Persson, H, Widen, B, Andersson, S, Svensson, L
Corylus avellana L. (hazel, Betulaceae) is a long-lived, widespread shrub in Europe, having its northern range margin in Fennoscandia and a postglacial history involving range-expansion from refugial...
Nilsson, L, Kahlert, J, Persson, H
The moult migration of Greylag Geese Anser anser from Scania, southernmost Sweden, was studied based on resightings of neck-banded individuals marked in the breeding areas. Most geese seen in...
Genet age in marginal populations of two clonal Carex species in the Siberian Arctic (2000)
Jonsdottir, IS, Augner, M, Fagerström, T, Persson, H, Stenström, A
During a Swedish-Russian expedition to northern Siberia 1994, we sampled two marginal populations of two Carex species at two high arctic sites (C. stuns Drej. on Faddeyevsky Island and C. ensifolia...
Linking plant nutrition and ecosystem processes (2000)
Bauer, G.A., Persson, H., Persson, T., Mund, M., Hein, M., Kummetz, E., ...
Exact two-loop vacuum polarization correctionto the Lamb shift in hydrogen-like ions (1997)
Plunien, G., Beier, T., Soff, G., Persson, H.
We present a calculation scheme for the two-loop vacuum polarization correction of order $\alpha^2$ to the Lamb shift of hydrogen-like high-Z atoms. The interaction with the external Coulomb field is...
Persson, H., Eriksson, S. V., Erhardt, L.
Two hundred and ten patients with clinical evidence of heart failure, developing after an acute myocardial infarction, were randomized to treatment with the β1 antagonist metoprolol 50–100mg...
PERSSON, H., LINDER-KLINGSELL, E., ERIKSSON, S. V., ERHARDT, L.
Clinical signs of heart failure based on predefined criteria were analysed in 217 survivors (
Nitrex - Nitrogen saturation experiments. (1992)
Wright, R.F., Emmett, B., Roelofs, J.G.M., Tietema, A., Verhoef, H.A., ...
Recurrence of SLE in transplanted kidneys: a follow-up transplant biopsy study (1992)
Nyberg, G., Blohmé, I., Persson, H., Olausson, M., Svalander, C.
Renal transplant biopsies were obtained from 16 patients with systemic lupus erythaematosus6 months to 11 years post-transplant. Eight biopsies were taken on clinical grounds while eight were...
Nitrex - nitrogen saturation eexperiments. (1991)
Wright, R.F., Emmet, B., Roelofs, J.G.M., Tietema, A., Verhoef, H.A., ...
Renal Transplantation in the Bardet-Biedl Syndrome, A Form of Laurence-Moon-Biedl Syndrome (1991)
Nordén, G., Friman, S., Frisenette-Fich, C., Persson, H., Karlberg, I.
Lönnerberg, P, Lendahl, U, Funakoshi, H, Arhlund-Richter, L, Persson, H, Ibáñez, C F
Acetylcholine, one of the main neurotransmitters in the nervous system, is synthesized by the enzyme choline acetyltransferase (ChAT; acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6). The...
Ilag, L L, Curtis, R, Glass, D, Funakoshi, H, Tobkes, N J, Ryan, T E, ...
Pan-neurotrophin 1 (PNT-1) is a synthetic trophic factor engineered by combining active domains of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and...
Frisén, J, Verge, V M, Fried, K, Risling, M, Persson, H, Trotter, J, ...
In situ hybridization on sections from the adult rat peripheral and central nervous systems demonstrated that trkB mRNA was expressed not only by neurons but also by cells in central nervous system...
Coexpression of neurotrophins and their receptors in neurons of the central nervous system.
Kokaia, Z, Bengzon, J, Metsis, M, Kokaia, M, Persson, H, Lindvall, O
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neuronal survival molecules which utilize the Trk family of tyrosine kinase receptors. Using double-label in situ...
Metsis, M, Timmusk, T, Arenas, E, Persson, H
The rat brain-derived neurotropic factor (BDNF) gene consists of four 5' exons linked to separate promoters and one 3' exon encoding the prepro-BDNF protein. To gain insights into the regulation of...
Lindvall, O, Ernfors, P, Bengzon, J, Kokaia, Z, Smith, M L, Siesjö, B K, ...
In situ hybridization was used to study expression of mRNAs for members of the nerve growth factor (NGF) family in the rat brain after 2 and 10 min of forebrain ischemia and 1 and 30 min of...
Frisén, J, Verge, V M, Cullheim, S, Persson, H, Fried, K, Middlemas, D S, ...
Expression of neurotrophins and neurotrophin receptors was examined with in situ hybridization and immunohistochemical techniques 10 days to 6 weeks after ventral or dorsal funiculus spinal cord...
Ibáñez, C F, Pelto-Huikko, M, Söder, O, Ritzèn, E M, Hersh, L B, Hökfelt, T, ...
The gene encoding choline acetyltransferase (ChAT; EC 2.3.1.6), the key enzyme in the synthesis of the neurotransmitter acetylcholine (ACh), is shown to be expressed in rat and human testes. High...
Ceccatelli, S, Ernfors, P, Villar, M J, Persson, H, Hökfelt, T
The effect of intracerebroventricular injection of the mitosis inhibitor colchicine on expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3...
Ernfors, P, Ibáñez, C F, Ebendal, T, Olson, L, Persson, H
We have used a pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) to prime rat...
Gene and mRNA for precursor polypeptide VI from adenovirus type 2.
We present a 1,040-base-pair-long sequences of adenoviruses type 2 DNA which encodes the complete gene for precursor polypeptide VI (pVI). pVI consists of 250 amino acids amounting to a molecular...
Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
Lundgren, E, Carballeira, N, Vazquez, R, Dubinina, E, Bränden, H, Persson, H, ...
The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells...
Persson, H, Katze, M G, Philipson, L
We studied the accumulation of viral mRNA in the presence of inhibitors of protein synthesis in an adenovirus type 5-transformed cell line (line 293 cells). An analysis of the endogenous viral mRNA's...
Purification of a native membrane-associated adenovirus tumor antigen.
Persson, H, Katze, M G, Philipson, L
A 15,000-dalton protein was purified from HeLa cells infected with adenovirus type 2. Proteins solubilized from a membrane fraction of lytically infected cells was used as the starting material for...
Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.
Ayer-LeLievre, C, Olson, L, Ebendal, T, Hallböök, F, Persson, H
In situ hybridization using beta-nerve growth factor (NGF) DNA probes was used to demonstrate NGF mRNA in spermatocytes and early spermatids of adult mouse. NGF mRNA-containing cells were also...
Schalling, M, Dagerlind, A, Brené, S, Hallman, H, Djurfeldt, M, Persson, H, ...
Expression and regulation of the catecholamine-synthesizing enzymes phenylethanolamine N-methyltransferase (PNMTase; S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase, EC 2.1.1.28) and...
Ernfors, P, Ebendal, T, Olson, L, Mouton, P, Strömberg, I, Persson, H
The rat beta nerve growth factor (NGF) gene was inserted into a mammalian expression vector and cotransfected with a plasmid conferring resistance to neomycin into mouse 3T3 fibroblasts. From this...
Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells.
Schalling, M, Persson, H, Pelto-Huikko, M, Odum, L, Ekman, P, Gottlieb, C, ...
In previous studies we have shown that the gene encoding cholecystokinin (CCK) is expressed in spermatogenic cells of several mammalian species. In the present study we show that a gene homologous to...
Persson, H, Rehfeld, J F, Ericsson, A, Schalling, M, Pelto-Huikko, M, Hökfelt, T
Expression of the gene encoding the neurotransmitter/neuromodulator cholecystokinin (CCK) was demonstrated in testis of several different species. Two testicular CCK mRNA transcripts of different...
Ericsson, A, Schalling, M, McIntyre, K R, Lundberg, J M, Larhammar, D, Seroogy, K, ...
Neuropeptide tyrosine (neuropeptide Y, NPY) is a potent vasoconstrictor with a wide distribution in the central and peripheral nervous systems. Here we show that high levels of rat NPY mRNA are also...
Structure and expression of the gene encoding the vasoactive intestinal peptide precursor.
Linder, S, Barkhem, T, Norberg, A, Persson, H, Schalling, M, Hökfelt, T, ...
The gene encoding the human vasoactive intestinal peptide (VIP) and the histidine-methionine amide (PHM-27) peptide hormone was isolated from lambda phage libraries. The human gene was found to be...
Structure and expression of the rat neuropeptide Y gene.
Larhammar, D, Ericsson, A, Persson, H
Neuropeptide Y is a 36-amino acid peptide that is abundant throughout the mammalian nervous system. It belongs to the same family of carboxyl-terminally amidated peptides as pancreatic polypeptide...
Virtanen, A, Aleström, P, Persson, H, Katze, M G, Pettersson, U
The nucleotide sequence of a 550 base pairs long segment, located between map positions 21 and 22.5 in the adenovirus type 2 genome has been determined. S1 nuclease mapping and sequence analysis of...
Whittemore, S R, Ebendal, T, Lärkfors, L, Olson, L, Seiger, A, Strömberg, I, ...
The presence of nerve growth factor (NGF) mRNA and protein in the rat central nervous system is documented. Blot-hybridization analysis showed an abundance of NGF mRNA in the hippocampus, cerebral...
A DRB (5,6 dichloro-beta-D-ribofuranosylbenzimidazole)-resistant adenovirus mRNA.
Vennström, B, Persson, H, Pettersson, U, Philipson, L
5,6-Dichloro-beta-D ribofuranosyl benzimidazole (DRB) inhibits transcription from the major late adenovirus promoter, located on the r-strand at map position 16.3 on the viral genome. 100-500...
B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor.
Leanderson, T, Lundgren, E, Ruuth, E, Borg, H, Persson, H, Coutinho, A
A T-cell hybridoma was derived by somatic cell hybridization between concanavalin A-activated BALB/c spleen cells and the AKR thymoma BW 5147. Media conditioned by hybridoma cells, even at high...
Persson, H, Jörnvall, H, Zabielski, J
Early region 3 of the adenovirus type 2 genome encodes three proteins with molecular weights of 16,000, 14,500, and 14,000 (E2/16, E3/14.5, and E3/14). The E3/16 protein is the precursor to the E3/19...
Purification and characterization of an early glycoprotein from adenovirus type 2-infected cells.
Persson, H, Signäs, C, Philipson, L
An adenovirus type 2 early glycoprotein with an apparent molecular weight of 19,000 (E19K) in sodium dodecyl sulfate-polyacrylamide gels has been extensively purified. Purification involved detergent...
In vitro translation with adenovirus polyribosomes.
Persson, H, Oberg, B, Philipson, L
Polyribosomes isolated from adenovirus type 2 (Ad2)-infected HeLa cells late in productive infection can be used for translation in cell-free systems. At least eight viral polypeptides are...
Purification and characterization of an early protein (E14K) from adenovirus type 2-infected cells.
Persson, H, Oberg, B, Philipson, L
One adenovirus type 2 (Ad2) early protein, with an apparent molecular weight of 14,000 in sodium dodecyl sulfate-polyacrylamide gels (E14K), was purified to homogeneity. Purification involved...
Persson, H, Pelto-Huikko, M, Metsis, M, Söder, O, Brene, S, Skog, S, ...
The gene encoding glutamic acid decarboxylase (GAD), the key enzyme in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid, is shown to be expressed in the testis of several...
Production and characterization of biologically active recombinant beta nerve growth factor.
Hallböök, F, Ebendal, T, Persson, H
DNA fragments encoding either rat or chicken beta nerve growth factor (NGF) were inserted in the expression vector p91023(B) for transient expression in COS cells. The two NGF constructs produced RNA...
Persson, H, Gray, H E, Godeau, F, Braunhut, S, Bellvé, A R
Different antisera raised against various regions of the human c-myc protein were used to identify four human c-myc proteins with apparent molecular masses in sodium dodecyl sulfate-polyacrylamide...
Persson, H, Gray, H E, Godeau, F
Synthesis of the c-myc gene product was measured during the entire cell cycle of subconfluent mouse 3T3 cells with an antibody raised against a human c-myc synthetic peptide. The antiserum recognized...
Katze, M G, Persson, H, Philipson, L
An adenovirus type 5 host range mutant (hr-1) located in region E1A and phenotypically defective in expressing viral messenger ribonucleic acid (RNA) from other early regions (Berk et al., Cell...
Kvist, S, Ostberg, L, Persson, H, Philipson, L, Peterson, P A
A rat cell line (A2T2C4) transformed with adenovirus type 2 elicited cytotoxic T lymphocytes in syngeneic rats. Cytotoxicity was abolished by a rabbit antiserum directed against the major...
Ibáñez, C F, Ilag, L L, Murray-Rust, J, Persson, H
Neurotrophin-mediated cell survival and differentiation of vertebrate neurons is caused by ligand-specific binding to the Trk family of tyrosine kinase receptors. However, sites in the neurotrophins...
Modulation of immune responses in newborn and adult mice by interferon.
Strannegård, O, Larsson, I, Lundgren, E, Miörner, H, Persson, H
Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the...
Forrest, D, Hallböök, F, Persson, H, Vennström, B
Thyroid hormones are essential for correct brain development, and since vertebrates express two thyroid hormone receptor genes (TR alpha and beta), we investigated TR gene expression during chick...
Ibáñez, C F, Ebendal, T, Persson, H
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two members of a family of neurotrophic factors which show both overlapping and distinct neurotrophic activities. Using...
Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2.
Johansson, K, Persson, H, Lewis, A M, Pettersson, U, Tibbetts, C, Philipson, L
Complementary strand-specific adenovirus DNA of full length or from endonuclease BamHI fragments was used as a probe to estimate the fractional representation and abundance of viral sequences in five...
Katze, M G, Persson, H, Philipson, L
Immunoprecipitation was used to identify adenovirus type 2 (ad2) tumor antigens synthesized in vivo. The antisera, prepared from tumor-bearing animals, reacted with a wide spectrum of ad2 early...
Structure and expression of the chicken beta nerve growth factor gene.
Ebendal, T, Larhammar, D, Persson, H
The 3' exon of the chicken beta nerve growth factor (NGF) gene was isolated by the use of a murine cDNA probe. DNA sequence analysis of the clone suggests a mature chicken NGF protein of 118 amino...
Godeau, F, Persson, H, Gray, H E, Pardee, A B
The combined use of a human c-myc probe and of an antibody raised against the human c-myc gene product demonstrated that the Xenopus cells contained a 2.5-kb c-myc transcript and synthesized a c-myc...
Ibáñez, C F, Hallböök, F, Ebendal, T, Persson, H
Selected amino acid residues in chicken nerve growth factor (NGF) were replaced by site-directed mutagenesis. Mutated NGF sequences were transiently expressed in COS cells and the yield of NGF...
Persson, H, Bennegård, K, Lundberg, P A, Svaninger, G, Lundholm, K
Circulating levels of thyroid hormones (T4, free T4, T3) and reverse tri-iodo thyronine (rT3) and thyroid-hormone binding globulin were related to the nutritional state of patients with cancer...
Acetylcholine in adrenergic terminals of the cat iris
Ehinger, B., Falck, B., Persson, H., Sporrong, B.
1. Acetylcholine was bio-assayed in the normal cat iris, and also after selective sympathetic or parasympathetic denervation. Sympathetic denervation caused no significant change in the acetylcholine...
Lönnerberg, P, Lendahl, U, Funakoshi, H, Arhlund-Richter, L, Persson, H, Ibáñez, C F
Acetylcholine, one of the main neurotransmitters in the nervous system, is synthesized by the enzyme choline acetyltransferase (ChAT; acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6). The...
Ilag, L L, Curtis, R, Glass, D, Funakoshi, H, Tobkes, N J, Ryan, T E, ...
Pan-neurotrophin 1 (PNT-1) is a synthetic trophic factor engineered by combining active domains of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and...
Frisén, J, Verge, V M, Fried, K, Risling, M, Persson, H, Trotter, J, ...
In situ hybridization on sections from the adult rat peripheral and central nervous systems demonstrated that trkB mRNA was expressed not only by neurons but also by cells in central nervous system...
Coexpression of neurotrophins and their receptors in neurons of the central nervous system.
Kokaia, Z, Bengzon, J, Metsis, M, Kokaia, M, Persson, H, Lindvall, O
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neuronal survival molecules which utilize the Trk family of tyrosine kinase receptors. Using double-label in situ...
Metsis, M, Timmusk, T, Arenas, E, Persson, H
The rat brain-derived neurotropic factor (BDNF) gene consists of four 5' exons linked to separate promoters and one 3' exon encoding the prepro-BDNF protein. To gain insights into the regulation of...
Lindvall, O, Ernfors, P, Bengzon, J, Kokaia, Z, Smith, M L, Siesjö, B K, ...
In situ hybridization was used to study expression of mRNAs for members of the nerve growth factor (NGF) family in the rat brain after 2 and 10 min of forebrain ischemia and 1 and 30 min of...
Frisén, J, Verge, V M, Cullheim, S, Persson, H, Fried, K, Middlemas, D S, ...
Expression of neurotrophins and neurotrophin receptors was examined with in situ hybridization and immunohistochemical techniques 10 days to 6 weeks after ventral or dorsal funiculus spinal cord...
Ibáñez, C F, Pelto-Huikko, M, Söder, O, Ritzèn, E M, Hersh, L B, Hökfelt, T, ...
The gene encoding choline acetyltransferase (ChAT; EC 2.3.1.6), the key enzyme in the synthesis of the neurotransmitter acetylcholine (ACh), is shown to be expressed in rat and human testes. High...
Ceccatelli, S, Ernfors, P, Villar, M J, Persson, H, Hökfelt, T
The effect of intracerebroventricular injection of the mitosis inhibitor colchicine on expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3...
Ernfors, P, Ibáñez, C F, Ebendal, T, Olson, L, Persson, H
We have used a pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) to prime rat...
Gene and mRNA for precursor polypeptide VI from adenovirus type 2.
We present a 1,040-base-pair-long sequences of adenoviruses type 2 DNA which encodes the complete gene for precursor polypeptide VI (pVI). pVI consists of 250 amino acids amounting to a molecular...
Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
Lundgren, E, Carballeira, N, Vazquez, R, Dubinina, E, Bränden, H, Persson, H, ...
The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells...
Persson, H, Katze, M G, Philipson, L
We studied the accumulation of viral mRNA in the presence of inhibitors of protein synthesis in an adenovirus type 5-transformed cell line (line 293 cells). An analysis of the endogenous viral mRNA's...
Purification of a native membrane-associated adenovirus tumor antigen.
Persson, H, Katze, M G, Philipson, L
A 15,000-dalton protein was purified from HeLa cells infected with adenovirus type 2. Proteins solubilized from a membrane fraction of lytically infected cells was used as the starting material for...
Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.
Ayer-LeLievre, C, Olson, L, Ebendal, T, Hallböök, F, Persson, H
In situ hybridization using beta-nerve growth factor (NGF) DNA probes was used to demonstrate NGF mRNA in spermatocytes and early spermatids of adult mouse. NGF mRNA-containing cells were also...
Schalling, M, Dagerlind, A, Brené, S, Hallman, H, Djurfeldt, M, Persson, H, ...
Expression and regulation of the catecholamine-synthesizing enzymes phenylethanolamine N-methyltransferase (PNMTase; S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase, EC 2.1.1.28) and...
Ernfors, P, Ebendal, T, Olson, L, Mouton, P, Strömberg, I, Persson, H
The rat beta nerve growth factor (NGF) gene was inserted into a mammalian expression vector and cotransfected with a plasmid conferring resistance to neomycin into mouse 3T3 fibroblasts. From this...
Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells.
Schalling, M, Persson, H, Pelto-Huikko, M, Odum, L, Ekman, P, Gottlieb, C, ...
In previous studies we have shown that the gene encoding cholecystokinin (CCK) is expressed in spermatogenic cells of several mammalian species. In the present study we show that a gene homologous to...
Persson, H, Rehfeld, J F, Ericsson, A, Schalling, M, Pelto-Huikko, M, Hökfelt, T
Expression of the gene encoding the neurotransmitter/neuromodulator cholecystokinin (CCK) was demonstrated in testis of several different species. Two testicular CCK mRNA transcripts of different...
Ericsson, A, Schalling, M, McIntyre, K R, Lundberg, J M, Larhammar, D, Seroogy, K, ...
Neuropeptide tyrosine (neuropeptide Y, NPY) is a potent vasoconstrictor with a wide distribution in the central and peripheral nervous systems. Here we show that high levels of rat NPY mRNA are also...
Structure and expression of the gene encoding the vasoactive intestinal peptide precursor.
Linder, S, Barkhem, T, Norberg, A, Persson, H, Schalling, M, Hökfelt, T, ...
The gene encoding the human vasoactive intestinal peptide (VIP) and the histidine-methionine amide (PHM-27) peptide hormone was isolated from lambda phage libraries. The human gene was found to be...
Structure and expression of the rat neuropeptide Y gene.
Larhammar, D, Ericsson, A, Persson, H
Neuropeptide Y is a 36-amino acid peptide that is abundant throughout the mammalian nervous system. It belongs to the same family of carboxyl-terminally amidated peptides as pancreatic polypeptide...
Virtanen, A, Aleström, P, Persson, H, Katze, M G, Pettersson, U
The nucleotide sequence of a 550 base pairs long segment, located between map positions 21 and 22.5 in the adenovirus type 2 genome has been determined. S1 nuclease mapping and sequence analysis of...
Whittemore, S R, Ebendal, T, Lärkfors, L, Olson, L, Seiger, A, Strömberg, I, ...
The presence of nerve growth factor (NGF) mRNA and protein in the rat central nervous system is documented. Blot-hybridization analysis showed an abundance of NGF mRNA in the hippocampus, cerebral...
A DRB (5,6 dichloro-beta-D-ribofuranosylbenzimidazole)-resistant adenovirus mRNA.
Vennström, B, Persson, H, Pettersson, U, Philipson, L
5,6-Dichloro-beta-D ribofuranosyl benzimidazole (DRB) inhibits transcription from the major late adenovirus promoter, located on the r-strand at map position 16.3 on the viral genome. 100-500...
B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor.
Leanderson, T, Lundgren, E, Ruuth, E, Borg, H, Persson, H, Coutinho, A
A T-cell hybridoma was derived by somatic cell hybridization between concanavalin A-activated BALB/c spleen cells and the AKR thymoma BW 5147. Media conditioned by hybridoma cells, even at high...
Persson, H, Jörnvall, H, Zabielski, J
Early region 3 of the adenovirus type 2 genome encodes three proteins with molecular weights of 16,000, 14,500, and 14,000 (E2/16, E3/14.5, and E3/14). The E3/16 protein is the precursor to the E3/19...
Purification and characterization of an early glycoprotein from adenovirus type 2-infected cells.
Persson, H, Signäs, C, Philipson, L
An adenovirus type 2 early glycoprotein with an apparent molecular weight of 19,000 (E19K) in sodium dodecyl sulfate-polyacrylamide gels has been extensively purified. Purification involved detergent...
In vitro translation with adenovirus polyribosomes.
Persson, H, Oberg, B, Philipson, L
Polyribosomes isolated from adenovirus type 2 (Ad2)-infected HeLa cells late in productive infection can be used for translation in cell-free systems. At least eight viral polypeptides are...
Purification and characterization of an early protein (E14K) from adenovirus type 2-infected cells.
Persson, H, Oberg, B, Philipson, L
One adenovirus type 2 (Ad2) early protein, with an apparent molecular weight of 14,000 in sodium dodecyl sulfate-polyacrylamide gels (E14K), was purified to homogeneity. Purification involved...
Persson, H, Pelto-Huikko, M, Metsis, M, Söder, O, Brene, S, Skog, S, ...
The gene encoding glutamic acid decarboxylase (GAD), the key enzyme in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid, is shown to be expressed in the testis of several...
Production and characterization of biologically active recombinant beta nerve growth factor.
Hallböök, F, Ebendal, T, Persson, H
DNA fragments encoding either rat or chicken beta nerve growth factor (NGF) were inserted in the expression vector p91023(B) for transient expression in COS cells. The two NGF constructs produced RNA...
Persson, H, Gray, H E, Godeau, F, Braunhut, S, Bellvé, A R
Different antisera raised against various regions of the human c-myc protein were used to identify four human c-myc proteins with apparent molecular masses in sodium dodecyl sulfate-polyacrylamide...
Persson, H, Gray, H E, Godeau, F
Synthesis of the c-myc gene product was measured during the entire cell cycle of subconfluent mouse 3T3 cells with an antibody raised against a human c-myc synthetic peptide. The antiserum recognized...
Katze, M G, Persson, H, Philipson, L
An adenovirus type 5 host range mutant (hr-1) located in region E1A and phenotypically defective in expressing viral messenger ribonucleic acid (RNA) from other early regions (Berk et al., Cell...
Kvist, S, Ostberg, L, Persson, H, Philipson, L, Peterson, P A
A rat cell line (A2T2C4) transformed with adenovirus type 2 elicited cytotoxic T lymphocytes in syngeneic rats. Cytotoxicity was abolished by a rabbit antiserum directed against the major...
Ibáñez, C F, Ilag, L L, Murray-Rust, J, Persson, H
Neurotrophin-mediated cell survival and differentiation of vertebrate neurons is caused by ligand-specific binding to the Trk family of tyrosine kinase receptors. However, sites in the neurotrophins...
Modulation of immune responses in newborn and adult mice by interferon.
Strannegård, O, Larsson, I, Lundgren, E, Miörner, H, Persson, H
Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the...
Forrest, D, Hallböök, F, Persson, H, Vennström, B
Thyroid hormones are essential for correct brain development, and since vertebrates express two thyroid hormone receptor genes (TR alpha and beta), we investigated TR gene expression during chick...
Ibáñez, C F, Ebendal, T, Persson, H
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two members of a family of neurotrophic factors which show both overlapping and distinct neurotrophic activities. Using...
Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2.
Johansson, K, Persson, H, Lewis, A M, Pettersson, U, Tibbetts, C, Philipson, L
Complementary strand-specific adenovirus DNA of full length or from endonuclease BamHI fragments was used as a probe to estimate the fractional representation and abundance of viral sequences in five...
Ibáñez, C F, Hallböök, F, Ebendal, T, Persson, H
Selected amino acid residues in chicken nerve growth factor (NGF) were replaced by site-directed mutagenesis. Mutated NGF sequences were transiently expressed in COS cells and the yield of NGF...
Katze, M G, Persson, H, Philipson, L
Immunoprecipitation was used to identify adenovirus type 2 (ad2) tumor antigens synthesized in vivo. The antisera, prepared from tumor-bearing animals, reacted with a wide spectrum of ad2 early...
Structure and expression of the chicken beta nerve growth factor gene.
Ebendal, T, Larhammar, D, Persson, H
The 3' exon of the chicken beta nerve growth factor (NGF) gene was isolated by the use of a murine cDNA probe. DNA sequence analysis of the clone suggests a mature chicken NGF protein of 118 amino...
Godeau, F, Persson, H, Gray, H E, Pardee, A B
The combined use of a human c-myc probe and of an antibody raised against the human c-myc gene product demonstrated that the Xenopus cells contained a 2.5-kb c-myc transcript and synthesized a c-myc...
Persson, H, Bennegård, K, Lundberg, P A, Svaninger, G, Lundholm, K
Circulating levels of thyroid hormones (T4, free T4, T3) and reverse tri-iodo thyronine (rT3) and thyroid-hormone binding globulin were related to the nutritional state of patients with cancer...
Acetylcholine in adrenergic terminals of the cat iris
Ehinger, B., Falck, B., Persson, H., Sporrong, B.
1. Acetylcholine was bio-assayed in the normal cat iris, and also after selective sympathetic or parasympathetic denervation. Sympathetic denervation caused no significant change in the acetylcholine...
Chronic diarrhoea after radiotherapy for gynaecological cancer: occurrence and aetiology.
Danielsson, A, Nyhlin, H, Persson, H, Stendahl, U, Stenling, R, Suhr, O
The occurrence of chronic diarrhoea was evaluated in 173 consecutive patients previously treated with radiation for gynaecological cancer. A survey of gastrointestinal symptoms showed a high...
Persson, H., Rythe'n-Alder, E., Melcher, A., Erhardt, L.
OBJECTIVE--To evaluate whether xamoterol, a partial agonist, would improve exercise time more than metoprolol in patients with mild to moderate heart failure after a myocardial infarction....
Ventilatory variables are strong prognostic markers in elderly patients with heart failure
Mejhert, M, Linder-Klingsell, E, Edner, M, Kahan, T, Persson, H
Objective: To evaluate the safety and prognostic capacity of cardiopulmonary exercise testing in patients ≥ 60 years old who are hospitalised with heart failure caused by left ventricular...
Limited long term effects of a management programme for heart failure
Mejhert, M, Kahan, T, Persson, H, Edner, M
Objective: To evaluate the effects of a nurse based outpatient management programme for elderly patients discharged with heart failure from a university hospital.