Chavez, Lukas, Bais, Abha S, Vingron, Martin, Lehrach, Hans, Adjaye, James, Herwig, Ralf
Abstract Background The transcription factor OCT4 is highly expressed in pluripotent embryonic stem cells which are derived from the inner cell mass of mammalian blastocysts. Pluripotency and self...
Zuccotti, Maurizio, Merico, Valeria, Sacchi, Lucia, Bellone, Michele, Brink, Thore C., Stefanelli, Mario, ...
BACKGROUND Our knowledge of what determines the mammalian oocyte developmental competence is meagre. By comparing the transcriptional profiles of developmentally competent surrounded nucleolus (SN)...
Regenbrecht, Christian RA, Jung, Marc, Lehrach, Hans, Adjaye, James
Abstract Background Genistein is an isoflavonoid present in soybeans that exhibits anti-carcinogenic properties. The issue of genistein as a potential anti-cancer drug has been addressed in some...
Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes (2008)
Zuccotti, Maurizio, Merico, Valeria, Sacchi, Lucia, Bellone, Michele, Brink, Thore C, Bellazzi, Riccardo, ...
Abstract Background The maternal contribution of transcripts and proteins supplied to the zygote is crucial for the progression from a gametic to an embryonic control of preimplantation development....
Control of early fate decisions in human ES cells by distinct states of TGFβ pathway activity (2008)
Greber, Boris, Lehrach, Hans, Adjaye, James
The mechanisms controlling self-renewal versus lineage commitment in human embryonic stem (hES) cells are not well understood. Nonetheless, current knowledge suggests a crucial role for TGFβ...
Regenbrecht, Christian R. A., Jung, Marc, Lehrach, Hans, Adjaye, James
Background Genistein is an isoflavonoid present in soybeans that exhibits anti-carcinogenic properties. The issue of genistein as a potential anti-cancer drug has been addressed in some papers, but...
Stemming cancer : functional genomics of cancer stem cells in solid tumors (2008)
Regenbrecht, Christian R. A., Lehrach, Hans, Adjaye, James
Cancer stem cells (CSCs) were discovered about 15 years ago in hematopoietic cancers. Subsequently, cancer stem cells were discovered in various solid tumors. Based on parallels with normal stem...
Molecular characterisation of signalling pathways in cancer stem cells (2008)
Regenbrecht, C. R. A., Wete, Y., Jodicke, A., Hugel, R., Walden, P., Jung, M., ...
Al-Hajj et al. (2003) were the first to identify and prospectively isolate a minority subpopulation of cells from human solid tumours that contained all of the in vivo tumour-forming abilities. The...
Human skin stem cells and the ageing process (2008)
Zouboulis, Christos C., Adjaye, James, Akamatsu, Hirohiko, Moe-Behrens, Gerd, Niemann, Catherin
In healthy individuals, skin integrity is maintained by epidermal stem cells which self-renew and generate daughter cells that undergo terminal differentiation. Despite accumulation of senescence...
Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes (2008)
Zuccotti, Maurizio, Merico, Valeria, Sacchi, Lucia, Bellone, Michele, Brink, Thore C., Bellazzi, Riccardo, ...
Background The maternal contribution of transcripts and proteins supplied to the zygote is crucial for the progression from a gametic to an embryonic control of preimplantation development. Here we...
Functional genomics of human pre-implantation development (2007)
Early mammalian embryogenesis is currently the focus of intense interest because of the potential of inner cell mass-derived embryonic stem cell lines in new therapeutic strategies. As such, creating...
Greber, Boris, Lehrach, Hans, Adjaye, James
Abstract Background Despite their distinct origins, human embryonic stem (hES) and embryonic carcinoma (hEC) cells share a number of similarities such as surface antigen expression, growth...
Adjaye, James, Herwig, Ralf, Brink, Thore C., Herrmann, Doris, Greber, Boris, Sudheer, Smita, ...
The present study investigated mRNA expression profiles of bovine oocytes and blastocysts by using a cross-species hybridization approach employing an array consisting of 15,529 human cDNAs as probe,...
Greber, Boris, Lehrach, Hans, Adjaye, James
Background Despite their distinct origins, human embryonic stem (hES) and embryonic carcinoma (hEC) cells share a number of similarities such as surface antigen expression, growth characteristics,...
Functional genomics of human pre-implantation development (2007)
Early mammalian embryogenesis is currently the focus of intense interest because of the potential of inner cell mass-derived embryonic stem cell lines in new therapeutic strategies. As such, creating...
Babaie, Yasmin, Herwig, Ralf, Greber, Boris, Brink, Thore C., Wruck, Wasco, Groth, Detlef, ...
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its...
Greber, Boris, Lehrach, Hans, Adjaye, James
Fibroblast growth factor 2 (FGF2) is known to promote self-renewal of human embryonic stem cells (hESCs). In addition, it has been shown that transforming growth factor ß (TGFß) signaling is...
Makrantonaki, Evgenia, Adjaye, James, Herwig, Ralf, Brink, Thore C., Groth, Detlef, Hultschig, Claus, ...
The importance of hormones in endogenous aging has been displayed by recent studies performed on animal models and humans. To decipher the molecular mechanisms involved in aging we maintained human...
The elucidation, unravelling and understanding of the molecular basis of transcriptional control during preimplantion development is of utmost importance if we are to intervene and eliminate or...
Adjaye, James, Huntriss, John, Herwig, Ralf, BenKahla, Alia, Brink, Thore C., Wierling, Christoph, ...
The primary differentiation event during mammalian development occurs at the blastocyst stage and leads to the delineation of the inner cell mass (ICM) and the trophectoderm (TE). We provide the...
Papakonstantinou, Eleni, Aletras, Alexios J., Glass, Evelyn, Tsogas, Panagiotis, Dionyssopoulos, Alexander, Adjaye, James, ...
Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Matrix metalloproteinases (MMP) have a predominant role in inflammatory...
James Adjaye, John Huntriss, Ralf Herwig, Alia Benkahla, Thore Brink, Claus Hultschig, ...
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Adjaye, James, Herwig, Ralf, Herrmann, Doris, Wruck, Wasco, BenKahla, Alia, Brink, Thore C, ...
Abstract Background Cross-species gene-expression comparison is a powerful tool for the discovery of evolutionarily conserved mechanisms and pathways of expression control. The usefulness of cDNA...
Adjaye,James, Herwig,Ralf, Herrmann,Doris, Wruck,Wasco, BenKahla,Alia, Brink,Thore C., ...
Background Cross-species gene-expression comparison is a powerful tool for the discovery of evolutionarily conserved mechanisms and pathways of expression control. The usefulness of cDNA microarrays...
Adjaye, James, Herwig, Ralf, Herrmann, Doris, Wruck, Wasco, BenKahla, Alia, Brink, Thore C., ...
Background Cross-species gene-expression comparison is a powerful tool for the discovery of evolutionarily conserved mechanisms and pathways of expression control. The usefulness of cDNA microarrays...
Genes containing the evolutionarily conserved homeodomain sequence encode a family of DNA-binding transcription factors whose functions are crucial for embryonic development in vertebrates,...
Goto, Tetsuya, Adjaye, James, Rodeck, Charles H., Monk, Marilyn
In mammals, primordial germ cells (PGCs) are first observed in the extraembryonic mesoderm from where they migrate through the hindgut and its mesentery to the genital ridge to colonize the...
Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays
Adjaye, James, Herwig, Ralf, Herrmann, Doris, Wruck, Wasco, BenKahla, Alia, Brink, Thore C, ...
Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays
Adjaye, James, Herwig, Ralf, Herrmann, Doris, Wruck, Wasco, BenKahla, Alia, Brink, Thore C, ...
Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
Zuccotti, Maurizio, Merico, Valeria, Sacchi, Lucia, Bellone, Michele, Brink, Thore C, Bellazzi, Riccardo, ...
Brink, Thore C., Demetrius, Lloyd, Lehrach, Hans, Adjaye, James
Individual differences in the rate of aging are determined by the efficiency with which an organism transforms resources into metabolic energy thus maintaining the homeostatic condition of its cells...