Constantin Bannert, Martin Vingron, Jens Stoye, Hannes Luz, Sebastian Böcker
These lecture notes are the result of a collaborative effort of many people. They result from a series of lectures given by Martin Vingron (MPI/FU Berlin) and Jens Stoye (Bielefeld University) and a...
BIOINFORMATICS ORIGINAL PAPER Sequence analysis Family specific rates of protein evolution (2008)
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic...
Thomas Meinel, Eike Staub, Antje Krause, Hannes Luz, Stefanie Hartmann, Ute Krämer, ...
sequence information to phylogenetic information SYSTERS superfamily 114462 comprises most of the Cation efflux domain proteins in Arabidopsis thaliana.
Family specific rates of protein evolution (2006)
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic...
About the interrelation of evolutionary rate and protein age (2006)
Luz, Hannes, Staub, Eike, Vingron, Martin
Evolutionary rate and gene age are interrelated when the age of a gene is assessed by the taxonomic distribution in the gene family. This is because homology detection by sequence comparison is...
Exercise 1 (dnaml) [2 points] (2006)
Download an alignment of 5 mitochondrial ATPases in hominids from the lectures’ website at
BIOINFORMATICS Family specific rates of protein evolution (2006)
Hannes Luz, Martin Vingron, Thomas Lengauer
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic...
Family specific rates of protein evolution (2006)
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic...
The SYSTERS Protein Family Database in 2005 (2005)
Meinel, Thomas, Krause, Antje, Luz, Hannes, Vingron, Martin, Staub, Eike
The SYSTERS project aims to provide a meaningful partitioning of the whole protein sequence space by a fully automatic procedure. A refined two-step algorithm assigns each protein to a family and a...
CORG: a database for COmparative Regulatory Genomics (2003)
Dieterich,Christoph, Wang,H., Rateitschak,K., Luz,Hannes, Vingron,Martin
Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a...
CORG: a database for COmparative Regulatory Genomics (2003)
Dieterich, Christoph, Wang, H., Rateitschak, K., Luz, Hannes, Vingron, Martin
Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a...
The SYSTERS Protein Family Database in 2005
Meinel, Thomas, Krause, Antje, Luz, Hannes, Vingron, Martin, Staub, Eike
The SYSTERS project aims to provide a meaningful partitioning of the whole protein sequence space by a fully automatic procedure. A refined two-step algorithm assigns each protein to a family and a...
The SYSTERS Protein Family Database in 2005
Meinel, Thomas, Krause, Antje, Luz, Hannes, Vingron, Martin, Staub, Eike
The SYSTERS project aims to provide a meaningful partitioning of the whole protein sequence space by a fully automatic procedure. A refined two-step algorithm assigns each protein to a family and a...
The SYSTERS Protein Family Database in 2005
Meinel, Thomas, Krause, Antje, Luz, Hannes, Vingron, Martin, Staub, Eike
The SYSTERS project aims to provide a meaningful partitioning of the whole protein sequence space by a fully automatic procedure. A refined two-step algorithm assigns each protein to a family and a...
The SYSTERS Protein Family Database in 2005
Meinel, Thomas, Krause, Antje, Luz, Hannes, Vingron, Martin, Staub, Eike
The SYSTERS project aims to provide a meaningful partitioning of the whole protein sequence space by a fully automatic procedure. A refined two-step algorithm assigns each protein to a family and a...