Steinhoff, Christine, Paulsen, Martina, Kielbasa, Szymon, Walter, Jörn, Vingron, Martin
Abstract Background In mammals, imprinted genes are regulated by an epigenetic mechanism that results in parental origin-specific expression. Though allele-specific regulation of imprinted genes has...
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the...
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the...
CpG Island Mapping by Epigenome Prediction (2007)
Christoph Bock, Jörn Walter, Martina Paulsen, Thomas Lengauer
CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by...
CpG Island Mapping by Epigenome Prediction (2007)
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Christoph Bock, Martina Paulsen, Sascha Tierling, Thomas Mikeska, Thomas Lengauer, Jörn Walter
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Bock, Christoph, Paulsen, Martina, Tierling, Sascha, Mikeska, Thomas, Lengauer, Thomas, Walter, Jörn
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Christoph Bock, Sabine Reither, Thomas Mikeska, Martina Paulsen, Jörn Walter, Thomas Lengauer
Summary: Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an interactivesoftwaretool that providesstart-to-endsupportfor...
Bock, Christoph, Lengauer, Thomas, Reither, Sabine, Mikeska, Thomas, Paulsen, Martina, Walter, Jörn
SUMMARY: Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an interactive software tool that provides start-to-end support for...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates (2005)
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Bock, Christoph, Reither, Sabine, Mikeska, Thomas, Paulsen, Martina, Walter, Jörn, Lengauer, Thomas
Summary: Manual processing of DNA methylation data from bisulphite sequencing is a tedious and error-prone task. Here we present an interactive software tool that provides start-to-end support for...
Bock, Christoph, Reither, Sabine, Mikeska, Thomas, Paulsen, Martina, Walter, Jörn, Lengauer, Thomas
Summary: Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an interactive software tool that provides start-to-end support for...
Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote (2004)
Lepikhov, Konstantin, Walter, Jörn
Abstract Background In the mouse zygote the paternal genome undergoes dramatic structural and epigenetic changes. Chromosomes are decondensed, protamines replaced by histones and DNA is rapidly and...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates (2004)
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Lopes, Susana, Lewis, Annabelle, Hajkova, Petra, Dean, Wendy, Oswald, Joachim, Forné, Thierry, ...
Imprinted genes and their control elements occur in clusters in the mammalian genome and carry epigenetic modifications. Observations from imprinting disorders suggest that epigenetic modifications...
The potential role of gene duplications in the evolution of imprinting mechanisms (2003)
Walter, Jörn, Paulsen, Martina
Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as non...
The potential role of gene duplications in the evolution of imprinting mechanisms (2003)
Walter, Jörn, Paulsen, Martina
Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as...
The potential role of gene duplications in the evolution of imprinting mechanisms (2003)
Walter, Jörn, Paulsen, Martina
Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as non...
El-Maarri, Osman, Herbiniaux, Ursula, Walter, Jörn, Oldenburg, Johannes
The precise mapping and quantification of DNA methylation as an epigenetic parameter during development and in diseased tissues is of great importance for functional genomics. Here we describe a...
Methylation profiles of DXPas34 during the onset of X-inactivation (2001)
Prissette, Marine, El-Maarri, Osman, Arnaud, Danielle, Walter, Jörn, Avner, Philip
X chromosome inactivation is controlled by the cis-acting X-inactivation centre (Xic). In addition to initiating inactivation, Xic, which includes the Xist gene, is involved in both a counting...
A Dominant Modifier of Transgene Methylation Is Mapped by QTL Analysis to Mouse Chromosome 13 (2001)
Valenza-Schaerly, Pascale, Pickard, Benjamin, Walter, Jörn, Jung, Martin, Pourcel, Lucille, Reik, Wolf, ...
Engemann, Sabine, Strödicke, Martin, Paulsen, Martina, Franck, Olivia, Reinhardt, Richard, Lane, Natasha, ...
The clustered organization of most imprinted genes in mammals suggests coordinated genetic and epigenetic control mechanisms. Comparisons between human and mouse will help in elucidating these...
Paulsen, Martina, El-Maarri, Osman, Engemann, Sabine, Strödicke, Martin, Franck, Olivia, Davies, Karen, ...
In human and mouse most imprinted genes are arranged in chromosomal clusters. This linked organization suggests coordinated mechanisms controlling imprinted expression. We have sequenced 250 kb in...
Schalkwyk, Leonard C., Jung, Martin, Daser, Angelika, Weiher, Michael, Walter, Jörn, Himmelbauer, Heinz, ...
Xu, Guo-Liang, Kapfer, Wolfgang, Walter, Jörn, Trautner, Thomas A.
The enzymes of the Bacillus subtilis BsuBI restriction/modification (R/M) system recognize the target sequence 5′CTGCAG. The genes of the BsuBi R/M system have been cloned and sequenced and their...
Kapfer, Wolfgang, Walter, Jörn, Trautner, Thomas A.
The restriction endonuclease (R.BsuFI) of Bacillus subtilis recognizes the target DNA sequence 5′ CCGG. The R.BsuFI gene was found in close proximity to the cognate M.BsuFI gene, which had...
Dean, Wendy, Santos, Fátima, Stojkovic, Miodrag, Zakhartchenko, Valeri, Walter, Jörn, Wolf, Eckhard, ...
Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter. Here we show that genome-wide reprogramming is...
El-Maarri, Osman, Herbiniaux, Ursula, Walter, Jörn, Oldenburg, Johannes
The precise mapping and quantification of DNA methylation as an epigenetic parameter during development and in diseased tissues is of great importance for functional genomics. Here we describe a...
Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality
Biniszkiewicz, Detlev, Gribnau, Joost, Ramsahoye, Bernard, Gaudet, François, Eggan, Kevin, Humpherys, David, ...
Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation...
Schalkwyk, Leonard C., Jung, Martin, Daser, Angelika, Weiher, Michael, Walter, Jörn, Himmelbauer, Heinz, ...
To facilitate whole-genome scan experiments, we selected a panel of 128 microsatellite markers on the basis of spacing and polymorphism in the strains DBA/2, BALB/c, AKR, C57BL/6, C57BL/10, A/J, C3H,...
A Dominant Modifier of Transgene Methylation Is Mapped by QTL Analysis to Mouse Chromosome 13
Valenza-Schaerly, Pascale, Pickard, Benjamin, Walter, Jörn, Jung, Martin, Pourcel, Lucille, Reik, Wolf, ...
The single-copy hepatitis B virus transgene in the E36 transgenic mouse strain undergoes methylation changes in a parent-of-origin, tissue, and strain-specific fashion. In a C57BL/6 background, the...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Bock, Christoph, Paulsen, Martina, Tierling, Sascha, Mikeska, Thomas, Lengauer, Thomas, Walter, Jörn
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Dean, Wendy, Santos, Fátima, Stojkovic, Miodrag, Zakhartchenko, Valeri, Walter, Jörn, Wolf, Eckhard, ...
Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter. Here we show that genome-wide reprogramming is...
El-Maarri, Osman, Herbiniaux, Ursula, Walter, Jörn, Oldenburg, Johannes
The precise mapping and quantification of DNA methylation as an epigenetic parameter during development and in diseased tissues is of great importance for functional genomics. Here we describe a...
Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality
Biniszkiewicz, Detlev, Gribnau, Joost, Ramsahoye, Bernard, Gaudet, François, Eggan, Kevin, Humpherys, David, ...
Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation...
Schalkwyk, Leonard C., Jung, Martin, Daser, Angelika, Weiher, Michael, Walter, Jörn, Himmelbauer, Heinz, ...
To facilitate whole-genome scan experiments, we selected a panel of 128 microsatellite markers on the basis of spacing and polymorphism in the strains DBA/2, BALB/c, AKR, C57BL/6, C57BL/10, A/J, C3H,...
A Dominant Modifier of Transgene Methylation Is Mapped by QTL Analysis to Mouse Chromosome 13
Valenza-Schaerly, Pascale, Pickard, Benjamin, Walter, Jörn, Jung, Martin, Pourcel, Lucille, Reik, Wolf, ...
The single-copy hepatitis B virus transgene in the E36 transgenic mouse strain undergoes methylation changes in a parent-of-origin, tissue, and strain-specific fashion. In a C57BL/6 background, the...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Bock, Christoph, Paulsen, Martina, Tierling, Sascha, Mikeska, Thomas, Lengauer, Thomas, Walter, Jörn
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
CpG Island Mapping by Epigenome Prediction
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by...
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
Derbinski, Jens, Gäbler, Jana, Brors, Benedikt, Tierling, Sascha, Jonnakuty, Sunitha, Hergenhahn, Manfred, ...
The role of central tolerance induction has recently been revised after the discovery of promiscuous expression of tissue-restricted self-antigens in the thymus. The extent of tissue representation...
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the...
Zhang, Yingying, Rohde, Christian, Tierling, Sascha, Jurkowski, Tomasz P., Bock, Christoph, Santacruz, Diana, ...
Differential DNA methylation is an essential epigenetic signal for gene regulation, development, and disease processes. We mapped DNA methylation patterns of 190 gene promoter regions on chromosome...