Scientific Commons: J. Scholmerich

Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease- modifying anti-rheumatic drugs (1997)

Straub, RH, Muller-Ladner, U, Lichtinger, T, Scholmerich, J, Menninger, H, Lang, B

High prolactin and low dehydroepiandrosterone sulphate serum levels in patients with severe systemic sclerosis (1997)

Straub, RH, Zeuner, M, Lock, G, Scholmerich, J, Lang, B

There is no association between polymyalgia rheumatica and acute parvovirus B19 infection

HEMAUER, A., MODROW, S., GEORGI, J., HELMKE, K., VAITH, P., LANG, B., ...

Microsatellite analysis in rheumatoid arthritis synovial fibroblasts

Kullmann, F., Widmann, T., Kirner, A., Justen, H., Wessinghage, D., Dietmaier, W., ...

OBJECTIVES—Rheumatoid arthritis (RA) is a chronic disease characterised by irreversible destruction of the affected joints. As aggressive transformed-appearing synovial fibroblasts are commonly...

Doppler ultrasound identifies increased resistive indices in SSc

Bregenzer, N, Distler, O, Meyringer, R, Scholmerich, J, Muller-Ladner, U, Lock, G

Leucocyte endothelial cell adhesion in indomethacin induced intestinal inflammation is correlated with faecal pH

Arndt, H, Palitzsch, K, Scholmerich, J

Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany

Low dose oral pH modified release budesonide for maintenance of steroid induced remission in Crohn's disease

Gross, V, Andus, T, Ecker, K, Raedler, A, Loeschke, K, Plauth, M, ...

a University of Regensburg, b University of Mainz, c University of Homburg, d University of Hamburg, e University of München, f University of Tübingen, g University of Freiburg, h Medicomp,...

Strictures in Crohn's disease are characterised by an accumulation of mast cells colocalised with laminin but not with fibronectin or vitronectin

Gelbmann, C, Mestermann, S, Gross, V, Kollinger, M, Scholmerich, J, Falk, W

BACKGROUND/AIMS—Intestinal fibrosis and stricture formation is an unresolved problem in Crohn's disease. The aim of this study was to investigate whether mast cells accumulate in these tissues and...

Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6

Daig, R, Rogler, G, Aschenbrenner, E, Vogl, D, Falk, W, Gross, V, ...

BACKGROUND—There is growing evidence that intestinal epithelial cells (IECs) are involved in the mucosal immune system. AIM—To assess the pattern of cytokines secreted by IECs and lamina...

Endoscopic fluorescence detection of low and high grade dysplasia in Barrett's oesophagus using systemic or local 5-aminolaevulinic acid sensitisation

Endlicher, E, Knuechel, R, Hauser, T, Szeimies, R, Scholmerich, J, Messmann, H

BACKGROUND AND AIMS—Barrett's oesophagus is associated with an increased risk of cancer. As dysplasia is not visible during routine endoscopy, random biopsies in the four quadrants every 1-2 cm are...

Imbalance of the interleukin 1 system in colonic mucosa—association with intestinal inflammation and interleukin 1 receptor agonist genotype 2

Andus, T, Daig, R, Vogl, D, Aschenbrenner, E, Lock, G, Hollerbach, S, ...

Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany

Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis

Harle, P, Pongratz, G, Weidler, C, Buttner, R, Scholmerich, J, Straub, R

Background: Hypoandrogenicity is common in obesity and in chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Adrenal androgens such as...

Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus

Straub, R, Weidler, C, Demmel, B, Herrmann, M, Kees, F, Schmidt, M, ...

Background: In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), patients demonstrate low levels of adrenal hormones.

Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo

Menzel, K, Hausmann, M, Obermeier, F, Schreiter, K, Dunger, N, Bataille, F, ...

The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shown...

Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium

Weidler, C, Holzer, C, Harbuz, M, Hofbauer, R, Angele, P, Scholmerich, J, ...

Objective: To investigate the correlation between density of nerve fibres and the presence of BDNF+ cells.

Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammation

Lippert, E, Gunckel, M, Brenmoehl, J, Bataille, F, Falk, W, Scholmerich, J, ...

Recently we identified galectin-3 (gal-3), which is secreted by colonic epithelial cells (CEC), to be a strong activator of colonic lamina propria fibroblasts (CLPF). Modulation of CLPF function may...

J. Scholmerich

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