K. Fransen

Proof of principle: an HIV p24 microsphere immunoassay with potential application to HIV clinical diagnosis (2009)

Ondoa, P., Vereecken, C., Asahchop, E. L., Litzroth, A., Diallo, A., Fransen, K., ...

The measurement of CD4 counts and viral loads on a single instrument such as an affordable flow cytometer could considerably reduce the cost related to the follow-up of antiretroviral therapy in...

Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database (2008)

Ruelle, J., Roman, F., Vandenbroucke, A. T., Lambert, C., Fransen, K., Echahidi, F., ...

BACKGROUND: Guidelines established for the treatment of HIV-1 infection and genotype interpretation do not apply for HIV-2. Data about antiretroviral (ARV) drug efficacy and resistance mutations is...

Prevalence and epidemiology of HIV type 1 drug resistance among newly diagnosed therapy-naive patients in Belgium from 2003 to 2006 (2008)

Vercauteren, J., Derdelinckx, I., Sasse, A., Bogaert, M., Ceunen, H., De Roo, A., ...

This study is the first prospective study to assess the prevalence, epidemiology, and risk factors of HIV-1 drug resistance in newly diagnosed HIV-infected patients in Belgium. In January 2003 it was...

Role of the laboratory in ensuring global access to ARV treatment for HIV-infected children: consensus statement on the performance of laboratory assays for early infant diagnosis (2008)

Stevens, W., Sherman, G., Downing, R., Parsons, L. M., Ou, C. Y., Crowley, S., ...

A two day meeting hosted by the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) was held in May 2006 in Entebbe, Uganda to review the laboratory...

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients (2007)

Steyaert, Sophia, HEYNDRICKX, L, Verhoye, Lieven, VERMOESEN, T, DONNERS, H, FRANSEN, K, ...

The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection (2007)

Steyaert, Sophia, Verhoye, Lieven, BEIRNAERT, E, DONNERS, H, FRANSEN, K, HEYNDRICKX, L, ...

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients (2007)

Steyaert, S., Heyndrickx, L., Verhoye, L., Vermoesen, T., Donners, H., Fransen, K., ...

Although a limited number of HIV-infected patients have broadly neutralizing antibodies, it has not been examined whether these antibodies can protect against infection with primary virus in vivo....

The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection (2007)

Steyaert, S., Verhoye, L., Beirnaert, E., Donners, H., Fransen, K., Heyndrickx, L., ...

The intrasplenic injection of human peripheral blood mononuclear cells (PBMCs) into severely immune deficient NOD/SCID mice, causes a massive and transient dominant expansion of human B cells in the...

Performance evaluation of the two protease sequencing primers of the Trugene HIV-1 genotyping kit (2006)

Garc¡a Ribas, S., Heyndrickx, L., Ondoa, P., Fransen, K.

This article describes the performance of the two protease sequencing modules available in the Trugene HIV-1 genotyping Kit on a sample population with a high prevalence of HIV-1 non-B subtypes...

Evaluation of HIV-1 p24 antigenemia and level of CD8+CD38+ T cells as surrogate markers of HIV-1 RNA viral load in HIV-1-infected patients in Dakar (2006)

Ondoa, P., Dieye, T. N., Vereecken, C., Camara, M., Diallo, A. A., Fransen, K., ...

Not the final published version

Dominant ex vivo cross-stimulation of CD8+ T-cells with whole soluble Gag protein in HIV-infected subjects (2006)

Tavernier, A., Jennes, W., Fransen, K., De Roo, A., Kestens, L.

Not the final published version

Pediatric human immunodeficiency virus screening in an African district hospital (2005)

DE BAETS, AJ, EDIDI, BS, KASALI, MJ, BEELAERT, G, SCHROOTEN, W, LITZROTH, A, ...

The effect of highly active antiretroviral treatment on viral load and antiretroviral drug levels in breast milk [research letter] (2005)

Colebunders, R., Hodossy, B., Burger, D., Daems, T., Roelens, K., Coppens, M., ...

Not the final published version

Pediatric human immunodeficiency virus screening in an African district hospital (2005)

De Baets, A. J., Edidi, B. S., Kasali, M. J., Beelaert, G., Schrooten, W., Litzroth, A., ...

In order to evaluate alternative tests and strategies to simplify pediatric human immunodeficiency virus (HIV) screening at the district hospital level, a cross-sectional exploratory study was...

Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells (2005)

Njai, H. F., Lewi, P. J., Janssen, C. G. M., Garcia, S., Fransen, K., Kestens, L., ...

This is the author’s version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might...

Five-year immunological outcome of highly active antiretroviral treatment in a clinical setting: results from a single HIV treatment centre (2004)

Florence, E, Van Esbroeck, M, Fransen, K, Desmet, P, Colebunders, R, Kestens, L, ...

Our objective was to study the evolution of CD4 cell count five years after starting highly active antiretroviral treatment (HAART) in a clinical setting. The study was performed at the HIV...

A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides (2004)

Van Herrewege, Y., Vanham, G., Michiels, J., Fransen, K., Kestens, L., Andries, K., ...

Five-year immunological outcome of highly active antiretroviral treatment in a clinical setting: results from a single HIV treatment centre (2004)

Florence, E, Van Esbroeck, M, Fransen, K, Desmet, P, Colebunders, R, Kestens, L, ...

Our objective was to study the evolution of CD4 cell count five years after starting highly active antiretroviral treatment (HAART) in a clinical setting. The study was performed at the HIV...

A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides (2004)

Van Herrewege, Y., Vanham, G., Michiels, J., Fransen, K., Kestens, L., Andries, K., ...

Current levels of drug resistance among therapy-naive HIV-infected patients have significant impact on treatment response [letter] (2004)

Derdelinckx, I., Van Laethem, K., Maes, B., Schrooten, Y., De Wit, S., Florence, E., ...

Not the final published version

The role of non-viral load surrogate markers in HIV-positive patient monitoring during antiviral treatment (2004)

Florence, E., Dreezen, C., Schrooten, W., Van Esbroeck, M., Kestens, L., Fransen, K., ...

Our objective was to study the evolution of CD4 cell count five years after starting highly active antiretroviral treatment (HAART) in a clinical setting. The study was performed at the HIV...

Five-year immunological outcome of highly active antiretroviral treatment in a clinical setting: results from a single HIV treatment centre (2004)

Schrooten, W., Florence, E., Dreezen, C., Van Esbroeck, M., Fransen, K., Alonso, A., ...

Our objective was to study the evolution of CD4 cell count five years after starting highly active antiretroviral treatment (HAART) in a clinical setting. The study was performed at the HIV...

Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in progressive HIV infection (2004)

Jennes, W., Vereecken, C., Fransen, K., De Roo, A., Kestens, L.

The protective role of beta-chemokines in HIV infection and disease remains controversial. Contradictory findings have been reported possibly as the result of different beta-chemokine detection...

In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides (2004)

Van Herrewege, Y., Michiels, J., Van Roey, J., Fransen, K., Kestens, L., Balzarini, J., ...

An in vitro model of monocyte-derived dendritic cells (MO-DC) and CD4(+) T cells, representing the primary targets of sexual human immunodeficiency virus (HIV) transmission, was used to evaluate the...

A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides (2004)

Van Herrewege, Y., Vanham, G., Michiels, J., Fransen, K., Kestens, L., Andries, K., ...

An in vitro model of monocyte-derived dendritic cells (MO-DC) and CD4(+) T cells, representing the primary targets of sexual human immunodeficiency virus (HIV) transmission, was used to evaluate the...

Virologic therapy response significantly correlates with the number of active drugs as evaluated using a LiPA HIV-1 resistance scoring system (2004)

Ziermann, R., Celis, L., Derdelinckx, I., Lambert, C., Veeck, J., Rizzo, M. G., ...

BACKGROUND: Resistance testing is increasingly accepted as a tool in guiding the selection of human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy in HIV-1 infected individuals who fail...

Performance of a quantitative human immunodeficiency virus type 1 p24 antigen assay on various HIV-1 subtypes for the follow-up of human immunodeficiency type 1 seropositive individuals. (2003)

Ribas, S G, Ondoa, P, Schüpbach, J, Fransen, K

The heat-denatured signal-amplified p24 antigen assay is a low-cost test allowing the determination of plasma levels of HIV-1 p24 antigen in infected patients. This assay may be appropriate for...

Performance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes (2003)

Derdelinckx, I., Van Laethem, K., Maes, B., Schrooten, Y., De Schouwer, K., De Wit, S., ...

In this study we evaluated the performance of the VERSANT HIV-1 Resistance Assays (LiPA) in detecting drug resistance in therapy-naive HIV-infected patients diagnosed in Belgium in 2000. We compared...

Performance of a quantitative human immunodeficiency virus type 1 p24 antigen assay on various HIV-1 subtypes for the follow-up of human immunodeficiency type 1 seropositive individuals (2003)

García Ribas, S., Ondoa, P., Schüpbach, J., Fransen, K.

The heat-denatured signal-amplified p24 antigen assay is a low-cost test allowing the determination of plasma levels of HIV-1 p24 antigen in infected patients. This assay may be appropriate for...

Accessibilité et contrôle de qualité au Laboratoire National de Référence VIH et IST du PNLS en RDC (2003)

Muwonga, J., Edidi, S., Atibu, L., Mama, N., Lepira, F., Tahiri, M., ...

Human and simian immunodeficiency virus-infected chimpanzees do not have increased intracellular levels of beta-chemokines in contrast to infected humans (2003)

Ondoa, P., Vereecken, C., Fransen, K., Colebunders, R., Heeney, J. L., ...

This study was undertaken to explain why chimpanzees infected with HIV-1 (human immunodeficiency virus type 1) or SIV(cpz) (simian immunodeficiency virus of chimpanzee) are relatively resistant to...

Role of baseline pol genotype in HIV-1 fitness evolution (2003)

Weber, J., Rangel, H. R., Chakraborty, B., Marotta, M. L., Valdez, H., Fransen, K., ...

Not the final published version

Ritonavir/saquinavir plus one nucleoside reverse transcriptase inhibitor (NRTI) versus indinavir plus two NRTIs in protease inhibitor-naive HIV-1-infected adults (IRIS study) (2002)

Florence, E., Dreezen, C., Desmet, P., Smets, E., Fransen, K., Vandercam, B., ...

This is the author’s version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might...

Comparative evaluation of eight commercial enzyme linked immunosorbent assays and 14 simple assays for detection of antibodies to HIV (2002)

Beelaert, G., Vercauteren, G., Fransen, K., Mangelschots, M., De Rooy, M., Garc¡a Ribas, S., ...

To evaluate the performance of 22 assays for the detection of antibodies to HIV. Twenty-two assays for the combined detection of antibodies to HIV-1 and HIV-2, were evaluated on the same panel of...

In vitro susceptibility to infection with SIVcpz and HIV-1 is lower in chimpanzee than in human peripheral blood mononuclear cells (2002)

Ondoa, P., Davis, D., Kestens, L., Vereecken, C., García Ribas, S., Fransen, K., ...

This study was undertaken to evaluate and compare the susceptibility of chimpanzee versus human peripheral blood mononuclear cells (PBMCs) to infection with SIVcpz and HIV-1 non-syncitium inducing...

Resistance testing in children changing human immunodeficiency virus type 1 protease inhibitor (2002)

Servais, J., Hainaut, M., Schmitz, V., Maes, P., Fransen, K., Vaira, D., ...

OBJECTIVE: To assess genotypic and phenotypic resistance testing in HIV-1-infected children failing a first protease inhibitor (PI) therapy. METHODS: In a multicenter observational study 21 children,...

Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission (2002)

Van Herrewege, Y., Penne, L., Vereecken, C., Fransen, K., Kestens, L., ...

Because prevention of heterosexual HIV transmission is not always possible, it is important to develop effective strategies of postexposure prophylaxis (PEP). Since in vivo comparison of drug potency...

Drug resistance among therapy-naive HIV-infected patients studied by sequencing and VERSANT (TM) HIV-1 resistance assays (LiPA) has limited impact on treatment response (2002)

Derdelinckx, Inge; U0034960, Maes, B, Schrooten, Yoeri; U0029701, Dewit, Sophie; U0052409, Florence, E, ...

Ritonavir/saquinavir plus one nucleoside reverse transcriptase inhibitor (NRTI) versus indinavir plus two NRTIs in protease inhibitor-naive HIV-1-infected adults (IRIS study) (2001)

Dreezen, C, Desmet, P, Smets, E, Fransen, K, Vandercam, B, ...

Objectives: To compare the efficacy, tolerability and safety of a ritonavir 400 mg/saquinavir hard gel fomulation 400 mg twice daily versus an indinavir 800 mg once every 8 In containing first-line...

Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzees (2001)

Ondoa, P, Kestens, L, Davis, D, Vereecken, C, Willems, B, Fransen, K, ...

In a longitudinal study we address the hypothesis that resistance to disease progression in lentivirus-infected chimpanzees is related to potent non-cytotoxic suppression of virus replication. In a...

Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzees (2001)

WILLEMS, Betty, Ondoa, P., Kestens, L., Davis, D., Vereecken, C., Fransen, K., ...

Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzees (2001)

WILLEMS, Betty, Ondoa, P., Kestens, L., Davis, D., Vereecken, C., Fransen, K., ...

Prevalence of genotypic resistance among antiretroviral drug-naive HTV-1-infected patients in Belgium. (2001)

VAN VAERENBERGH, K, DEBAISIEUX, L, De Cabooter, Nancy, DECLERCQ, C, DESMET, K, FRANSEN, K, ...

Quantitative assay for group M (subtype A-H) and group O HIV-1 RNA detection in plasma (2001)

Ernest, I., Alexandre, I., Zammatteo, N., Herman, M., Houbion, A., De Leener, F., ...

A quantitative HIV-1 test is described based on a competitive RT-PCR assay combined with a sandwich hybridization as a detection system. The internal RNA standard (IS) was designed specifically to be...

Evaluation of four HIV antigen tests (2001)

Fransen, K., Beelaert, G.

A direct comparison of different HIV antigen assays is very helpful in making an informed choice, not only for the testing laboratories but also for healthcare workers in the developing world who are...

Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzees (2001)

Ondoa, P., Kestens, L., Davis, D., Vereecken, C., Willems, B., Fransen, K., ...

In a longitudinal study we address the hypothesis that resis tance to disease progression in lentivirus-infected chimpanzees is related to potent non-cytotoxic suppression of virus replication. In a...

Prevalence of genotypic resistance among antiretroviral drug-naive HIV-1 infected patients in Belgium (2001)

Van Vaerenbergh, K., Debaisieux, L., De Cabooter, N., Declercq, C., Desmet, K., Fransen, K., ...

This is the author’s version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might...

Blinded, multicenter quality control study for the quantification of human immunodeficiency virus type 1 RNA in plasma by the Belgian AIDS reference laboratories (2000)

Debaisieux, L, Fransen, K, Marissens, D, Miller, K, Vaira, D, ...

OBJECTIVE: In order to evaluate the interlaboratory variation of HIV-1 RNA measurements in plasma, the Belgian AIDS reference laboratories organized a blinded multicenter quality control study....

The HIV-2 genotype and the HIV-1 syncytium-inducing phenotype are associated with a lower virus replication in dendritic cells (2000)

Vanham, G, Van Tendeloo, V, Willems, B, Penne, L, Kestens, L, Beirnaert, E, ...

During sexual transmission, HIV infects the mucosal dendritic cells and is transferred to CD4 T cells. Whether HIV variants of a particular genetic (sub)type or phenotype selectively infect dendritic...

Natural residues versus antiretroviral drug-selected mutations in HIV type 1 group O reverse transcriptase and protease related to virological drug failure in vivo (2000)

Baar, M.P. De, Janssens, W., Ronde, A. De, Fransen, K., Colebunders, R., Kestens, L., ...

Blinded, multicenter quality control study for the quantification of human immunodeficiency virus type 1 RNA in plasma by the Belgian AIDS reference laboratories. (2000)

MUYLDERMANS, G, DEBAISIEUX, L, FRANSEN, K, MARISSENS, D, MILLER, K, VAIRA, D, ...

HIV-1 genetic variability in Cameroon. (2000)

HEYNDRICKX, L, JANSSENS, W, NDUMBE, PM, VEREECKEN, K, COPPENS, S, DE HOUWER, K, ...

HIV-1 viral load and scrub typhus [letter] (2000)

Colebunders, R., Fransen, K., Florence, E., Vanham, G.

Natural residues versus antiretroviral drug-selected mutations in HIV type 1 group O reverse transcriptase and protease related to virological drug failure in vivo (2000)

De Baar, M. P., Janssens, W., De Ronde, A., Fransen, K., Colebunders, R., Kestens, L., ...

HIV-1 group O viruses were first recognized as a distinct subgroup of HIV-1 with the isolation and characterization in 1990 of a virus (ANT70) from a woman (individual A) and her spouse (individual...

HIV-1 genetic variability in Cameroon [letter] (2000)

Heyndrickx, L., Janssens, W., Ndumbe, P. M., Vereecken, K., Coppens, S., De Houwer, K., ...

Not the final published version

Blinded, multicenter quality control study for the quantification of human immunodeficiency virus type 1 RNA in plasma by the Belgian AIDS reference laboratories (2000)

Muyldermans, G., Debaisieux, L., Fransen, K., Marissens, D., Miller, K., Vaira, D., ...

The definitive version is available at www3.interscience.wiley.com

HIV-associated dysfunction of in vitro IL-12 production depends on the nature of the stimulus and on the CD4 T-cell count of the patient [letter] (2000)

Vanham, G., Penne, L., Fransen, K., Kestens, L., De Brabander, M.

The HIV-2 genotype and the HIV-1 syncytium-inducing phenotype are associated with a lower virus replication in dendritic cells (2000)

Vanham, G., Van Tendeloo, V., Willems, B., Penne, L., Kestens, L., Beirnaert, E., ...

During sexual transmission, HIV infects the mucosal dendritic cells and is transferred to CD4 T cells. Whether HIV variants of a particular genetic (sub)type or phenotype selectively infect dendritic...

Interpatient genetic variability of HIV-1 group O. (1999)

JANSSENS, W, HEYNDRICKX, L, NKENGASONG, J, BEIRNAERT, E, VEREECKEN, K, ...

Intrapatient variability of HIV type 1 group O ANT70 during a 10-Year follow-up (1999)

Janssens, W, Nkengasong, J, Heyndrickx, L, Vereecken, Karen; U0002243, Coppens, S, ...

HIV-1 ANT70 is the first HIV-1 group O virus isolate obtained from a 25-year-old Cameroonian woman, who seroconverted in March 1987, This individual has remained asymptomatic and clinically healthy...

Sequence note - HIV type 1 C2V3 env diversity among Belgian individuals (1998)

Heyndrickx, L, Janssens, W, Coppens, S, Vereecken, Karen; U0002243, Willems, B, Fransen, K, ...

Evaluation of different V3 peptides in an enzyme immunoassay for specific Hiv type 1 group O antibody detection (1998)

Ondoa, P., Willems, B., Fransen, K., Nkengasong, J.N., Janssens, W., Heyndrickx, L., ...

Lack of correlation between V3-loop peptide enzyme immunoassay serologic subtyping and genetic sequencing (1998)

Nkengasong, J.N., Willems, B., Janssens, W., Cheingsong-Popov, R., Heyndrickx, L., Barin, F., ...

Isolation of HIV-1 RNA from plasma: evaluation of seven different methods for extraction (part two). (1998)

FRANSEN, K, MORTIER, D, HEYNDRICKX, L, VERHOFSTEDE, C, JANSSENS, W

Sequence note - HIV type 1 C2V3 env diversity among Belgian individuals. (1998)

HEYNDRICKX, L, JANSSENS, W, COPPENS, S, VEREECKEN, K, WILLEMS, B, FRANSEN, K, ...

Genetic variation of HIV type 1: Relevance of interclade variation to vaccine development. (1998)

NYAMBI, PN, BEIRNAERT, E, DAVIS, D, FRANSEN, K, HEYNDRICKX, L, ...

Isolation of HIV-1 RNA from plasma: evaluation of seven different methods for extraction (part two) (1998)

Fransen, K., Mortier, D., Heyndrickx, L., Verhofstede, Chris, Janssens, W.

Some new commercial methods for the extraction of viral RNA have been introduced recently. In addition to the study published previously (Verhofstede, C., Reniers, S., Van Wanzeele, F., Plum J.,...

Virologic, immunologic, and clinical follow-up of a couple infected by the human immunodeficiency virus type one, group O (1997)

Nkengasong, JN, Fransen, K, Willems, B, Karita, E, Vingerhoets, J, Kestens, L, ...

The pathogenic course (virologic, immunologic, and clinical changes) of infection due to human immunodeficiency virus type one (HIV-1) group O viruses is unknown at present. To address this issue,...

Virologic, immunologic and clinical follow-up of a couple infected by the human immunodeficiency virus type one, group O (1997)

WILLEMS, Betty, Nkengasong, J.N., Fransen, K., Karita, E., Vingerhoets, J., Kestens, L., ...

Virologic, immunologic and clinical follow-up of a couple infected by the human immunodeficiency virus type one, group O (1997)

WILLEMS, Betty, Nkengasong, J.N., Fransen, K., Karita, E., Vingerhoets, J., Kestens, L., ...

Genetic variability of HIV type 1 in Benin (1996)

Heyndrickx, L, Janssens, W, Alary, M, Fransen, K, Vereecken, Karen; U0002243, Coppens, S, ...

Isolation of HIV-1 RNA from plasma: Evaluation of eight different extraction methods. (1996)

Verhofstede, Chris, FRANSEN, K, MARISSENS, D, Verhelst, Rita, VANDERGROEN, G, LAUWERS, S, ...

Epidemiological and molecular characteristics of HIV infection in Gabon, 1986-1994 (1996)

Delaporte, Eric, Janssens, W., Peeters, Martine, Buvé, A., Dibanga, G., Perret, J.L., ...

Detection of HIV-1 RNA in plasma and serum samples using the NASBA amplification system compared to RNA-PCR (1995)

Kok, W, Goubau, P, Fransen, K, Kievits, T, ...

The presence of HIV-1 RNA in the plasma and serum of European and African patients was monitored using RNA-polymerase chain reaction (RNA-PCR) and the new isothermal NASBA nucleic acid amplification...

Standardisation of primers and an algorithm for HIV-1 diagnostic PCR evaluated in patients harbouring strains of diverse geographical origin. The Belgian AIDS Reference Laboratories (1995)

Fransen, K, Debaisieux, L, Marissens, D, Sprecher, S, Vaira, D, ...

Eight Belgian AIDS Reference Laboratories established a multicentre quality control to evaluate the performance of their diagnostic human immunodeficiency virus type 1 (HIV-1) DNA polymerase chain...

Virologic and serologic characteristics of a natural chimpanzee lentivirus infection (1995)

WILLEMS, Betty, Peeters, M., Janssens, W., Vanden Haesevelde, M., Fransen, K., Heyndrickx, L., ...

Virologic and serologic characteristics of a natural chimpanzee lentivirus infection (1995)

WILLEMS, Betty, Peeters, M., Janssens, W., Vanden Haesevelde, M., Fransen, K., Heyndrickx, L., ...

STANDARDIZATION OF PRIMERS AND AN ALGORITHM FOR HIV-1 DIAGNOSTIC PCR EVALUATED IN PATIENTS HARBORING STRAINS OF DIVERSE GEOGRAPHICAL ORIGIN. (1995)

VANDAMME, AM, FRANSEN, K, DEBAISIEUX, L, MARISSENS, D, SPRECHER, S, VAIRA, D, ...

RISK-FACTORS FOR MOTHER-TO-CHILD TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION. (1995)

BWAYO, J, Temmerman, Marleen, NYONGO, AO, FRANSEN, K, COPPENS, M, PIOT, P

Reduced capacity of antibodies from patients infected with hiv-1 group-o to neutralize primary isolates of hiv-1 group-m viruses (1995)

Nyambi, P, Nkengasong, J, Peeters, M, Simon, F, Eberle, J, Jansens, W, ...

Correlation between genetic and biological properties of biologically cloned hiv type-1 viruses representing subtype-a, subtype-b, and subtype-d (1995)

Zhong, P, Peeters, M, Janssens, W, Fransen, K, Heyndrickx, L, Vanham, G, ...

The relationship between the genetic variability in the V3 loop and the biological characteristics of 38 biological clones from 5 European and 7 African HIV-1 isolates belonging to 3 different...

Genetic and phylogenetic analysis of hiv type-1 in gabon (1995)

Janssens, W, Heyndrickx, L, Fransen, K, Delaporte, E, Peeters, M, Perret, Jl, ...

Biological phenotypes of hiv-1 subtype-a and subtype-b strains of diverse origins (1995)

Nkengasong, Jn, Peeters, M, Zhong, P, Willems, B, Janssens, W, Heyndrickx, L, ...

The identification of specific biologic phenotypic traits that can be correlated with different HIV-1 genetic subtypes was sought. The genetic subtypes were determined by either sequencing...

Design and evaluation of new, highly sensitive and specific primers for polymerase chain-reaction detection of hiv-7 infected primary lymphocytes (vol 8, pg 317, 1994) (1995)

Fransen, K, Zhong, P, Debeenhouwer, H, Carpels, G, Peeters, M, Louwagie, J, ...

Reduced capacity of antibodies from patients infected with human immunodeficiency virus type 1 (HIV-1) group O to neutralize primary isolates of HIV-1 group M viruses (1995)

Nyambi, P.N., Nkengasong, J., Peeters, Martine, Simon, F., Eberle, J., Janssens, Wouter, ...

Cross-neutralizing antibodies to hiv-1(ant70) and hiv-1(iiib) in sera of african and belgian hiv-1-infected individuals (1994)

Nkengasong, Jn, Peeters, M, Ndumbe, P, Janssens, W, Willems, B, Fransen, K, ...

Objectives: To determine the neutralizing antibody patterns to HIV-1(ANT70) (ANT70) and HIV-1(IIIB)(IIIB) in human sera obtained from HIV-1-infected individuals from different African countries and...

Quantification of human immunodeficiency virus in plasma by RNA PCR, viral culture, and p24 antigen detection (1994)

Fransen, K, Peeters, M, De Beenhouwer, H, Piot, P

A semiquantitative PCR technique for detecting human immunodeficiency virus type 1 (HIV-1) RNA in plasma was compared with quantitative viral culture and p24 antigen detection in plasma. Ninety-three...

Effect of methodology on detection of HIV-1/HIV-2 dual infections in Côte d'Ivoire (1994)

Peeters, M, Fransen, K, Gershy-Damet, G M, Willems, B, Koffi, K, Coulibaly, M, ...

Dual seroreactivity to the human immunodeficiency virus (HIV) types 1 and 2 is common in Côte d'Ivoire. To assess whether dual infection is the reason for dual seroreactivity, different methods for...

Detection of Human Immunodeficiency-Virus Type-1 (HTV-1) in Heel Prick Blood on Filter-Paper from Children Born to HIV-1-Seropositive Mothers. (1994)

NYAMBI, PN, FRANSEN, K, DEBEENHOUWER, H, CHOMBA, EN, Temmerman, Marleen, NDINYAACHOLA, JO, ...

GENETIC-VARIABILITY OF HIV TYPE-1 IN KENYA. (1994)

JANSSENS, W, HEYNDRICKX, L, FRANSEN, K, Temmerman, Marleen, LEONAERS, A, IVENS, T, ...

Isolation of simian immunodeficiency viruses from 2 sooty mangabeys in cote-divoire - virological-characterization and genetic-characterization and relationship to other hiv type-2 and sivsm/mac strains (1994)

Janssens, W, Fransen, K, Brandful, J, Heyndrickx, L, Koffi, K, ...

Objective: To search for the presence of SIV in sooty mangabeys and other monkey species in Cote d'Ivoire, West Africa, and to compare viral isolates with HIV-2 strains from the same region.

Phylogenetic analysis of a new chimpanzee lentivirus siv(cpz-gab2) from a wild-captured chimpanzee from gabon (1994)

Fransen, K, Peeters, M, Heyndrickx, L, Motte, J, Bedjabaga, L, ...

Genetic and antigenic variability of hiv type-1 in brazil (1994)

Janssens, W, Heyndrickx, L, Motte, J, Fransen, K, Peeters, M, ...

Six Brazilian strains of human immunodeficiency virus type 1 (HIV-1) were isolated from infected individuals residing in different regions of Brazil between 1987 and 1989. Phylogenetic analysis based...

Genetic and phylogenetic analysis of env subtypes G and H in Central Africa (1994)

Janssens, W., Heyndrickx, L., Fransen, K., Motte, J., Peeters, Martine, Nkengasong, J.N., ...

Phylogenetic analysis of a new chimpanzee lentivirus SIVcpz-gab2 from a wild-captured chimpanzee from Gabon (1994)

Janssens, W., Fransen, K., Peeters, Martine, Heyndrickx, L., Motte, J., Bedjabaga, L., ...

Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes (1993)

McCutchan, F E, Peeters, M, Brennan, T P, Sanders-Buell, E, Eddy, G A, ...

OBJECTIVE: To determine the extent of genetic variation among internationally collected HIV-1 isolates, to analyse phylogenetic relationships and the geographic distribution of different variants....

Genetic, antigenic and biological characteristics of sivcpz-ant isolates, derived from a naturally infected chimpanzee (1993)

Kestens, L, Fransen, K, Nkengasong, J, Heeney, J, Vandenhaesevelde, M, ...

Virological and polymerase chain reaction studies of HIV-1/HIV-2 dual infection in Côte d'Ivoire (1992)

Gershy-Damet, G M, Fransen, K, Koffi, K, Coulibaly, M, Delaporte, E, ...

Dual serological reactivity to the human immunodeficiency virus (HIV) types 1 and 2 is common in Côte d'Ivoire. To assess whether dual infection is the reason for dual seropositivity we sought HIV-1...

Genetic comparison of HIV-1 isolates from Africa, Europe, and North America (1992)

McCutchan, F, Peeters, M, Fransen, K, Piot, P, ...

Henry M. Jackson Foundation, Rockville, MD 20850.

Isolation and characterization of a new chimpanzee lentivirus (simian immunodeficiency virus isolate cpz-ant) from a wild-captured chimpanzee (1992)

Fransen, K, Delaporte, E, Gershy-Damet, G M, Kestens, L, ...

OBJECTIVE: To assess the prevalence of infection with simian immunodeficiency virus (SIV) isolate cpz, a lentivirus closely related to HIV-1, in chimpanzees, and to obtain new SIVcpz isolates....

Immunological and molecular characterization of immunodeficiency virus isolates from wild captured chimpanzees (1992)

Restens, L, Fransen, K, Vandenhaesevelde, M, Saman, E, Gigase, P, ...

Further characterization of 2 immunodeficiency virus isolates from wild captured chimpanzees (1991)

Fransen, K, Delaporte, E, Vandenhaesevelde, M, Saman, E, Piot, P, ...

Multivariate analysis of human immunodeficiency virus type 1 neutralization data.

Nyambi, P N, Nkengasong, J, Lewi, P, Andries, K, Janssens, W, Fransen, K, ...

We report on the use of spectral map analysis of the inter- and intraclade neutralization data of 14 sera of human immunodeficiency virus type 1 (HIV-1)-infected individuals and 16 primary isolates,...

Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant.

Nyambi, P N, Lewi, P, Peeters, M, Janssens, W, Heyndrickx, L, Fransen, K, ...

Here we report on the use of spectral map analysis of time-paired sequential neutralization data of 11 serum samples of a chimpanzee naturally infected with a simian immunodeficiency virus...

Quantification of human immunodeficiency virus in plasma by RNA PCR, viral culture, and p24 antigen detection.

Van Kerckhoven, I, Fransen, K, Peeters, M, De Beenhouwer, H, Piot, P

A semiquantitative PCR technique for detecting human immunodeficiency virus type 1 (HIV-1) RNA in plasma was compared with quantitative viral culture and p24 antigen detection in plasma. Ninety-three...

Detection of human immunodeficiency virus type 1 (HIV-1) in heel prick blood on filter paper from children born to HIV-1-seropositive mothers.

Nyambi, P N, Fransen, K, De Beenhouwer, H, Chomba, E N, Temmerman, M, Ndinya-Achola, J O, ...

The human immunodeficiency virus type 1 (HIV-1) DNA PCR results of 94 dried blood spot (DBS) samples on filter paper and corresponding venous blood in EDTA obtained from infants born to...

Pediatric Human Immunodeficiency Virus Screening in an African District Hospital

De Baets, A. J., Edidi, B. S., Kasali, M. J., Beelaert, G., Schrooten, W., Litzroth, A., ...

In order to evaluate alternative tests and strategies to simplify pediatric human immunodeficiency virus (HIV) screening at the district hospital level, a cross-sectional exploratory study was...

Multivariate analysis of human immunodeficiency virus type 1 neutralization data.

Nyambi, P N, Nkengasong, J, Lewi, P, Andries, K, Janssens, W, Fransen, K, ...

We report on the use of spectral map analysis of the inter- and intraclade neutralization data of 14 sera of human immunodeficiency virus type 1 (HIV-1)-infected individuals and 16 primary isolates,...

Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant.

Nyambi, P N, Lewi, P, Peeters, M, Janssens, W, Heyndrickx, L, Fransen, K, ...

Here we report on the use of spectral map analysis of time-paired sequential neutralization data of 11 serum samples of a chimpanzee naturally infected with a simian immunodeficiency virus...

Quantification of human immunodeficiency virus in plasma by RNA PCR, viral culture, and p24 antigen detection.

Van Kerckhoven, I, Fransen, K, Peeters, M, De Beenhouwer, H, Piot, P

A semiquantitative PCR technique for detecting human immunodeficiency virus type 1 (HIV-1) RNA in plasma was compared with quantitative viral culture and p24 antigen detection in plasma. Ninety-three...

Detection of human immunodeficiency virus type 1 (HIV-1) in heel prick blood on filter paper from children born to HIV-1-seropositive mothers.

Nyambi, P N, Fransen, K, De Beenhouwer, H, Chomba, E N, Temmerman, M, Ndinya-Achola, J O, ...

The human immunodeficiency virus type 1 (HIV-1) DNA PCR results of 94 dried blood spot (DBS) samples on filter paper and corresponding venous blood in EDTA obtained from infants born to...

Pediatric Human Immunodeficiency Virus Screening in an African District Hospital

De Baets, A. J., Edidi, B. S., Kasali, M. J., Beelaert, G., Schrooten, W., Litzroth, A., ...

In order to evaluate alternative tests and strategies to simplify pediatric human immunodeficiency virus (HIV) screening at the district hospital level, a cross-sectional exploratory study was...

Role of the Laboratory in Ensuring Global Access to ARV Treatment for HIV-Infected Children: Consensus Statement on the Performance of Laboratory Assays for Early Infant Diagnosis

Stevens, W, Downing, R, Parsons, L.M, Crowley, S, ...

A two day meeting hosted by the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) was held in May 2006 in Entebbe, Uganda to review the laboratory...