Veron, Philippe, Boutin, Sylvie, Martin, Samia, Chaperot, Laurence, Plumas, Joel, Davoust, Jean, ...
Abstract Background Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. Among the different DC subsets,...
Dendritic cell maturation and antigen presentation in the absence of invariant chain
Rovere, Patrizia, Zimmermann, Valérie S., Forquet, Frédérique, Demandolx, Denis, Trucy, Jeannine, Ricciardi-Castagnoli, Paola, ...
In immature dendritic cells (DCs), major histocompatibility complex class II molecules accumulate in peptide-loading compartments and, during DC maturation, are exported to the cell surface in...
High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy
Gross, David-Alexandre, Graff-Dubois, Stéphanie, Opolon, Paule, Cornet, Sébastien, Alves, Pedro, Bennaceur-Griscelli, Annelise, ...
Most of the human tumor-associated antigens (TAAs) characterized thus far are derived from nonmutated “self”-proteins. Numerous strategies have been developed to break tolerance to TAAs,...
Dendritic cell maturation and antigen presentation in the absence of invariant chain
Rovere, Patrizia, Zimmermann, Valérie S., Forquet, Frédérique, Demandolx, Denis, Trucy, Jeannine, Ricciardi-Castagnoli, Paola, ...
In immature dendritic cells (DCs), major histocompatibility complex class II molecules accumulate in peptide-loading compartments and, during DC maturation, are exported to the cell surface in...
High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy
Gross, David-Alexandre, Graff-Dubois, Stéphanie, Opolon, Paule, Cornet, Sébastien, Alves, Pedro, Bennaceur-Griscelli, Annelise, ...
Most of the human tumor-associated antigens (TAAs) characterized thus far are derived from nonmutated “self”-proteins. Numerous strategies have been developed to break tolerance to TAAs,...
Salaun, Bruno, Pacheco, Nathalie, Pacheco, Yves, Riesler, Arnaud, Isaac, Sylvie, ...
Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, a member of the lysosomal associated membrane protein (LAMP) family, is specifically expressed by human DCs on activation....
Berard, Frederic, Blanco, Patrick, Davoust, Jean, Neidhart-Berard, Eve-Marie, Nouri-Shirazi, Mahyar, Taquet, Nicolas, ...
The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T cell clones against multiple tumor...
Interleukin 15 Skews Monocyte Differentiation into Dendritic Cells with Features of Langerhans Cells
Mohamadzadeh, Mansour, Berard, Frederic, Essert, Gregory, Chalouni, Cecile, Pulendran, Bali, Davoust, Jean, ...
Langerhans cells (LCs) represent a subset of immature dendritic cells (DCs) specifically localized in the epidermis and other mucosal epithelia. As surrounding keratinocytes can produce interleukin...
Bell, Diana, Chomarat, Pascale, Broyles, Denise, Netto, George, Harb, Ghada Moumneh, Lebecque, Serge, ...
We have analyzed the presence of immature and mature dendritic cells (DCs) within adenocarcinoma of the breast using immunohistochemistry. Immature DCs were defined by expression of CD1a-, Langerin-,...
Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures
Winzler, Claudia, Rovere, Patrizia, Rescigno, Maria, Granucci, Francesca, Penna, Giuseppe, Adorini, Luciano, ...
The signals controlling the checkpoints of dendritic cells (DC) maturation and the correlation between phenotypical and functional maturational stages were investigated in a defined model system of...
Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells
Beatty, Wandy L., Méresse, Stéphane, Gounon, Pierre, Davoust, Jean, Mounier, Joëlle, Sansonetti, Philippe J., ...
Bacterial lipopolysaccharide (LPS) at the apical surface of polarized intestinal epithelial cells was previously shown to be transported from the apical to the basolateral pole of the epithelium...