferation-controlled and -controlling genes. (1985)

Herrlich, P., Angel, P., Poeting, A., Schorpp, M., Mallick, U., Rahmsdorf, H.J.

Ebashi, S. [Hrsg.]

UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells. (1984)

Schorpp, M., Mallick, U., Rahmsdorf, H.J., Herrlich, P.

Cell, 37(1984) S.861-68

Genetic changes in mammalian cells reminiscent of an SOS response. (1984)

Herrlich, P., Mallick, U., Ponta, H., Rahmsdorf, H.J.

Human Genetics, 67(1984) S.360-68

Regulation of MHC class II-associated invariant chain synthesis. (1984)

Rahmsdorf, H.J., Forni, L., Mallick, U., Herrlich, P.

Disease Markers, 2(1984) S.161-68

Proliferation-controlled genes in primary human fibroblasts. (1984)

Angel, P., Poeting, A., Rahmsdorf, H.J., Mallick, U., Herrlich, P.

6th Conf.on Macromolecular Synthesis Gene Expression, Hamburg, May 30 - June 3, 1984

UV light induces in human fibroblasts a secreted factor which replaces UV in the induction of gene products. (1984)

Schorpp, M., Mallick, U., Rahmsdorf, H.J., Herrlich, P.

6th Conf.on Macromolecular Synthesis Gene Expression, Hamburg, May 30 - June 3, 1984

An UV inducible factor regulates carcinogen and carcinogen dependent gene expression. (1984)

Angel, P., Schorpp, M., Poeting, A., Rahmsdorf, H.J., Mallick, U., Herrlich, P.

Cold Spring Harbor Meeting Cell Proliferation and Cancer: Growth Factors and Transformation, Cold Spring Harbor, N.Y., September 19-23, 1984

Biologische Wirkung von Strahlung: Neue Ergebnisse und Entwicklungen. (1984)

Rahmsdorf, H.J., Herrlich, P., Schorpp, M., Angel, P., Luecke-Huhle, C., Poeting, A., ...

Strahlung und Radionuklide in der Umwelt: Tagung der Arbeitsgemeinschaft der Grossforschungseinrichtungen, Bonn, 8.-9.November 1984

12-0-tetradecanoylphorbol 13-acetat-induclible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts. (1983)

Mallick, U., Rahmsdorf, H.J., Yamamoto, N., Ponta, H., Wegner, R.D., Herrlich, P.

Proceedings of the National Academy of Sciences of the United States of America, 79(1982) S.7886-90

Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication. (1983)

Rahmsdorf, H.J., Koch, N., Mallick, U., Herrlich, P.

The EMBO Journal, 2(1983) S.811-16

Transfection of human genomic wild-type DNA into Xeroderma pigmentosum group A. (1983)

Poeting, A., Luecke-Huhle, C., Pech, M., Herrlich, P., Rahmsdorf, H.J.

Broerse, J.J. [Hrsg.]

Ionisierende Strahlung aktiviert Gene. (1982)

Herrlich, P., Rahmsdorf, H.J., Hieber, L., Luecke-Huhle, C., Ponta, H., Mallick, U.

Wissenschaftliche Vortragsveranstaltung der Arbeitsgemeinschaft der Grossforschungseinrichtungen, Wissenschaftszentrum, Bonn, 4.-5.November 1982

A B-lymphocyte-specific high-turnover protein: constitutive expression in resting B cells and induction of synthesis in proliferating cells. (1982)

Rahmsdorf, H.J., Mallick, U., Ponta, H., Herrlich, P.

Cell, 29(1982) S.459-68

Arresting replication induces Ia associated invariant chain synthesis in proliferating B cells. (1982)

Rahmsdorf, H.J., Mallick, U., Herrlich, P., Koch, N.

Joint Meeting of the Nordic Biochemical Society and the Gesellschaft fuer Biologische Chemie, Damp/Kiel, September 27-29, 1982

Radiation and mutagen inducible mammalian genes. (1982)

Herrlich, P., Rahmsdorf, H.J., Mallick, U., Ponta, H., Hieber, L., Luecke-Huhle, C., ...

Biochemie, 64(1982) S.707-08

B lymphocyte specific nuclear proteins are induced by mutagenic treatment. (1982)

Herrlich, P., Rahmsdorf, H.J., Ponta, H., Mallick, U.

Special FEBS-Meeting (Federation of European Biochemical Societies), Athinai, GR, April 25-29, 1982

Biennial report 1979/80. (1981)

Hotz, G., [Hrsg.], Appel, H., Coquerelle, T., Dertinger, H.F., Fabiani, L., ...

KfK-3200 (Juli 81)

An inducible DNA-binding protein in mammalian cells. (1981)

Mallick, U., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

10th Annual ICN-UCLA Symp. 'Molecular and Cellular Biology', Keystone, Colo., February 8 - March 20, 1981

Regulation of phosphorylation of myosin heavy chain during the chemotactic response of dictyostelium cells. (1981)

Malchow, D., Boehme, R., Rahmsdorf, H.J.

European Journal of Biochemistry, 117(1981) S.213-18

TPA-inducible proteins are synthesized at elevated rate in Bloom's syndrome. (1981)

Mallick, U., Rahmsdorf, H.J., Yamamoto, N., Ponta, H., Herrlich, P.

Meeting of the Internat.Soc.of Developmental Biologists, Basel, CH, August 28 - September 1, 1981

Differentiated cells from balb/c mice differ in their radiosensitivity. (1981)

Rahmsdorf, H.J., Ponta, H., Baechle, M., Mallick, U., Weibezahn, K.F., Herrlich, P.

Experimental Cell Research, 136(1981) S.111-17

Protein 'X' synthesis in mammalian cells. (1981)

Mallick, U., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Seeberg, E.; Kleppe, K. [Hrsg.]

Different DNA repair capacity in various differentiated cells. (1980)

Rahmsdorf, H.J., Ponta, H., Mallick, U., Weibezahn, K.F., Herrlich, P.

2nd Internat.Congress on Cell Biology, Berlin, August 31 - September 5, 1980.

Stop of replication induces and represses the synthesis of specific proteins in mammalian cells. (1980)

Mallick, U., Rahmsdorf, H.J., Ponta, H., Coquerelle, T., Eife, R., Herrlich, P.

2nd Internat.Congress on Cell Biology, Berlin, August 31 - September 5, 1980.

Virus T7: a probe of cellular control mechanisms. (1979)

Herrlich, P., Schweiger, M., Rahmsdorf, H.J., Ponta, H., Spoerel, N., Pfennig-Yeh, M.L., ...

Rosenthal, S., Bielka, H. (u.a.Hrsg.): Gene functions. Oxford,New York,N.Y.: Pergamon Pr.1979. (FEBS Federation of European Biochemical Societies, 12th meeting, Dresden 1978. Vol.51.) S.337-346

Protein kinase action as a mediator of chemotaxis and differentiation in the cellular slime mold, dictyostelium discoideum. (1979)

Rahmsdorf, H.J.

Krause, E.G. (u.a.Hrsg.): Cyclic nucleotides and protein phosphorylation in cell regulation. Oxford,New York,N.Y.: Pergamon Pr.1979. (FEBS Federation of European Biochemical Societies, 12th meeting,...

Wir lernen von einem Schleimpilz Mechanismen zellulaerer Differenzierung und Bewegung. (1979)

Rahmsdorf, H.J.

KfK-Nachrichten, 11(1979) No 4, S.45

Inhibition of development in Dictyostelium discoideum by sugars.

Rickenberg, H V, Rahmsdorf, H J, Campbell, A, North, M J, Kwasniak, J, Ashworth, J M

Sugars such as glucose, maltose, and trehalose, which are metabolized by Dictyostelium discoideum and which enhance vegetative growth, inhibit the development of the slime mold at concentrations...

UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells.

Stein, B, Krämer, M, Rahmsdorf, H J, Ponta, H, Herrlich, P

UV irradiation, but not visible sunlight, induces the transcription of human immunodeficiency virus type 1 (HIV-1). Chimeric constructs carrying all or parts of the HIV-1 long terminal repeat linked...

A new cAMP response element in the transcribed region of the human c-fos gene.

Härtig, E, Loncarević, I F, Büscher, M, Herrlich, P, Rahmsdorf, H J

In NIH 3T3 cells the c-fos gene is induced rapidly and transiently by cAMP. As shown by the analysis of 3T3 cells stably transfected with promoter mutants of the human c-fos gene this induction does...

Posttranscriptional regulation of c-fos mRNA expression.

Rahmsdorf, H J, Schönthal, A, Angel, P, Litfin, M, Rüther, U, Herrlich, P

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only by transcriptional activation but also at the level of turnover of the gene product. Here we present...

12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.

Mallick, U, Rahmsdorf, H J, Yamamoto, N, Ponta, H, Wegner, R D, Herrlich, P

A set of proteins, which in normal fibroblasts were barely, if at all, detectable, were synthesized at an increased rate in fibroblasts from patients with Bloom syndrome (BS). The same set of...

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

Stein, B, Rahmsdorf, H J, Steffen, A, Litfin, M, Herrlich, P

UV irradiation of human and murine cells enhances the transcription of several genes. Here we report on the primary target of relevant UV absorption, on pathways leading to gene activation, and on...

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

Angel, P, Baumann, I, Stein, B, Delius, H, Rahmsdorf, H J, Herrlich, P

Genomic clones coding for human fibroblast collagenase were isolated. By constructing and transfecting mutants with 5' and 3' deletion mutations of the 5' control region of the gene into human or...

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

Angel, P, Pöting, A, Mallick, U, Rahmsdorf, H J, Schorpp, M, Herrlich, P

We used nucleic acid hybridization and cDNA cloning techniques to isolate human sequences that respond to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). These clones were used as...

Protein Kinase Induction in Escherichia coli by Bacteriophage T7

Rahmsdorf, H. J., Pai, S. H., Ponta, P., Herrlich, P., Roskoski, R., Schweiger, M., ...

After bacteriophage T7 infection, a protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) activity can be demonstrated in E. coli in vivo by sodium dodecyl sulfate-polyacrylamide gel...

Translational Control Induced by Bacteriophage T7

Herrlich, P., Rahmsdorf, H. J., Pai, S. H., Schweiger, M.

Phage T7 discontinues host gene expression by translational and transcriptional control mechanisms. Translational control is exerted by the T7 translational-repressor. This protein inhibits the...

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

Heck, S, Kullmann, M, Gast, A, Ponta, H, Rahmsdorf, H J, Herrlich, P, ...

Steroid receptors activate and repress genes. An important class of genes that they repress is controlled by the transcription factor AP-1. The activity of AP-1 is inhibited by the receptor, a...

Autoregulation of fos: the dyad symmetry element as the major target of repression.

König, H, Ponta, H, Rahmsdorf, U, Büscher, M, Schönthal, A, Rahmsdorf, H J, ...

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection...

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

Radler-Pohl, A, Sachsenmaier, C, Gebel, S, Auer, H P, Bruder, J T, Rapp, U, ...

Irradiation of cells with ultraviolet light (UV) leads to modifications of c-Jun resembling those elicited by phorbol esters or oncogenes, and to enhanced transcription of AP-1-dependent genes. The...

Effect of sugars on early biochemical events in development of Dictyostelium discoideum.

Rahmsdorf, H J, Cailla, H L, Spitz, E, Moran, M J, Rickenberg, H V

Metabolizable sugars blocked development of the slime mold Dictyostelium discoideum; the same sugars also inhibited the formation of contact sites "A", of membranal 3':5'-cyclic adenosine...

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

Knebel, A, Rahmsdorf, H J, Ullrich, A, Herrlich, P

Several non-physiologic agents such as radiation, oxidants and alkylating agents induce ligand-independent activation of numerous receptor tyrosine kinases (RTKs) and of protein tyrosine kinases at...

Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication.

Rahmsdorf, H J, Koch, N, Mallick, U, Herrlich, P

The expression of the H2 Ia-associated invariant chain (Ii) has been determined by pulse labeling cells with [35S]methionine and resolving the proteins. Expression is maximal in noncycling peripheral...

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo.

König, H, Ponta, H, Rahmsdorf, H J, Herrlich, P

Phorbol esters stimulate and glucocorticoid hormones down-regulate a variety of promoters such as that of the collagenase gene through the transcription factor AP-1 (Fos/Jun). We now show by genomic...

Comparison of human stromelysin and collagenase by cloning and sequence analysis.

Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...

A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase.

Iordanov, M, Bender, K, Ade, T, Schmid, W, Sachsenmaier, C, Engel, K, ...

Changes in environmental conditions such as the addition of growth factors or irradiation of cells in culture first affect immediate response genes. We have shown previously that short wavelength UV...

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV.

Bender, K, Göttlicher, M, Whiteside, S, Rahmsdorf, H J, Herrlich, P

NF-kappaB activation in response to UV irradiation of HeLa cells or of primary human skin fibroblasts occurs with two overlapping kinetics but totally different mechanisms. Although both mechanisms...

Inhibition of development in Dictyostelium discoideum by sugars.

Rickenberg, H V, Rahmsdorf, H J, Campbell, A, North, M J, Kwasniak, J, Ashworth, J M

Sugars such as glucose, maltose, and trehalose, which are metabolized by Dictyostelium discoideum and which enhance vegetative growth, inhibit the development of the slime mold at concentrations...

UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells.

Stein, B, Krämer, M, Rahmsdorf, H J, Ponta, H, Herrlich, P

UV irradiation, but not visible sunlight, induces the transcription of human immunodeficiency virus type 1 (HIV-1). Chimeric constructs carrying all or parts of the HIV-1 long terminal repeat linked...

A new cAMP response element in the transcribed region of the human c-fos gene.

Härtig, E, Loncarević, I F, Büscher, M, Herrlich, P, Rahmsdorf, H J

In NIH 3T3 cells the c-fos gene is induced rapidly and transiently by cAMP. As shown by the analysis of 3T3 cells stably transfected with promoter mutants of the human c-fos gene this induction does...

Posttranscriptional regulation of c-fos mRNA expression.

Rahmsdorf, H J, Schönthal, A, Angel, P, Litfin, M, Rüther, U, Herrlich, P

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only by transcriptional activation but also at the level of turnover of the gene product. Here we present...

12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.

Mallick, U, Rahmsdorf, H J, Yamamoto, N, Ponta, H, Wegner, R D, Herrlich, P

A set of proteins, which in normal fibroblasts were barely, if at all, detectable, were synthesized at an increased rate in fibroblasts from patients with Bloom syndrome (BS). The same set of...

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

Stein, B, Rahmsdorf, H J, Steffen, A, Litfin, M, Herrlich, P

UV irradiation of human and murine cells enhances the transcription of several genes. Here we report on the primary target of relevant UV absorption, on pathways leading to gene activation, and on...

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

Angel, P, Baumann, I, Stein, B, Delius, H, Rahmsdorf, H J, Herrlich, P

Genomic clones coding for human fibroblast collagenase were isolated. By constructing and transfecting mutants with 5' and 3' deletion mutations of the 5' control region of the gene into human or...

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

Angel, P, Pöting, A, Mallick, U, Rahmsdorf, H J, Schorpp, M, Herrlich, P

We used nucleic acid hybridization and cDNA cloning techniques to isolate human sequences that respond to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). These clones were used as...

Protein Kinase Induction in Escherichia coli by Bacteriophage T7

Rahmsdorf, H. J., Pai, S. H., Ponta, P., Herrlich, P., Roskoski, R., Schweiger, M., ...

After bacteriophage T7 infection, a protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) activity can be demonstrated in E. coli in vivo by sodium dodecyl sulfate-polyacrylamide gel...

Translational Control Induced by Bacteriophage T7

Herrlich, P., Rahmsdorf, H. J., Pai, S. H., Schweiger, M.

Phage T7 discontinues host gene expression by translational and transcriptional control mechanisms. Translational control is exerted by the T7 translational-repressor. This protein inhibits the...

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

Heck, S, Kullmann, M, Gast, A, Ponta, H, Rahmsdorf, H J, Herrlich, P, ...

Steroid receptors activate and repress genes. An important class of genes that they repress is controlled by the transcription factor AP-1. The activity of AP-1 is inhibited by the receptor, a...

Autoregulation of fos: the dyad symmetry element as the major target of repression.

König, H, Ponta, H, Rahmsdorf, U, Büscher, M, Schönthal, A, Rahmsdorf, H J, ...

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection...

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

Radler-Pohl, A, Sachsenmaier, C, Gebel, S, Auer, H P, Bruder, J T, Rapp, U, ...

Irradiation of cells with ultraviolet light (UV) leads to modifications of c-Jun resembling those elicited by phorbol esters or oncogenes, and to enhanced transcription of AP-1-dependent genes. The...

Effect of sugars on early biochemical events in development of Dictyostelium discoideum.

Rahmsdorf, H J, Cailla, H L, Spitz, E, Moran, M J, Rickenberg, H V

Metabolizable sugars blocked development of the slime mold Dictyostelium discoideum; the same sugars also inhibited the formation of contact sites "A", of membranal 3':5'-cyclic adenosine...

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

Knebel, A, Rahmsdorf, H J, Ullrich, A, Herrlich, P

Several non-physiologic agents such as radiation, oxidants and alkylating agents induce ligand-independent activation of numerous receptor tyrosine kinases (RTKs) and of protein tyrosine kinases at...

Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication.

Rahmsdorf, H J, Koch, N, Mallick, U, Herrlich, P

The expression of the H2 Ia-associated invariant chain (Ii) has been determined by pulse labeling cells with [35S]methionine and resolving the proteins. Expression is maximal in noncycling peripheral...

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo.

König, H, Ponta, H, Rahmsdorf, H J, Herrlich, P

Phorbol esters stimulate and glucocorticoid hormones down-regulate a variety of promoters such as that of the collagenase gene through the transcription factor AP-1 (Fos/Jun). We now show by genomic...

Comparison of human stromelysin and collagenase by cloning and sequence analysis.

Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...

A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase.

Iordanov, M, Bender, K, Ade, T, Schmid, W, Sachsenmaier, C, Engel, K, ...

Changes in environmental conditions such as the addition of growth factors or irradiation of cells in culture first affect immediate response genes. We have shown previously that short wavelength UV...

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV.

Bender, K, Göttlicher, M, Whiteside, S, Rahmsdorf, H J, Herrlich, P

NF-kappaB activation in response to UV irradiation of HeLa cells or of primary human skin fibroblasts occurs with two overlapping kinetics but totally different mechanisms. Although both mechanisms...

H. J. Rahmsdorf

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