Jyotika Sharma

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

Belland, Robert J., Zhong, Guangming, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, Sharma, Jyotika, ...

Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological agent of debilitating sexually transmitted and ocular diseases in humans. The organism is an obligate...

Intramolecular Dimerization Is Required for the Chlamydia-Secreted Protease CPAF To Degrade Host Transcriptional Factors

Dong, Feng, Sharma, Jyotika, Xiao, Yanming, Zhong, Youmin, Zhong, Guangming

We previously identified a chlamydial protein designated CPAF (chlamydia protease/proteasome-like activity factor) that is secreted into host cell cytosol for degrading host transcription factors...

Human Antibody Responses to a Chlamydia-Secreted Protease Factor

Sharma, Jyotika, Bosnic, Anthony M., Piper, Jeanna M., Zhong, Guangming

We have previously identified a chlamydia-secreted protein (designated chlamydial proteasome/protease-like activity factor, or CPAF) in the cytosol of chlamydia-infected cells. Although CPAF is known...

Inhibition of Proteolytic Activity of a Chlamydial Proteasome/Protease-Like Activity Factor by Antibodies from Humans Infected with Chlamydia trachomatis

Sharma, Jyotika, Dong, Feng, Pirbhai, Mustak, Zhong, Guangming

We have previously shown that individuals infected with Chlamydia trachomatis can develop a robust antibody response to a chlamydia-secreted protein (designated chlamydial proteasome/protease-like...

Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins

Sharma, Jyotika, Zhong, Youmin, Dong, Feng, Piper, Jeanna M., Wang, Guqi, Zhong, Guangming

The available chlamydial genome sequences have made it possible to comprehensively analyze host responses to all chlamydial proteins, which is essential for further understanding of chlamydial...

The Hypothetical Protein CT813 Is Localized in the Chlamydia trachomatis Inclusion Membrane and Is Immunogenic in Women Urogenitally Infected with C. trachomatis

Chen, Chaoqun, Chen, Ding, Sharma, Jyotika, Cheng, Wen, Zhong, Youmin, Liu, Kaiyang, ...

Using antibodies raised with chlamydial fusion proteins, we have localized a protein encoded by hypothetical open reading frame CT813 in the inclusion membrane of Chlamydia trachomatis. The detection...

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

Belland, Robert J., Zhong, Guangming, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, Sharma, Jyotika, ...

Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological agent of debilitating sexually transmitted and ocular diseases in humans. The organism is an obligate...

Intramolecular Dimerization Is Required for the Chlamydia-Secreted Protease CPAF To Degrade Host Transcriptional Factors

Dong, Feng, Sharma, Jyotika, Xiao, Yanming, Zhong, Youmin, Zhong, Guangming

We previously identified a chlamydial protein designated CPAF (chlamydia protease/proteasome-like activity factor) that is secreted into host cell cytosol for degrading host transcription factors...

Human Antibody Responses to a Chlamydia-Secreted Protease Factor

Sharma, Jyotika, Bosnic, Anthony M., Piper, Jeanna M., Zhong, Guangming

We have previously identified a chlamydia-secreted protein (designated chlamydial proteasome/protease-like activity factor, or CPAF) in the cytosol of chlamydia-infected cells. Although CPAF is known...

Inhibition of Proteolytic Activity of a Chlamydial Proteasome/Protease-Like Activity Factor by Antibodies from Humans Infected with Chlamydia trachomatis

Sharma, Jyotika, Dong, Feng, Pirbhai, Mustak, Zhong, Guangming

We have previously shown that individuals infected with Chlamydia trachomatis can develop a robust antibody response to a chlamydia-secreted protein (designated chlamydial proteasome/protease-like...

Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins

Sharma, Jyotika, Zhong, Youmin, Dong, Feng, Piper, Jeanna M., Wang, Guqi, Zhong, Guangming

The available chlamydial genome sequences have made it possible to comprehensively analyze host responses to all chlamydial proteins, which is essential for further understanding of chlamydial...

The Hypothetical Protein CT813 Is Localized in the Chlamydia trachomatis Inclusion Membrane and Is Immunogenic in Women Urogenitally Infected with C. trachomatis

Chen, Chaoqun, Chen, Ding, Sharma, Jyotika, Cheng, Wen, Zhong, Youmin, Liu, Kaiyang, ...

Using antibodies raised with chlamydial fusion proteins, we have localized a protein encoded by hypothetical open reading frame CT813 in the inclusion membrane of Chlamydia trachomatis. The detection...