Jana Sefcikova

The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysis (2007)

Sefcikova, Jana, Krasovska, Maryna V., Sponer, Jirí, Walter, Nils G.

The genome of the human hepatitis delta virus (HDV) harbors a self-cleaving catalytic RNA motif, the genomic HDV ribozyme, whose crystal structure shows the dangling nucleotides 5′ of the cleavage...

The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysis

Sefcikova, Jana, Krasovska, Maryna V., Šponer, Jiří, Walter, Nils G.

The genome of the human hepatitis delta virus (HDV) harbors a self-cleaving catalytic RNA motif, the genomic HDV ribozyme, whose crystal structure shows the dangling nucleotides 5′ of the cleavage...

Cations and Hydration in Catalytic RNA: Molecular Dynamics of the Hepatitis Delta Virus Ribozyme

Krasovska, Maryna V., Sefcikova, Jana, Réblová, Kamila, Schneider, Bohdan, Walter, Nils G., Šponer, Jiří

The hepatitis delta virus (HDV) ribozyme is an RNA enzyme from the human pathogenic HDV. Cations play a crucial role in self-cleavage of the HDV ribozyme, by promoting both folding and chemistry....

Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme

Sefcikova, Jana, Krasovska, Maryna V., ŠpačkovÁ, Nad'a, Šponer, Ji[rcaron]Í, Walter, Nils G.

The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme...

Distinct Double- and Single-Stranded DNA Binding of E. coli Replicative DNA Polymerase III α Subunit

McCauley, Micah J., Shokri, Leila, Sefcikova, Jana, Venclovas, Česlovas, Beuning, Penny J., Williams, Mark C.