Hypertrophic Cardiomyopathy, Jeanne James, Yan Zhang, Hanna Osinska, Atsushi Sanbe, Raisa Klevitsky, ...
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Proinflammatory consequences of transgenic Fas ligand expression in the heart
Nelson, David P., Setser, Elizabeth, Hall, D. Greg, Schwartz, Steven M., Hewitt, Timothy, Klevitsky, Raisa, ...
Expression of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues can result in severe neutrophil infiltration and tissue destruction. The consequences of...
Regulation of cardiac contractility by Rab4-modulated β2-adrenergic receptor recycling
Odley, Amy, Hahn, Harvey S., Lynch, Roy A., Marreez, Yehia, Osinska, Hanna, Robbins, Jeffrey, ...
Catecholaminergic activation of myocardial β-adrenergic receptors (βAR) is the principle mechanism regulating cardiac function. Agonists desensitize βAR through G protein-coupled receptor...
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis
Sanbe, Atsushi, Osinska, Hanna, Saffitz, Jeffrey E., Glabe, Charles G., Kayed, Rakez, Maloyan, Alina, ...
An R120G missense mutation in the small heat shock protein α-B-crystallin (CryABR120G) causes desmin-related cardiomyopathy (DRM). DRM is characterized by the formation of aggregates containing...
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy
Sanbe, Atsushi, Osinska, Hanna, Villa, Chet, Gulick, James, Klevitsky, Raisa, Glabe, Charles G., ...
Amyloid oligomers, similar to the toxic entities found in Alzheimer's disease patients and in other amyloid-based diseases, are present in cardiomyocytes derived from human heart-failure patients and...
A Transgenic Rabbit Model for Human Troponin I-based Hypertrophic Cardiomyopathy
Sanbe, Atsushi, James, Jeanne, Tuzcu, Volkan, Nas, Selman, Martin, Lisa, Gulick, James, ...
Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
Sadayappan, Sakthivel, Gulick, James, Osinska, Hanna, Martin, Lisa A., Hahn, Harvey S., Dorn, Gerald W., ...
The role of cardiac myosin binding protein-C (cMyBP-C) phosphorylation in cardiac physiology or pathophysiology is unclear. To investigate the status of cMyBP-C phosphorylation in vivo, we determined...
Maloyan, Alina, Sanbe, Atsushi, Osinska, Hanna, Westfall, Margaret, Robinson, Dustin, Imahashi, Ken-ichi, ...
Proinflammatory consequences of transgenic Fas ligand expression in the heart
Nelson, David P., Setser, Elizabeth, Hall, D. Greg, Schwartz, Steven M., Hewitt, Timothy, Klevitsky, Raisa, ...
Expression of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues can result in severe neutrophil infiltration and tissue destruction. The consequences of...
Regulation of cardiac contractility by Rab4-modulated β2-adrenergic receptor recycling
Odley, Amy, Hahn, Harvey S., Lynch, Roy A., Marreez, Yehia, Osinska, Hanna, Robbins, Jeffrey, ...
Catecholaminergic activation of myocardial β-adrenergic receptors (βAR) is the principle mechanism regulating cardiac function. Agonists desensitize βAR through G protein-coupled receptor...
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis
Sanbe, Atsushi, Osinska, Hanna, Saffitz, Jeffrey E., Glabe, Charles G., Kayed, Rakez, Maloyan, Alina, ...
An R120G missense mutation in the small heat shock protein α-B-crystallin (CryABR120G) causes desmin-related cardiomyopathy (DRM). DRM is characterized by the formation of aggregates containing...
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy
Sanbe, Atsushi, Osinska, Hanna, Villa, Chet, Gulick, James, Klevitsky, Raisa, Glabe, Charles G., ...
Amyloid oligomers, similar to the toxic entities found in Alzheimer's disease patients and in other amyloid-based diseases, are present in cardiomyocytes derived from human heart-failure patients and...
Cardiac myosin binding protein c phosphorylation is cardioprotective
Sadayappan, Sakthivel, Osinska, Hanna, Klevitsky, Raisa, Lorenz, John N., Sargent, Michelle, Molkentin, Jeffrey D., ...
Cardiac myosin binding protein C (cMyBP-C) has three phosphorylatable serines at its N terminus (Ser-273, Ser-282, and Ser-302), and the residues' phosphorylation states may alter thick filament...