Sarcolemma-localized nNOS is required to maintain activity after mild exercise (2008)
Kobayashi, Yvonne M., Rader, Erik P., Crawford, Robert W., Iyengar, Nikhil K., Thedens, Daniel R., Faulkner, John A., ...
Many neuromuscular conditions are characterized by an exaggerated exercise- induced fatigue response that is disproportionate to activity level. This fatigue is not necessarily correlated with...
Garvey, Sean M., Miller, Sara E., Claflin, Dennis R., Faulkner, John A., Hauser, Michael A.
Myotilin is a muscle-specific Z-disc protein with putative roles in myofibril assembly and structural upkeep of the sarcomere. Several myotilin point mutations have been described in patients with...
Li, Sheng, Kimura, En, Ng, Rainer, Fall, Brent M., Meuse, Leonard, Reyes, Morayma, ...
A promising approach for treating Duchenne muscular dystrophy (DMD) is by autologous cell transplantation of myogenic stem cells transduced with a therapeutic expression cassette. Development of this...
Garvey, Sean M., Miller, Sara E., Claflin, Dennis R., Faulkner, John A., Hauser, Michael A.
Myotilin is a muscle-specific Z-disc protein with putative roles in myofibril assembly and structural upkeep of the sarcomere. Several myotilin point mutations have been described in patients with...
Li, Sheng, Kimura, En, Ng, Rainer, Fall, Brent M., Meuse, Leonard, Reyes, Morayma, ...
A promising approach for treating Duchenne muscular dystrophy (DMD) is by autologous cell transplantation of myogenic stem cells transduced with a therapeutic expression cassette. Development of this...
Number of contractions to maintain mass and force of a denervated rat muscle (2004)
Dow, Douglas E., Cederna, Paul S., Hassett, Cheryl A., Kostrominova, Tatiana Y., Faulkner, John A., Dennis, Robert G.
Within 5 weeks, denervated extensor digitorum longus (EDL) muscles of rats lose 66% of mass, 91% of force, and 76% of fiber cross-sectional area (CSA). We previously determined the parameters of...
Functional Development of Engineered Skeletal Muscle from Adult and Neonatal Rats (2001)
Kosnik, Paul E., Faulkner, John A., Dennis, Robert G.
A myooid is a three-dimensional skeletal muscle construct cultured from mammalian myoblasts and fibroblasts. The purpose was to compare over several weeks in culture the morphology, excitability, and...
Favour,Cutting B., Faulkner,John A., Kolias,James
Attention was focused on three variables: (1) The role of exercise in raising the hematocrit; (2) the role of physical fitness in preserving a degree of homeostasis close to an hematocrit level of 40...
Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice (1995)
Phelps, Stephanie F., Hauser, Michael A., Cole, Neil M., Rafael, Jill A., Hinkle, Richard T., Faulkner, John A., ...
Duchenne and Becker muscular dystrophy are caused by defects in the dystrophin gene, and are candidates for treatment by gene therapy. We have shown previously that overexpression of a full-length...
Whole skeletal muscle transplantation: Mechanisms responsible for functional deficits (1994)
Faulkner, John A., Carlson, Bruce M., Kadhiresan, Veerichetty A.
One aspect of tissue engineering of skeletal muscle involves the transposition and transplantation of whole muscles to treat muscles damaged by injury or disease. The transposition of whole muscles...
Prevention of dystrophic pathology in mdx mice by a truncated dystrophin isoform (1994)
Rafael, Jill A., Sunada, Yoshihide, Cole, Neil M., Campbell, Kevin P., Faulkner, John A., Chamberlain, Jeffrey S.
The C-terminal domain of dystrophin is alternatively spliced to produce a variety of tissue and developmental stage-specific isoforms. Recent studies suggest that the C-terminal domain binds to the...
Reinnervation of long-term denervated rat muscle freely grafted into an innervated limb (1988)
Carlson, Bruce M., Faulkner, John A.
This experiment was designed to test the hypothesis that in the presence of regenerating nerve fibers long-term denervated skeletal muscle does not become reinnervated. This hypothesis was tested in...
Guelinckx, Paul J., Faulkner, John A., Essig, David A.
In rabbits, 9 g rectus femoris (RFM) muscles were grafted with tendon repair and with (1) nerves and blood vessels intact, (2) nerves intact and blood vessels anastomosed, or (3) nerves and blood...
The response of arterioles in skeletal muscle grafts to vasoactive agents (1987)
Burton, Harold W., Faulkner, John A.
Arteriolar responses to the vasodilator adenosine and to the vasoconstrictor norepinephrine (NE) were examined in small bundles of extensor digitorum longus muscle grafted onto the cheek pouches of...
Contractile properties of standard and nerve-intact muscle grafts in the rat (1985)
Faulkner, John A., Carlson, Bruce M.
The contractile properties of standard and nerve-intact grafts of extensor digitorum longus muscles of rats were compared in vitro. Fourteen days after grafting, the time to peak tension and the...
Abnormal neuromuscular transmission in an infantile myasthenic syndrome (1984)
Albers, James W., Faulkner, John A., Dorovini-Zis, Katerina, Barald, Kate F., Must, Rachel E., Ball, Richard D.
A term infant required intubation for respiratory depression. Examination revealed hypotonia and areflexia with intact extraocular movements. Electrodiagnostic studies demonstrated defective...
Motor unit function in skeletal muscle autografts of rats (1984)
Cote, Claude, Faulkner, John A.
Standard and nerve-intact grafts of the extensor digitorum longus (EDL) muscles of rats do not fully recover control values for maximum tetanic tension (Po). We compared the physiologic properties of...
Faulkner, John A., Weiss, Stefani W., McGeachie, John K.
Small fiber bundles from the extensor digitorum longus (EDL) muscle were transplanted into the hamster cheek pouch to observe the process of revascularization. We tested the hypothesis that blood...
Weiss, Stefani W., Faulkner, John A.
Revascularization of bundles of skeletal muscle fibers transplanted into the cheek pouch of hamsters was examined previously by intravital and light microscopy. Some blood vessels survived the...
Characteristics of cat skeletal muscles grafted with intact nerves or with anastomosed nerves (1983)
Faulkner, John A., McCully, Kevin K., Watters, Christopher R., White, Timothy P.
Grafting of 3-g extensor digitorum longus (EDL) muscles of cats may be made with (i) severence of the nerve with spontaneous reinnervation, termed standard grafts (ii) severence of the nerve with...
Relationship among fibre type, myosin ATPase activity and contractile properties (1982)
Maxwell, Leo C., Faulkner, John A., Murphy, Richard A.
At least two types of skeletal muscle myosin have been described which differ in ATPase activity and stability in alkaline or acidic media. Differences in ATPase characteristics distinguish Type I...
Translocation of the temporalis muscle for treatment of facial paralysis (1982)
White, Timothy P., Faulkner, John A., Markley, John M., Maxwell, Leo C.
Our purpose was to characterize in the rhesus monkey the structure and function of vascularized temporalis muscle flaps innervated by the facial nerve after translocation into the site of the...
Faulkner, John A., McCully, Kevin K., Carlson, David S.
The hypothesis was tested that increasing the resting length of the masseter and temporalis muscles by a bite-opening appliance with or without detachment and re-attachment of the masseter would not...
Maxwell, Leo C., Carlson, David S., McNamara, James A., Faulkner, John A.
Histochemical properties, muscle fiber cross-sectional area, muscle fiber length, and the oxidative capacity of masticatory muscles of female rhesus monkeys were assessed following alteration in...
Maxwell, Leo C., Carlson, David S., Faulkner, John A.
Muscle fibres of the masseter and temporalis muscles of female rhesus monkeys which had been edentulous for 4.5 yr were analysed histochemically. Fibres were classified on the basis of activities of...
Protein synthesis in skeletal muscle following acute exhaustive exercise (1979)
Rogers, Peter A., Jones, George H., Faulkner, John A.
Cell-free and whole-tissue protein synthesis was studied in skeletal muscle of untrained male guinea pigs that had undergone a treadmill run to exhaustion. Experiments using explants from the...
Neuroanastomosis of orthotopically transplanted palmaris longus muscles (1979)
Maxwell, Leo C., Faulkner, John A., Markley, John M., Winborn, D. R.
Palmaris longus (PML) muscles of rhesus monkeys were transplanted, with or without anastomosis of the median nerve, to the nerve stump of the autograft. Because PML autografts revascularize...
Seasonal acclimatization to temperature in cardueline finches (1978)
Carey, Cynthia, Maxwell, Leo C., Faulkner, John A., Dawson, William R.
1. Seasonal variation in body constituents and utilization of lipid, protein, and carbohydrate during cold stress in American goldfinches were studied to determine relations of these functions to the...
Mufti, Shahzad A., Carlson, Bruce M., Maxwell, Leo C., Faulkner, John A.
Normal or pre-denervated extensor digitorum longus (EDL) muscles were successfully grafted in place of the contralateral EDL muscles in cats. Histological preparations of 57 grafts were examined at...
Skeletal muscle fiber regeneration following heterotopic autotransplantation in cats (1976)
Faulkner, John A., Maxwell, Leo C., Mufti, Shahzad A., Carlson, Bruce M.
Whole 3 g extensor digitorum longus (EDL) muscles of cats were autotransplanted. The EDL muscles were either transplanted without denervation prior to transplantation (normal transplants) or...
Sarcospan-Deficient Mice Maintain Normal Muscle Function
Lebakken, Connie S., Venzke, David P., Hrstka, Ronald F., Consolino, Christina M., Faulkner, John A., Williamson, Roger A., ...
Sarcospan is an integral membrane component of the dystrophin-glycoprotein complex (DGC) found at the sarcolemma of striated and smooth muscle. The DGC plays important roles in muscle function and...
Sarcospan-Deficient Mice Maintain Normal Muscle Function
Lebakken, Connie S., Venzke, David P., Hrstka, Ronald F., Consolino, Christina M., Faulkner, John A., Williamson, Roger A., ...
Sarcospan is an integral membrane component of the dystrophin-glycoprotein complex (DGC) found at the sarcolemma of striated and smooth muscle. The DGC plays important roles in muscle function and...
Vasilaki, Aphrodite, Simpson, Deborah, McArdle, Francis, McLean, Lynne, Beynon, Robert J., Van Remmen, Holly, ...
Oxidation of skeletal muscle proteins has been reported to occur following contractions, with ageing, and with a variety of disease states, but the nature of the oxidised proteins has not been...
Force and power output of fast and slow skeletal muscles from mdx mice 6-28 months old
Lynch, Gordon S, Hinkle, Richard T, Chamberlain, Jeffrey S, Brooks, Susan V, Faulkner, John A
Differences in the effect of age on structure-function relationships of limb muscles of mdx (dystrophin null) and control mice have not been resolved. We tested the hypotheses that, compared with...
Progressive Muscular Dystrophy in α-Sarcoglycan–deficient Mice
Duclos, Franck, Straub, Volker, Moore, Steven A., Venzke, David P., Hrstka, Ron F., Crosbie, Rachelle H., ...
Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder caused by mutations in the α-sarcoglycan gene. To determine how α-sarcoglycan deficiency leads to muscle fiber...
Crawford, Gregory E., Faulkner, John A., Crosbie, Rachelle H., Campbell, Kevin P., Froehner, Stanley C., Chamberlain, Jeffrey S.
Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellular matrix through the dystrophin associated protein (DAP) complex. The COOH-terminal domain of...
Tendons of myostatin-deficient mice are small, brittle, and hypocellular
Mendias, Christopher L., Bakhurin, Konstantin I., Faulkner, John A.
Tendons play a significant role in the modulation of forces transmitted between bones and skeletal muscles and consequently protect muscle fibers from contraction-induced, or high-strain, injuries....
Lynch, Gordon S., Faulkner, John A., Brooks, Susan V.
The deficit in force generation is a measure of the magnitude of damage to sarcomeres caused by lengthening contractions of either single fibers or whole muscles. In addition, permeabilized single...
Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice
Ng, Rainer, Metzger, Joseph M., Claflin, Dennis R., Faulkner, John A.
Duchenne Muscular Dystrophy is a genetic disease caused by the lack of the protein dystrophin. Dystrophic muscles are highly susceptible to contraction-induced injury, and following contractile...
Han, Renzhi, Kanagawa, Motoi, Yoshida-Moriguchi, Takako, Rader, Erik P., Ng, Rainer A., Michele, Daniel E., ...
Skeletal muscle basal lamina is linked to the sarcolemma through transmembrane receptors, including integrins and dystroglycan. The function of dystroglycan relies critically on posttranslational...
Panchangam, Appaji, Claflin, Dennis R., Palmer, Mark L., Faulkner, John A.
A laser-diffraction technique was developed that rapidly reports the lengths of sarcomeres (Ls) in serially connected sectors of permeabilized single fibers. The apparatus translates a laser beam...