VANDEVYVER, Caroline, Canarelli, Stephane, Bossen, Claudia, Fisch, Igor, MOTMANS, Kris, RAUS, Jef, ...
Monoclonal antibody (mAb) 5D10 is directed against the human breast cancer cell line MCF-7. Biochemical characterization of the antibody epitope was attempted and revealed a complex, most likely...
VANDEVYVER, Caroline, Canarelli, Stephane, Bossen, Claudia, Fisch, Igor, MOTMANS, Kris, RAUS, Jef, ...
Monoclonal antibody (mAb) 5D10 is directed against the human breast cancer cell line MCF-7. Biochemical characterization of the antibody epitope was attempted and revealed a complex, most likely...
Hellings, Niels, Hensen, Karen, Rummens, Jean-Luc, Medaer, Robert, D'hooghe, Marie B, ...
Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting...
HELLINGS, Niels, RAUS, Jef, STINISSEN, Piet
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS with presumed autoimmune origin. Pathogenic autoimmune responses in MS are thought to be the result of a breakdown of self...
VENKEN, Koen, HELLINGS, Niels, Hensen, K., Rummens, J., MEDAER, Rob, D'hooghe, M., ...
Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting...
Barkhof, F, STINISSEN, Piet, MEDAER, Rob, HELLINGS, Niels, VANROOSE, Erwin, RAUS, Jef
Hasselt Univ, Diepenbeek, Belgium. Image Anal Ctr, Amsterdam, Netherlands.
STINISSEN, Piet, MEDAER, Rob, HELLINGS, Niels, Barkhof, F, RAUS, Jef
Hasselt Univ, Biomedisch Onderzoeksinstituut, Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. VU Med Ctr, Image Anal Ctr, Amsterdam, Netherlands.
Linsen, Loes, Thewissen, Marielle, Baeten, Kurt, Somers, Veerle, Geusens, Piet, Raus, Jef, ...
Abstract Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA)...
LINSEN, Loes, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Transnatl Univ Limburg, Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
LINSEN, Loes, SOMERS, Veerle, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
LINSEN, Loes, SOMERS, Veerle, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Transnatl Univ Limburg, Biomed Onderzoeksinst, Limburgs Univ Ctr, Diepenbeek, Belgium.
LINSEN, Loes, THEWISSEN, Marielle, BAETEN, Kurt, SOMERS, Veerle, GEUSENS, Piet, RAUS, Jef, ...
Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA) remains...
Parity-induced changes in global gene expression in the human mammary gland (2005)
VERLINDEN, Ilse, GUNGOR, Nejla, WOUTERS, Kristien, JANSSENS, Jaak, RAUS, Jef, MICHIELS, Luc
The protective effect of an early first full-term pregnancy in relation to breast cancer risk is well established, but the molecular and cell-specific changes in the human mammary gland involved...
THEWISSEN, Marielle, LINSEN, Loes, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Although telomerase activity is important in normal immune function, it is unclear whether telomerase or telomerase (dys)regulation plays a role in the pathogenic immune response in autoimmune...
Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients (2005)
THEWISSEN, Marielle, LINSEN, Loes, SOMERS, Veerle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Patients with T-cell-mediated autoimmune diseases show immune system abnormalities that resemble the typical characteristics of autoimmune dysfunction described in the elderly. In addition, the...
LINSEN, Loes, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Transnatl Univ Limburg, Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
LINSEN, Loes, SOMERS, Veerle, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
LINSEN, Loes, SOMERS, Veerle, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Transnatl Univ Limburg, Biomed Onderzoeksinst, Limburgs Univ Ctr, Diepenbeek, Belgium.
LINSEN, Loes, THEWISSEN, Marielle, BAETEN, Kurt, SOMERS, Veerle, GEUSENS, Piet, RAUS, Jef, ...
Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA) remains...
Parity-induced changes in global gene expression in the human mammary gland (2005)
VERLINDEN, Ilse, GUNGOR, Nejla, WOUTERS, Kristien, JANSSENS, Jaak, RAUS, Jef, MICHIELS, Luc
The protective effect of an early first full-term pregnancy in relation to breast cancer risk is well established, but the molecular and cell-specific changes in the human mammary gland involved...
The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated...
BUNTINX, Mieke, MOREELS, Marjan, VANDENABEELE, Frank, LAMBRICHTS, Niels, RAUS, Jef, STEELS, Paul, ...
Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Myelin and oligodendrocytes are considered the major targets of injury caused by a cell-mediated immune response....
Van Hummelen, P, BUNTINX, Mieke, GIELEN, Ellen, RAUS, Jef, AMELOOT, Marcel, STEELS, Paul, ...
Cytokines, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), can initiate dual effects resulting in either cell growth or cell death. In this study, the human...
VENKEN, Koen, HELLINGS, Niels, SCHUERMANS, Joke, RAUS, Jef, STINISSEN, Piet
Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
VANDERLOCHT, Joris, HELLINGS, Niels, VANDENABEELE, Frank, MOREELS, Marjan, RAUS, Jef, STINISSEN, Piet, ...
Limburgs Univ Ctr, Diepenbeek, Belgium. McGill Univ, Montreal, PQ, Canada.
VERLINDEN, Ilse, JANSSENS, Jaak, RAUS, Jef, MICHIELS, Luc
The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated...
VANDER BORGHT, Ann, LINSEN, Loes, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Objective. To further understand the role of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANK-L) in rheumatoid arthritis (RA), we studied the levels of RANK-L and...
A panel of novel candidate antigens in multiple sclerosis revealed by phage cDNA display (2004)
SOMERS, Veerle, GOVARTS, Cindy, RAUS, Jef, STINISSEN, Piet
Univ Limburg, Limburgs Univ Ctr, Biomed Onderzoeksinst BIOMED, Diepenbeek, Belgium.
Anti-ergotypic T cell responses in healthy controls and multiple sclerosis patients (2004)
HELLINGS, Niels, GOVARTS, Cindy, RAUS, Jef, STINISSEN, Piet
Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
Different gene expression in the breast after pregnancy. (2004)
RAUS, Jef, GUNGOR, Nejla, VERLINDEN, Ilse, MICHIELS, Luc, JANSSENS, Jaak
Limburgs Univ Centrum, Hasselt, Belgium.
Protein biomarkers for breast cancer prevention (2004)
JANSSENS, Jaak, VERLINDEN, Ilse, GUNGOR, Nejla, RAUS, Jef, MICHIELS, Luc
Protein biomarkers suitable for the prevention of breast cancer must be extremely sensitive, easily detectable and highly correlated with the disease. They should be expressed in the reversible phase...
T-cell vaccination in multiple sclerosis: update on clinical application and mode of action (2004)
HELLINGS, Niels, RAUS, Jef, STINISSEN, Piet
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Autoreactive T cells specific for myelin antigens are considered to play a prominent role in the...
Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients (2004)
DUMONT, Debora, NOBEN, Jean-Paul, STINISSEN, Piet, RAUS, Jef, ROBBEN, Johan
Limburgs Univ Ctr, Diepenbeek, Belgium.
Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients (2004)
DUMONT, Debora, NOBEN, Jean-Paul, RAUS, Jef, STINISSEN, Piet, ROBBEN, Johan
Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system. Disease mechanisms in multiple sclerosis at the molecular level remain poorly understood and no...
BUNTINX, Mieke, MOREELS, Marjan, VANDENABEELE, Frank, LAMBRICHTS, Niels, RAUS, Jef, STEELS, Paul, ...
Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Myelin and oligodendrocytes are considered the major targets of injury caused by a cell-mediated immune response....
Van Hummelen, P, BUNTINX, Mieke, GIELEN, Ellen, RAUS, Jef, AMELOOT, Marcel, STEELS, Paul, ...
Cytokines, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), can initiate dual effects resulting in either cell growth or cell death. In this study, the human...
VENKEN, Koen, HELLINGS, Niels, SCHUERMANS, Joke, RAUS, Jef, STINISSEN, Piet
Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
VANDERLOCHT, Joris, HELLINGS, Niels, VANDENABEELE, Frank, MOREELS, Marjan, RAUS, Jef, STINISSEN, Piet, ...
Limburgs Univ Ctr, Diepenbeek, Belgium. McGill Univ, Montreal, PQ, Canada.
VERLINDEN, Ilse, JANSSENS, Jaak, RAUS, Jef, MICHIELS, Luc
The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated...
VANDER BORGHT, Ann, LINSEN, Loes, THEWISSEN, Marielle, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Objective. To further understand the role of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANK-L) in rheumatoid arthritis (RA), we studied the levels of RANK-L and...
A panel of novel candidate antigens in multiple sclerosis revealed by phage cDNA display (2004)
SOMERS, Veerle, GOVARTS, Cindy, RAUS, Jef, STINISSEN, Piet
Univ Limburg, Limburgs Univ Ctr, Biomed Onderzoeksinst BIOMED, Diepenbeek, Belgium.
Anti-ergotypic T cell responses in healthy controls and multiple sclerosis patients (2004)
HELLINGS, Niels, GOVARTS, Cindy, RAUS, Jef, STINISSEN, Piet
Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
Different gene expression in the breast after pregnancy. (2004)
RAUS, Jef, GUNGOR, Nejla, VERLINDEN, Ilse, MICHIELS, Luc, JANSSENS, Jaak
Limburgs Univ Centrum, Hasselt, Belgium.
Protein biomarkers for breast cancer prevention (2004)
JANSSENS, Jaak, VERLINDEN, Ilse, GUNGOR, Nejla, RAUS, Jef, MICHIELS, Luc
Protein biomarkers suitable for the prevention of breast cancer must be extremely sensitive, easily detectable and highly correlated with the disease. They should be expressed in the reversible phase...
T-cell vaccination in multiple sclerosis: update on clinical application and mode of action (2004)
HELLINGS, Niels, RAUS, Jef, STINISSEN, Piet
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Autoreactive T cells specific for myelin antigens are considered to play a prominent role in the...
Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients (2004)
DUMONT, Debora, NOBEN, Jean-Paul, STINISSEN, Piet, RAUS, Jef, ROBBEN, Johan
Limburgs Univ Ctr, Diepenbeek, Belgium.
Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients (2004)
DUMONT, Debora, NOBEN, Jean-Paul, RAUS, Jef, STINISSEN, Piet, ROBBEN, Johan
Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system. Disease mechanisms in multiple sclerosis at the molecular level remain poorly understood and no...
VANDERLOCHT, Joris, HELLINGS, Niels, Dreesen, E, BUNTINX, Mieke, DE RYCK, Leen, RAUS, Jef, ...
Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
MOREELS, Marjan, VANDENABEELE, Frank, DE RYCK, Leen, STINISSEN, Piet, RAUS, Jef, LAMBRICHTS, Ivo
Limburgs Univ Ctr, Biomed Onderzoeksinst, Sch Life Sci, B-3590 Diepenbeek, Belgium. Limburgs Univ Ctr, Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
VAN DER AA, Annegret, HELLINGS, Niels, Bernard, CCA, RAUS, Jef, STINISSEN, Piet
Autoimmune T-cell reactivity to myelin components may be implicated in the initiation or maintenance of the inflammation leading to myelin destruction in multiple sclerosis (MS). Myelin...
VAN DER AA, Annegret, HELLINGS, Niels, MEDAER, Rob, PALMERS, Yvan, RAUS, Jef, STINISSEN, Piet, ...
Myelin-reactive T cells are considered to play an essential role in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. We have previously studied the...
Role of calcium in IFN-gamma and TNF-alpha-induced cell death in oligodendrocytes (2003)
GIELEN, Ellen, SMETS, Ilse, STINISSEN, Piet, RAUS, Jef, STEELS, Paul, AMELOOT, Marcel
Limburgs Univ Ctr, Biomed Onderzoeksinst, Sch Life Sci, B-3590 Diepenbeek, Belgium. Limburgs Univ Ctr, Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
BUNTINX, Mieke, VANDERLOCHT, Joris, HELLINGS, Niels, VANDENABEELE, Frank, LAMBRICHTS, Ivo, RAUS, Jef, ...
Oligodendrocytes, the myelin-forming cells of the central nervous system, are the target of pathogenic immune responses in multiple sclerosis. Primary cultures of human oligodendrocytes have been...
Effects of transforming growth factor beta on astrocytes and oligodendrocyte lineage cells (2003)
MOREELS, Marjan, VANDENABEELE, Frank, DE RYCK, Lena, STINISSEN, Piet, RAUS, Jef, LAMBRICHTS, Ivo
Long-term effects of T cell vaccination in multiple sclerosis (2003)
STINISSEN, Piet, HERMANS, Guy, HELLINGS, Niels, MEDAER, Robert, RAUS, Jef
VANDERLOCHT, Joris, HELLINGS, Niels, Dreesen, E, BUNTINX, Mieke, DE RYCK, Leen, RAUS, Jef, ...
Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. Limburgs Univ Ctr, Biomed Onderzoeksinst, Diepenbeek, Belgium.
MOREELS, Marjan, VANDENABEELE, Frank, DE RYCK, Leen, STINISSEN, Piet, RAUS, Jef, LAMBRICHTS, Ivo
Limburgs Univ Ctr, Biomed Onderzoeksinst, Sch Life Sci, B-3590 Diepenbeek, Belgium. Limburgs Univ Ctr, Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
VAN DER AA, Annegret, HELLINGS, Niels, Bernard, CCA, RAUS, Jef, STINISSEN, Piet
Autoimmune T-cell reactivity to myelin components may be implicated in the initiation or maintenance of the inflammation leading to myelin destruction in multiple sclerosis (MS). Myelin...
VAN DER AA, Annegret, HELLINGS, Niels, MEDAER, Rob, PALMERS, Yvan, RAUS, Jef, STINISSEN, Piet, ...
Myelin-reactive T cells are considered to play an essential role in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. We have previously studied the...
Role of calcium in IFN-gamma and TNF-alpha-induced cell death in oligodendrocytes (2003)
GIELEN, Ellen, SMETS, Ilse, STINISSEN, Piet, RAUS, Jef, STEELS, Paul, AMELOOT, Marcel
Limburgs Univ Ctr, Biomed Onderzoeksinst, Sch Life Sci, B-3590 Diepenbeek, Belgium. Limburgs Univ Ctr, Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
BUNTINX, Mieke, VANDERLOCHT, Joris, HELLINGS, Niels, VANDENABEELE, Frank, LAMBRICHTS, Ivo, RAUS, Jef, ...
Oligodendrocytes, the myelin-forming cells of the central nervous system, are the target of pathogenic immune responses in multiple sclerosis. Primary cultures of human oligodendrocytes have been...
Effects of transforming growth factor beta on astrocytes and oligodendrocyte lineage cells (2003)
MOREELS, Marjan, VANDENABEELE, Frank, DE RYCK, Lena, STINISSEN, Piet, RAUS, Jef, LAMBRICHTS, Ivo
Long-term effects of T cell vaccination in multiple sclerosis (2003)
STINISSEN, Piet, HERMANS, Guy, HELLINGS, Niels, MEDAER, Robert, RAUS, Jef
The relationship among history of falls, osteoporosis, and fractures in postmenopausal women (2002)
Autier, Philip, Vanhoof, Johan, Declerck, Kathy, Raus, Jef
OBJECTIVE: To study the relative contribution of osteoporosis and falls to the occurrence of symptomatic fractures in postmenopausal women. DESIGN: Retrospective survey of current osteoporosis in...
Rosen, Clifford, Sommer, Andreas, McKay, Malcolm, Rosen, David, ...
The administration of recombinant human IGF-I complexed with its predominant binding protein IGF binding protein-3 (rhIGF-I/IGFBP-3) may allow the safe administration of higher doses of IGF-I than...
Vanderborght, A, De Keyser, F, De Backer, M, Malaise, M, Baeten, D, ...
Objective. To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A...
Jacobs, A, NOBEN, Jean-Paul, GIELEN, Brigitte, ROYACKERS, Erik, MISSOTTEN, Marleen, RAUS, Jef
A screening method was developed to monitor the illegal use of synthetic corticosteroids in cattle. Diethyl ether extracts from spiked feces samples were cleaned-up by solid phase extraction followed...
The relationship among history of falls, osteoporosis, and fractures in postmenopausal women (2002)
Autier, P, Declerck, K, GEUSENS, Piet, RAUS, Jef, VANHOOF, Johan
Objective: To study the relative contribution of osteoporosis and falls to the occurrence of symptomatic fractures in postmenopausal women. Design: Retrospective survey of current osteoporosis in...
Insights into the immunopathogenesis of multiple sclerosis (2002)
HELLINGS, Niels, RAUS, Jef, STINISSEN, Piet
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Significant progress has been made in our understanding of the etiology of MS. MS is widely believed to...
BUNTINX, Mieke, STINISSEN, Piet, STEELS, Paul, AMELOOT, Marcel, RAUS, Jef
In this review, new insights into the immunopathogenesis of multiple sclerosis (MS) are discussed, with special focus on the potential mechanisms leading to neuroinflammation in MS-that is, the role...
Boonen, S, Rosen, C, Bouillon, R, Sommer, A, McKay, M, Rosen, D, ...
The administration of recombinant human IGF-I complexed with its predominant binding protein IGF binding protein-3 (rhIGF-I/IGFBP-3) may allow the safe administration of higher doses of IGF-I than...
BUNTINX, Mieke, AMELOOT, Marcel, STEELS, Paul, JANSSEN, Paul, MEDAER, Rob, GEUSENS, Piet, ...
Autoreactive T lymphocytes are considered to play a crucial role in orchestrating a chronic inflammation in the central nervous system (CNS) of multiple sclerosis (MS) patients and in the joints of...
HELLINGS, Niels, Gellin, G., MEDAER, Rob, BRUCKERS, Liesbeth, PALMERS, Yvan, RAUS, Jef, ...
In multiple sclerosis (MS), T-cells are considered to be critical in coordinating an immunopathological cascade that results in myelin damage. We investigated whether clinical disease activity or...
Vanderborght, A, De Keyser, F, De Backer, M, Malaise, M, Baeten, D, ...
Objective. To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A...
Jacobs, A, NOBEN, Jean-Paul, GIELEN, Brigitte, ROYACKERS, Erik, MISSOTTEN, Marleen, RAUS, Jef
A screening method was developed to monitor the illegal use of synthetic corticosteroids in cattle. Diethyl ether extracts from spiked feces samples were cleaned-up by solid phase extraction followed...
The relationship among history of falls, osteoporosis, and fractures in postmenopausal women (2002)
Autier, P, Declerck, K, GEUSENS, Piet, RAUS, Jef, VANHOOF, Johan
Objective: To study the relative contribution of osteoporosis and falls to the occurrence of symptomatic fractures in postmenopausal women. Design: Retrospective survey of current osteoporosis in...
Insights into the immunopathogenesis of multiple sclerosis (2002)
HELLINGS, Niels, RAUS, Jef, STINISSEN, Piet
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Significant progress has been made in our understanding of the etiology of MS. MS is widely believed to...
BUNTINX, Mieke, STINISSEN, Piet, STEELS, Paul, AMELOOT, Marcel, RAUS, Jef
In this review, new insights into the immunopathogenesis of multiple sclerosis (MS) are discussed, with special focus on the potential mechanisms leading to neuroinflammation in MS-that is, the role...
Boonen, S, Rosen, C, Bouillon, R, Sommer, A, McKay, M, Rosen, D, ...
The administration of recombinant human IGF-I complexed with its predominant binding protein IGF binding protein-3 (rhIGF-I/IGFBP-3) may allow the safe administration of higher doses of IGF-I than...
Vandevyver, C, GEUSENS, Piet, STINISSEN, Piet, VANHOOF, Johan, RAUS, Jef, MICHIELS, Luc
Limburgs Univ Ctr, Maastricht, Netherlands. Univ Maastricht, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek, Belgium.
Geusens, P, Vosse, D, Vanhoof, J, Van Tubergen, A, VAN DER HEIJDE, Desiree, ...
Objective. To study the prevalence of deformities of vertebrae and inter-vertebral discs in patients with ankylosing spondylitis (AS) in relation to fixed hyperkyphosis of the spine. Methods....
Vosse, D, Vanhoof, J, GEUSENS, Piet, VAN DER HEIJDE, Desiree, RAUS, Jef
Univ Hosp, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Inst Biomed Res, Diepenbeek, Belgium.
Baree, M, Verhoeven, C, D'hooghe, MB, Bernard, CCA, HELLINGS, Niels, MEDAER, Rob, ...
Myelin proteins, including myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) are candidate autoantigens in MS, It is not clear whether MS patients...
Lodewyckx, L, Vandevyver, C, Van Steenbergen, W, VANDERVORST, Carine, RAUS, Jef, MICHIELS, Luc
A method for mutation detection in the alpha-1 antitrypsin gene (protease inhibitor 1; PI) has been developed using denaturing gradient gel electrophoresis of PCR amplified gene fragments. Using this...
VANDER BORGHT, Ann, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Objectives: To review the role of T lymphocytes in the pathogenesis of rheumatoid arthritis (RA) and discuss the relevance of the components of the trimolecular complex (synovial T cells,...
Vandevyver, C, GEUSENS, Piet, STINISSEN, Piet, VANHOOF, Johan, RAUS, Jef, MICHIELS, Luc
Limburgs Univ Ctr, Maastricht, Netherlands. Univ Maastricht, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek, Belgium.
Geusens, P, Vosse, D, Vanhoof, J, Van Tubergen, A, VAN DER HEIJDE, Desiree, ...
Objective. To study the prevalence of deformities of vertebrae and inter-vertebral discs in patients with ankylosing spondylitis (AS) in relation to fixed hyperkyphosis of the spine. Methods....
Vosse, D, Vanhoof, J, GEUSENS, Piet, VAN DER HEIJDE, Desiree, RAUS, Jef
Univ Hosp, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Inst Biomed Res, Diepenbeek, Belgium.
Baree, M, Verhoeven, C, D'hooghe, MB, Bernard, CCA, HELLINGS, Niels, MEDAER, Rob, ...
Myelin proteins, including myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) are candidate autoantigens in MS, It is not clear whether MS patients...
Lodewyckx, L, Vandevyver, C, Van Steenbergen, W, VANDERVORST, Carine, RAUS, Jef, MICHIELS, Luc
A method for mutation detection in the alpha-1 antitrypsin gene (protease inhibitor 1; PI) has been developed using denaturing gradient gel electrophoresis of PCR amplified gene fragments. Using this...
VANDER BORGHT, Ann, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Objectives: To review the role of T lymphocytes in the pathogenesis of rheumatoid arthritis (RA) and discuss the relevance of the components of the trimolecular complex (synovial T cells,...
High prevalence of vertebral deformities in hyperkyphosis of ankylosing spondylitis. (2000)
Vosse, D, GEUSENS, Piet, VAN DER HEIJDE, Desiree, VANHOOF, Johan, RAUS, Jef
Univ Maastricht, Maastricht, Netherlands. Limburg Univ Ctr, Biomed Res Inst, Diepenbeek, Belgium.
Vertebral wedging and spinal deformity in ankylosing spondylitis (2000)
Vosse, D, GEUSENS, Piet, VANHOOF, Johan, VAN DER HEIJDE, Desiree, RAUS, Jef
Maastricht Univ, Acad Hosp, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Inst Biomed Res, DWI, Diepenbeek, Belgium.
Declerck, K, Bischoff, H, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
Limburgs Univ Ctr, Inst Biomed Res, DWI, Diepenbeek, Belgium. Maastricht Univ, Acad Hosp, Dept Rheumatol, Maastricht, Netherlands. Univ Basel, Dept Orthopaed Rheumatol & Geriatr, Basel, Switzerland.
Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins (2000)
Jorens, PG, Ceulemans, B, Van Bever, HP, Bossaert, LL, Ieven, M, Goossens, H, ...
Objective: After implicating Streptococcus pyogenes as causing acute disseminated encephalomyelitis (ADEM) in a child, we wanted to prove that in vivo activation of autoreactive T lymphocytes by...
Hermans, G, MEDAER, Rob, RAUS, Jef, STINISSEN, Piet
Pathogenic autoreactive T cells can be targeted by T cell vaccination (TCV), a procedure in which patients are immunized with autologous attenuated pathogenic T cells. We reported previously that TCV...
Vandevyver, C, VANDER BORGHT, Ann, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Objective. Autoreactive T cells may contribute to the pathogenesis of rheumatoid arthritis (RA). We studied the T-cell receptor (TCR) V-gene repertoire in the blood and synovium of early and chronic...
Long term detection of norethandrolone in cattle: an in vivo study (2000)
VAN PUYMBROECK, Mark, ADRIAENSENS, Peter, VANDERZANDE, Dirk, LEYSSENS, Luc, NOBEN, Jean-Paul, RAUS, Jef, ...
VAN PUYMBROECK, Mark, ADRIAENSENS, Peter, VANDERZANDE, Dirk, LEYSSENS, Luc, NOBEN, Jean-Paul, RAUS, Jef, ...
High prevalence of vertebral deformities in hyperkyphosis of ankylosing spondylitis. (2000)
Vosse, D, GEUSENS, Piet, VAN DER HEIJDE, Desiree, VANHOOF, Johan, RAUS, Jef
Univ Maastricht, Maastricht, Netherlands. Limburg Univ Ctr, Biomed Res Inst, Diepenbeek, Belgium.
Vertebral wedging and spinal deformity in ankylosing spondylitis (2000)
Vosse, D, GEUSENS, Piet, VANHOOF, Johan, VAN DER HEIJDE, Desiree, RAUS, Jef
Maastricht Univ, Acad Hosp, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Inst Biomed Res, DWI, Diepenbeek, Belgium.
Declerck, K, Bischoff, H, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
Limburgs Univ Ctr, Inst Biomed Res, DWI, Diepenbeek, Belgium. Maastricht Univ, Acad Hosp, Dept Rheumatol, Maastricht, Netherlands. Univ Basel, Dept Orthopaed Rheumatol & Geriatr, Basel, Switzerland.
Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins (2000)
Jorens, PG, Ceulemans, B, Van Bever, HP, Bossaert, LL, Ieven, M, Goossens, H, ...
Objective: After implicating Streptococcus pyogenes as causing acute disseminated encephalomyelitis (ADEM) in a child, we wanted to prove that in vivo activation of autoreactive T lymphocytes by...
Hermans, G, MEDAER, Rob, RAUS, Jef, STINISSEN, Piet
Pathogenic autoreactive T cells can be targeted by T cell vaccination (TCV), a procedure in which patients are immunized with autologous attenuated pathogenic T cells. We reported previously that TCV...
Vandevyver, C, VANDER BORGHT, Ann, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
Objective. Autoreactive T cells may contribute to the pathogenesis of rheumatoid arthritis (RA). We studied the T-cell receptor (TCR) V-gene repertoire in the blood and synovium of early and chronic...
Long term detection of norethandrolone in cattle: an in vivo study (2000)
VAN PUYMBROECK, Mark, ADRIAENSENS, Peter, VANDERZANDE, Dirk, LEYSSENS, Luc, NOBEN, Jean-Paul, RAUS, Jef, ...
VAN PUYMBROECK, Mark, ADRIAENSENS, Peter, VANDERZANDE, Dirk, LEYSSENS, Luc, NOBEN, Jean-Paul, RAUS, Jef, ...
Boonen, A, Schoon, E, Declerck, K, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
Limburgs Univ Ctr, Inst Biomed Res, DWI, Diepenbeek, Belgium. Acad Hosp, Dept Rheumatol, Maastricht, Netherlands. Acad Hosp, Dept Gastroenterol, Maastricht, Netherlands.
Hermans, G, Denzer, U, Lohse, A, RAUS, Jef, STINISSEN, Piet
Myelin basic protein (MBP)-reactive T cells may play an important role in the autoimmune pathogenesis of multiple sclerosis (MS). MBP-reactive T cells can be specifically targeted by T cell...
Newton, DL, Pollock, D, DiTullio, P, Echelard, Y, Harvey, M, Wilburn, B, ...
Antibodies fused to human enzymes offer an alternative to specifically targeting tumors with antibodies linked to plant or bacterial toxins. Since large amounts of these reagents can be administered...
Autoreactive T lymphocytes in multiple sclerosis: pathogenic role and therapeutic targeting (1999)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by...
Pollock, D, DiTullio, P, Echelard, Y, Harvey, M, Wilburn, B, Williams, J, ...
Antibodies fused to human enzymes offer an alternative to specifically targeting tumors with antibodies linked to plant or bacterial toxins. Since large amounts of these reagents can be administered...
Autoreactive T lymphocytes in multiple sclerosis: pathogenic role and therapeutic targeting (1999)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by...
Vandevyver, C, Declerck, K, Cassiman, JJ, Boonen, S, VANHOOF, Johan, STINISSEN, Piet, ...
The PvuII polymorphism of the estrogen receptor (ESR) gene and its relation to bone mineral density (BMD), fracture history, and muscle strength was studied in 313 postmenopausal (76 +/- 5 years)...
Van Puymbroeck, M, Kuilman, MEM, Maas, RFM, Witkamp, RF, Leyssens, L, Van Miert, ASJPAM, ...
The metabolism of the illegal growth promoter ethylestrenol (EES) was evaluated in bovine liver cells and subcellular fractions of bovine liver preparations. Incubations with bovine microsomal...
Vandevyver, C, VANDER BORGHT, Ann, VAN DER AA, Annegret, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
The analysis of T cell receptor variable (TCR V) gene repertoires in blood or tissues may provide important information when studying immunopathological mechanisms. The overexpression of a TCR gene...
VAN PUYMBROECK, Mark, LEYSSENS, Luc, HENDRIKS, Lutgard, VANDERZANDE, Dirk, ADRIAENSENS, Peter, JACOBS, Marie-Paule, ...
JANSSENS, Jaak, BRUCKERS, Liesbeth, LODEWYCKX, Linda, MOLENBERGHS, Geert, RAUS, Jef, Motmans, K., ...
Prognosis of very young breast cancer patients (1999)
Janssens, J., BRUCKERS, Liesbeth, MOLENBERGHS, Geert, MICHIELS, Luc, Staelens, Y., Deleu, M., ...
Boonen, A, Schoon, E, Declerck, K, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
Limburgs Univ Ctr, Inst Biomed Res, DWI, Diepenbeek, Belgium. Acad Hosp, Dept Rheumatol, Maastricht, Netherlands. Acad Hosp, Dept Gastroenterol, Maastricht, Netherlands.
Hermans, G, Denzer, U, Lohse, A, RAUS, Jef, STINISSEN, Piet
Myelin basic protein (MBP)-reactive T cells may play an important role in the autoimmune pathogenesis of multiple sclerosis (MS). MBP-reactive T cells can be specifically targeted by T cell...
Newton, DL, Pollock, D, DiTullio, P, Echelard, Y, Harvey, M, Wilburn, B, ...
Antibodies fused to human enzymes offer an alternative to specifically targeting tumors with antibodies linked to plant or bacterial toxins. Since large amounts of these reagents can be administered...
Autoreactive T lymphocytes in multiple sclerosis: pathogenic role and therapeutic targeting (1999)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by...
Vandevyver, C, Declerck, K, Cassiman, JJ, Boonen, S, VANHOOF, Johan, STINISSEN, Piet, ...
The PvuII polymorphism of the estrogen receptor (ESR) gene and its relation to bone mineral density (BMD), fracture history, and muscle strength was studied in 313 postmenopausal (76 +/- 5 years)...
Van Puymbroeck, M, Kuilman, MEM, Maas, RFM, Witkamp, RF, Leyssens, L, Van Miert, ASJPAM, ...
The metabolism of the illegal growth promoter ethylestrenol (EES) was evaluated in bovine liver cells and subcellular fractions of bovine liver preparations. Incubations with bovine microsomal...
Vandevyver, C, VANDER BORGHT, Ann, VAN DER AA, Annegret, GEUSENS, Piet, RAUS, Jef, STINISSEN, Piet
The analysis of T cell receptor variable (TCR V) gene repertoires in blood or tissues may provide important information when studying immunopathological mechanisms. The overexpression of a TCR gene...
VAN PUYMBROECK, Mark, LEYSSENS, Luc, HENDRIKS, Lutgard, VANDERZANDE, Dirk, ADRIAENSENS, Peter, JACOBS, Marie-Paule, ...
JANSSENS, Jaak, BRUCKERS, Liesbeth, LODEWYCKX, Linda, MOLENBERGHS, Geert, RAUS, Jef, Motmans, K., ...
Dequeker, J, Stalmans, R, Boonen, S, Joly, J, Nijs, J, GEUSENS, Piet, ...
Objective-To study the effect of cyclic etidronate in secondary prevention of corticosteroid induced osteoporosis. Methods-A double blind, randomised placebo controlled study comparing cyclic...
LEYSSENS, Luc, VAN PUYMBROECK, Mark, RAUS, Jef
Aqueous solutions containing methandriol (MAD) were incubated with Succus helix pomatia (SHP) or beta-glucuronidase from Escherichia coli (EC). SHP, used for enzymatic hydrolysis of urinary steroid...
Vandevyver, C, MICHIELS, Luc, RAUS, Jef, FRANCOIS, Baudouin
Limburgs Univ Ctr, B-3590 Diepenbeek, Belgium. Dr Willems Inst, B-3590 Diepenbeek, Belgium.Michiels, L, Dr Willems Inst, Universitaire Campus, B-3590 Diepenbeek, Belgium.
Metabolites in feces can be important markers for the abuse of anabolic steroids in cattle (1998)
VAN PUYMBROECK, Mark, LEYSSENS, Luc, VANDERZANDE, Dirk, GELAN, Jan, RAUS, Jef
In Belgium to control the abuse of anabolic steroids in cattle, urine samples have been gradually replaced by feces samples, because the latter can be obtained more easily from living animals. Urine...
In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle (1998)
Kuilman, MEM, Maas, RFM, Witkamp, RF, VAN PUYMBROECK, Mark, LEYSSENS, Luc, VANDERZANDE, Dirk, ...
Current veterinary residue analysis mainly focuses on the monitoring of residues of the administered parent compound. However, it is possible that larger amounts of metabolites are excreted and that...
Kuilman, MEM, Maas, RFM, Witkamp, RF, VAN PUYMBROECK, Mark, LEYSSENS, Luc, VANDERZANDE, Dirk, ...
17 alpha-Boldenone (17 alpha-BOL) and/or 17 beta-boldenone (17 beta-BOL) appear occasionally in fecal matter of cattle. In addition to 17 alpha-BOL, a whole array of boldenone related substances can...
Vandevyver, C, Motmans, K, Zhang, JW, STINISSEN, Piet, RAUS, Jef
Autoimmune mechanisms involving T-cell responses to (a) myelin autoantigen(s), such as myelin basic protein (MBP), are thought to contribute to the pathogenesis of multiple sclerosis (MS), Cytokines...
Myelin reactive T cells in the autoimmune pathogenesis of multiple sclerosis (1998)
STINISSEN, Piet, MEDAER, Rob, RAUS, Jef
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination. Although it is widely accepted that demyelination in MS results from on active...
Zhang, JW, Vandevyver, C, Hermans, G, STINISSEN, Piet, RAUS, Jef
To explore the hypothesis that gamma delta T cells may regulate activated alpha beta T cells, we studied gamma delta T cell responses to alpha beta T cell clones in Multiple Sclerosis (MS) patients...
T cell vaccination for the treatment of multiple sclerosis (1998)
ZHANG, Jingwu, STINISSEN, Piet, MEDAER, Robert, RAUS, Jef, Truyen, L.
Janssens, J., BRUCKERS, Liesbeth, Motmans, K., Lodewijckx, Linda, Staelens, Y., MOLENBERGHS, Geert, ...
Dequeker, J, Stalmans, R, Boonen, S, Joly, J, Nijs, J, GEUSENS, Piet, ...
Objective-To study the effect of cyclic etidronate in secondary prevention of corticosteroid induced osteoporosis. Methods-A double blind, randomised placebo controlled study comparing cyclic...
LEYSSENS, Luc, VAN PUYMBROECK, Mark, RAUS, Jef
Aqueous solutions containing methandriol (MAD) were incubated with Succus helix pomatia (SHP) or beta-glucuronidase from Escherichia coli (EC). SHP, used for enzymatic hydrolysis of urinary steroid...
Vandevyver, C, MICHIELS, Luc, RAUS, Jef, FRANCOIS, Baudouin
Limburgs Univ Ctr, B-3590 Diepenbeek, Belgium. Dr Willems Inst, B-3590 Diepenbeek, Belgium.Michiels, L, Dr Willems Inst, Universitaire Campus, B-3590 Diepenbeek, Belgium.
Metabolites in feces can be important markers for the abuse of anabolic steroids in cattle (1998)
VAN PUYMBROECK, Mark, LEYSSENS, Luc, VANDERZANDE, Dirk, GELAN, Jan, RAUS, Jef
In Belgium to control the abuse of anabolic steroids in cattle, urine samples have been gradually replaced by feces samples, because the latter can be obtained more easily from living animals. Urine...
In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle (1998)
Kuilman, MEM, Maas, RFM, Witkamp, RF, VAN PUYMBROECK, Mark, LEYSSENS, Luc, VANDERZANDE, Dirk, ...
Current veterinary residue analysis mainly focuses on the monitoring of residues of the administered parent compound. However, it is possible that larger amounts of metabolites are excreted and that...
Kuilman, MEM, Maas, RFM, Witkamp, RF, VAN PUYMBROECK, Mark, LEYSSENS, Luc, VANDERZANDE, Dirk, ...
17 alpha-Boldenone (17 alpha-BOL) and/or 17 beta-boldenone (17 beta-BOL) appear occasionally in fecal matter of cattle. In addition to 17 alpha-BOL, a whole array of boldenone related substances can...
Vandevyver, C, Motmans, K, STINISSEN, Piet, Zhang, JW, RAUS, Jef
Autoimmune mechanisms involving T-cell responses to (a) myelin autoantigen(s), such as myelin basic protein (MBP), are thought to contribute to the pathogenesis of multiple sclerosis (MS), Cytokines...
Myelin reactive T cells in the autoimmune pathogenesis of multiple sclerosis (1998)
STINISSEN, Piet, MEDAER, Rob, RAUS, Jef
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination. Although it is widely accepted that demyelination in MS results from on active...
Vandevyver, C, Hermans, G, STINISSEN, Piet, RAUS, Jef, Zhang, JW
To explore the hypothesis that gamma delta T cells may regulate activated alpha beta T cells, we studied gamma delta T cell responses to alpha beta T cell clones in Multiple Sclerosis (MS) patients...
T cell vaccination for the treatment of multiple sclerosis (1998)
ZHANG, Jingwu, STINISSEN, Piet, MEDAER, Robert, RAUS, Jef, Truyen, L.
Vandevyver, C, Cassiman, JJ, Boonen, S, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
Osteoporotic fragility fractures are related to bone density and injury, which are both related to muscle strength, The influence of genetic factors, such as the vitamin D receptor (VDR) polymorphism...
Vandevyver, C, Cassiman, JJ, Philippaerts, L, Mertens, J, GEUSENS, Piet, VANHOOF, Johan, ...
DR WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,CENTRUM MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM.
Hermans, G, Hauben, L, VandenBergLoonen, E, Zhang, JW, STINISSEN, Piet, RAUS, Jef
Myelin basic protein (MBP)-reactive T cells have been implicated in the autoimmune pathogenesis of multiple sclerosis (MS). In this study, rye examined the cytokine profile of 531 primary...
Treatment with etidronate for men with idiopathic osteoporosis (1997)
Dequeker, J, Nijs, J, Joly, J, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
KATHOLIEKE UNIV LEUVEN,ARTHRIT & METAB BONE DIS RES UNIT,B-3001 LOUVAIN,BELGIUM.Geusens, P, LIMBURGS UNIV CTR,DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
Celis, L, Vandevyver, C, Dequeker, J, Zhang, JW, GEUSENS, Piet, RAUS, Jef
Objective. To examine the reactivity pattern and T cell receptor (TCR) characteristics of mycobacterial heat-shock protein 65 (hsp65)-reactive T cells generated from paired synovial fluid (SF) and...
Isolation and quantification of episomal expression vectors in human T cells (1997)
Motmans, K, Thirion, S, Vandevyver, C, RAUS, Jef
LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. DR L WILLEMS INST,DIEPENBEEK,BELGIUM.
Expression of the human chorionic gonadotropin beta subunit in human cancer biopsies (1997)
Lodewyckx, L, Motmans, K, Vandevyver, C, JANSSENS, Jaak, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,B-3590 DIEPENBEEK,BELGIUM.
Re-directing human T cell specificity by functional expression of a chimeric T cell receptor (1997)
Motmans, K, Lodewyckx, L, Vandevyver, C, JANSSENS, Jaak, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,B-3590 DIEPENBEEK,BELGIUM.
Prospects for T cell vaccination in multiple sclerosis (1997)
Zhang, JW, MEDAER, Rob, STINISSEN, Piet, RAUS, Jef
Accumulating evidence indicates that multiple sclerosis, a chronic inflammatory disease of the central nervous system, has an autoimmune origin. Since T cells reactive to myelin basic protein (MBP)...
Vandevyver, C, Cassiman, JJ, PHILIPPAERTS, Linda, RAUS, Jef, GEUSENS, Piet
WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,CTR MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM.
Vandevyver, C, Wylin, T, Cassiman, JJ, RAUS, Jef, GEUSENS, Piet
It is well established that genetic factors contribute to bone turnover and bone density, Evidence exists suggesting that a major part of this genetic influence may be due to polymorphisms in the...
Zhang, JW, STINISSEN, Piet, RAUS, Jef
Accumulating evidence indicates that multiple sclerosis (MS) is an autoimmune disease mediated by autoreactive T lymphocytes with specificity for myelin antigens. Initially, the evidence to support...
Treatment with etidronate in men with idiopathic osteoporosis (1997)
GEUSENS, Pieter, VANHOOF, Johan, RAUS, Jef, Dequeker, J., Nijs, J., Joly, J.
Mono- and bispecific single-chain antibody fragments for use in cancer therapy (1997)
HEYLIGEN, Harry, RAUS, Jef, VANDEVYVER, Caroline, Thirion, S., Motmans, K.
Vandevyver, C, Cassiman, JJ, Boonen, S, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
Osteoporotic fragility fractures are related to bone density and injury, which are both related to muscle strength, The influence of genetic factors, such as the vitamin D receptor (VDR) polymorphism...
Vandevyver, C, Cassiman, JJ, Philippaerts, L, Mertens, J, GEUSENS, Piet, VANHOOF, Johan, ...
DR WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,CENTRUM MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM.
Hermans, G, Hauben, L, VandenBergLoonen, E, STINISSEN, Piet, RAUS, Jef, Zhang, JW
Myelin basic protein (MBP)-reactive T cells have been implicated in the autoimmune pathogenesis of multiple sclerosis (MS). In this study, rye examined the cytokine profile of 531 primary...
Treatment with etidronate for men with idiopathic osteoporosis (1997)
Dequeker, J, Nijs, J, Joly, J, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
KATHOLIEKE UNIV LEUVEN,ARTHRIT & METAB BONE DIS RES UNIT,B-3001 LOUVAIN,BELGIUM.Geusens, P, LIMBURGS UNIV CTR,DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
Celis, L, Vandevyver, C, Dequeker, J, GEUSENS, Piet, RAUS, Jef, Zhang, JW
Objective. To examine the reactivity pattern and T cell receptor (TCR) characteristics of mycobacterial heat-shock protein 65 (hsp65)-reactive T cells generated from paired synovial fluid (SF) and...
Isolation and quantification of episomal expression vectors in human T cells (1997)
Motmans, K, Thirion, S, Vandevyver, C, RAUS, Jef
LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. DR L WILLEMS INST,DIEPENBEEK,BELGIUM.
Expression of the human chorionic gonadotropin beta subunit in human cancer biopsies (1997)
Lodewyckx, L, Motmans, K, Vandevyver, C, JANSSENS, Jaak, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,B-3590 DIEPENBEEK,BELGIUM.
Re-directing human T cell specificity by functional expression of a chimeric T cell receptor (1997)
Motmans, K, Lodewyckx, L, Vandevyver, C, JANSSENS, Jaak, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,B-3590 DIEPENBEEK,BELGIUM.
Prospects for T cell vaccination in multiple sclerosis (1997)
MEDAER, Rob, STINISSEN, Piet, RAUS, Jef, Zhang, JW
Accumulating evidence indicates that multiple sclerosis, a chronic inflammatory disease of the central nervous system, has an autoimmune origin. Since T cells reactive to myelin basic protein (MBP)...
Vandevyver, C, Cassiman, JJ, PHILIPPAERTS, Linda, RAUS, Jef, GEUSENS, Piet
WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,CTR MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM.
Vandevyver, C, Wylin, T, Cassiman, JJ, RAUS, Jef, GEUSENS, Piet
It is well established that genetic factors contribute to bone turnover and bone density, Evidence exists suggesting that a major part of this genetic influence may be due to polymorphisms in the...
STINISSEN, Piet, RAUS, Jef, Zhang, JW
Accumulating evidence indicates that multiple sclerosis (MS) is an autoimmune disease mediated by autoreactive T lymphocytes with specificity for myelin antigens. Initially, the evidence to support...
Treatment with etidronate in men with idiopathic osteoporosis (1997)
GEUSENS, Pieter, VANHOOF, Johan, RAUS, Jef, Dequeker, J., Nijs, J., Joly, J.
Mono- and bispecific single-chain antibody fragments for use in cancer therapy (1997)
HEYLIGEN, Harry, RAUS, Jef, VANDEVYVER, Caroline, Thirion, S., Motmans, K.
Heterogeneity of bone loss and loss of muscle strength in elderly women. (1996)
GEUSENS, Piet, VANHOOF, Johan, MERTENS, Johan, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.
GEUSENS, Piet, VANHOOF, Johan, VANDERVORST, Carine, RAUS, Jef, Vankrieken, L
DR WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM. DIAGNOST PROD CORP,LOS ANGELES,CA.
Motmans, K, Thirion, S, Vandevyver, C, HEYLIGEN, Harie, JANSSENS, Jaak, RAUS, Jef
Monoclonal antibodies (Mabs) are a potential key component for the treatment of cancer, because of their specificity and multiple effector functions, Hybridoma technology and progress in genetic...
Rapid identification of PKU-associated mutations by multiplex DGGE analysis of the PAH gene (1996)
Vandevyver, C, MICHIELS, Luc, FRANCOIS, Baudouin, RAUS, Jef
A system of five sets of multiplex polymerase chain reaction amplifications followed by denaturing gel electrophoresis analysis allows rapid analysis of all 13 exons of the phenylalanine hydroxylase...
Cytokine profile of human myelin basic protein reactive T cells (1996)
Hermans, G, Hauben, L, Zhang, J, STINISSEN, Piet, RAUS, Jef
Hermans, G, LIMBURGS UNIV CENTRUM,MS RES & IMMUNOL DEPT,DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
Motmans, K, Vandevyver, C, RAUS, Jef
A fast method is reported for the precise and accurate quantification of cytokine mRNA, based on a quantitative polymerase chain reaction (PCR) assay. Post-PCR detection of the amplification products...
Mono- and bispecific single-chain antibody fragments for cancer therapy (1996)
Thirion, S, Motmans, K, Vandevyver, C, HEYLIGEN, Harie, JANSSENS, Jaak, RAUS, Jef
Especially when dealing,vith solid cancers, single-chain antibody fragments (scFvs) have a lot of advantages. Due to their small size (27 kDa), these proteins clear more rapidly from the blood, and...
T cell vaccination: Clinical application in autoimmune diseases (1996)
Zhang, J, STINISSEN, Piet, MEDAER, Rob, RAUS, Jef
T cell responses to myelin basic protein (MBP) are implicated to play an important role in the pathogenesis of multiple sclerosis (MS). These MBP autoreactive T cells are found to undergo in vivo...
Zhang, J, Vandevyver, C, STINISSEN, Piet, MEDAER, Rob, RAUS, Jef
Although the etiology and pathogenesis of multiple Sclerosis (MS) remain elusive, accumulating evidence indicates that MS is a chronic inflammatory disease with an autoimmune component, mediated by...
Zhang, JW, Vandevyver, C, STINISSEN, Piet, RAUS, Jef
DR L WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.
PCR cloning and sequencing of a CD3-specific monoclonal antibody (1996)
Thirion, S, Motmans, K, Vandevyver, C, HEYLIGEN, Harie, RAUS, Jef
LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.Thirion, S, DR L WILLEMS INST,UNIV CAMPUS,GEBOUW A,B-3590 DIEPENBEEK,BELGIUM.
Rapid identification of PKU-associated mutations by multiplex DGGE analysis of the PAG gene (1996)
MICHIELS, Luc, FRANÇOIS, Baudoin, RAUS, Jef, VANDEVYVER, Caroline
PCR-cloning and sequencing of an anti-CD3 monoclonal antibody (1996)
HEYLIGEN, Harry, RAUS, Jef, VANDEVYVER, Caroline, Thirion, S., Motmans, K.
Heterogeneity of bone loss and loss of muscle strength in elderly women. (1996)
GEUSENS, Piet, VANHOOF, Johan, MERTENS, Johan, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.
GEUSENS, Piet, VANHOOF, Johan, VANDERVORST, Carine, RAUS, Jef, Vankrieken, L
DR WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM. DIAGNOST PROD CORP,LOS ANGELES,CA.
Motmans, K, Thirion, S, Vandevyver, C, HEYLIGEN, Harie, JANSSENS, Jaak, RAUS, Jef
Monoclonal antibodies (Mabs) are a potential key component for the treatment of cancer, because of their specificity and multiple effector functions, Hybridoma technology and progress in genetic...
Rapid identification of PKU-associated mutations by multiplex DGGE analysis of the PAH gene (1996)
Vandevyver, C, MICHIELS, Luc, FRANCOIS, Baudouin, RAUS, Jef
A system of five sets of multiplex polymerase chain reaction amplifications followed by denaturing gel electrophoresis analysis allows rapid analysis of all 13 exons of the phenylalanine hydroxylase...
Cytokine profile of human myelin basic protein reactive T cells (1996)
Hermans, G, Hauben, L, STINISSEN, Piet, RAUS, Jef, Zhang, JK
Hermans, G, LIMBURGS UNIV CENTRUM,MS RES & IMMUNOL DEPT,DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
Motmans, K, Vandevyver, C, RAUS, Jef
A fast method is reported for the precise and accurate quantification of cytokine mRNA, based on a quantitative polymerase chain reaction (PCR) assay. Post-PCR detection of the amplification products...
Mono- and bispecific single-chain antibody fragments for cancer therapy (1996)
Thirion, S, Motmans, K, Vandevyver, C, HEYLIGEN, Harie, JANSSENS, Jaak, RAUS, Jef
Especially when dealing,vith solid cancers, single-chain antibody fragments (scFvs) have a lot of advantages. Due to their small size (27 kDa), these proteins clear more rapidly from the blood, and...
T cell vaccination: Clinical application in autoimmune diseases (1996)
STINISSEN, Piet, MEDAER, Rob, RAUS, Jef, Zhang, JK
T cell responses to myelin basic protein (MBP) are implicated to play an important role in the pathogenesis of multiple sclerosis (MS). These MBP autoreactive T cells are found to undergo in vivo...
Vandevyver, C, STINISSEN, Piet, MEDAER, Rob, RAUS, Jef, Zhang, JK
Although the etiology and pathogenesis of multiple Sclerosis (MS) remain elusive, accumulating evidence indicates that MS is a chronic inflammatory disease with an autoimmune component, mediated by...
Vandevyver, C, STINISSEN, Piet, RAUS, Jef, Zhang, JK
DR L WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.
PCR cloning and sequencing of a CD3-specific monoclonal antibody (1996)
Thirion, S, Motmans, K, Vandevyver, C, HEYLIGEN, Harie, RAUS, Jef
LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.Thirion, S, DR L WILLEMS INST,UNIV CAMPUS,GEBOUW A,B-3590 DIEPENBEEK,BELGIUM.
Rapid identification of PKU-associated mutations by multiplex DGGE analysis of the PAG gene (1996)
MICHIELS, Luc, FRANÇOIS, Baudoin, RAUS, Jef, VANDEVYVER, Caroline
PCR-cloning and sequencing of an anti-CD3 monoclonal antibody (1996)
HEYLIGEN, Harry, RAUS, Jef, VANDEVYVER, Caroline, Thirion, S., Motmans, K.
FEASIBILITY OF A TRANSPORTABLE DEVICE TO MEASURE BONE-DENSITY IN PRIMARY-CARE SETTINGS (1995)
NIJS, J, DEQUEKER, J, GEUSENS, Piet, RAUS, Jef
LIMBURGS UNIV CENTRUM,DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,B-3001 LOUVAIN,BELGIUM.
EFFECT OF PAMIDRONATE ON ANTIGEN-SPECIFIC AND NONSPECIFIC T-LYMPHOCYTE PROLIFERATION (1995)
CELIS, L, ZHANG, J, GEUSENS, Piet, RAUS, Jef
DR L WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.
VANDEVYVER, C, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.
GHABANBASANI, MZ, GU, XX, SPAEPEN, M, VANDEVYVER, C, MARYNEN, P, CARTON, H, ...
The association of some HLA class IT alleles with multiple sclerosis (MS) has been amply documented. In the present study the role of HLA class II haplotypes and genotypes and of polymorphic amino...
CHIN, Y, VANDEVIJVER, C, ZHANG, JW, JANSSENS, Jaak, BLEUS, Josianne, RAUS, Jef
A total of forty-one tumor infiltrating T cell lines (TIL) were cloned, in the presence of interleukin-2, from nine breast tumor and five melanoma specimens with limiting dilution in a microculture...
TRUYEN, L, ZHANG, JW, MEDAER, Rob, STINISSEN, Piet, RAUS, Jef
In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete...
MATYUS, L, BENE, L, HEILIGEN, H, DAMJANOVICH, S, RAUS, Jef
The topological relationship of transferrin receptor (TfR) has been studied relative to the heavy and light chains of the HLA class I molecules, class II molecules, interleukin-2 receptor alpha-chain...
VANDEVYVER, C, ZHANG, JW, STINISSEN, Piet, RAUS, Jef
gamma delta T cells have been implicated as playing a role in the demyelinating processes of multiple sclerosis (MS). However, the nature of the ligands which lead to activation and accumulation of...
ZHANG, JW, VANDEVYVER, C, STINISSEN, Piet, RAUS, Jef
Autoreactive T cells specific for myelin basic protein (MBP) are implicated in the pathogenesis of multiple sclerosis, The mechanism by which MBP-reactive T cells are regulated in vivo remains...
QUANTIFICATION OF CYTOKINE MESSENGER-RNA EXPRESSION BY RT-PCR AND ELECTROCHEMILUMINESCENCE (1995)
VANDEVYVER, C, MOTMANS, K, RAUS, Jef
Variable gene expression constitutes a major mechanism for controlling cell development and cell function. To investigate these changed mRNA levels, a sensitive and quantitative assay is required. We...
SPAEPEN, M, GU, XX, VANDEVYVER, C, CASSIMAN, JJ, GEUSENS, Piet, RAUS, Jef
UNIV LOUVAIN,CTR HUMAN GENET,LOUVAIN,BELGIUM. DR L WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.
Variable gene expression, thus giving rise to Variable mRNA levels, constitutes a major mechanism for controlling cell development and cell function. In order to investigate these changed mRNA...
VANDEVYVER, C, MERTENS, N, VANDENELSEN, P, ZHANG, JW, MEDAER, Rob, RAUS, Jef
Myelin basic protein (MBP)-reactive T cells are thought to play an important role in the pathogenesis of multiple sclerosis (MS). In some patients with MS, these autoreactive T cells display a...
VANDEVYVER, C, CASSIMAN, JJ, GEUSENS, Piet, RAUS, Jef
The association of rheumatoid arthritis (RA) with HLA-DRB1 alleles indicates that at least one RA susceptibility gene is linked to the HLA class II region. Transporter associated with protein...
VANDEVYVER, C, VANDEGAER, L, NIES, J, TUYLS, L, HAFLER, DA, ZHANG, JW, ...
Infiltrating gamma delta T cells are potentially involved in the central nervous system demyelination in multiple sclerosis (MS). To further study this hypothesis, we analyzed the frequency and...
ZHANG, JW, VANDEVYVER, C, MERTENS, N, VANDENBERGLOONEN, E, STINISSEN, Piet, RAUS, Jef
Autoreactive T cells specific for myelin basic protein (MBP) are part of the normal T cell repertoire and are present both in patients with multiple sclerosis (MS) and healthy individuals. There is...
FEASIBILITY OF A TRANSPORTABLE DEVICE TO MEASURE BONE-DENSITY IN PRIMARY-CARE SETTINGS (1995)
NIJS, J, DEQUEKER, J, GEUSENS, Piet, RAUS, Jef
LIMBURGS UNIV CENTRUM,DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,B-3001 LOUVAIN,BELGIUM.
EFFECT OF PAMIDRONATE ON ANTIGEN-SPECIFIC AND NONSPECIFIC T-LYMPHOCYTE PROLIFERATION (1995)
CELIS, L, GEUSENS, Piet, RAUS, Jef, Zhang, JK
DR L WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.
VANDEVYVER, C, GEUSENS, Piet, VANHOOF, Johan, RAUS, Jef
DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.
GHABANBASANI, MZ, GU, XX, SPAEPEN, M, VANDEVYVER, C, MARYNEN, P, CARTON, H, ...
The association of some HLA class IT alleles with multiple sclerosis (MS) has been amply documented. In the present study the role of HLA class II haplotypes and genotypes and of polymorphic amino...
CHIN, Y, VANDEVIJVER, C, JANSSENS, Jaak, BLEUS, Josianne, RAUS, Jef, Zhang, JK
A total of forty-one tumor infiltrating T cell lines (TIL) were cloned, in the presence of interleukin-2, from nine breast tumor and five melanoma specimens with limiting dilution in a microculture...
TRUYEN, L, MEDAER, Rob, STINISSEN, Piet, RAUS, Jef, Zhang, JK
In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete...
MATYUS, L, BENE, L, HEILIGEN, H, DAMJANOVICH, S, RAUS, Jef
The topological relationship of transferrin receptor (TfR) has been studied relative to the heavy and light chains of the HLA class I molecules, class II molecules, interleukin-2 receptor alpha-chain...
VANDEVYVER, C, STINISSEN, Piet, RAUS, Jef, Zhang, JK
gamma delta T cells have been implicated as playing a role in the demyelinating processes of multiple sclerosis (MS). However, the nature of the ligands which lead to activation and accumulation of...
VANDEVYVER, C, STINISSEN, Piet, RAUS, Jef, Zhang, JK
Autoreactive T cells specific for myelin basic protein (MBP) are implicated in the pathogenesis of multiple sclerosis, The mechanism by which MBP-reactive T cells are regulated in vivo remains...
QUANTIFICATION OF CYTOKINE MESSENGER-RNA EXPRESSION BY RT-PCR AND ELECTROCHEMILUMINESCENCE (1995)
VANDEVYVER, C, MOTMANS, K, RAUS, Jef
Variable gene expression constitutes a major mechanism for controlling cell development and cell function. To investigate these changed mRNA levels, a sensitive and quantitative assay is required. We...
SPAEPEN, M, GU, XX, VANDEVYVER, C, CASSIMAN, JJ, GEUSENS, Piet, RAUS, Jef
UNIV LOUVAIN,CTR HUMAN GENET,LOUVAIN,BELGIUM. DR L WILLEMS INST,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.
Variable gene expression, thus giving rise to Variable mRNA levels, constitutes a major mechanism for controlling cell development and cell function. In order to investigate these changed mRNA...
VANDEVYVER, C, MERTENS, N, VANDENELSEN, P, MEDAER, Rob, RAUS, Jef, Zhang, JK
Myelin basic protein (MBP)-reactive T cells are thought to play an important role in the pathogenesis of multiple sclerosis (MS). In some patients with MS, these autoreactive T cells display a...
VANDEVYVER, C, CASSIMAN, JJ, GEUSENS, Piet, RAUS, Jef
The association of rheumatoid arthritis (RA) with HLA-DRB1 alleles indicates that at least one RA susceptibility gene is linked to the HLA class II region. Transporter associated with protein...
VANDEVYVER, C, VANDEGAER, L, NIES, J, TUYLS, L, HAFLER, DA, STINISSEN, Piet, ...
Infiltrating gamma delta T cells are potentially involved in the central nervous system demyelination in multiple sclerosis (MS). To further study this hypothesis, we analyzed the frequency and...
Zhang, JK, VANDEVYVER, C, STINISSEN, Piet, VANDENBERG-LOONEN, E, RAUS, Jef
Autoreactive T cells specific for myelin basic protein (MBP) are part of the normal T cell repertoire and are present both in patients with multiple sclerosis (MS) and healthy individuals. There is...
ENDOGENIC NORTESTOSTERONE IN CATTLE (1994)
DEBRABANDER, HF, VANHENDE, J, BATJOENS, P, SMETS, F, POTTIE, G, VANGINKEL, L, ...
When residues of nortestosterone (NT) were Found in the urine of cattle, racehorses or bodybuilders, exogenic administration was thought to be proven. In previous literature, no records were found of...
CHIN, Y, JANSSENS, Jaak, BLEUS, Josianne, ZHANG, Yinhuo, RAUS, Jef
51 T cell lines/clones were established from tumor-infiltrating lymphocytes of nine breast tumors by limiting dilution. All the lines/clones were exclusively CD3+ and expressed either CD4 (57%) or...
HETEROGENEITY OF PHENYLKETONURIA IN BELGIUM AT THE GENOTYPE-PHENOTYPE LEVEL (1994)
VERELST, P, FRANCOIS, Baudouin, PHILIPPAERTS, Linda, RAUS, Jef, VANDEVYVER, C
LIMBURGS UNIV CENTRUM,B-3590 DIEBENBEEK,BELGIUM.FRANCOIS, B, VZW,DL WILLEMS INST,UNIV CAMPUS,B-3590 DIEBENBEEK,BELGIUM.
HENDRIKS, Lutgardis, GIELEN, Brigitte, LEYSSENS, Luc, RAUS, Jef
LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.HENDRIKS, L, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
PCR CLONING OF THE ANTIGEN-BINDING DOMAINS OF AN MCF7-SPECIFIC MONOCLONAL-ANTIBODY (1994)
MOTMANS, K, VANDEVYVER, C, RAUS, Jef
LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.MOTMANS, K, DR L WILLEMS INST,UNIV CAMPUS,GEBOUW A,B-3590 DIEPENBEEK,BELGIUM.
LEYSSENS, Luc, ROYACKERS, Erik, GIELEN, Brigitte, MISSOTTEN, Marleen, CZECH, Jan, NOBEN, Jean-Paul, ...
Seven metabolites of 4-chlorotestosterone acetate were identified in urine of cattle that received a single injection of the drug. The steroids were isolated by means of a series of clean-up steps...
Autoreactive T cells specific for myelin proteins, such as myelin basic protein (MBP), are thought to play an important role in the pathogenesis of multiple sclerosis (MS). In MS, these MBP-reactive...
T-CELL RECEPTOR-DELTA LOCUS POLYMORPHISM IN RHEUMATOID-ARTHRITIS (1994)
VANDEVYVER, C, CASSIMAN, JJ, GEUSENS, Piet, RAUS, Jef
In order to identify new susceptibility markers for Rheumatoid Arthritis (RA), we analysed the dinucleotide repeat polymorphism at the T cell receptor delta locus (TCRD) in 65 RA patients and 99...
VANDEVYVER, C, CASSIMAN, JJ, STINISSEN, Piet, RAUS, Jef
Multiple sclerosis (MS) is known to be associated with HLA-DR2, but it is possible that additional major histocompatibility complex (MHC) genes confer disease susceptibility. The most recent...
VANDEVYVER, C, RAUS, P, CASSIMAN, JJ, RAUS, Jef, STINISSEN, Piet, PHILIPPAERTS, Linda
We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not...
VANDEVYVER, C, GU, XX, SPAEPEN, M, CASSIMAN, JJ, GEUSENS, Piet, PHILIPPAERTS, Linda, ...
Objectives-To investigate whether T-cell receptor (TCR) beta chain germline alleles, either alone or in combination with a particular HLA-genotype, are associated with rheumatoid arthritis (RA)....
T-CELL VACCINATION IN MULTIPLE-SCLEROSIS - HOPES AND FACTS (1994)
Six MS-patients were inoculated three times with autologous attenuated MBP-specific T cell clones at two month intervals. No toxic effects were observed. After the third inoculation the precursor...
VANDEVYVER, C, BUYSE, I, GHABANBASANI, Z, CARTON, H, CASSIMAN, JJ, PHILIPPAERTS, Linda, ...
There are compelling data to indicate that the susceptibility to multiple sclerosis (MS) is inherited, at least in part. Particular HLA genotypes may be associated with MS and recently also...
VANDEVYVER, C, CASSIMAN, JJ, STINISSEN, Piet, RAUS, Jef
In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA-class II-typed, chronic progressive multiple sclerosis...
ZHANG, JW, MARKOVICPLESE, S, LACET, B, WEINER, HL, HAFLER, DA, RAUS, Jef
Equal numbers of CD4(+) T cells recognizing myelin basic protein (MBP) and proteolipid protein (PLP) are found in the circulation of normal individuals and multiple sclerosis (MS) patients. We...
ENDOGENIC NORTESTOSTERONE IN CATTLE (1994)
DEBRABANDER, HF, VANHENDE, J, BATJOENS, P, SMETS, F, POTTIE, G, VANGINKEL, L, ...
When residues of nortestosterone (NT) were Found in the urine of cattle, racehorses or bodybuilders, exogenic administration was thought to be proven. In previous literature, no records were found of...
CHIN, Y, JANSSENS, Jaak, BLEUS, Josianne, RAUS, Jef, Zhang, JK
51 T cell lines/clones were established from tumor-infiltrating lymphocytes of nine breast tumors by limiting dilution. All the lines/clones were exclusively CD3+ and expressed either CD4 (57%) or...
HETEROGENEITY OF PHENYLKETONURIA IN BELGIUM AT THE GENOTYPE-PHENOTYPE LEVEL (1994)
VERELST, P, FRANCOIS, Baudouin, PHILIPPAERTS, Linda, RAUS, Jef, VANDEVYVER, C
LIMBURGS UNIV CENTRUM,B-3590 DIEBENBEEK,BELGIUM.FRANCOIS, B, VZW,DL WILLEMS INST,UNIV CAMPUS,B-3590 DIEBENBEEK,BELGIUM.
HENDRIKS, Lutgardis, GIELEN, Brigitte, LEYSSENS, Luc, RAUS, Jef
LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.HENDRIKS, L, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
PCR CLONING OF THE ANTIGEN-BINDING DOMAINS OF AN MCF7-SPECIFIC MONOCLONAL-ANTIBODY (1994)
MOTMANS, K, VANDEVYVER, C, RAUS, Jef
LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.MOTMANS, K, DR L WILLEMS INST,UNIV CAMPUS,GEBOUW A,B-3590 DIEPENBEEK,BELGIUM.
LEYSSENS, Luc, ROYACKERS, Erik, GIELEN, Brigitte, MISSOTTEN, Marleen, CZECH, Jan, NOBEN, Jean-Paul, ...
Seven metabolites of 4-chlorotestosterone acetate were identified in urine of cattle that received a single injection of the drug. The steroids were isolated by means of a series of clean-up steps...
Autoreactive T cells specific for myelin proteins, such as myelin basic protein (MBP), are thought to play an important role in the pathogenesis of multiple sclerosis (MS). In MS, these MBP-reactive...
T-CELL RECEPTOR-DELTA LOCUS POLYMORPHISM IN RHEUMATOID-ARTHRITIS (1994)
VANDEVYVER, C, CASSIMAN, JJ, GEUSENS, Piet, RAUS, Jef
In order to identify new susceptibility markers for Rheumatoid Arthritis (RA), we analysed the dinucleotide repeat polymorphism at the T cell receptor delta locus (TCRD) in 65 RA patients and 99...
VANDEVYVER, C, CASSIMAN, JJ, STINISSEN, Piet, RAUS, Jef
Multiple sclerosis (MS) is known to be associated with HLA-DR2, but it is possible that additional major histocompatibility complex (MHC) genes confer disease susceptibility. The most recent...
VANDEVYVER, C, RAUS, P, CASSIMAN, JJ, RAUS, Jef, STINISSEN, Piet, PHILIPPAERTS, Linda
We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not...
VANDEVYVER, C, GU, XX, SPAEPEN, M, CASSIMAN, JJ, GEUSENS, Piet, PHILIPPAERTS, Linda, ...
Objectives-To investigate whether T-cell receptor (TCR) beta chain germline alleles, either alone or in combination with a particular HLA-genotype, are associated with rheumatoid arthritis (RA)....
T-CELL VACCINATION IN MULTIPLE-SCLEROSIS - HOPES AND FACTS (1994)
Six MS-patients were inoculated three times with autologous attenuated MBP-specific T cell clones at two month intervals. No toxic effects were observed. After the third inoculation the precursor...
VANDEVYVER, C, BUYSE, I, GHABANBASANI, Z, CARTON, H, CASSIMAN, JJ, PHILIPPAERTS, Linda, ...
There are compelling data to indicate that the susceptibility to multiple sclerosis (MS) is inherited, at least in part. Particular HLA genotypes may be associated with MS and recently also...
VANDEVYVER, C, CASSIMAN, JJ, STINISSEN, Piet, RAUS, Jef
In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA-class II-typed, chronic progressive multiple sclerosis...
MARKOVICPLESE, S, LACET, B, WEINER, HL, HAFLER, DA, RAUS, Jef, Zhang, JK
Equal numbers of CD4(+) T cells recognizing myelin basic protein (MBP) and proteolipid protein (PLP) are found in the circulation of normal individuals and multiple sclerosis (MS) patients. We...
POTTIE, G, BAGYARY, S, HENDRIKS, Lutgardis, GIELEN, Brigitte, HAESEN, Veronique, RAUS, Jef
Within the scope of the control of the illegal use of naturally occurring steroids in veal calves, an evaluation was made of two commercially available kits for the determination of estradiol-17beta...
BENNUN, A, BACH, MA, DAVIES, TF, RAUS, Jef
FAC MED NECKER ENFANTS MALAD,DEPT PATHOL IMMUN,PARIS,FRANCE. DR L WILLEMS INST,DEPT IMMUNOL,DIEPENBEEK,BELGIUM. CUNY MT SINAI SCH MED,DEPT MED,NEW YORK,NY 10029.BENNUN, A, WEIZMANN INST SCI,DEPT CELL...
VANDEVYVER, C, STEUKERS, M, LAMBRECHT, Johan, HEYLIGEN, Harie, RAUS, Jef
A murine/human chimeric antibody, with specificity for the human interleukin-2 receptor, was developed by genetic engineering. For this purpose, the light and heavy chain variable region exons...
MOTMANS, K, VANDEVYVER, C, RAUS, Jef
DR L WILLEMS INST,DEPT BIOTECHNOL IMMUNOL,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.
NICHOLLS, PJ, JOHNSON, VG, ANDREW, SM, HOOGENBOOM, HR, YOULE, RJ, RAUS, Jef
Chimeric proteins consisting of a fusion between binding-deficient mutants of diphtheria toxin (DT) or Pseudomonas exotoxin A (PE) and a single-chain antibody (E6 sFv) against the human transferrin...
T-CELL VACCINATION IN AUTOIMMUNE-DISEASES - FROM LABORATORY TO CLINIC (1993)
DR L WILLEMS INST,MULTIPLE SCLEROSIS RES UNIT,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM.ZHANG, JW, DR L WILLEMS INST,DEPT IMMUNOL,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
MHC-RESTRICTED DEPLETION OF HUMAN MYELIN BASIC-PROTEIN REACTIVE T-CELLS BY T-CELL VACCINATION (1993)
HAFLER, D, ZHANG, Yinhuo, MEDAER, Rob, STINISSEN, Piet, RAUS, Jef
Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell...
Psychopathological correlates of hyperhaptoglobinemia during major depression (1993)
RAUS, Jef, Maes, M., Scharpé, S., Cooreman, W., Uyttenbroeck, W., Suy, E., ...
POTTIE, G, BAGYARY, S, HENDRIKS, Lutgardis, GIELEN, Brigitte, HAESEN, Veronique, RAUS, Jef
Within the scope of the control of the illegal use of naturally occurring steroids in veal calves, an evaluation was made of two commercially available kits for the determination of estradiol-17beta...
BENNUN, A, BACH, MA, DAVIES, TF, RAUS, Jef
FAC MED NECKER ENFANTS MALAD,DEPT PATHOL IMMUN,PARIS,FRANCE. DR L WILLEMS INST,DEPT IMMUNOL,DIEPENBEEK,BELGIUM. CUNY MT SINAI SCH MED,DEPT MED,NEW YORK,NY 10029.BENNUN, A, WEIZMANN INST SCI,DEPT CELL...
VANDEVYVER, C, STEUKERS, M, LAMBRECHT, Johan, HEYLIGEN, Harie, RAUS, Jef
A murine/human chimeric antibody, with specificity for the human interleukin-2 receptor, was developed by genetic engineering. For this purpose, the light and heavy chain variable region exons...
MOTMANS, K, VANDEVYVER, C, RAUS, Jef
DR L WILLEMS INST,DEPT BIOTECHNOL IMMUNOL,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.
NICHOLLS, PJ, JOHNSON, VG, ANDREW, SM, HOOGENBOOM, HR, YOULE, RJ, RAUS, Jef
Chimeric proteins consisting of a fusion between binding-deficient mutants of diphtheria toxin (DT) or Pseudomonas exotoxin A (PE) and a single-chain antibody (E6 sFv) against the human transferrin...
T-CELL VACCINATION IN AUTOIMMUNE-DISEASES - FROM LABORATORY TO CLINIC (1993)
DR L WILLEMS INST,MULTIPLE SCLEROSIS RES UNIT,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM.ZHANG, JW, DR L WILLEMS INST,DEPT IMMUNOL,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
MHC-RESTRICTED DEPLETION OF HUMAN MYELIN BASIC-PROTEIN REACTIVE T-CELLS BY T-CELL VACCINATION (1993)
HAFLER, D, MEDAER, Rob, STINISSEN, Piet, RAUS, Jef, Zhang, JK
Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell...
Psychopathological correlates of hyperhaptoglobinemia during major depression (1993)
RAUS, Jef, Maes, M., Scharpé, S., Cooreman, W., Uyttenbroeck, W., Suy, E., ...
PHENOTYPIC ANALYSIS OF TUMOR-INFILTRATING LYMPHOCYTES FROM HUMAN BREAST-CANCER (1992)
CHIN, Y, VANDEPITTE, J, VANDENBRANDE, J, OPDEBEEK, L, JANSSENS, Jaak, RAUS, Jef
Suspensions of fresh tumor-infiltrating lymphocytes (TIL) were prepared from 30 human breast ductal adenocarcinomas. To evaluate the phenotypic pattern of the isolated TIL, lymphocyte surface markers...
CHIN, Y, JANSSENS, Jaak, SMEYERS, Els, BLEUS, Josianne, ZHANG, Yinhuo, RAUS, Jef
Expansion of tumor infiltrating lymphocytes (TIL) in vitro is hampered by several factors, including a limited amount of lymphocytes obtained from different tumors, unknown target antigens and...
MAES, M, SCHARPE, S, BOSMANS, E, VANDEWOUDE, M, SUY, E, UYTTENBROECK, W, ...
1. Leukocyte enumeration through flow cytometry has revealed that severe depression may be accompanied by a systemic immune activation, indicative of an inflammatory response. The latter condition...
MAES, M, LAMBRECHTS, J, BOSMANS, E, JACOBS, J, SUY, E, DEJONCKHEERE, C, ...
Several studies have reported a suppressed immune function (e.g. blast transformation) during depression. In an attempt to define the cellular basis of the reported immune disorders, the present...
HASHIM, GA, YING, C, VANDENBERGLOONEN, E, ZHANG, Yinhuo, MEDAER, Rob, RAUS, Jef
A panel of 90 myelin basic protein (MBP)-specific T-cell lines were derived from peripheral blood of eight with multiple sclerosis and four normal subjects. The precursor frequency of MBP-reactive T...
HUMANIZATION OF IMMUNOTOXINS (1992)
RYBAK, SM, HOOGENBOOM, HR, MEADE, HM, SCHWARTZ, D, YOULE, RJ, RAUS, Jef
The construction and expression of a chimeric gene encoding a mouse/human antibody to the human transferrin receptor fused to the gene for angiogenin, a human homolog of pancreatic RNase, are...
NOEL, A, SIMON, N, FOIDART, JM, RAUS, Jef
The ability to transplant human tumors into athymic nude mice allows studies of tumor cells in vivo. However, after s.c. injection the incidence of tumor and metastases in nude mice is frequently...
SCHREURS, M, ZHANG, Yinhuo, MEDAER, Rob, RAUS, Jef
DR L WILLEMS INST,DEPT IMMUNOL,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM. MULTIPLE SCLEROSIS CLIN & REHABIL CTR,OVERPELT,BELGIUM. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.
PHENOTYPIC ANALYSIS OF TUMOR-INFILTRATING LYMPHOCYTES FROM HUMAN BREAST-CANCER (1992)
CHIN, Y, VANDEPITTE, J, VANDENBRANDE, J, OPDEBEEK, L, JANSSENS, Jaak, RAUS, Jef
Suspensions of fresh tumor-infiltrating lymphocytes (TIL) were prepared from 30 human breast ductal adenocarcinomas. To evaluate the phenotypic pattern of the isolated TIL, lymphocyte surface markers...
CHIN, Y, JANSSENS, Jaak, SMEYERS, Els, BLEUS, Josianne, RAUS, Jef, Zhang, JK
Expansion of tumor infiltrating lymphocytes (TIL) in vitro is hampered by several factors, including a limited amount of lymphocytes obtained from different tumors, unknown target antigens and...
MAES, M, SCHARPE, S, BOSMANS, E, VANDEWOUDE, M, SUY, E, UYTTENBROECK, W, ...
1. Leukocyte enumeration through flow cytometry has revealed that severe depression may be accompanied by a systemic immune activation, indicative of an inflammatory response. The latter condition...
MAES, M, LAMBRECHTS, J, BOSMANS, E, JACOBS, J, SUY, E, DEJONCKHEERE, C, ...
Several studies have reported a suppressed immune function (e.g. blast transformation) during depression. In an attempt to define the cellular basis of the reported immune disorders, the present...
HASHIM, GA, YING, C, VANDENBERGLOONEN, E, MEDAER, Rob, RAUS, Jef, Zhang, JK
A panel of 90 myelin basic protein (MBP)-specific T-cell lines were derived from peripheral blood of eight with multiple sclerosis and four normal subjects. The precursor frequency of MBP-reactive T...
HUMANIZATION OF IMMUNOTOXINS (1992)
RYBAK, SM, HOOGENBOOM, HR, MEADE, HM, SCHWARTZ, D, YOULE, RJ, RAUS, Jef
The construction and expression of a chimeric gene encoding a mouse/human antibody to the human transferrin receptor fused to the gene for angiogenin, a human homolog of pancreatic RNase, are...
NOEL, A, SIMON, N, FOIDART, JM, RAUS, Jef
The ability to transplant human tumors into athymic nude mice allows studies of tumor cells in vivo. However, after s.c. injection the incidence of tumor and metastases in nude mice is frequently...
SCHREURS, M, MEDAER, Rob, RAUS, Jef, Zhang, JK
DR L WILLEMS INST,DEPT IMMUNOL,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM. MULTIPLE SCLEROSIS CLIN & REHABIL CTR,OVERPELT,BELGIUM. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.
MAES, M, BOSMANS, E, SUY, E, DEJONCKHEERE, C, VANDERVORST, Carine, RAUS, Jef
We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing...
MAES, M, DHONDT, P, SUY, E, MINNER, B, VANDERVORST, Carine, RAUS, Jef
1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and...
MAES, M, MINNER, B, SUY, E, DHONDT, P, JACOBS, Marie-Paule, RAUS, Jef
We determined baseline 0800h plasma cortisol concentrations, 24-hr urinary free cortisol (UFC) excretion, the post-dexamethasone cortisol values at 0800h and 1600h, and the 0800h dexamethasone...
CONSTRUCTION AND EXPRESSION OF ANTIBODY TUMOR-NECROSIS-FACTOR FUSION PROTEINS (1991)
HOOGENBOOM, HR, VOLCKAERT, G, RAUS, Jef
The construction, expression and secretion of two genetically engineered antibody-cytokine hybrid fusion proteins is described. To target tumor necrosis factor (TNF) to tumor cells, recombinant...
HOOGENBOOM, HR, VOLCKAERT, G, RAUS, Jef
The construction, synthesis and secretion of a genetically engineered antibody-cytokine fusion molecule is described. To target tumor necrosis factor (TNF) to tumor cells, recombinant antibody...
DRIESSEN, C, JACOBS, A, LEYSSENS, Luc, CZECH, Jan, RAUS, Jef
A highly specific and sensitive method for the simultaneous detection of seven beta-2-receptor agonists in bovine liver homogenates and urine was developed. A 10-g amount of liver was homogenized and...
BENNUN, A, LIBLAU, RS, COHEN, L, LEHMANN, D, TOURNIERLASSERVE, E, ROSENZWEIG, A, ...
Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic...
A MURINE MONOCLONAL-ANTIBODY TO HUMAN BREAST-CANCER CELLS ASSOCIATED WITH DNA PLOIDY STATUS (1991)
CHIN, Y, PLESSERS, L, VANDEPITTE, J, RAUS, Jef
A murine monoclonal antibody, 5D10, raised against the human breast cancer cell line MCF7 reacted preferably with mammary carcinomas and weakly with normal epithelial cells. The antigens recognised...
YING, C, HENDERIKX, P, CHOU, CH, ZHANG, Yinhuo, MEDAER, Rob, RAUS, Jef
DR L WILLEMS INST,DEPT IMMUNOL,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
MAES, M, BOSMANS, E, SUY, E, DEJONCKHEERE, C, VANDERVORST, Carine, RAUS, Jef
In an attempt to delineate the pathophysiology underpinning the previously reported blunted lymphocyte responses to mitogenic stimulation in depressed patients, we measured the following immune...
DECREASED SERUM DIPEPTIDYL PEPTIDASE-IV ACTIVITY IN MAJOR DEPRESSION (1991)
MAES, M, DEMEESTER, I, VANHOOF, G, SCHARPE, S, BOSMANS, E, VERKERK, R, ...
It has been recently shown that severe depression is characterized by immune dysfunctions such as blunted mitogen-induced blast transformation, which is linked to interleukin-2 (IL-2) mechanisms, and...
MAES, M, MINNER, B, SUY, E, VANDERVORST, Carine, RAUS, Jef
In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre...
MAES, M, DEJONCKHEERE, C, SCHOTTE, C, COSYNS, P, SUY, E, VANDERVORST, Carine, ...
In order to investigate pituitary alpha-melanocyte-stimulating hormone (alpha-MSH), intact (1-39 structure) adrenocorticotropic hormone (ACTH), and adrenal cortisol secretion, we measured 8 a.m....
MAES, M, SUY, E, MINNER, B, VANDERVORST, Carine, RAUS, Jef
To investigate the relationships between pre- and postdexamethasone hypothalamic-pituitary-adrenal (HPA) axis functioning in depression, we measured the levels of baseline and postdexamethasone...
MAES, M, BOSMANS, E, SUY, E, MINNER, B, RAUS, Jef
In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to...
MAES, M, BOSMANS, E, SUY, E, DEJONCKHEERE, C, VANDERVORST, Carine, RAUS, Jef
To determine whether depression might be associated with serologic indices of autoimmune processes or active virus infections, we measured the following parameters in healthy controls, minor, simple...
Postdexamethason intact en multisequentieel ACTH in melancholia (1991)
RAUS, Jef, Maes, M., Vandervorst, C., Suy, E., Martin, M., Minner, B., ...
Decreased dispeptidyl-peptidase IV activity in serum of major depressed patients (1991)
RAUS, Jef, Maes, M., De Meester, I., Scharpé, S., Bosmans, E., Vandervorst, C.
MAES, M, BOSMANS, E, SUY, E, DEJONCKHEERE, C, VANDERVORST, Carine, RAUS, Jef
We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing...
MAES, M, DHONDT, P, SUY, E, MINNER, B, VANDERVORST, Carine, RAUS, Jef
1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and...
MAES, M, MINNER, B, SUY, E, DHONDT, P, JACOBS, Marie-Paule, RAUS, Jef
We determined baseline 0800h plasma cortisol concentrations, 24-hr urinary free cortisol (UFC) excretion, the post-dexamethasone cortisol values at 0800h and 1600h, and the 0800h dexamethasone...
CONSTRUCTION AND EXPRESSION OF ANTIBODY TUMOR-NECROSIS-FACTOR FUSION PROTEINS (1991)
HOOGENBOOM, HR, VOLCKAERT, G, RAUS, Jef
The construction, expression and secretion of two genetically engineered antibody-cytokine hybrid fusion proteins is described. To target tumor necrosis factor (TNF) to tumor cells, recombinant...
HOOGENBOOM, HR, RAUS, Jef, VOLCKAERT, G
The construction, synthesis and secretion of a genetically engineered antibody-cytokine fusion molecule is described. To target tumor necrosis factor (TNF) to tumor cells, recombinant antibody...
LEYSSENS, Luc, DRIESSEN, C, JACOBS, A, CZECH, Jan, RAUS, Jef
A highly specific and sensitive method for the simultaneous detection of seven beta-2-receptor agonists in bovine liver homogenates and urine was developed. A 10-g amount of liver was homogenized and...
BENNUN, A, LIBLAU, RS, COHEN, L, LEHMANN, D, TOURNIERLASSERVE, E, ROSENZWEIG, A, ...
Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic...
A MURINE MONOCLONAL-ANTIBODY TO HUMAN BREAST-CANCER CELLS ASSOCIATED WITH DNA PLOIDY STATUS (1991)
CHIN, Y, PLESSERS, L, VANDEPITTE, J, RAUS, Jef
A murine monoclonal antibody, 5D10, raised against the human breast cancer cell line MCF7 reacted preferably with mammary carcinomas and weakly with normal epithelial cells. The antigens recognised...
Zhang, JK, YING, C, HENDERIKX, P, MEDAER, Rob, CHOU, CH, RAUS, Jef
DR L WILLEMS INST,DEPT IMMUNOL,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
MAES, M, BOSMANS, E, SUY, E, DEJONCKHEERE, C, VANDERVORST, Carine, RAUS, Jef
In an attempt to delineate the pathophysiology underpinning the previously reported blunted lymphocyte responses to mitogenic stimulation in depressed patients, we measured the following immune...
DECREASED SERUM DIPEPTIDYL PEPTIDASE-IV ACTIVITY IN MAJOR DEPRESSION (1991)
MAES, M, DEMEESTER, I, SCHARPE, S, BOSMANS, E, VANDERVORST, Carine, RAUS, Jef, ...
It has been recently shown that severe depression is characterized by immune dysfunctions such as blunted mitogen-induced blast transformation, which is linked to interleukin-2 (IL-2) mechanisms, and...
MAES, M, MINNER, B, SUY, E, VANDERVORST, Carine, RAUS, Jef
In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre...
MAES, M, DEJONCKHEERE, C, VANDERVORST, Carine, SCHOTTE, C, COSYNS, P, RAUS, Jef, ...
In order to investigate pituitary alpha-melanocyte-stimulating hormone (alpha-MSH), intact (1-39 structure) adrenocorticotropic hormone (ACTH), and adrenal cortisol secretion, we measured 8 a.m....
MAES, M, VANDERVORST, Carine, SUY, E, MINNER, B, RAUS, Jef
To investigate the relationships between pre- and postdexamethasone hypothalamic-pituitary-adrenal (HPA) axis functioning in depression, we measured the levels of baseline and postdexamethasone...
MAES, M, BOSMANS, E, SUY, E, MINNER, B, RAUS, Jef
In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to...
MAES, M, BOSMANS, E, SUY, E, VANDERVORST, Carine, DEJONCKHEERE, C, RAUS, Jef
To determine whether depression might be associated with serologic indices of autoimmune processes or active virus infections, we measured the following parameters in healthy controls, minor, simple...
Postdexamethason intact en multisequentieel ACTH in melancholia (1991)
RAUS, Jef, Maes, M., Vandervorst, C., Suy, E., Martin, M., Minner, B., ...
Decreased dispeptidyl-peptidase IV activity in serum of major depressed patients (1991)
Maes, M., De Meester, I., Vanhoof, G, Scharpé, S., Bosmans, E., Vandervorst, C., ...
It has been recently shown that severe depression is characterized by immune dysfunctions such as blunted mitogen-induced blast transformation, which is linked to interleukin-2 (IL-2) mechanisms, and...
Linsen, Loes, Thewissen, Marielle, Baeten, Kurt, Somers, Veerle, Geusens, Piet, Raus, Jef, ...
Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA) remains...
Linsen, Loes, Thewissen, Marielle, Baeten, Kurt, Somers, Veerle, Geusens, Piet, Raus, Jef, ...
Natural killer T (NKT) cells have been implicated in the regulatory immune mechanisms that control autoimmunity. However, their precise role in the pathogenesis of rheumatoid arthritis (RA) remains...