Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients (2009)
Horie, Yukihiro, Kitaichi, Nobuyoshi, Katsuyama, Yoshihiko, Yoshida, Kazuhiko, Miura, Toshie, Ota, Masao, ...
Purpose: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder against melanocytes. Polymorphisms of the protein tyrosine phosphatase non-receptor 22 gene (PTPN22) have recently been reported...
Complex divergence at a microsatellite marker C1_2_5 in the lineage of HLA-Cw/-B haplotype (2009)
Daisuke Shichi, Masao Ota, Yoshihiko Katsuyama, Hidetoshi Inoko, Taeko K Naruse, Akinori Kimura
Masato Ohtsuka, Takayuki Warita, Takayuki Sakurai, Satoshi Watanabe, Hidetoshi Inoko, Masahiro Sato
We developed Cre-loxP-based systems, termed CRTEIL and CETRIZ, which allow gene switching in a noninvasive manner. Single transfection with pCRTEIL resulted in predominant expression of red...
Association of TLR4 polymorphisms with Behcet's disease in a Korean population (2009)
Horie, Yukihiro, Meguro, Akira, Ota, Masao, Kitaichi, Nobuyoshi, Katsuyama, Yoshihiko, Takemoto, Yuko, ...
Objectives. HLA-B51 is strongly associated with Behçet's disease (BD) in any ethnic background. We recently reported that another gene, Toll-like receptor-4 (TLR4) is also implicated in BD in a...
Masato Ohtsuka, Takayuki Warita, Takayuki Sakurai, Satoshi Watanabe, Hidetoshi Inoko, Masahiro Sato
We developed Cre-loxP-based systems, termed CRTEIL and CETRIZ, which allow gene switching in a noninvasive manner. Single transfection with pCRTEIL resulted in predominant expression of red...
Ohtsuka, Masato, Inoko, Hidetoshi, Kulski, Jerzy K, Yoshimura, Shinichi
Abstract Background The mouse has more than 30 Major histocompatibility complex ( Mhc ) class Ib genes, most of which exist in the H2 region of chromosome 17 in distinct gene clusters. Although...
The amphioxus genome illuminates vertebrate origins and cephalochordate biology (2008)
Holland, Linda Z., Albalat, Ricard, Azumi, Kaoru, Benito-Gutiérrez, Èlia, Blow, Matthew J., Bronner-Fraser, Marianne, ...
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we...
Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease. (2007)
Horie, Yukihiro, Kitaichi, Nobuyoshi, Takemoto, Yuko, Namba, Kenichi, Yoshida, Kazuhiko, Hirose, Shigeto, ...
PURPOSE: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with...
Hosomichi, Kazuyoshi, Shiina, Takashi, Suzuki, Shingo, Tanaka, Masayuki, Shimizu, Sayoko, Iwamoto, Shigehisa, ...
Abstract Background The quail and chicken major histocompatibility complex ( Mhc ) genomic regions have a similar overall organization but differ markedly in that the quail has an expanded number of...
Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. (2006)
Horie, Yukihiro, Takemoto, Yuko, Miyazaki, Akiko, Namba, Kenichi, Kase, Satoru, Yoshida, Kazuhiko, ...
PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and...
Luo, Meizhong, Kim, HyeRan, Kudrna, Dave, Sisneros, Nicholas B, Lee, So-Jeong, Mueller, Christopher, ...
Abstract Background Sharks are members of the taxonomic class Chondrichthyes, the oldest living jawed vertebrates. Genomic studies of this group, in comparison to representative species in other...
Mizuta, Ikuko, Satake, Wataru, Nakabayashi, Yuko, Ito, Chiyomi, Suzuki, Satoko, Momose, Yoshio, ...
Parkinson's disease (PD), one of the most common human neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. PD is a complex...
Mizuta, Ikuko, Satake, Wataru, Nakabayashi, Yuko, Ito, Chiyomi, Suzuki, Satoko, Momose, Yoshio, ...
Parkinson's disease (PD), one of the most common human neurodegenerative diseases, is characterized by loss of dopaminergic neurons in the substantia nigra of the midbrain. PD is a complex disorder,...
Bmc Genomics, Kazuyoshi Hosomichi, Takashi Shiina, Shingo Suzuki, Masayuki Tanaka, Sayoko Shimizu, ...
Research article The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken
Whole Genome Association Study of Rheumatoid Arthritis Using 27,039 Microsatellites (2005)
Gen Tamiya, Minori Shinya, Tadashi Imanishi, Tomoki Ikuta, Koichi Okamoto, Koh Furugaki, ...
© The Author 2005. Published by Oxford University Press. All rights reserved The online version of this article has been published under an open access model. Users are entitled to use, reproduce,...
Mizutani, Akiko, Ohtsuka, Masato, Kimura, Minoru, Tanaka, Masafumi, Inoko, Hidetoshi
The Cre-loxP system has been used for genetic engineering in many organisms ranging from E. coli to mouse. It is known that intermolecular recombination between two loxP sites is substantially less...
Whole genome association study of rheumatoid arthritis using 27,039 microsatellites (2005)
Tamiya, Gen, Shinya, Minori, Imanishi, Tadashi, Ikuta, Tomoki, Makino, Satoshi, Okamoto, Koichi, ...
A major goal of current human genome-wide studies is to identify the genetic basis of complex disorders. However, the availability of an unbiased, reliable, cost efficient and comprehensive...
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites (2005)
Tamiya, Gen, Shinya, Minori, Imanishi, Tadashi, Ikuta, Tomoki, Makino, Satoshi, Okamoto, Koichi, ...
A major goal of current human genome-wide studies is to identify the genetic basis of complex disorders. However, the availability of an unbiased, reliable, cost efficient and comprehensive...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
The genomic sequence and comparative analysis of the rat major histocompatibility complex (2004)
Hurt,Peter, Walter,Lutz, Sudbrak,Ralf, Klages,Sven, Mueller,Ines, Shiina,Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
The genomic sequence and comparative analysis of the rat major histocompatibility complex (2004)
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Mueller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Novel algorithm for automated genotyping of (2004)
Toshiko Matsumoto, Wataru Yukawa, Yasuyuki Nozaki, Ryo Nakashige, Minori Shinya, Satoshi Makino, ...
microsatellites
Kulski, Jerzy K., Anzai, Tatsuya, Shiina, Takashi, Inoko, Hidetoshi
The alpha block of the human and chimpanzee Major Histocompatibility Complex (MHC) class I genomic region contains 10-11 duplicated MHC class I genes, including the HLA/Patr-A, -G and -F genes. In...
Kulski, Jerzy K, Anzai, Tatsuya, Shiina, Takashi, Inoko, Hidetoshi
The alpha block of the human and chimpanzee major histocompatibility complex (MHC) class I genomic region contains 10 to 11 duplicated MHC class I genes, including the HLA/Patr-A, -G, and -F genes....
Ohtsuka, Masato, Horiuchi, Shohei, Kulski, Jerzy K., Kimura, Minoru, Inoko, Hidetoshi
The web software CHOP was developed to visualize the ‘wobbling’ in the third codon position of aligned DNA sequences. The simple features of this tool allow users to easily find regions suspected...
The Genomic Sequence and Comparative Analysis of the Rat Major Histocompatibility Complex (2004)
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Müller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Novel algorithm for automated genotyping of microsatellites (2004)
Matsumoto, Toshiko, Yukawa, Wataru, Nozaki, Yasuyuki, Nakashige, Ryo, Shinya, Minori, Makino, Satoshi, ...
Microsatellites or short tandem repeats (STRs) are abundant in the human genome with easily assayed polymorphisms, providing powerful genetic tools for mapping both Mendelian and complex traits....
Kulski, Jerzy K., Anzai, Tatsuya, Shiina, Takashi, Inoko, Hidetoshi
The alpha block of the human and chimpanzee Major Histocompatibility Complex (MHC) class I genomic region contains 10-11 duplicated MHC class I genes, including the HLA/Patr-A, -G and -F genes. In...
Isolation and characterization of three genes paralogous to mouse Ring3 (2001)
Taniguchi, Yasushi, Suzuki, Hiroyuki, Ohtsuka, Masato, Kikuchi, Natsuko, Kimura, Minoru, Inoko, Hidetoshi
HOXD3 regulates expression of JAGGED1, a ligand for Notch receptors (2001)
Taniguchi, Yasushi, Sato, Masahiro, Tanaka, Osamu, Sekiguchi, Masaki, Inoko, Hidetoshi, Kimura, Minoru
Shiina, Takashi, Ando, Asako, Suto, Yumiko, Kasai, Fumio, Shigenari, Atsuko, Takishima, Nobusada, ...
Isolation and characterization of three genes paralogous to mouse Ring3 (2001)
Taniguchi, Yasushi, Suzuki, Hiroyuki, Ohtsuka, Masato, Kikuchi, Natsuko, Kimura, Minoru, Inoko, Hidetoshi
Syntenic chromosomal areas share paralogous genes which are believed to have been generated by repeated duplication of an ancestral gene. The human RING3 gene is known to have paralogous...
HOXD3 regulates expression of JAGGED1, a ligand for Notch receptors (2001)
Taniguchi, Yasushi, Sato, Masahiro, Tanaka, Osamu, Sekiguchi, Masaki, Inoko, Hidetoshi, Kimura, Minoru
We generated transgenic mouse embryos expressing the human HOXD3 homeobox gene in the central nervous system (CNS) utilizing the Wnt1 expression vector. Whole mount in situ hybridization analysis...
Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...
Ito, Yoshiyasu, Ando, Asako, Ando, Hironori, Ando, Junko, Saijoh, Yukio, Inoko, Hidetoshi, ...
The Hsc70t gene is a Hsp70 homolog gene expressed constitutively in spermatids in mice. This gene is linked to two heat-inducible Hsp70 genes, Hsp70.1 and Hsp70.3, located in the MHC class III...
Demonstration of the requirement for self antigen in the activation of autoreactive T cells (1992)
Sugita, Masahiko, Kumagai, Shunichi, Ota, Masao, Inoko, Hidetoshi, Tsuji, Kimiyoshi, Imura, Hiroo
An HLA-DR4-restricted T cell clone (26G11), which was reactive to autogolous non-T cells without any nominal antigens, was established from an unlmmunized normal subject that was DR1/4 positive....
Kannagi, Mari, Harada, Shinji, Maruyama, Ikuro, Inoko, Hidetoshi, Igarashi, Hisanaga, Kuwashima, Gorou, ...
We established long-term cell lines of cytotoxic T lymphocytes (CTL) specific for human T cell leukemia virus type I (HTLV-I) from peripheral blood lymphocytes (PBL) of a patient with...
Linkage of TNF genes to the HLA-B locus (1987)
Inoko, Hidetoshi, Trowsdale, John
pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) α and β genes. They vere shown to be linked to the HLA-B locus; analagous to their location...
Mizuki, Nobuhisa, Ota, Masao, Kimura, Minoru, Ohno, Shigeaki, Ando, Hitoshi, Katsuyama, Yoshihiko, ...
A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on...
Shiina, Takashi, Tamiya, Gen, Oka, Akira, Takishima, Nobusada, Yamagata, Tetsushi, Kikkawa, Eri, ...
The intensely studied MHC has become the paradigm for understanding the architectural evolution of vertebrate multigene families. The 4-Mb human MHC (also known as the HLA complex) encodes genes...
A basolateral sorting motif in the MICA cytoplasmic tail
Suemizu, Hiroshi, Radosavljevic, Mirjana, Kimura, Minoru, Sadahiro, Sotaro, Yoshimura, Shinichi, Bahram, Seiamak, ...
The MHC class I chain-related MICA molecule is a stress-induced, highly polymorphic, epithelia-specific, membrane-bound glycoprotein interacting with the activating NK cell receptor NKG2D and/or...
Anzai, Tatsuya, Shiina, Takashi, Kimura, Natsuki, Yanagiya, Kazuyo, Kohara, Sakae, Shigenari, Atsuko, ...
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their...
Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...
Double anal fin (Da) is a medaka with an autosomal semidominant mutation that causes mirror image duplication of the ventral region concentrating on the caudal region. The chromosomal location of the...
Shiina, Takashi, Ando, Asako, Suto, Yumiko, Kasai, Fumio, Shigenari, Atsuko, Takishima, Nobusada, ...
Human chromosomes 1q21–q25, 6p21.3–22.2, 9q33–q34, and 19p13.1–p13.4 carry clusters of paralogous loci, to date best defined by the flagship 6p MHC region. They have presumably been created...
Kawamura, Kazuyuki, Yamamura, Takashi, Yokoyama, Kazumasa, Chui, De-Hua, Fukui, Yoshinori, Sasazuki, Takehiko, ...
In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and...
The Genomic Sequence and Comparative Analysis of the Rat Major Histocompatibility Complex
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Müller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Ohtsuka, Masato, Horiuchi, Shohei, Kulski, Jerzy K., Kimura, Minoru, Inoko, Hidetoshi
The web software CHOP was developed to visualize the ‘wobbling’ in the third codon position of aligned DNA sequences. The simple features of this tool allow users to easily find regions suspected...
Novel algorithm for automated genotyping of microsatellites
Matsumoto, Toshiko, Yukawa, Wataru, Nozaki, Yasuyuki, Nakashige, Ryo, Shinya, Minori, Makino, Satoshi, ...
Microsatellites or short tandem repeats (STRs) are abundant in the human genome with easily assayed polymorphisms, providing powerful genetic tools for mapping both Mendelian and complex traits....
Genomic evolution of MHC class I region in primates
Fukami-Kobayashi, Kaoru, Shiina, Takashi, Anzai, Tatsuya, Sano, Kazumi, Yamazaki, Masaaki, Inoko, Hidetoshi, ...
To elucidate the origins of the MHC-B-MHC-C pair and the MHC class I chain-related molecule (MIC)A-MICB pair, we sequenced an MHC class I genomic region of humans, chimpanzees, and rhesus monkeys and...
Fine Localization of a Major Disease-Susceptibility Locus for Diffuse Panbronchiolitis
Keicho, Naoto, Ohashi, Jun, Tamiya, Gen, Nakata, Koichiro, Taguchi, Yoshio, Azuma, Arata, ...
Diffuse panbronchiolitis affecting East Asians is strongly associated with the class I human leukocyte antigen (HLA) alleles. Recent observations suggest that a major disease-susceptibility gene may...
Luo, Meizhong, Kim, HyeRan, Kudrna, Dave, Sisneros, Nicholas B, Lee, So-Jeong, Mueller, Christopher, ...
Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, ...
A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an...
Mizuki, Nobuhisa, Ota, Masao, Kimura, Minoru, Ohno, Shigeaki, Ando, Hitoshi, Katsuyama, Yoshihiko, ...
A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on...
Shiina, Takashi, Tamiya, Gen, Oka, Akira, Takishima, Nobusada, Yamagata, Tetsushi, Kikkawa, Eri, ...
The intensely studied MHC has become the paradigm for understanding the architectural evolution of vertebrate multigene families. The 4-Mb human MHC (also known as the HLA complex) encodes genes...
A basolateral sorting motif in the MICA cytoplasmic tail
Suemizu, Hiroshi, Radosavljevic, Mirjana, Kimura, Minoru, Sadahiro, Sotaro, Yoshimura, Shinichi, Bahram, Seiamak, ...
The MHC class I chain-related MICA molecule is a stress-induced, highly polymorphic, epithelia-specific, membrane-bound glycoprotein interacting with the activating NK cell receptor NKG2D and/or...
Anzai, Tatsuya, Shiina, Takashi, Kimura, Natsuki, Yanagiya, Kazuyo, Kohara, Sakae, Shigenari, Atsuko, ...
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their...
Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...
Double anal fin (Da) is a medaka with an autosomal semidominant mutation that causes mirror image duplication of the ventral region concentrating on the caudal region. The chromosomal location of the...
Shiina, Takashi, Ando, Asako, Suto, Yumiko, Kasai, Fumio, Shigenari, Atsuko, Takishima, Nobusada, ...
Human chromosomes 1q21–q25, 6p21.3–22.2, 9q33–q34, and 19p13.1–p13.4 carry clusters of paralogous loci, to date best defined by the flagship 6p MHC region. They have presumably been created...
Kawamura, Kazuyuki, Yamamura, Takashi, Yokoyama, Kazumasa, Chui, De-Hua, Fukui, Yoshinori, Sasazuki, Takehiko, ...
In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and...
Okamoto, Koichi, Makino, Satoshi, Yoshikawa, Yoko, Takaki, Asumi, Nagatsuka, Yumie, Ota, Masao, ...
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a complex etiology in which environmental factors within a genetically susceptible host maneuver the innate and adaptive arms of...
The Genomic Sequence and Comparative Analysis of the Rat Major Histocompatibility Complex
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Müller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Ohtsuka, Masato, Horiuchi, Shohei, Kulski, Jerzy K., Kimura, Minoru, Inoko, Hidetoshi
The web software CHOP was developed to visualize the ‘wobbling’ in the third codon position of aligned DNA sequences. The simple features of this tool allow users to easily find regions suspected...
Novel algorithm for automated genotyping of microsatellites
Matsumoto, Toshiko, Yukawa, Wataru, Nozaki, Yasuyuki, Nakashige, Ryo, Shinya, Minori, Makino, Satoshi, ...
Microsatellites or short tandem repeats (STRs) are abundant in the human genome with easily assayed polymorphisms, providing powerful genetic tools for mapping both Mendelian and complex traits....
Genomic evolution of MHC class I region in primates
Fukami-Kobayashi, Kaoru, Shiina, Takashi, Anzai, Tatsuya, Sano, Kazumi, Yamazaki, Masaaki, Inoko, Hidetoshi, ...
To elucidate the origins of the MHC-B-MHC-C pair and the MHC class I chain-related molecule (MIC)A-MICB pair, we sequenced an MHC class I genomic region of humans, chimpanzees, and rhesus monkeys and...
Fine Localization of a Major Disease-Susceptibility Locus for Diffuse Panbronchiolitis
Keicho, Naoto, Ohashi, Jun, Tamiya, Gen, Nakata, Koichiro, Taguchi, Yoshio, Azuma, Arata, ...
Diffuse panbronchiolitis affecting East Asians is strongly associated with the class I human leukocyte antigen (HLA) alleles. Recent observations suggest that a major disease-susceptibility gene may...
Luo, Meizhong, Kim, HyeRan, Kudrna, Dave, Sisneros, Nicholas B, Lee, So-Jeong, Mueller, Christopher, ...
Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, ...
A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an...
Hosomichi, Kazuyoshi, Shiina, Takashi, Suzuki, Shingo, Tanaka, Masayuki, Shimizu, Sayoko, Iwamoto, Shigehisa, ...
Genomewide Association Analysis of Human Narcolepsy and a New Resistance Gene
Kawashima, Minae, Tamiya, Gen, Oka, Akira, Hohjoh, Hirohiko, Juji, Takeo, Ebisawa, Takashi, ...
Human narcolepsy is a hypersomnia that is affected by multiple genetic and environmental factors. One genetic factor strongly associated with narcolepsy is the HLA-DRB1*1501-DQB1*0602 haplotype in...
Uenishi, Hirohide, Hiraiwa, Hideki, Yamamoto, Ryuji, Yasue, Hiroshi, Takagaki, Yohtaroh, Shiina, Takashi, ...
A complete genomic region of 131·2 kb including the swine T-cell receptor α/δ constant region (TRAC/TRDC) and joining segments (TRAJ/TRDJ) was sequenced. The structure of this region was...
Genetic Analysis of Craniofacial Traits in the Medaka
Kimura, Tetsuaki, Shimada, Atsuko, Sakai, Noriyoshi, Mitani, Hiroshi, Naruse, Kiyoshi, Takeda, Hiroyuki, ...
Family and twin studies suggest that a substantial genetic component underlies individual differences in craniofacial morphology. In the current study, we quantified 444 craniofacial traits in 100...
Kimura, Tetsuaki, Kobayashi, Terukazu, Munkhbat, Batmunkh, Oyungerel, Ganjuur, Bilegtsaikhan, Tsolmon, Anar, Damdinsuren, ...
We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short...
Kulski, Jerzy K., Shigenari, Atsuko, Shiina, Takashi, Ota, Masao, Hosomichi, Kazuyoshi, James, Ian, ...
The frequency and HLA-A allelic associations of a HERVK9 DNA structural polymorphism located in close proximity to the highly polymorphic HLA-A gene within the major histocompatibility complex (MHC)...
The amphioxus genome illuminates vertebrate origins and cephalochordate biology
Holland, Linda Z., Albalat, Ricard, Azumi, Kaoru, Benito-Gutiérrez, Èlia, Blow, Matthew J., Bronner-Fraser, Marianne, ...
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we...
Detecting Linkage between a Trait and a Marker in a Random Mating Population without Pedigree Record
Mano, Shuhei, Endo, Takaho A., Oka, Akira, Ozawa, Akira, Gojobori, Takashi, Inoko, Hidetoshi
Modern linkage-based approaches employing extended pedigrees are becoming powerful tools for localizing complex quantitative trait loci. For these linkage mapping methods, it is necessary to...
Ohtsuka, Masato, Warita, Takayuki, Sakurai, Takayuki, Watanabe, Satoshi, Inoko, Hidetoshi, Sato, Masahiro
We developed Cre-loxP-based systems, termed CRTEIL and CETRIZ, which allow gene switching in a noninvasive manner. Single transfection with pCRTEIL resulted in predominant expression of red...
Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
Horie, Yukihiro, Kitaichi, Nobuyoshi, Katsuyama, Yoshihiko, Yoshida, Kazuhiko, Miura, Toshie, Ota, Masao, ...
Yamane, Takahiro, Mok, Jeewon, Oka, Akira, Okada, Eiichi, Nishizaki, Ritsuko, Meguro, Akira, ...
MYP2 was reported for a candidate locus associated with high grade myopia by linkage analysis, but no candidate gene has been detected. We report an association study in the Japanese population using...
A single nucleotide polymorphism analysis of the LAMA1 gene in Japanese patients with high myopia
Sasaki, Sayaka, Ota, Masao, Meguro, Akira, Nishizaki, Ritsuko, Okada, Eiichi, Mok, Jeewon, ...
Although a myopia susceptibility gene has not yet been elucidated, ten candidate regions (MYP1–MYP10) have been associated with myopia by linkage analysis employing large pedigrees. We report...
A Novel System of Polymorphic and Diverse NK Cell Receptors in Primates
Averdam, Anne, Petersen, Beatrix, Rosner, Cornelia, Neff, Jennifer, Roos, Christian, Eberle, Manfred, ...
There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors...