Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells. (2004)
Bretschneider, Till, Diez, Stefan, Anderson, Kurt, Heuser, John, Clarke, Margaret, Muller-Taubenberger, Annette, ...
BACKGROUND: In the cortical region of motile cells, the actin network rapidly reorganizes as required for movement in various directions and for cell-to-substrate adhesion. The analysis of actin...
Gendelman, Howard, Westervelt, Peter, Henkel, Timothy, Trowbridge, David B., Orenstein, Jan, Heuser, John, ...
The regulation of human immunodeficiency virus type 1 infection and replication in primary monocytes was investigated by mutagenesis of recombinant proviral clones containing an env determinant...
Thanassi, David G., Saulino, Evan T., Lombardo, Mary-Jane, Roth, Robyn, Heuser, John, Hultgren, Scott J.
Bacterial virulence factors are typically surface-associated or secreted molecules that in Gram-negative bacteria must cross the outer membrane (OM). Protein translocation across the bacterial OM is...
Håkansson, Sebastian, Morisaki, Hiroshi, Heuser, John, Sibley, L. David
Toxoplasma gondii is a member of the phylum Apicomplexa, a diverse group of intracellular parasites that share a unique form of gliding motility. Gliding is substrate dependent and occurs without...
Sahoo, Nivedita, Beatty, Wandy, Heuser, John, Sept, David, Sibley, L. David
Toxoplasma is a protozoan parasite in the phylum Apicomplexa, which contains a number of medically important parasites that rely on a highly unusual form of motility termed gliding to actively...
Targeted Chemical Disruption of Clathrin Function in Living Cells
Moskowitz, Howard S., Heuser, John, McGraw, Timothy E., Ryan, Timothy A.
The accurate assignment of molecular roles in membrane traffic is frequently complicated by the lack of specific inhibitors that can work on rapid time scales. Such inhibition schemes would...
Thanassi, David G., Saulino, Evan T., Lombardo, Mary-Jane, Roth, Robyn, Heuser, John, Hultgren, Scott J.
Bacterial virulence factors are typically surface-associated or secreted molecules that in Gram-negative bacteria must cross the outer membrane (OM). Protein translocation across the bacterial OM is...
Håkansson, Sebastian, Morisaki, Hiroshi, Heuser, John, Sibley, L. David
Toxoplasma gondii is a member of the phylum Apicomplexa, a diverse group of intracellular parasites that share a unique form of gliding motility. Gliding is substrate dependent and occurs without...
Targeted Chemical Disruption of Clathrin Function in Living Cells
Moskowitz, Howard S., Heuser, John, McGraw, Timothy E., Ryan, Timothy A.
The accurate assignment of molecular roles in membrane traffic is frequently complicated by the lack of specific inhibitors that can work on rapid time scales. Such inhibition schemes would...
Sahoo, Nivedita, Beatty, Wandy, Heuser, John, Sept, David, Sibley, L. David
Toxoplasma is a protozoan parasite in the phylum Apicomplexa, which contains a number of medically important parasites that rely on a highly unusual form of motility termed gliding to actively...
Szajner, Patricia, Weisberg, Andrea S., Lebowitz, Jacob, Heuser, John, Moss, Bernard
During morphogenesis, poxviruses undergo a remarkable transition from spherical immature forms to brick-shaped infectious particles lacking helical or icosahedral symmetry. In this study, we show...
Three-dimensional “deep-etch” electron microscopy (DEEM) resolves a longstanding controversy concerning poxvirus morphogenesis. By avoiding fixative-induced membrane distortions that confounded...
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
Stamm, Luisa M., Morisaki, J. Hiroshi, Gao, Lian-Yong, Jeng, Robert L., McDonald, Kent L., Roth, Robyn, ...
Mycobacteria are responsible for a number of human and animal diseases and are classical intracellular pathogens, living inside macrophages rather than as free-living organisms during infection....
Warren, Robin A., Kessels, Michael M., Keen, James H., Heuser, John, Drubin, David G.
Huntingtin-interacting protein 1 related (Hip1R) is a novel component of clathrin-coated pits and vesicles and is a mammalian homologue of Sla2p, an actin-binding protein important for both actin...