New Modeling Approaches Using Detailed Kinetics for Advanced Engines (2009)
Meeks, E., Ando, H., Dean, A. M., Hodgson, D., Koshi, M., ...
Nan, R., Gor, J., Lengyel, I., Perkins, S.J.
Polymorphisms in factor H (FH), a major regulator of complement activation, and the accumulation of high zinc concentrations in the outer retina are both associated with age-related macular...
High concentration of zinc in sub-retinal pigment epithelial deposits (2007)
Lengyel, I., Flinn, J.M., Peto, T., Linkous, D.H., Cano, K., Bird, A.C., ...
One of the hallmarks of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in Western societies, is the accumulation of sub-retinal pigment epithelial deposits...
Partial and full agonism in endomorphin derivatives: comparison by null and operational model (2006)
Rónai, A.Z., Al-Khrasani, M., Benyhe, S., Lengyel, I., Kocsis, L., Orosz, G., ...
The partial μ-opioid receptor pool inactivation strategy in isolated mouse vas deferens was used to determine partial agonism of endomorphins and their analogs (endomorphin-1-ol,...
Lengyel, I., Voss, K., Cammaroto, M., Bradshaw, K., Brent, V., ...
A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long-term potentiation (LTP). However, attempts to inhibit the expression of LTP...
Association of drusen deposition with choroidal intercapillary pillars in the aging human eye (2004)
Lengyel, I., Tufail, A., Al Hosaini, H., Luthert, P., Bird, A.C., Jeffery, G.
Purpose: To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye...
Enhanced G-protein activation by a mixture of Abeta(25-35), Abeta(1-40/42) and zinc (2004)
Molnár, Z., Kovács, P., Laczkó, I., Soós, K., Fülöp, L., Penke, B., ...
β-Amyloid peptides (Aβs) bind to several G-protein coupled receptor proteins and stimulate GTPase activity in neurons. In this study we determined the effects of Aβ(1–42), Aβ(1–40),...
Lengyel, I., Voss, K., Cammarota, M., Bradshaw, K., Brent, V., Murphy, K.P., ...
A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long-term potentiation (LTP). However, attempts to inhibit the expression of LTP...
S100B-mediated inhibition of the phosphorylation of GFAP is prevented by TRTK-12 (2004)
Frizzo, J.K., Tramontina, F., Bortoli, E., Gottfried, C., Leal, R.B., Lengyel, I., ...
S100B belongs to a family of calcium-binding proteins involved in cell cycle and cytoskeleton regulation. We observed an inhibitory effect of S100B on glial fibrillary acidic protein (GFAP)...
Lengyel, I., Voss, K., Cammarota, M., Bradshaw, K., Brent, V., ...
A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long-term potentiation (LTP). However, attempts to inhibit the expression of LTP...
Lengyel, I., Voss, K., Cammarota, M., Bradshaw, K., Brent, V., ...
A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long-term potentiation (LTP). However, attempts to inhibit the expression of LTP...
Side chain modifications change the binding and agonist properties of endomorphin 2 (2002)
Lengyel, I., Orosz, G., Biyashev, D., Kocsis, L., Al-Khrasani, M., Rónai, A., ...
Side chain modifications were introduced to endomorphin 2 (E2) to improve its binding properties and biological activity. A number of C-terminal modifications decreased the binding affinity to the...
Influence of degradation on binding properties and biological activity of endomorphin 1 (2001)
Szatmári, I., Biyashev, D., Tömböly, C., Tóth, G., Mácsai, M., Szabó, G., ...
The recently-isolated endogenous peptide endomorphin 1 has high affinity for the μ opioid receptor and plays an important role in analgesia. Several of its degradation products have been isolated...
Al-Khrasani, M., Orosz, G., Kocsis, L., Farkas, V., Magyar, A., Lengyel, I., ...
The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol) function were compared to the parent amidated compounds in isolated organs (longitudinal muscle strip of...
Auto-inhibition of Ca(2+)/calmodulin-dependent protein kinase II by its ATP-binding domain (2001)
Lengyel, I., Nairn, A., McCluskey, A., Tóth, G., Penke, B., Rostas, J.
Ca(2+)/calmodulin dependent protein kinase (CaMPK) II is a key enzyme in many physiological processes. The enzyme is inactive unless Ca(2+)/CaM binds to it. In this inactive form CaMPK-II does not...
Lengyel, I., Cammarota, M., Brent, V.A., Rostas, J.A.
Measurement of the proportion of calcium/calmodulin-stimulated protein kinase II (CaMPK-II) that is autonomously active or phosphorylated on Thr(286) is thought to provide an index of the degree to...
Lengyel, I., Cammarota, M., Brent, V. A., Rostas, J. A. P.
Measurement of the proportion of calcium/calmodulin-stimulated protein kinase II (CaMPK-II) that is autonomously active or phosphorylated on Thr286 is thought to provide an index of the degree to...
Lengyel, I., Cammarota, M., Brent, V. A., Rostas, J. A. P.
Measurement of the proportion of calcium/calmodulin-stimulated protein kinase II (CaMPK-II) that is autonomously active or phosphorylated on Thr286 is thought to provide an index of the degree to...
Lengyel, I., Fieuw-Makaroff, S., Hall, A.L., Sim, A.T., Rostas, J.A., Dunkley, P.R.
Calcium/calmodulin-dependent protein kinase II (CaMPK-II) is a key regulatory enzyme in living cells. Modulation of its activity, therefore, could have a major impact on many cellular processes. We...
Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase (2000)
Xue, J., Wang, X., Malladi, C.S., Kinoshita, M., Milburn, P.J., Lengyel, I., ...
The septins are a family of GTPase enzymes, some of which are required for the cytokinesis stage of cell division and others of which are associated with exocytosis. We purified and cloned the cDNA...
Lengyel, I., Olesen, L.E., Nichol, K.A., Brain, K.L., Wang, X., Robinson, P.J., ...
Production of nitric oxide and the activation of protein kinases are required for long-term potentiation of synaptic transmission at the giant synapses in chicken ciliary ganglion. In the present...
Cheah, T.B., Bobrovskaya, L., Gonçalves, C.A., Hall, A., Elliott, R., Lengyel, I., ...
A method for simultaneous measurement of tyrosine hydroxylase (TH) activation and phosphorylation in permeabilised and intact bovine adrenal chromaffin cells (BACCs) was established. Permeabilised...
A chemical approach to designing Turing patterns in reaction-diffusion systems.
A systematic approach is suggested to design chemical systems capable of displaying stationary, symmetry-breaking reaction diffusion patterns (Turing structures). The technique utilizes the fact that...
A chemical approach to designing Turing patterns in reaction-diffusion systems.
A systematic approach is suggested to design chemical systems capable of displaying stationary, symmetry-breaking reaction diffusion patterns (Turing structures). The technique utilizes the fact that...