James Cleland Paton

Shiga Toxin-producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement (2009)

Newton, Hayley J., Sloan, Joan, Bulach, Dieter M., Seemann, Torsten, Allison, Cody C., Tauschek, Marija, ...

Most Shiga toxin–producing Escherichia coli (STEC) infections that are associated with severe sequelae such as hemolytic uremic syndrome (HUS) are caused by attaching and effacing pathogens that...

Shiga Toxin-producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement (2009)

Newton, Hayley J., Sloan, Joan, Bulach, Dieter M., Seemann, Torsten, Allison, Cody C., Tauschek, Marija, ...

Most Shiga toxin–producing Escherichia coli (STEC) infections that are associated with severe sequelae such as hemolytic uremic syndrome (HUS) are caused by attaching and effacing pathogens that...

Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung (2009)

Arevalo, Maria T., Xu, Qingfu, Paton, James Cleland, Hollingshead, Susan K., Pichichero, Michael E., Briles, David E., ...

Streptococcus pneumoniae is a major bacterial respiratory pathogen. Current licensed pneumococcal polysaccharide and polysaccharide–protein conjugate vaccines are administered by an intramuscular...

Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung (2009)

Arevalo, Maria T., Xu, Qingfu, Paton, James Cleland, Hollingshead, Susan K., Pichichero, Michael E., Briles, David E., ...

Streptococcus pneumoniae is a major bacterial respiratory pathogen. Current licensed pneumococcal polysaccharide and polysaccharide–protein conjugate vaccines are administered by an intramuscular...

Shiga Toxin-producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement (2009)

Newton, Hayley J., Sloan, Joan, Bulach, Dieter M., Seemann, Torsten, Allison, Cody C., Tauschek, Marija, ...

Most Shiga toxin–producing Escherichia coli (STEC) infections that are associated with severe sequelae such as hemolytic uremic syndrome (HUS) are caused by attaching and effacing pathogens that...

Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung (2009)

Arevalo, Maria T., Xu, Qingfu, Paton, James Cleland, Hollingshead, Susan K., Pichichero, Michael E., Briles, David E., ...

Streptococcus pneumoniae is a major bacterial respiratory pathogen. Current licensed pneumococcal polysaccharide and polysaccharide–protein conjugate vaccines are administered by an intramuscular...

Cleavage of BiP by Subtilase Cytotoxin (2008)

Paton, Adrienne Webster, Paton, James Cleland, Backer, Marina V., Backer, Joseph M.

Cleavage of BIP (Immunoglobulin binding protein) by subtilase toxin and its application to inhibiting growth of or killing of cells. This has application to treatment of cancers and to conformational...

Cleavage of BiP by Subtilase Cytotoxin (2008)

Paton, Adrienne Webster, Paton, James Cleland, Backer, Marina V., Backer, Joseph M.

Cleavage of BIP (Immunoglobulin binding protein) by subtilase toxin and its application to inhibiting growth of or killing of cells. This has application to treatment of cancers and to conformational...

Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae (2008)

Taut, Katharina, Winter, Christine, Briles, David E., Paton, James Cleland, Christman, John W., Maus, Regina, ...

Katharina Taut, Christine Winter, David E. Briles, James C. Paton, John W. Christman, Regina Maus, Rolf Baumann, Tobias Welte and Ulrich A. Maus

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease (2008)

Kadioglu, A., Weiser, Jeffrey N., Paton, James Cleland, Andrew, P. W.

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an...

Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae (2008)

Taut, Katharina, Winter, Christine, Briles, David E., Paton, James Cleland, Christman, John W., Maus, Regina, ...

Katharina Taut, Christine Winter, David E. Briles, James C. Paton, John W. Christman, Regina Maus, Rolf Baumann, Tobias Welte and Ulrich A. Maus

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease (2008)

Kadioglu, A., Weiser, Jeffrey N., Paton, James Cleland, Andrew, P. W.

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an...

Induction of CC and CXC Chemokines in Human Antigen‐Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll‐Like Receptor 4, NF‐κB, and Mitogen‐Activated Protein Kinases (2008)

Bernatoniene, J., Zhang, Q., Dogan, Semih, Mitchell, T. J., Paton, James Cleland, Finn, A.

Background. Choline‐binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic...

Induction of CC and CXC Chemokines in Human Antigen‐Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll‐Like Receptor 4, NF‐κB, and Mitogen‐Activated Protein Kinases (2008)

Bernatoniene, J., Zhang, Q., Dogan, Semih, Mitchell, T. J., Paton, James Cleland, Finn, A.

Background. Choline‐binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic...

Pneumonococcal histidine triad proteins are regulated by the Zn²⁺-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H (2008)

Ogunniyi, Abiodun David, Grabowicz, Marcin, Mahdi, Layla Khalid, Cook, Jan, Gordon, David L., Sadlon, Tania A., ...

The pneumococcal histidine triad (Pht) proteins are a recently recognized family of surface proteins, comprising 4 members: PhtA, PhtB, PhtD, and PhtE. They are being promoted for inclusion in a...

Pneumonococcal histidine triad proteins are regulated by the Zn2+ -dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H (2008)

Ogunniyi, Abiodun David, Grabowicz, Marcin, Mahdi, Layla Khalid, Cook, Jan, Gordon, David L., Sadlon, Tania A., ...

The pneumococcal histidine triad (Pht) proteins are a recently recognized family of surface proteins, comprising 4 members: PhtA, PhtB, PhtD, and PhtE. They are being promoted for inclusion in a...

Cleavage of BiP by Subtilase Cytotoxin (2008)

Paton, Adrienne Webster, Paton, James Cleland, Backer, Marina V., Backer, Joseph M.

Cleavage of BIP (Immunoglobulin binding protein) by subtilase toxin and its application to inhibiting growth of or killing of cells. This has application to treatment of cancers and to conformational...

Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae (2008)

Taut, Katharina, Winter, Christine, Briles, David E., Paton, James Cleland, Christman, John W., Maus, Regina, ...

Katharina Taut, Christine Winter, David E. Briles, James C. Paton, John W. Christman, Regina Maus, Rolf Baumann, Tobias Welte and Ulrich A. Maus

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease (2008)

Kadioglu, A., Weiser, Jeffrey N., Paton, James Cleland, Andrew, P. W.

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an...

Induction of CC and CXC Chemokines in Human Antigen‐Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll‐Like Receptor 4, NF‐κB, and Mitogen‐Activated Protein Kinases (2008)

Bernatoniene, J., Zhang, Q., Dogan, Semih, Mitchell, T. J., Paton, James Cleland, Finn, A.

Background. Choline‐binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic...

Pneumonococcal histidine triad proteins are regulated by the Zn²⁺-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H (2008)

Ogunniyi, Abiodun David, Grabowicz, Marcin, Mahdi, Layla Khalid, Cook, Jan, Gordon, David L., Sadlon, Tania A., ...

The pneumococcal histidine triad (Pht) proteins are a recently recognized family of surface proteins, comprising 4 members: PhtA, PhtB, PhtD, and PhtE. They are being promoted for inclusion in a...

Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response (2007)

Takano, Yosuke, Hiramatsu, Nobuhiko, Okamura, Maro, Hayakawa, Kunihiro, Shimada, Tsuyoshi, Kasai, Ayumi, ...

K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. However, molecular mechanisms involved have not been...

Modulation of adherence invasion and tumor necrosis factor alpha secretion during the early stages of infection by Strepococcus pneumoniae ClpL (2007)

Tu, Le Nhat, Jeong, Hye-Yoon, Kwon, Hyog-Young, Ogunniyi, Abiodun David, Paton, James Cleland, Pyo, Suhk-Neung, ...

Heat shock proteins (HSPs) play a pivotal role as chaperones in the folding of native and denatured proteins and can help pathogens penetrate host defenses. However, the underlying mechanism(s) of...

Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response (2007)

Takano, Yosuke, Hiramatsu, Nobuhiko, Okamura, Maro, Hayakawa, Kunihiro, Shimada, Tsuyoshi, Kasai, Ayumi, ...

K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. However, molecular mechanisms involved have not been...

Modulation of adherence invasion and tumor necrosis factor alpha secretion during the early stages of infection by Strepococcus pneumoniae ClpL (2007)

Tu, Le Nhat, Jeong, Hye-Yoon, Kwon, Hyog-Young, Ogunniyi, Abiodun David, Paton, James Cleland, Pyo, Suhk-Neung, ...

Heat shock proteins (HSPs) play a pivotal role as chaperones in the folding of native and denatured proteins and can help pathogens penetrate host defenses. However, the underlying mechanism(s) of...

Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response (2007)

Takano, Yosuke, Hiramatsu, Nobuhiko, Okamura, Maro, Hayakawa, Kunihiro, Shimada, Tsuyoshi, Kasai, Ayumi, ...

K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. However, molecular mechanisms involved have not been...

Modulation of adherence invasion and tumor necrosis factor alpha secretion during the early stages of infection by Strepococcus pneumoniae ClpL (2007)

Tu, Le Nhat, Jeong, Hye-Yoon, Kwon, Hyog-Young, Ogunniyi, Abiodun David, Paton, James Cleland, Pyo, Suhk-Neung, ...

Heat shock proteins (HSPs) play a pivotal role as chaperones in the folding of native and denatured proteins and can help pathogens penetrate host defenses. However, the underlying mechanism(s) of...

Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children (2006)

Zhang, Q. B., Bernatoniene, J., Bagrade, L., Paton, James Cleland, Mitchell, T. J., Hammerschmidt, S., ...

Nasopharyngeal tonsils (adenoids) are part of human nasopharynx-associated lymphoid tissue, which may play an important role in local defense against pneumococci. Recent studies with animals have...

Treatment and Prevention of Enteric Infections With Toxin-binding Probiotics (2006)

Paton, Adrienne Webster, Morona, Renato, Paton, James Cleland

Nearly all antibiotics aim at killing the bacteria, which eventually develop antibiotic resistance under ‘survival pressure’. The pathology exerted by many pathologic bacteria is through...

Serum and mucosal antibody respnses to pneumococcal protein antigens in children: relationships with carriage status (2006)

Zhang, Q., Bernatoniene, J., Bagrade, L., Pollard, A. J., Mitchell, T. J., Paton, James Cleland, ...

Streptococcus pneumoniae causes significant morbidity and mortality especially in children. Some pneumococcal protein antigens can protect mice against infection. Little information is available...

Recombinant bacterium expressing an oligosaccharide receptor mimic (2006)

Paton, Adrienne Webster, Morona, Renato, Paton, James Cleland

Publication Number: WO/2001/019960, Publication Date: 22.03.2001, International Filing Date: 09.09.2000, Chapter 2 Demand Filed: 22.03.2001

Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children (2006)

Zhang, Q. B., Bernatoniene, J., Bagrade, L., Paton, James Cleland, Mitchell, T. J., Hammerschmidt, S., ...

Nasopharyngeal tonsils (adenoids) are part of human nasopharynx-associated lymphoid tissue, which may play an important role in local defense against pneumococci. Recent studies with animals have...

Treatment and Prevention of Enteric Infections With Toxin-binding Probiotics (2006)

Paton, Adrienne Webster, Morona, Renato, Paton, James Cleland

Nearly all antibiotics aim at killing the bacteria, which eventually develop antibiotic resistance under ‘survival pressure’. The pathology exerted by many pathologic bacteria is through...

Recombinant bacterium expressing an oligosaccharide receptor mimic (2006)

Paton, Adrienne Webster, Morona, Renato, Paton, James Cleland

Publication Number: WO/2001/019960, Publication Date: 22.03.2001, International Filing Date: 09.09.2000, Chapter 2 Demand Filed: 22.03.2001

Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children (2006)

Zhang, Q. B., Bernatoniene, J., Bagrade, L., Paton, James Cleland, Mitchell, T. J., Hammerschmidt, S., ...

Nasopharyngeal tonsils (adenoids) are part of human nasopharynx-associated lymphoid tissue, which may play an important role in local defense against pneumococci. Recent studies with animals have...

Treatment and Prevention of Enteric Infections With Toxin-binding Probiotics (2006)

Paton, Adrienne Webster, Morona, Renato, Paton, James Cleland

Nearly all antibiotics aim at killing the bacteria, which eventually develop antibiotic resistance under ‘survival pressure’. The pathology exerted by many pathologic bacteria is through...

Recombinant bacterium expressing an oligosaccharide receptor mimic (2006)

Paton, Adrienne Webster, Morona, Renato, Paton, James Cleland

Publication Number: WO/2001/019960, Publication Date: 22.03.2001, International Filing Date: 09.09.2000, Chapter 2 Demand Filed: 22.03.2001

Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2 (2005)

Khan, A. Q., Chen, Qingwen, Wu, Z-Q., Paton, James Cleland, Snapper, C. M.

Little is known regarding the role of Toll-like receptors (TLRs) in regulating protein- and polysaccharide-specific immunoglobulin (Ig) isotype production in response to an in vivo challenge with an...

Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli (2005)

Talbot, Ursula Maria, Paton, James Cleland, Paton, Adrienne Webster

We have recently described a novel AB5 cytotoxin produced by certain Shiga toxin-producing Escherichia coli strains. The A subunit of this toxin is a subtilase-like serine protease, while the B...

Vaccine comprising recombinant CIpP protein of streptococcus Pneumoniae (2005)

Rhee, D., Kwon, H., Choi, M., Ogunniyi, Abiodun David, Paton, James Cleland

Publication Number: WO/2005/063283; Publication Date: 14.07.2005; International Filing Date: 31.12.2003

Treatment and prevention of enterotoxigenic escherichia coli diarrhoeas (2005)

Paton, Adrienne Webster, Paton, James Cleland, Morona, Renato

Publication Number: WO/2005/089775; Publication Date: 29.09.2005; International Filing Date: 17.03.2005; Chapter 2 Demand Filed: 14.10.2005

Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2 (2005)

Khan, A. Q., Chen, Qingwen, Wu, Z-Q., Paton, James Cleland, Snapper, C. M.

Little is known regarding the role of Toll-like receptors (TLRs) in regulating protein- and polysaccharide-specific immunoglobulin (Ig) isotype production in response to an in vivo challenge with an...

Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli (2005)

Talbot, Ursula Maria, Paton, James Cleland, Paton, Adrienne Webster

We have recently described a novel AB5 cytotoxin produced by certain Shiga toxin-producing Escherichia coli strains. The A subunit of this toxin is a subtilase-like serine protease, while the B...

Vaccine comprising recombinant CIpP protein of streptococcus Pneumoniae (2005)

Rhee, D., Kwon, H., Choi, M., Ogunniyi, Abiodun David, Paton, James Cleland

Publication Number: WO/2005/063283; Publication Date: 14.07.2005; International Filing Date: 31.12.2003

Treatment and prevention of enterotoxigenic escherichia coli diarrhoeas (2005)

Paton, Adrienne Webster, Paton, James Cleland, Morona, Renato

Publication Number: WO/2005/089775; Publication Date: 29.09.2005; International Filing Date: 17.03.2005; Chapter 2 Demand Filed: 14.10.2005

Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2 (2005)

Khan, A. Q., Chen, Qingwen, Wu, Z-Q., Paton, James Cleland, Snapper, C. M.

Little is known regarding the role of Toll-like receptors (TLRs) in regulating protein- and polysaccharide-specific immunoglobulin (Ig) isotype production in response to an in vivo challenge with an...

Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli (2005)

Talbot, Ursula Maria, Paton, James Cleland, Paton, Adrienne Webster

We have recently described a novel AB5 cytotoxin produced by certain Shiga toxin-producing Escherichia coli strains. The A subunit of this toxin is a subtilase-like serine protease, while the B...

Vaccine comprising recombinant CIpP protein of streptococcus Pneumoniae (2005)

Rhee, Dong-Kwon, Kwon, Hyog-Young, Choi, M., Ogunniyi, Abiodun David, Paton, James Cleland

Publication Number: WO/2005/063283; Publication Date: 14.07.2005; International Filing Date: 31.12.2003

Treatment and prevention of enterotoxigenic escherichia coli diarrhoeas (2005)

Paton, Adrienne Webster, Paton, James Cleland, Morona, Renato

Publication Number: WO/2005/089775; Publication Date: 29.09.2005; International Filing Date: 17.03.2005; Chapter 2 Demand Filed: 14.10.2005

Cytotoxin with a subtilase domain (2004)

Paton, Adrienne Webster, Paton, James Cleland

Publication Number: WO/2005/061714, Publication Date: 07.07.2005, International Filing Date: 21.12.2004

Cytotoxin with a subtilase domain (2004)

Paton, Adrienne Webster, Paton, James Cleland

Publication Number: WO/2005/061714, Publication Date: 07.07.2005, International Filing Date: 21.12.2004

Cytotoxin with a subtilase domain (2004)

Paton, Adrienne Webster, Paton, James Cleland

Publication Number: WO/2005/061714, Publication Date: 07.07.2005, International Filing Date: 21.12.2004

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins (2003)

Jenkins, C., Perry, N. T., Cheasty, T., Shaw, D. J., Frankel, G., Dougan, G., ...

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The...

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins (2003)

Jenkins, C., Perry, N. T., Cheasty, T., Shaw, D. J., Frankel, G., Dougan, G., ...

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The...

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins (2003)

Jenkins, C., Perry, N. T., Cheasty, T., Shaw, D. J., Frankel, G., Dougan, G., ...

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The...

Studies on the membrane lipids of Bacillus amyloliquefaciens and their relation to extracellular protein secretion (1979)

Paton, James Cleland

1. The major phospholipids extracted from Bacillus amylolique - faciens were cardiolipin, phosphatidylycerol and phosphatidylethanolamine. 2. The distribution of these phospholipids between the two...

Studies on the membrane lipids of Bacillus amyloliquefaciens and their relation to extracellular protein secretion (1979)

Paton, James Cleland

1. The major phospholipids extracted from Bacillus amylolique - faciens were cardiolipin, phosphatidylycerol and phosphatidylethanolamine. 2. The distribution of these phospholipids between the two...

Studies on the membrane lipids of Bacillus amyloliquefaciens and their relation to extracellular protein secretion (1979)

Paton, James Cleland

1. The major phospholipids extracted from Bacillus amylolique - faciens were cardiolipin, phosphatidylycerol and phosphatidylethanolamine. 2. The distribution of these phospholipids between the two...