Grisham,J. W., Leong,G. F., Hole,B. V.
Previous attempts to heterotopically autograft parts of liver were reviewed. This review suggested that both adequate bile drainage and adequate blood flow were necessary for successful autografting...
Leong,G. F., Grisham,J. W., Hole ,B. V., Albright,M. L.
Functioning, heterotopic, partial hepatic autografts without portal blood supply were used to investigate factors controlling regeneration of liver after partial hepatectomy in rats. Following...
Grisham,J. W., Leong,G. F., Albright,M. L., Emerson,J. D.
Exchange transfusion of blood (75 to 80 percent replacement of blood of recipient animals) was used to study the effect of blood-borne influences on labeling of DNA and occurrence of mitoses in...
Grisham, J W, Greenberg, D S, Kaufman, D G, Smith, G J
Exposure of C3H 10T1/2 Cl 8 cells, synchronized by release from confluence-induced arest of proliferation, to different concentrations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 30 min at...
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y, Nishiura, T, Hellerbrand, C, Behrns, K E, Schoonhoven, R, Grisham, J W, ...
Although NFkappaB binding activity is induced during liver regeneration after partial hepatectomy, the physiological consequence of this induction is unknown. We have assessed the role of NFkappaB...
In vitro assay of cytotoxicity with cultured liver: accomplishments and possibilities.
Grisham, J W, Charlton, R K, Kaufman, D G
Tissue cultures offer potential advantages for assaying the toxicity of chemicals and for evaluating tissue susceptibility to toxic agents. Several properties of cultured cells hinder the immediate,...
Grisham, J W, Greenberg, D S, Kaufman, D G, Smith, G J
Exposure of C3H 10T1/2 Cl 8 cells, synchronized by release from confluence-induced arest of proliferation, to different concentrations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 30 min at...
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y, Nishiura, T, Hellerbrand, C, Behrns, K E, Schoonhoven, R, Grisham, J W, ...
Although NFkappaB binding activity is induced during liver regeneration after partial hepatectomy, the physiological consequence of this induction is unknown. We have assessed the role of NFkappaB...
In vitro assay of cytotoxicity with cultured liver: accomplishments and possibilities.
Grisham, J W, Charlton, R K, Kaufman, D G
Tissue cultures offer potential advantages for assaying the toxicity of chemicals and for evaluating tissue susceptibility to toxic agents. Several properties of cultured cells hinder the immediate,...
Coleman, W. B., McCullough, K. D., Esch, G. L., Faris, R. A., Hixson, D. C., Smith, G. J., ...
After intrahepatic transplantation into livers of adult syngeneic German-strain Fischer 344 rats that are deficient for the bile canalicular enzyme dipeptidyl peptidase IV (DPP-IV), cultured WB-F344...
Black, K. A., McFarland, R. D., Grisham, J. W., Smith, G. J.
The mechanisms involved in cell death caused by carcinogens that methylate DNA are poorly understood. In this study, the cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was studied in...
Lee, L. W., Tsao, M. S., Grisham, J. W., Smith, G. J.
Many studies have shown that cultured rat liver epithelial cells can be neoplastically transformed by repeated or long-continued exposure to chemical carcinogens. These cells also may transform...
Tsao, M. S., Grisham, J. W., Nelson, K. G., Smith, J. D.
A diploid population of cultured rat hepatic epithelial cells that expresses the "oval" cell phenotype was exposed briefly and repetitively to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and the...
Smith, G. J., Grisham, J. W., Fatteh, M. M.
The cytotoxic effect of methyl methanesulfonate (MMS) on C3H 10T1/2 cells is characterized by a complex pattern of changes in the permeability of the cell membrane to trypan blue and, therefore,...
Coleman, W. B., Wennerberg, A. E., Smith, G. J., Grisham, J. W.
Following intrahepatic transplantation in adult syngeneic Fischer 344 rats, diploid cultured rat liver epithelial cells (WB-F344), modified to carry the Escherichia coli beta-galactosidase reporter...
The histology and ultrastructure of more than 100 tumors produced by a chemically transformed rat liver epithelial cell line and its single-cell-derived clonal subpopulations were studied....