Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes (2008)
Brühl, H., Mack, M., Niedermeier, M., Lochbaum, D., Schölmerich, J., Straub, R. H.
Objectives. We have characterized the expression and the function of the chemokine receptor CCR7 on fibroblast-like synoviocytes (FLS) of patients with RA and OA and on dermal fibroblasts. Methods....
Fatal Pneumocystis pneumonia following rituximab administration for rheumatoid arthritis (2008)
Teichmann, L. L., Woenckhaus, M., Vogel, C., Salzberger, B., Schölmerich, J., Fleck, M.
Role of adipose tissue as an inflammatory organ in human diseases (2006)
Schäffler, A., Müller-Ladner, U., Schölmerich, J., Büchler, C.
Reviews on the inflammatory role of adipose tissue outside the field of metabolism are rare. There is increasing evidence provided by numerous basic research studies from nearly all internal medicine...
Behandlungspfade – praktikable Hilfe für den behandelnden Arzt? (2006)
Audebert, F. X., Büttner, R., Hartmann, P., Schölmerich, J., Bollheimer, L. C.
Zusammenfassung Leitlinien, Behandlungspfade und klinische Algorithmen sind heutzutage beliebte Instrumente zur Qualitätssicherung und Ökonomisierung von ärztlicher Arbeit. Diese Begriffe werden...
Defining high-fat-diet rat models: metabolic and molecular effects of different fat types (2006)
Buettner, R., Parhofer, K. G., Woenckhaus, M., Wrede, C. E., Kunz-Schughart, L. A., Schölmerich, J., ...
High-fat (HF)-diet rodent models have contributed significantly to the analysis of the pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly between different...
Rieder, F., Schneidewind, A., Bolder, U., Zorger, N., Schölmerich, J., Schäffler, A., ...
Detecting the source of obscure gastrointestinal bleeding can be difficult. Capsule endoscopy is a promising diagnostic tool for investigating patients with this condition, although identifying the...
Sarzi-Puttini, P., Atzeni, F., Schölmerich, J., Cutolo, M., Straub, R. H.
BACKGROUND: Insulin-like growth factor 1 (IGF1) is an important determinant of muscle mass because it promotes growth and suppresses protein degradation. IGF1 is decreased in rheumatoid arthritis and...
Folgeerkrankungen nach gastrointestinalen Operationen (2006)
Zuber-Jerger, I., Schölmerich, J., Klebl, F.
Gastrointestinal surgery may not only lead to early postoperative complications but also chronic consequences. These have therapeutic implications for affected patients. The kind and extent of...
Wrede, C. E., Buettner, R., Bollheimer, L. C., Schölmerich, J., Hellerbrand, C.
OBJECTIVE: Unexplained hepatic iron overload with increased serum ferritin (SF) values has been associated with the insulin resistance syndrome (IRS), defined by the presence of one or more of the...
Travis, S P L, Beglinger, C, Kupcinkas, L, Geboes, K, ...
John Radcliffe Hospital, Oxford OX3 9DU, UK. Eduard.Stange@rbk.de
Härle, P., Straub, R. H., Wiest, R., Mayer, A., Schölmerich, J., Atzeni, F., ...
OBJECTIVE: To study in parallel the outflow of the sympathetic nervous system (SNS) and the hypothalamic-pituitary adrenal (HPA) axis tone in systemic lupus erythematosus (SLE) and rheumatoid...
Bregenzer, N., Schäffler, A., Gelbmann, C. M., Steinkamp, M., Reinshagen, M., Schölmerich, J., ...
INTRODUCTION: We have examined the association of bone mineral density of patients with inflammatory bowel disease with a polymorphism in the gene encoding the vitamin D receptor. The...
Tarner, IH, Büchler, C, Schölmerich, J, Neumann, E, Gay, S, Schäffler, A, ...
No abstract available.
Härle, P., Bongartz, T., Schölmerich, J., Müller-Ladner, U., Straub, R. H.
Objectives. Rheumatoid arthritis (RA) is characterized by variable degrees of joint inflammation, joint destruction, progressive disability and premature death. Destruction of joint cartilage and...
Härle, P., Bongartz, T., Schölmerich, J., Müller-Ladner, U., Straub, R. H.
Objectives. Rheumatoid arthritis (RA) is characterized by variable degrees of joint inflammation, joint destruction, progressive disability and premature death. Destruction of joint cartilage and...
Bongartz, T., Coras, B., Vogt, T., Schölmerich, J., Müller-Ladner, U.
Objectives. Psoriatic arthritis (PsA) is an inflammatory joint disease, in which early neovascularization of affected skin and synovial tissue represents an important pathogenetic step in the disease...
The potential role of adiponectin in driving arthritis (2004)
Müller-Ladner, U, Ehling, A, Neumann, E, Tarner, IH, Herfarth, H, Grifka, J, ...
No abstract available.
Bongartz, T., Coras, B., Vogt, T., Schölmerich, J., Müller-Ladner, U.
Objectives. Psoriatic arthritis (PsA) is an inflammatory joint disease, in which early neovascularization of affected skin and synovial tissue represents an important pathogenetic step in the disease...
Bongartz, T., Coras, B., Vogt, T., Schölmerich, J., Müller-Ladner, U.
Objectives. Psoriatic arthritis (PsA) is an inflammatory joint disease, in which early neovascularization of affected skin and synovial tissue represents an important pathogenetic step in the disease...
Bosserhoff,A. K., Moser,M., Schölmerich,J., Buettner,R., Hellerbrand,C.
The novel human gene MIA2 encoding a melanoma inhibitory activity (MIA) homologous protein was identified by a GenBank(TM) search. MIA2, together with MIA, OTOR, and TANGO, belongs to the novel MIA...
Tarner, IH, Neumann, E, Judex, M, Schölmerich, J, Gay, S, Müller-Ladner, U
No abstract available.
Bosserhoff, A. K., Moser, M., Schölmerich, J., Buettner, R., Hellerbrand, C.
The novel human gene MIA2 encoding a melanoma inhibitory activity (MIA) homologous protein was identified by a GenBank(TM) search. MIA2, together with MIA, OTOR, and TANGO, belongs to the novel MIA...
Straub, RH, Schuld, A, Mullington, J, Haack, M, Schölmerich, J, Pollmächer, T
Dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS) inhibit T-helper lymphocyte type 2 immune reactions and exert anti- inflammatory effects in some chronic inflammatory diseases. Both DHEA and,...
H. Brunner, F. Hausmann, R. C. Krieg, E. Endlicher, J. Schölmerich, R. Knuechel, ...
Photodynamic diagnosis (PDD) and photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)–induced protoporphyrin IX (PPIX) is an interesting approach to detect and treat dysplasia and early...
Double and triple gene transfer in arthritis (2001)
Müller-Ladner, U, Neumann, E, Fleck, M, Pap, T, Gay, RE, Robbins, PD, ...
No abstract available.
Straub, R. H., Glück, T., Cutolo, M., Georgi, J., Helmke, K., Schölmerich, J., ...
Objectives. To determine the correlation between inflammatory cytokines and adrenal hormones in patients with polymyalgia rheumatica (PMR) and to compare the ratio of serum cortisol and...
Schultz, M., Munro, K., Tannock, G. W., Melchner, I., Göttl, C., Schwietz, H., ...
An overly aggressive immune response to the intestinal microflora in a genetically susceptible host background has been implicated in the pathogenesis of inflammatory bowel diseases. We measured the...
Schultz, M., Munro, K., Tannock, G. W., Melchner, I., Göttl, C., Schwietz, H., ...
An overly aggressive immune response to the intestinal microflora in a genetically susceptible host background has been implicated in the pathogenesis of inflammatory bowel diseases. We measured the...
Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis.
Messmann, H, Vogt, W, Holstege, A, Lock, G, Heinisch, A, Von Fürstenberg, A, ...
BACKGROUND/AIMS: By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to...
Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.
Daig, R, Andus, T, Aschenbrenner, E, Falk, W, Schölmerich, J, Gross, V
To test whether there is a difference in the expression of interleukin 8 (IL8) between Crohn's disease and ulcerative colitis and to determine the main site of its synthesis this study analysed IL8...
Messmann, H, Endlicher, E, Freunek, G, Rümmele, P, Schölmerich, J, Knüchel, R
Background and aims: Longstanding ulcerative colitis (UC), especially in the presence of epithelial dysplasia, is associated with an increased risk of developing cancer. As dysplasia is not visible...
Gene expression pattern of laser microdissected colonic crypts of adenomas with low grade dysplasia
Lechner, S, Müller-Ladner, U, Renke, B, Schölmerich, J, Rüschoff, J, Kullmann, F
Background and aims: Colorectal epithelial cells are prone to malignant transformation. Therefore, identification of differences in gene expression in the process from normal colonic crypts to...
Gelbmann, C M, Leeb, S N, Vogl, D, Maendel, M, Herfarth, H, Schölmerich, J, ...
Background: CD40 has been shown to be a functional activation antigen on a variety of cell types involved in immune responses. As intestinal fibroblasts and myofibroblasts may play a role during...
Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis
Paul, G, Bataille, F, Obermeier, F, Bock, J, Klebl, F, Strauch, U, ...
Haem-oxygenase-1 (HO-1) has been shown to exert anti-inflammatory, anti-apoptotic and anti-proliferative effects. We investigated HO-1 expression in patients with inflammatory bowel disease (IBD) and...
Obermeier, F, Kojouharoff, G, Hans, W, Schölmerich, J, Gross, V, Falk, W
Excess nitric oxide formation caused by the activity of the inducible nitric oxide synthase has been implicated as a toxic effector molecule in the pathogenesis of experimental colitis and...
Herfarth, H, Brand, K, Rath, H C, Rogler, G, Schölmerich, J, Falk, W
In acute DSS-induced colitis nuclear factor (NF)-κ B-dependent inflammatory cytokines including IL-1 and tumour necrosis factor-alpha (TNF-α) are up-regulated. Here we examined the effects of...
Hausmann, M, Spöttl, T, Andus, T, Rothe, G, Falk, W, Schölmerich, J, ...
Macrophages play a central role during the pathogenesis of inflammation. In normal intestinal mucosa surface expression of typical macrophage markers such as CD14, CD16, CD11b or T-cell...
Farkas, S, Herfarth, H, Rössle, M, Schroeder, J, Steinbauerauer, M, Guba, M, ...
Leucocyte recruitment to sites of intestinal inflammation is a crucial, multi-step process that leads ultimately to the accumulation of cells in the inflamed tissue. We established a new in vivo...
Morphological characterisation of Crohn’s disease fistulae
Bataille, F, Klebl, F, Rümmele, P, Schroeder, J, Farkas, S, Wild, P-J, ...
Background: Fistulae are a common complication in up to 35% of all patients with Crohn’s disease. Their therapy is difficult and frequently unsatisfactory. To date, no histological comparison of...
Schreyer, A G, Rath, H C, Kikinis, R, Völk, M, Schölmerich, J, Feuerbach, S, ...
Aim: Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatory...
A rare case of hypalbuminaemic oedema
Merger, M, Andus, T, Schlottmann, K, Timmer, A, Schölmerich, J, Messmann, H, ...
Straub, R H, Stebner, K, Härle, P, Kees, F, Falk, W, Schölmerich, J
Background: In the intestinal tract, the role of sympathetic neurotransmitters has been largely ignored in mucosal neuroimmunology.
Obermeier, F, Strauch, U G, Dunger, N, Grunwald, N, Rath, H C, Herfarth, H, ...
Background and methods: Cytosin-guanosin dinucleotide (CpG) motifs of bacterial DNA are known to be potent activators of innate immunity. We have shown previously that administration of CpG...
Strauch, U G, Obermeier, F, Grunwald, N, Gürster, S, Dunger, N, Schultz, M, ...
Background: The resident flora plays a critical role in initiation and perpetuation of intestinal inflammation, as demonstrated in experimental models of colitis where animals fail to develop disease...
Härle*, P, Straub*, R H, Wiest, R, Mayer, A, Schölmerich, J, Atzeni, F, ...
Sequential Combination Therapy Leading to Sustained Remission in a Patient with SAPHO Syndrome
Huber, C.E, Judex, A.G, Freyschmidt, J, Feuerbach, S, Schölmerich, J, Müller-Ladner, U
The SAPHO syndrome represents a variety of clinically similar disorders with the key features of hyperostotic bone lesions in combination with chronic pustular skin disease. The respective...
Hausmann, M, Paul, G, Kellermeier, S, Frey, I, Schölmerich, J, Falk, W, ...
Haem oxygenase-1 (HO-1) up-regulation was suggested to reduce mucosal tissue damage in inflammatory bowel disease (IBD) and an up-regulation of HO-1 expression in patients with Crohn's disease (CD)...
Endlicher, E, Rümmele, P, Hausmann, F, Krieg, R, Knüchel, R, Rath, H C, ...
Photodynamic diagnosis and especially therapy after sensitization with 5-aminolevulinic acid (ALA) is hampered by limitations of uptake and distribution of ALA due to its hydrophilic nature. Chemical...
Herfarth, H, Tjaden, C, Lukas, M, Obermeier, F, Dilger, K, Müller, R, ...