Kues, W. A., Sudheer, S., Herrmann, D., Carnwath, J. W., Havlicek, V., Besenfelder, U., ...
Bovine embryos can be generated by in vitro fertilization or somatic nuclear transfer; however, these differ from their in vivo counterparts in many aspects and exhibit a higher proportion of...
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress (2007)
Ralser, Markus, Wamelink, Mirjam M., Kowald, Axel, Gerisch, Birgit, Heeren, Gino, Struys, Eduard A., ...
Background Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an...
High-throughput identification of potential Arabidopsis MAP kinases substrates (2005)
Feilner, T, Hultschig, C., Lee, J., Meyer, S., Immink, R.G.H., Koenig, A., ...
Mitogen-activated protein kinase (MAPK) cascades are universal and highly conserved signal transduction modules in eucaryotes, including plants. These protein phosphorylation cascades link...
A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome. (2005)
Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, FH., Goehler, H., ...
High-throughput identification of potential Arabidopsis MAP kinases substrates. (2005)
Feilner, T., Hultschig, C., Lee, J., Meyer, S., Immink, RG., Koenig, A., ...
Mouse Protein Arrays from a TH1 Cell cDNA library for antibody screening and serum profiling. (2005)
Gutjahr, C., Murphy, D., Lueking, A., Koenig, A., Janitz, M., O´Brien, J., ...
DNA sequence and comparative analysis of chimpanzee chromosome 22 (2004)
Watanabe, H., Fujiyama, A., Hattory, M., Taylor, T. D., Toyoda, A., Kuroki, Y., ...
Hilson, P., Allemeersch, J., Altmann, T, Aubourg, S, Avon, A., Beynon, J., ...
Microarray transcript profiling and RNA interference are two new technologies crucial for large-scale gene function studies in multicellular eukaryotes. Both rely on sequence-specific hybridization...
Illiger, J., Herwig, R., Steinfath, M., Przewieslik, T., Elge, T., Bull, C., ...
We report the establishment of highly non-redundant unigene sets consisting of cDNA clones derived from T lymphocytes and natural killer cells. Each set consists of 10 506 and 13 409 clones,...
GABI – The German Plant Genome Research Program Progress Report 1999 – 2004 (2004)
Kersten, B., Feilner, T., Kramer, A., Possling, A., Wehrmeyer, S., Lehrach, H., ...
Generation of Arabidopsis protein chips for antibody and serum screening (2003)
Kersten, B., Feilner, T., Kramer, A., Wehrmeyer, S., Possling, A., Witt, I., ...
Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left–right asymmetry (2002)
Olbrich, H., Häffner, K., Kispert, A., Völkel, A., Volz, A., Sasmaz, G., ...
Primary ciliary dyskinesia (PCD, MIM 242650) is characterized by recurrent infections of the respiratory tract due to reduced mucociliary clearance and by sperm immobility. Half of the affected...
The genome sequence of Schizosaccharomyces pombe (2002)
Gwilliam, R, Rajandream, M-A, Lyne, M, Lyne, R, Stewart, A, ...
We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The...
The genome sequence of Schizosaccharomyces pombe (2002)
Wood, V., Gwilliam, R., Rajandream, M. A., Lyne, M., Lyne, R., Stewart, A., ...
We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The...
The genome sequence of Schizosaccharomyces pombe (2002)
Wood, V., Gwilliam, R., Rajandream, M. A., Lyne, M., Lyne, R., Stewart, A., ...
We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The...
DEFOG: A Practical Scheme for Deciphering Families of Genes (2002)
Fuchs, T., Malecova, B., Linhart, C., Sharan, R., Khen, M., Herwig, R., ...
X-digitise: visualization of hybridization experiments (2002)
Wruck, W., Griffiths, H., Steinfath, M., Lehrach, H., Radelof, U., O'Brien, J.
Initial sequencing and analysis of the human genome (2001)
Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, J, ...
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and...
Functional annotation of mouse genome sequences. (2001)
Nadeau, H., Balling, R., Barsh, G., Beier, D., Brown, S. D. M., Bucan, M., ...
Wiles, M. V., Vauti, F., Otte, J., Ruiz, P., Füchtbauer, A., ...
Characterization of the Hydra lamin and its gene; a molecular phylogeny of metazoan lamins. (1999)
Erber, A., Riemer, D., Hofemeister, H., Bovenschulte, M., Stick, R., Panopoulou, G., ...
Comparative gene expression profiling by oligonucleotide fingerprinting (1998)
Meier-Ewert, S, Lange, J, Gerst, H, Herwig, R, Schmitt, A, Freund, J, ...
IXDB, an X chromosome integrated database (1998)
Leser, U, Wagner, R, Grigoriev, A, Lehrach, H, Roest Crollius, H
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix (1998)
Tait, D, Riccio, M, Sittler, A, Scherzinger, E, Santi, S, Ognibene, A, ...
Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene (1998)
Lorenz, B, Francis, F, Gempel, K, Boddrich, A, Josten, M, Schmahl, W, ...
Aberrant processing of the Fugu HD (FrHD) mRNA in mouse cells and in transgenic mice (1997)
Sathasivam, K, Baxendale, S, Mangiarini, L, Bertaux, F, Hetherington, C, Kanazawa, I, ...
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia (1997)
Strom, TM, Francis, F, Lorenz, B, Boddrich, A, Econs, MJ, Lehrach, H, ...
Rowe, PS, Oudet, CL, Francis, F, Sinding, C, Pannetier, S, Econs, MJ, ...
HIP-I: a huntingtin interacting protein isolated by the yeast two- hybrid system (1997)
Wanker, EE, Rovira, C, Scherzinger, E, Hasenbank, R, Walter, S, Tait, D, ...
An integrated YAC map of the human X chromosome (1996)
Crollius, HR, Ross, MT, Grigoriev, A, Knights, CJ, Holloway, E, Misfud, J, ...
Hunter, KW, Riba, L, Schalkwyk, L, Clark, M, Resenchuk, S, Beeghly, A, ...
Neri, C, Albanese, V, Lebre, AS, Holbert, S, Saada, C, Bougueleret, L, ...
Dinucleotide repeat polymorphism at the DXS1683 locus (1994)
Econs, M.J., Francis, F., Rowe, P.S.N., Speer, M.C., O'Riordan, J.L.H., Lehrach, H., ...
Dinucleotide repeat polymorphism at the DXS1683 locus (1994)
Econs, MJ, Francis, F, Rowe, PS, Speer, MC, O'Riordan, JL, Lehrach, H, ...
Snell, R.G., Doucette-Stamm, L.A., Gillespie, K.M., Taylor, S.A.M., Riba, L., Bates, G.P., ...
Flanking recombination events have defined the Huntington Disease gene candidate region to between D4S10 and D4S98, about 2.2Mb. Because of the large size of the candidate region and the likely large...
Radiation hybrid map spanning the huntington disease gene region of chromosome 4 (1992)
Altherr, Michael R., Altherr, Michael R., Plummer, Sarah, Plummer, Sarah, Bates, G., Bates, G., ...
Radiation hybrid (RH) mapping was used to construct a map of 11 markers in the distal 4 Mb of the short arm of chromosome 4, the region containing the Huntington disease gene. Two different methods...
The direct screening of cosmid libraries with YAC clones (1991)
Baxendale, S., Bates, G.P., MacDonald, M.E., Gusella, J.F., Lehrach, H.
A YAC contig across the fragile X site defines the region of fragility (1991)
Hirst, M.C., Rack, K., Nakahori, Y., Roche, A., Bell, M.V., Flynn, G., ...
The fragile X syndrome is a common cause of mental retardation and Is associated with a fragile site at Xq27.3 (FRAXA). Recently, evidence has been presented for the role of methylation and genomlc...
The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2 (1990)
Stubbs, L., Huxley, C., Hogan, B., Evans, T., Fried, M., Duboule, D., ...
Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has...
The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2 (1990)
Stubbs, L., Poustka, A., Baron, A., Lehrach, H., Lonai, P., Duboule, D.
Two different loci of Antennapedia-related homeobox-containing genes have been shown to map to mouse chromosome 2: the HOX-5 complex and the Hox-4.1 gene. These independently derived loci are likely...
Carig, A.G., Nizetic, D., Hoheisel, J.D., Zehetner, G., Lehrach, H.
To allow the efficient construction of ordered clone libraries, we have been investigating the use of ‘oligonucleotide fingerprinting’ as an approach to identify overlapping clones, and...
Pohl, T.M., Zimmer, M., MacDonald, M.E., Smith, B., Bucan, M., Poustka, A., ...
Linking clones contain sequences flanking recognition sites for enzymes cutting rarely in mammalian DNA. They can be used to obtain and correlate both physical and genetic mapping information over...
Bucan, M, Herrmann, BG, Frischauf, AM, Bautch, VL, Bode, V, Silver, LM, ...
Silver, LM, Hammer, M, Fox, H, Garrels, J, Bucan, M, Herrmann, B, ...
Brain tubutin and actin cDNA sequence: isolation of recombinant plasmids (1980)
Ginzburg, I., De Baetselier, A., Walker, M.D., Behar, L., Lehrach, H., Frischauf, A.M., ...
Rat brain mRNA enriched for tubulin and actin sequences was used to prepare double stranded cDNA. A library of recombinant clones was constructed by inserting the dsDNA into the Pstl site of pBR322...
A subcloning strategy for DNA sequence analysis (1980)
Frischauf, A.M., Garoff, H., Lehrach, H.
We describe here a new strategy of fragment preparation for sequencing procedures using endlabelled DNA fragments as substrates (2,3) which is directly applicable to DNA fragments cloned into the Pst...
Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.
Brown, M A, Jones, K A, Nicolai, H, Bonjardim, M, Black, D, McFarlane, R, ...
BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the...
Nizetić, D, Zehetner, G, Monaco, A P, Gellen, L, Young, B D, Lehrach, H
We have constructed cosmid libraries from flow-sorted human chromosomes X and 21, each of which contains greater than 30 genome equivalents, and have developed systems allowing permanent storage of...
Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.
Larin, Z, Monaco, A P, Lehrach, H
Yeast artificial chromosome (YAC) libraries have been difficult to construct with average insert sizes greater than 400 kilobase pairs when DNA is size-fractionated in low-melting-point agarose. By...
Physical map of human Xq27-qter: localizing the region of the fragile X mutation.
Poustka, A, Dietrich, A, Langenstein, G, Toniolo, D, Warren, S T, Lehrach, H
We describe a physical map of the end of the long arm of the human X chromosome encompassing the region from Xq27.2 to the q telomere, inclusive of the chromosomal band Xq28. This region is of...
A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.
Rubock, M J, Larin, Z, Cook, M, Papalopulu, N, Krumlauf, R, Lehrach, H
We have isolated two genes, Hox-2.8 and Hox-2.9, from the mouse homeobox cluster Hox-2, located on chromosome 11. A 120-kilobase yeast artificial chromosome (YAC) containing a large region of the...
Simplified handling of high-density genetic filters using rigid plastic laminates.
Bancroft, D R, O'Brien, J K, Guerasimova, A, Lehrach, H
Wet membranes in DNA hybridisation procedures can be very difficult to handle. This adds considerable time to the length of experiments and is a serious obstacle to the performance of large-scale...
IXDB, an X chromosome integrated database.
Leser, U, Wagner, R, Grigoriev, A, Lehrach, H, Roest Crollius, H
The integrated X chromosome database (IXDB) is a repository for physical mapping data of the human X chromosome. Its current content is the result of a strict integration of data stemming from many...
Comparative gene expression profiling by oligonucleotide fingerprinting.
Meier-Ewert, S, Lange, J, Gerst, H, Herwig, R, Schmitt, A, Freund, J, ...
The use of hybridisation of synthetic oligonucleotides to cDNAs under high stringency to characterise gene sequences has been demonstrated by a number of groups. We have used two cDNA libraries of 9...
Büssow, K, Cahill, D, Nietfeld, W, Bancroft, D, Scherzinger, E, Lehrach, H, ...
We have developed a technique to establish catalogues of protein products of arrayed cDNA clones identified by DNA hybridisation or sequencing. A human fetal brain cDNA library was directionally...
Radelof, U, Hennig, S, Seranski, P, Steinfath, M, Ramser, J, Reinhardt, R, ...
Large-scale genomic sequencing projects generally rely on random sequencing of shotgun clones, followed by different gap closing strategies. To reduce the overall effort and cost of those projects...
IXDB, an X chromosome integrated database (update).
Leser, U, Roest Crollius, H, Lehrach, H, Sudbrak, R
Chromosome specific databases are an important research tool as they integrate data from different directions, such as genetic and physical mapping data, expression data, sequences etc. They...
A method of one-step enzyme labelling of short oligonucleotide probes for filter hybridisation.
Guerasimova, A, Ivanov, I, Lehrach, H
Here we describe a method of labelling short oligonucleotide probes with enzyme without purification or chemical modifications. Biotinylated oligonucleotides as short as 10 nt are coupled with...
Riedel, H, Lehrach, H, Garoff, H
The nucleotide sequence at the junction between the nonstructural and the structural genes of the Semliki Forest virus 42S RNA genome has been determined from cloned cDNA. With the aid of S1-mapping,...
Scholler, P, Karger, A E, Meier-Ewert, S, Lehrach, H, Delius, H, Hoheisel, J D
To test the effectiveness of ordering shotgun DNA-templates prior to sequence analysis, the 450 kb left arm of yeast chromosome XII was randomly subcloned into a phagemid vector. Clones were ordered...
Mott, R, Grigoriev, A, Maier, E, Hoheisel, J, Lehrach, H
A complete set of software tools to aid the physical mapping of a genome has been developed and successfully applied to the genomic mapping of the fission yeast Schizosaccharomyces pombe. Two...
Labelling oligonucleotides to high specific activity (I).
Craig, A G, Nizetic, D, Lehrach, H
The normal procedure for labelling oligonucleotides radioactively is the use of polynucleotide kinase and gamma 32P-ATP. However, this has the disadvantage of only introducing one labelled base per...
Brain tubulin and actin cDNA sequences: isolation of recombinant plasmids.
Ginzburg, I, De Baetselier, A, Walker, M D, Behar, L, Lehrach, H, Frischauf, A M, ...
Rat brain mRNA enriched for tubulin and actin sequences was used to prepare double stranded cDNA. A library of recombinant clones was constructed by inserting the dsDNA into the Pst1 site of pBR322...
A subcloning strategy for DNA sequence analysis.
Frischauf, A M, Garoff, H, Lehrach, H
We describe here a new strategy of fragment preparation for sequencing procedures using endlabelled DNA fragments as substrates (2,3) which is directly applicable to DNA fragments cloned into the Pst...
Garoff, H, Riedel, H, Lehrach, H
We describe a peptide sequencing procedure which can be used to verify an amino acid sequence which is derived from a nucleotide sequence. One first labels the protein with a 3H- and a 14C-labelled...
Construction and characterization of type II collagen complementary deoxyribonucleic acid clones.
Lukens, L N, Frischauf, A M, Pawlowski, P J, Brierley, G T, Lehrach, H
The mRNA for type II collagen was purified from embryonic chick sternum or from purified sternal chondrocytes with guanidine thiocyanate as the extractant. Double-stranded cDNAs to procollagen mRNAs...
Monaco, A P, Lam, V M, Zehetner, G, Lennon, G G, Douglas, C, Nizetic, D, ...
A direct hybridization protocol is described for screening cosmid and yeast artificial chromosome libraries with pools of Alu-PCR products from somatic cell or irradiation hybrids. This method...
Patel, K, Cox, R, Shipley, J, Kiely, F, Frazer, K, Cox, D R, ...
We describe a simple PCR based technique which can be used to isolate sequences adjacent to rare cutter sites and can subsequently be employed for the construction of long range physical maps. The...
W (A or T) sequences as probes and primers suitable for genomic mapping and fingerprinting.
Drmanac, R, Nizetic, D, Lennon, G G, Beitverda, A, Lehrach, H
A limitation to the use of oligonucleotide probes as tools for genetic and physical mapping has been the low hybridization positive frequency obtained by oligonucleotides of sufficient length to...
The direct screening of cosmid libraries with YAC clones.
Baxendale, S, Bates, G P, MacDonald, M E, Gusella, J F, Lehrach, H
A mouse specific polymerase chain reaction (PCR) primer: probe generation from somatic cell hybrids.
Craig, A G, Nizetic, D, Hoheisel, J D, Zehetner, G, Lehrach, H
To allow the efficient construction of ordered clone libraries, we have been investigating the use of 'oligonucleotide fingerprinting' as an approach to identify overlapping clones, and ultimately...
A method for the generation of YAC transgenic mice by pronuclear microinjection.
Schedl, A, Larin, Z, Montoliu, L, Thies, E, Kelsey, G, Lehrach, H, ...
Yeast artificial chromosomes (YACs) represent the latest generation of vectors which have the great advantage of large insert size. The introduction of YACs into mammalian cells and organisms has...
Control of partial digestion combining the enzymes dam methylase and MboI.
Hoheisel, J D, Nizetic, D, Lehrach, H
A method is described which allows the preparation of reproducible partial digests without previous establishment of the incubation conditions. It is based on a combined application of dam methylase...
The analysis of partial digestion products extending from the telomere of the human X and Y chromosomes, visualised by hybridisation to a probe located close to the telomere, was used to establish a...
A computer program package for restriction map analysis and manipulation.
Programs for the calculation, storage and analysis of restriction maps derived from the analysis of partial digestion products from end labelled DNA (1,2,3) and their correlation with digestion - and...
Selective isolation of cosmid clones by homologous recombination in Escherichia coli.
Poustka, A, Rackwitz, H R, Frischauf, A M, Hohn, B, Lehrach, H
A procedure for selection of specific cosmid clones by homologous recombination between cosmid clones from a library and sequences cloned into a plasmid has been developed. Cosmid libraries...
Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase.
Rosenberg, U B, Kunz, G, Frischauf, A, Lehrach, H, Mähr, R, Eppenberger, H M, ...
Sequences complementary to muscle poly(A)+RNA were cloned in the plasmid pBR322 and the resulting colonies were screened by colony hybridization with labeled cDNA derived from skeletal muscle and...
Katcoff, D, Nudel, U, Zevin-Sonkin, D, Carmon, Y, Shani, M, Lehrach, H, ...
The construction and partial characterization of recombinant bacterial plasmids carrying DNA sequences that hybridize with rat skeletal muscle actin and a myosin light chain mRNA is described. DNA of...
Garoff, H, Frischauf, A M, Simons, K, Lehrach, H, Delius, H
The amino acid sequence of the capsid (C) protein was deduced from the nucleotide sequence of the C gene. This part of the viral 42S RNA genome was transcribed into double-stranded cDNA. The cDNA was...
Construction and characterization of a 2.5-kilobase procollagen clone.
Lehrach, H, Frischauf, A M, Hanahan, D, Wozney, J, Fuller, F, Crkvenjakov, R, ...
Recombinant bacterial plasmids have been constructed by inserting double-stranded chicken procollagen cDNA sequences linked to chemically synthesized decanucleotides containing HindIII sites into the...
Genetic and molecular mapping of the Hmt region of mouse.
Richards, S, Bucan, M, Brorson, K, Kiefer, M C, Hunt, S W, Lehrach, H, ...
We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies...
Deletions in immunoglobulin mu chains.
Köhler, G, Potash, M J, Lehrach, H, Shulman, M J
Eight mutant hybridoma lines are described, which synthesize short immunoglobulin mu chains. Four internal deletions were mapped by Southern blot analysis. They are shown to remove DNA from either...
Jäckle, H., Almeida, J. C. De, Galler, R., Kluding, H., Lehrach, H.
The large Balbiani rings of the chironomids produce giant internally repeated transcripts that are translated into silk-like proteins used for protective tubes. We have cloned fragments of the...
Barlow, D P, Bućan, M, Lehrach, H, Hogan, B L, Gough, N M
The two murine haemopoietic growth factors, granulocyte-macrophage colony stimulating factor (GM-CSF) and Multi-CSF (interleukin 3) stimulate the proliferation and differentiation of an overlapping...
Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island.
Rappold, G A, Stubbs, L, Labeit, S, Crkvenjakov, R B, Lehrach, H
We have used an approach based on the observation of CpG-rich regions near the 5' end of many genes to screen a panel of cosmids derived from the t-complex and tested candidate sequences for evidence...
Bućan, M, Yang-Feng, T, Colberg-Poley, A M, Wolgemuth, D J, Guenet, J L, Francke, U, ...
Probes from the m6 homeo box cluster were mapped to mouse chromosome 6 by somatic cell genetics, in situ hybridisation, and by a Mus spretus--Mus musculus backcross mapping system. In addition, the...
Fine mapping of the McLeod locus (XK) to a 150-380-kb region in Xp21.
Ho, M F, Monaco, A P, Blonden, L A, Van Ommen, G J, Affara, N A, Ferguson-Smith, M A, ...
McLeod syndrome, characterized by acanthocytosis and the absence of a red-blood-cell Kell antigen (Kx), is a multisystem disorder involving a late-onset myopathy, splenomegaly, and neurological...
Complex patterns of linkage disequilibrium in the Huntington disease region.
MacDonald, M E, Lin, C, Srinidhi, L, Bates, G, Altherr, M, Whaley, W L, ...
The genetic defect causing Huntington disease (HD) has been mapped to 4p16.3 by linkage analysis using DNA markers. Two apparently contradictory classes of recombination events in HD kindreds...
Defined physical limits of the Huntington disease gene candidate region.
Bates, G P, MacDonald, M E, Baxendale, S, Youngman, S, Lin, C, Whaley, W L, ...
The Huntington disease (HD) gene has been mapped 4 cM distal to D4S10 within the telomeric chromosome band, 4p16.3. The published physical map of this region extends from D4S10 to the telomere but...
Bates, G. P., MacDonald, M. E., Baxendale, S., Sedlacek, Z., Youngman, S., Romano, D., ...
The Huntington disease (HD) gene has been mapped to the most distal subband of chromosome 4p. Analysis of recombination events has not provided an unequivocal location of the HD gene, but it...
Hollenbach, B, Scherzinger, E, Schweiger, K, Lurz, R, Lehrach, H, Wanker, E E
We have shown previously by electron microscopy that the purified glutathione S-transferase (GST)-Huntington's disease (HD) exon 1 fusion protein with 51 glutamine residues (GST-HD51) is an oligomer,...
Kues, W. A., Sudheer, S., Herrmann, D., Carnwath, J. W., Havlicek, V., Besenfelder, U., ...
Bovine embryos can be generated by in vitro fertilization or somatic nuclear transfer; however, these differ from their in vivo counterparts in many aspects and exhibit a higher proportion of...
Stemming Cancer: Functional Genomics of Cancer Stem Cells in Solid Tumors
Regenbrecht, C. R. A., Lehrach, H., Adjaye, J.
Cancer stem cells (CSCs) were discovered about 15 years ago in hematopoietic cancers. Subsequently, cancer stem cells were discovered in various solid tumors. Based on parallels with normal stem...