Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis (2009)
Lemaire, K, Quintens, R, Van Lommel, L, Geboes, K, ...
Geboes, K, ...
Background: Severe duodeno-gastro-oesophageal reflux (DGOR) is a risk factor for oesophagitis and Barrett's oesophagus. Patients with non-erosive reflux disease (NERD) have a slight increase in DGOR....
Expression of chemokines and gelatinase B in sympathetic ophthalmia (2007)
Geboes, K, ...
PurposeTo examine the expression of gelatinase B (matrix metalloproteinase-9) and the chemokines monocyte chemotactic protein-1 (CCL2/MCP-1) and stromal cell-derived factor-1 (CXCL12/SDF-1) in...
Helicobacter pylori, the pathologist's point of view (2007)
Department of Pathology, U.Z. St. Raphaël, Catholic University Leuven, Belgium.
Expression of antiapoptotic and proapoptotic molecules in diabetic retinas (2007)
PurposeTo investigate the expression of the antiapoptotic and proapoptotic markers in diabetic retinas.MethodsIn total, 12 donor eyes from six subjects with diabetes mellitus, and 10 eyes from five...
Neural mechanisms of early postinflammatory dysmotility in rat small intestine (2006)
Geboes, K, Andrioli, A, Janssens, J, ...
Although human postinflammatory dysmotility is known, so far animal studies have primarily investigated changes during inflammation. Here, we focused on postinflammatory changes in rat jejunal...
Anti-outer membrane of porin C and anti-I2 antibodies in indeterminate colitis (2006)
Colombel, J-F, Landers, C, Poulain, D, Geboes, K, ...
Review article: the nature of oesophageal injury in gastro-oesophageal reflux disease (2006)
The purpose of this review was to explore issues relating to the nature of oesophageal injury in gastro-oesophageal reflux disease. Several structural and functional elements of the oesophageal...
Aerssens, J, De Hoogt, R, Peeters, P, Verhasselt, P, Van Eyken, P, ...
The bowel flora is implicated in Crohn's disease (CD) pathogenesis but its precise role is still unclear. Several non-mutually exclusive hypotheses have been proposed: an unidentified persistent...
Hommes, D W, Colombel, J-F, Gendre, J-P, Oldenburg, B, ...
INTRODUCTION: This study was designed to evaluate the safety of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease (CD). PATIENTS AND...
Aggressive systemic mastocytosis complicated by protein-losing enteropathy (2006)
Barakauskienė, A, Peeters, C, Geboes, K
A 46-year-old woman was admitted to the hospital with complaints of chronic diarrhoea, vomiting and severe muscle weakness. Clinical examination showed a lethargic, malnourished, dehydrated patient...
Chakass, D, Thuru, X, Zerbib, P, Tsicopoulos, A, Geboes, K, ...
BACKGROUND AND AIMS: Recent studies with mu opioid receptor (MOR) deficient mice support a physiological anti-inflammatory effect of MOR at the colon interface. To better understand the potential...
A new approach to the validation of tissue microarrays (2006)
Perneel, C, De Schutter, H, Borghys, D, ...
Although tissue microarrays (TMA) have been widely used for a number of years, it is still not clear how many core biopsies should be taken to determine a reliable value for percentage positivity or...
Expression of growth factors in the conjunctiva from patients with active trachoma (2006)
PURPOSE: The blinding complications of trachoma are associated with progressive conjunctival fibrosis due to excessive accumulation of extracellular matrix (ECM) components. We studied the processes...
Travis, S P L, Beglinger, C, Kupcinkas, L, Geboes, K, ...
John Radcliffe Hospital, Oxford OX3 9DU, UK. Eduard.Stange@rbk.de
Immunopathogenesis of conjunctival remodelling in vernal keratoconjunctivitis (2006)
Al-Mansouri, S, Tabbara, K F, Geboes, K
PURPOSE: To study the processes involved in mediating conjunctival remodelling in vernal keratoconjunctivitis (VKC) by investigating the expression of integrin receptors, epidermal growth factor...
Geboes, K, Janssens, J, ...
Shen, Chong; U0037090, Maerten, Philippe; U0006925, Van Assche, Ge, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358
Maerten, Philippe; U0006925, Shen, Chong; U0037090, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358
Effects of interleukin 4 on CD25(+)CD4(+) regulatory T cell function (2005)
Maerten, Philippe; U0006925, Shen, Chong; U0037090, Bullens, DM, Van Gool, Stefaan; U0011326, Geboes, K, ...
Chronic urticaria involves the gastroduodenal mucosa as well as the skin (2005)
Minnei, F, Wetzels, C, Van Eyken, P, Ambu, R, Faa, G, ...
Geboes, K, Verbrugghe, K, De Vuyst, L, Vanhoutte, T, Huys, G, ...
Amongst the various claimed beneficial effects of pro- and prebiotics for the human host, it has been hypothesised that functional foods are able to suppress the generation and accumulation of toxic...
PURPOSE: Nitric oxide (NO) mediates vascular endothelial growth factor (VEGF)-induced angiogenesis and vascular hyperpermeability. This study was undertaken to study the cellular distribution of...
Colpaert, S, Liu, Zhe, ...
An imbalance of immunoregulatory factors and/or cells contributes to uncontrolled mucosal T cell activation and inflammation in Crohn's disease (CD). Bioactive interleukin (IL)-18 has been shown to...
Immunomodulatory role of IL-4 on regulatory T cells in vitro and in experimentel colitis (2004)
Maerten, Philippe; U0006925, Shen, Chong; U0037090, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358
Shen, Chong; U0037090, Maerten, Philippe; U0006925, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358
Maerten, P., Shen, C., Colpaert, S., Liu, Z., Bullens, D. A. M., Van Assche, G., ...
An imbalance of immunoregulatory factors and/or cells contributes to uncontrolled mucosal T cell activation and inflammation in Crohn's disease (CD). Bioactive interleukin (IL)-18 has been shown to...
Report of an Amsterdam working group on Barrett esophagus (2003)
Correa, P, Van Eeden, S, Geboes, K, Drillenburg, P, Vieth, M, ...
Department of Pathology, Academic Medical Center Amsterdam, The Netherlands. g.j.offerhaus@amc.uva.nl
Margaritis, V, Wyndaele, J, Geboes, K
PURPOSE: Human papilloma virus infections of the anogenital region are very common and cause condylomata acuminata; cervical, penile, vulvar, or perianal intraepithelial neoplasia; and more rarely,...
Immuno-histochemical evaluation of conjunctival remodelling in vernal keratoconjunctivitis (2003)
Meersschaert, A, Al-Kharashi, S A, Geboes, K
PURPOSE: To study the expression of the extracellular matrix (ECM) proteins, tenascin, laminin, and fibronectin in the conjunctiva of patients with active vernal keratoconjunctivitis (VKC). METHODS:...
Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy (2003)
Valamanesh, F, Vazquez-Tello, A, El-Asrar, A M, Checchin, D, Brault, S, ...
BACKGROUND: Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase...
BACKGROUND: The incidence of gastric cardiac adenocarcinoma has increased in the last decades. Gaining insight into the pathogenesis of this lesion is hampered by the limited knowledge of the origin...
BACKGROUND/AIMS: T lymphocytes are present in increased numbers in the conjunctiva of patients with vernal keratoconjunctivitis (VKC) and their activation has a central role in the pathogenesis of...
Metabolic fate of dietary protein is significantly correlated with renal function (2002)
Geypens, Benny; U0001694, Kuypers, Dirk; U0046355, Maes, B, Geboes, K, ...
Microscopic colitis with giant cells (2002)
Croes, R, Staels, F, Geboes, K
AIMS: Collagenous colitis and lymphocytic colitis are the two types of microscopic colitis with specific morphological features. In this report we describe a new histopathological subtype of...
Maerten, PP, Colpaert, S, Chen, C, Geboes, K, ...
D'Haens, G, Noman, M, Aerden, I, ...
Infliximab induces apoptosis of human monocytes in vitro and in THP-1-SCID-mice model (2002)
Shen, Chong; U0037090, Colpaert, S, Maerten, Philippe; U0006925, Geboes, K, Rutgeerts, Paul; U0007636, ...
Put, W, Geboes, K, Grillet, B, ...
Chemokines are mediators of innate and acquired immunity. CCL18, also designated pulmonary and activation-regulated chemokine (PARC), dendritic cell-derived CC chemokine-1 (DC-CK1), alternative...
Understanding inflammatory bowel disease--the clinician's perspective (2001)
The treatment of patients with ulcerative colitis and Crohn's disease is a huge challenge to the clinician mainly because the etiology of IBD is still completely unknown. Pathogenetic mechanisms, in...
Expression of chemokine receptors in vernal keratoconjunctivitis (2001)
BACKGROUND/AIMS: Chemokines are small peptides which are potent activators and chemoattractants for leucocyte subpopulations. Their action is mediated by a family of seven transmembrane spanning...
Liu, Z, De Greef, B, Geboes, K
BACKGROUND: The administration of indometacin to rats increases intestinal permeability and induces inflammatory pathology of the small bowel. This represents a potential model for Crohn's disease....
Gelatinase B in vernal keratoconjunctivitis (2001)
Van Aelst, I, Al-Mansouri, S, Geboes, K
OBJECTIVES: To investigate the expression of gelatinase B in the conjunctiva of patients with vernal keratoconjunctivitis (VKC) and the cellular source of this enzyme. METHODS: Conjunctival biopsy...
PURPOSE: Inducible nitric oxide synthase has been implicated in the pathogenesis of cerebral ischemic damage, in the angiogenic process and in diabetic vascular damage. This study was undertaken to...
Al-Kharashi, S A, Al-Mansouri, S, Geboes, K
PURPOSE: Vernal keratoconjunctivitis (VKC) is associated with T-helper 2 (TH2)-like cell response and increased immunoglobulin (Ig) E production. Recent studies have suggested that interactions...
Etanercept in the treatment of active refractory Crohn's disease: a single-center pilot trial (2001)
Swijsen, C, Noman, M, Lemmens, L, Agbahiwe, H, ...
OBJECTIVES: Etanercept, an injectable tumor necrosis factor (TNF) receptor fusion protein, binds and inactivates human TNF and is used in active rheumatoid arthritis. Blocking TNF with monoclonal...
Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease (2001)
Malchow, H, Jacyna, M, Nielsen, O H, Rask-Madsen, J, ...
BACKGROUND AND AIMS: New lesions of Crohn's disease occur early after ileal or ileocolonic resection and ileocolonic anastomosis. We performed a double blind controlled trial to evaluate the safety...
D'Haens, G, Lemmens, L, Geboes, K, Vandeputte, L, Van Acker, F, ...
BACKGROUND & AIMS: Cyclosporine has been effective in patients with steroid-refractory attacks of ulcerative colitis (UC). We investigated the effects of intravenous (IV) cyclosporine as single IV...
Shealy, D, D'Haens, G, Geboes, K, ...
BACKGROUND: Anti-TNFalpha therapy with infliximab is effective for Crohn's disease. Infliximab neutralizes the biological activities of TNFalpha, a cytokine involved in host-defence against certain...
Expression of CD23/CD21 and CD40/CD40 ligand in vernal keratoconjunctivitis (2001)
PURPOSE: The overproduction of immunoglobulin E (IgE) antibodies is associated with vernal keratoconjunctivitis (VKC). CD23/CD21 and CD40/CD40 ligand (CD40L) interactions have been proposed to be...
PURPOSE: Exfoliated or soiled free malignant cells have serious consequences in patients undergoing gastrointestinal cancer surgery. The present study evaluates the toxicity and efficacy of cytotoxic...
Arts, J, Zeegers, M, D'Haens, G, Geboes, K, ...
In vitro evaluation of IL-18 effects in Crohn's disease (2001)
Maerten, Philippe; U0006925, Colpaert, Stefaan; U0021314, Liu, Z, Geboes, K, Ceuppens, Jan; U0014358, Rutgeerts, Paul; U0007636, ...
Reinisch, W, Sendid, B, Poulain, D, Peeters, M, ...
Chemokines in the limbal form of vernal keratoconjunctivitis (2000)
BACKGROUND/AIMS: Chemokines are a family of low molecular weight cytokines that attract and activate leucocytes. The CC chemokines act on eosinophils, basophils, monocytes, and lymphocytes,...
Enhanced production of IL-8 in chronic but not in early ileal lesions of Crohn's disease (CD) (2000)
Colombel, J F, Gambiez, L, Emilie, D, Geboes, K, ...
Distinct Th1/Th2 patterns have been observed during the evolution of CD. The aim of this study was to compare neutrophil involvement and IL-8 mRNA and protein expression during early recurrent...
Strictures are a common complication of Crohn's disease and an indication for surgery in approximately 50% of patients. Morphologic studies have shown that fibrosis of the submucosa and muscularis...
Multifocal epithelioid angiosarcoma of the small intestine (2000)
Delvaux, V, Sciot, Raphael; U0010292, Neuville, B, Peeters, M, ...
A 67-year-old man presented with weight loss, intermittent severe abdominal pain and melaena. Initial radiology (including abdominal ultrasonography), gastroscopy and colonoscopy did not demonstrate...
Early vascular changes in Crohn's disease: an endoscopic fluorescence study (2000)
Mordon, S, Geboes, K, Klein, O, Debaert, A, Cortot, A, ...
BACKGROUND AND STUDY AIMS: Early recurrent lesions occurring after surgery in Crohn's disease may be the result of localized vasculitis. The aim of this study was use fluorescence endoscopy to...
The Vienna classification of gastrointestinal epithelial neoplasia (2000)
Riddell, R H, Kato, Y, Borchard, F, Cooper, H S, Dawsey, S M, ...
BACKGROUND: Use of the conventional Western and Japanese classification systems of gastrointestinal epithelial neoplasia results in large differences among pathologists in the diagnosis of...
Crohn's disease and intestinal endometriosis: an intriguing co-existence (2000)
D'Haens, G, Cokelaere, K, D'Hoore, A, ...
OBJECTIVES: We present a series of eight female patients who came to surgery for complicated Crohn's disease of the terminal ileum (n = 7) or colon (n = 1). Indications for surgery were medically...
Geboes, K, ...
Increased expression of CD40 and CD40 ligand (CD40L or CD154) has been found in inflamed mucosa of human inflammatory bowel disease (IBD), and interactions between these molecules seem to be involved...
Hofland, I, Geboes, K, Varia, M, Raleigh, J, ...
PURPOSE: To assess diffusion limited hypoxia in human tumors using image analysis of vasculature and to compare it with the bioreductive marker pimonidazole as an independent method. MATERIALS AND...
IL-15 shares biological activities but no significant sequence homology with IL-2. It induces T cell recruitment to sites of inflammation, T cell proliferation, and cytokine production and rescue...
Expression of gelatinase B in trachomatous conjunctivitis (2000)
Geboes, K, Al-Kharashi, S A, Al-Mosallam, A A, Paemen, L, ...
BACKGROUND/AIMS: Gelatinase B is a matrix metalloproteinase involved in extracellular matrix (ECM) breakdown often associated with scarring and other pathological disorders. It was investigated...
Ewe, K, Gassull, M A, Geboes, K, Jewell, D, Pallone, F, ...
OBJECTIVE: To obtain information on the clinical experience with azathioprine (AZA), 6-mercaptopurine (6-MP), cyclosporin A (CyA) and methotrexate (MTX) in the treatment of patients with inflammatory...
Cassagnou, M, Peeters, M, Geboes, K, ...
Blockade of CD28/CTLA-4-B7 costimulatory pathway in colitic scid mice (2000)
Liu, Z, Colpaert, Stefaan; U0021314, Ceuppens, JL, Geboes, K, Rutgeerts, Paul; U0007636
The commensal flora triggers recurrent ileal Crohn's disease after ileocolonic resection (2000)
Geboes, K, D'Haens, G, ...
DNA-aneuploidy in colorectal carcinoma in Crohn's disease (2000)
Befrits, R, Karlen, P, Ost, A, Rubio, C, Tribukait B Rutgeerts, Paul; U0007636, Geboes, K, ...
Sweet's syndrome in a patient with Crohn's disease (1999)
Crohn's disease is rarely associated with Sweet's syndrome. We report a 32-year old woman who presented with diarrhea, fever and disseminated erythematous plaques on the arms and the trunk. After...
Amount and fate of egg protein escaping assimilation in the small intestine of humans (1999)
Studies attempting to evaluate protein assimilation in humans have hitherto relied on either ileostomy subjects or intubation techniques. The availability of stable isotope-labeled protein allowed us...
Endoscopic and histologic healing of Crohn's (ileo-) colitis with azathioprine (1999)
BACKGROUND: The correlation between disease activity and endoscopic findings in Crohn's disease is poor. Corticosteroids induce symptom relief without consistent improvement of endoscopic lesions....
Different gastritis features are linked to different gastric neoplasms (1999)
Pittaluga, S, ...
OBJECTIVES: Helicobacter pylori infection induces gastritis, which may evolve to carcinoma or lymphoma. Whether duration of infection and inflammation pattern determine the outcome of the neoplastic...
D'Haens, G R, De Boer, M, ...
CD40 ligand (CD40L or CD154), a type II membrane protein with homology to TNF, is transiently expressed on activated T cells and known to be important for B cell Ig production and for activation and...
Baert, Frank; U0004588, Wouters, K, D'Haens, G, Hoang, P, Naegels, S, D'Heygere, F, ...
BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical...
Radioimmunoguided surgery for colorectal carcinoma (1999)
Geboes, K, ...
Department of Abdominal Surgery, K.U. Leuven, Belgium.
Cell kinetic measurements: principles, guidelines for treatment? (1999)
Department of Radiotherapy, University Hospital Gasthuisberg, Leuven, Belgium.
Tierens, A, Stul, M, Pittaluga, S, Geboes, K, ...
Gastric low grade MALT lymphomas show a pattern of somatic mutations in their rearranged immunoglobulin genes, indicative of antigen selection. This provides evidence for antigen stimulation in the...
Inflammatory alterations in mesenteric adipose tissue in Crohn's disease (1999)
Ernst, O, Geboes, K, Gambiez, L, Berrebi, D, Müller-Alouf, H, ...
BACKGROUND & AIMS: Abnormalities of fat in the mesentery including adipose tissue hypertrophy and fat wrapping have been long recognized on surgical specimens as characteristic features of Crohn's...
Thijs, T, Geboes, K, Peeters, TL
To test the hypothesis that the changes in intestinal contractility, which accompany inflammation of the gut, are agonist specific, we compared the response of inflamed strips to substance P (SP),...
Mebis, Joseph; U0009630, Geboes, K, Yap, P
The presence of organic material in the intestinal lumen is reported to interfere with the efficacy of cancericidals when used in low concentrations to prevent anastomotic recurrence in colorectal...
Van Deventer, S, Van Hogezand, R, Chalmers, D, Kothe, C, Baert, F, ...
BACKGROUND & AIMS: Tumor necrosis factor (TNF) is a pivotal cytokine in intestinal inflammation. Controlled trials using a chimeric anti-TNF antibody (infliximab) have shown its efficacy in...
Mebis, Joseph; U0009630, Geboes, K, Yap, P
BACKGROUND: Segmental intraluminal instillation of several tumoricidal agents including povidone-iodine has been advocated to prevent anastomotic recurrence after colonic resection for colorectal...
Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus (1999)
Wright, N A, Meltzer, S J, Triadafilopoulos, G, Geboes, K, Casson, A G, ...
The incidence of adenocarcinoma of the esophagus has been increasing in developing countries over the last three decades and probably reflects a genuine increase in the incidence of its recognized...
Calcifying fibrous pseudotumor is a recently described distinctive lesion, characterized by the presence of abundant hyalinized collagen with psammomatous or dystrophic calcifications and a...
BACKGROUND: Proliferating cells in neoplasms usually show rapid cell cycle times and high rates of glycolysis. Tumor glucose utilization (TuGluc), potential cell doubling time (Tpot), and the effect...
Abnormalities in mucin gene expression in Crohn's disease (1999)
Desreumaux, P, Debailleul, V, Gambiez, L, Geboes, K, ...
Alterations in the structure and/or quantity of mucins could alter the barrier function of mucus and play a role in initiating and maintaining mucosal inflammation in Crohn's disease. To investigate...
Baert, F J, D'Haens, G R, Peeters, M, Hiele, Martin; U0011266, Schaible, T F, Shealy, D, ...
BACKGROUND & AIMS: Anti-tumor necrosis factor alpha monoclonal antibody treatment (infliximab) reduces clinical signs and symptoms in patients with Crohn's disease. The effects of infliximab on...
Proinflammatory effects of IL-10 in pathological ileal Crohn's disease (1999)
Colpaert, Stefaan; U0021314, Liu, Z, Adé, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...
Are lympho-epithelial lesions the diagnostic hallmark of gastric marginal zone cell lymphomas (1999)
Driessen, A, Ectors, Nadine; U0016969, Peeters, M, Demeester, X, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, ...
Driessen, A, Ectors, Nadine; U0016969, Peeters, M, Demeester, X, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, ...
D'Haens, G, Sels, F, Aerden, I, ...
CD40 ligand is overexpressed and induces cytokine production in inflammatory bowel disease (1999)
Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...
Interleukin-15 induces T cell activation in inflammatory bowel disease (1999)
Liu, Z, Colpaert, Stefaan; U0021314, Ade, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...
Blockade of CD40 signaling improves experimental colitis in scid mice (1999)
Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Ceuppens, Jan; U0014358, Geboes, K, ...
Driessen, A, Ectors, Nadine; U0016969, Peeters, M, Demeester, X, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, ...
Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, GR, Ceuppens, JL, Rutgeerts, Paul; U0007636, Geboes, K
Effect of cA2 on pathological ileum of Crohn's disease: not merely TNF down regulation (1999)
Colpaert, Stefaan; U0021314, Liu, Z, Ade, M, D'Haens, G, Rutgeerts, Paul; U0007636, Geboes, K, ...
Inflammatory lesions of the myenteric plexus in Crohn's disease (1999)
Geboes, K, Rutgeerts, Paul; U0007636
Falk Symposium 106
Baert, F, Wouters, K, D'Haens, G, Hoang, P, Naegels, S, D'Heygere, F, ...
BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical...
Chen, I, Desreumaux, P, Najib, J, Fruchart, J C, Geboes, K, ...
The development of colorectal cancer, one of the most frequent cancers, is influenced by prostaglandins and fatty acids. Decreased prostaglandin production, seen in mice with mutations in the...
Gelatinase B in proliferative vitreoretinal disorders (1998)
Veckeneer, M, Geboes, K, Van Aelst, I, ...
PURPOSE: To investigate whether gelatinases A and B are involved in the pathogenesis of proliferative vitreoretinal disorders. METHODS: In a prospective study of 101 consecutive patients, vitreous...
BACKGROUND: In recent years Tpot (potential doubling time) has been measured before treatment in human tumors in an attempt to estimate the proliferation taking place during a course of irradiation....
D'Haens, G R, Geboes, K, Peeters, M, Baert, Frank; U0004588, Penninckx, Freddy; U0018132, Rutgeerts, Paul; U0007636
BACKGROUND & AIMS: Postoperative recurrence of Crohn's disease may be triggered by agents in the fecal stream. The aim of this study was to examine intestinal mucosal inflammation induced by contact...
Aerts, R, Driessen, A, Van Hoe, L, ...
A 43-year-old man presented with abdominal discomfort caused by relapsing pancreatitis. Radiological examination revealed a multilocular cystic mass in the tail of the pancreas, which was resected....
PURPOSE: Colonoscopy with biopsy(ies) is performed in patients with colorectal cancer for diagnosis and screening of synchronous lesions. There is some fear of spreading the disease related to...
Immunopathogenesis of conjunctival scarring in trachoma (1998)
Geboes, K, Tabbara, K F, Al-Kharashi, S A
PURPOSE: Trachoma, a chronic follicular conjunctivitis caused by infection with Chlamydia trachomatis, is the leading cause of preventable blindness. The blinding complications are associated with...
An immunohistochemical study of collagens in trachoma and vernal keratoconjunctivitis (1998)
Geboes, K, Al-Kharashi, S A, Al-Mosallam, A A, Tabbara, K F, Al-Rajhi, A A, ...
PURPOSE: To analyse the distribution and types of collagen in the conjunctiva of patients with trachoma and vernal keratoconjunctivitis (VKC). METHODS: Conjunctival biopsy specimens were collected...
Collagen content and types in trachomatous conjunctivitis (1998)
Geboes, K, Al-Kharashi, S A, Tabbara, K F
PURPOSE: To study alterations in conjunctival collagen in the conjunctiva of patients with active trachoma. METHODS: We studied conjunctival biopsy specimens obtained from nine subjects with active...
Expression of interleukin-15 in inflammatory bowel disease (1998)
Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Ceuppens, Jan; U0014358, Geboes, K, ...
Expression of CD40 and CD40L in inflammatory bowel disease (1998)
Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Ceuppens, Jan; U0014358, Geboes, K, ...
D'Haens, G, Colpaert, Stefaan; U0021314, Peeters, M, Baert, Frank; U0004588, Penninckx, Freddy; U0018132, Rutgeerts, Paul; U0007636, ...
Lemmens, L, Vandeputte, L, Peeters, M, ...
Colpaert, Stefaan; U0021314, Liu, Z, Degreef, B, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...
Hiele, Martin; U0011266, Gevers, Anna-Maria; U0004709, Mertens, Luc; U0010600, Van Hoe, L, Van Cutsem, Eric; U0003840, Macken, L, ...
Are collagenous and lymphocytic colitis one disease? A histologic analysis of 178 cases (1998)
Wouters, K, Baert, Frank; U0004588, Sempoux, C, Tanghe, W, Marichal, M, Cuvelier, C, ...
Microscopic Barrett's esophagus: relationship to acid and bile reflux in man (1998)
Van Vaerenbergh, W, Tack, Jan; U0015849, Geboes, K, Gevers, Anna-Maria; U0004709, Rutgeerts, Paul; U0007636, Lerut, Antoon; U0004205, ...
Microscopic Barrett's esophagus: Relationship to acid and bile reflux in man (1998)
Van Vaerenbergh, W, Tack, Jan; U0015849, Geboes, K, Gevers, Anna-Maria; U0004709, Rutgeerts, Paul; U0007636, Lerut, Antoon; U0004205, ...
Adhesion molecules in vernal keratoconjunctivitis (1997)
Geboes, K, Al-Kharashi, S, Tabbara, K F
AIMS/BACKGROUND: Adhesion molecules play a key role in the selective recruitment of different leucocyte population to inflammatory sites. The purpose of the present study was to investigate the...
Non-alcoholic duct destructive chronic pancreatitis (1997)
Ectors, Nadine; U0016969, Maillet, B, Aerts, R, Geboes, K, Donner, A, Borchard, F, ...
BACKGROUND: The pathology of non-alcoholic chronic pancreatitis has not yet been sufficiently studied. AIMS: To identify the major changes of pancreatic tissue in patients surgically treated for...
D'Haens, G, Geboes, K, Peeters, M, Baert, Frank; U0004588, Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636
OBJECTIVES: It is generally believed that the mucosal inflammation in ulcerative colitis is characterized by a diffuse, continuous involvement starting from the rectum without "skip areas." It was...
Tumour cell kinetics could help in predicting the optimal duration of treatment for the individual patient. In order to assess the importance of cell kinetics in oesophageal cancer, 63 patients with...
Schurmans, P, Huys, S, Geboes, K, ...
BACKGROUND: Endoscopic ultrasound (EUS) is considered to be the best staging technique for cancer of the esophagus or the esophagogastric junction. This study evaluates the relation between...
Previously, we have assessed the efficacy of different cytotoxic agents on the viability of SW620 human colonic carcinoma cells in vitro. In this study, we have investigated the tumoricidal efficacy...
Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease (1997)
Brandt, E, Gambiez, L, Emilie, D, Geboes, K, Klein, O, ...
BACKGROUND & AIMS: Chronic intestinal lesions of patients with Crohn's disease (CD) are associated with a T helper (Th) 1-type cytokine profile, including high levels of interleukin 2 (IL-2) and...
BACKGROUND & AIMS: Standard corticosteroid therapy for Crohn's ileitis induces symptom relief without improvement of endoscopically visible lesions. In this study, the effect of azathioprine therapy...
Expression of gelatinase B in early recurrent Crohn's disease (1997)
Geboes, K, Paemen, L, D'Haens, G, Peeters, M, ...
Driessen, A, Ectors, Nadine; U0016969, Creemers, Johannes; U0017572, Penninckx, Freddy; U0018132, Geboes, K
Katholieke Univ Leuven Hosp,Dept Pathol,Louvain,Belgium; Limburgs Univ Ctr,Dept Histol,Diepenbeek,Belgium
Endometriosis and Crohn's disease (1997)
Cokelaere, K, Ectors, Nadine; U0016969, Baert, Frank; U0004588, Rutgeerts, Paul; U0007636, Geboes, K
Driessen, A, Vanginneken, C, Creemers, J, Weyns, A, Ectors, Nadine; U0016969, Geboes, K
Katholieke Univ Leuven Hosp,Dept Pathol,Louvain,Belgium; Univ Antwerp,Dept Morphol Vet Anat Embryol,B-2020 Antwerp,Belgium; Limburgs Univ Ctr,Dept Histol,Diepenbeek,Belgium
Hofland, I, Ramaekers, M, Ivanyi, D, Balm, A J, Geboes, K, ...
PURPOSE: To determine the feasibility of using cytokeratin antibodies to distinguish normal and malignant cells in human tumors using flow cytometry. The goal was ultimately to increase the accuracy...
Two groups of patients referred for suspicion of acute appendicitis were compared to evaluate the accuracy of preoperative ultrasonography (US) and surgical decision-making. In one retrospective...
Gastric emptying and Helicobacter pylori infection in duodenal ulcer disease (1996)
Ghoos, Y F, Maes, B D, Geypens, B J, Geboes, K, ...
The pathogenetic link between Helicobacter pylori gastritis and duodenal ulcer is still unknown. Fast gastric emptying of liquids might be important in the pathogenesis of gastric metaplasia of the...
Geboes, K, ...
Gastric gland heterotopia with extensive lymphoid stroma: a gastric lymphoepithelial cyst (1996)
Benign submucosal epithelial lesions of the stomach are rare. Their morphological aspect and pathogenesis and hence classification are unclear. The literature on this subject consists mainly of case...
An immunohistochemical study of topical cyclosporine in vernal keratoconjunctivitis (1996)
PURPOSE: To determine the immunomodulating effects of topical cyclosporine on the immune cells in the conjunctival biopsy specimens obtained from patients with active vernal keratoconjunctivitis....
Colorectal cancer in colonic Crohn's disease-High frequency of DNA-aneuploidy (1996)
Löfberg, R, Befrits, R, Sjökvist, U, Karlen, P, Ost, A, Rubio, C, ...
Impressive histologic improvement after TNF antibody (cA2) therapy in active Crohn's disease (1996)
Baert, FJ, D'Haens, GR, Geboes, K, Ectors, Nadine; U0016969, Peeters, M, Rutgeerts, Paul; U0007636
Staging of rectal tumors by means of endoscopic ultrasound (1996)
Hiele, Martin; U0011266, Kockaerts, Y, Schurmans, P, Geboes, K, Rutgeerts, Paul; U0007636
Ectors, Nadine; U0016969, Driessen, A, Veereman, Genevieve; U0017937, Rutgeerts, Paul; U0007636, Geboes, K
Monoclonal IL-10 therapy decreases ileocolonic inflammation in Crohn's disease (1996)
Baert, Frank; U0004588, Geboes, K, Peeters, M, DHaens, G, Rutgeerts, Paul; U0007636
Schiepers, C, Geboes, K, ...
Rutgeerts, Paul; U0007636, Hiele, Martin; U0011266, Geboes, K, Peeters, M, Penninckx, Freddy; U0018132, Aerts, Raymond; U0002616, ...
BACKGROUND/AIMS: New lesions recur within weeks to months after ileal resection and ileocolonic anastomosis for Crohn's ileitis. A double-blind controlled trial was performed using metronidazole to...
Intermittent subobstruction and cholestasis as complications of duodenal amyloid tumours (1995)
Baldewijns, M, Ectors, Nadine; U0016969, Verbeeck, G, Janssens, J, De Schepper, J, Ponette, Eric; U0002870, ...
Amyloidosis confined to the duodenum is uncommon. In the present report the history of an 83-year old patient, admitted for vomiting and heavy epigastric pain, is described. Radiographic and...
BACKGROUND/AIMS: Heat-shock protein (Hsp) 60 is an immunodominant antigen of mycobacteria and other microorganisms that is highly homologous to its human counterpart. Hsp60 may provide a link between...
Adenocarcinoma of the rectum with a solitary metastasis to the urethra in a female (1995)
Adenocarcinoma of the urethra is extremely rare, constituting 10 to 20% of all primary urethral malignancies in women. As in men, the squamous carcinoma accounts for 70% of all urethral tumours....
Gastric metaplasia in the distal duodenum - Crohn's disease rather than peptic ulcer disease (1995)
Ectors, Nadine; U0016969, Geboes, K, Rutgeerts, Paul; U0007636, Broeckaert, L, D'Haens, G, Janssens, J
No induction of cytokine release by hsp-65 in biopsy cultures from crohns-disease patients (1995)
Peeters, M, Dhaens, G, Peetermans, Willy; U0017444, Ceuppens, Jan; U0014358, Geboes, K, Rutgeerts, Paul; U0007636
Geboes, K, Van Thillo, J, Leysen, J, ...
The importance of intratumour variability of cell kinetics was studied in 60 patients with cancer of the oesophagus. Five biopsies per tumour were taken. The labelling index, S-phase duration and...
Three cases of non-tumoural tight stenosis of the bifurcation of the hilar bile ducts (1994)
Baert, A L, ...
Stenosis of the bifurcation of the hepatic bile duct is usually caused by malignant lesion. We report on three different causes of benign stenosis of the hepatic confluence with a similar...
Increased permeability of macroscopically normal small bowel in Crohn's disease (1994)
Peeters, M, Ghoos, Yvo; U0005088, Maes, B, Hiele, Martin; U0011266, Geboes, K, Vantrappen, Gaston; U0017164, ...
To investigate permeability alterations of the macroscopically normal jejunum in Crohn's disease, the permeation of two probes was measured during perfusion of an isolated jejunal segment. The data...
The natural history of esophageal Crohn's disease: three patterns of evolution (1994)
We carried out a clinical and endoscopic follow-up study of 14 patients with Crohn's disease of the esophagus. The diagnosis was based on the combination of endoscopic and histologic examinations...
CT findings in nonmucosal eosinophilic gastroenteritis (1994)
Vanghillewe, K, Baert, A L, Geboes, K, Stevens, E
A 22-year-old patient with eosinophilic gastroenteritis with predominantly submucosal and muscular involvement is presented. The benefits of CT, using water as an orally administered contrast agent,...
Imaging of polypoid endoluminal growing bile duct tumors (1994)
Biebau, G, Gelin, J, Baert, A L, ...
We reviewed the radiological documents and protocols of 196 cases of bile duct tumors examined over a period of 12 years: 20 of them (10.2%) presented with a polypoid endoluminal growth. The aim of...
Clinical relevance of nitric oxide in the gut (1994)
Boeckxstaens, G E, Mebis, Joseph; U0009630, Janssens, J, Geboes, K, De Man, J G, Herman, A G, ...
Appendectomy protects against ulcerative colitis (1994)
BACKGROUND/AIMS: Defining risk factors for ulcerative colitis (UC) is important to better understand the pathogenesis of this idiopathic disease. One factor modulating the disease is smoking. A pilot...
Dillemans, B, Marnette, J M, ...
Barrett's carcinoma occurred in 66 of 331 patients with adenocarcinomas of the esophagus or gastroesophageal junction. Only 32 (46%) of these patients had a history of gastroesophageal reflux. A...
Huysmans, V, Geboes, K, ...
Permeability tests are widely used to investigate the pathogenesis of various gastrointestinal diseases including coeliac disease, infectious diarrhoea, and inflammatory bowel disease. In Crohn's...
D'Haens, G, Hiele, Martin; U0011266, Rutgeerts, Paul; U0007636, Geboes, K
Earlier studies regarding possible primary immune disturbances participating in the pathogenesis of Crohn's disease yielded conflicting results. Peripheral blood lymphocyte subsets and lymphocyte...
Squamous papilloma of the oesophagus and human papilloma virus (1994)
Van Cutsem, Eric; U0003840, Geboes, K, Snoeck, Robert; U0012760, Janssens, J, Rutgeerts, Paul; U0007636, De Clercq, Erik; U0003934
Dewyspelaere, J, Rutgeerts, Paul; U0007636, Broeckaert, L, Willemse, P, Gevers, Anna-Maria; U0004709, Van Cutsem, Eric; U0003840, ...
Ectors, Nadine; U0016969, Geboes, K, Rutgeerts, Paul; U0007636, Delabie, J, Desmet, Valeer; U0011957, Janssens, J
Ulcerative jejunitis in patients with established ulcerative colitis (1994)
Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, Geboes, K, Desmet, Valeer; U0011957
Inflammatory fibroid polyp of the ileum (1993)
Serrien, B, Bleus, E, Geboes, K, ...
We report a patient who presented with recurrent right upper quadrant colics after a previous cholecystectomy. Radiological examination revealed the presence of a polypoid mass in the ileum caused by...
Proctitis and rectal stenosis induced by nonsteroidal antiinflammatory suppositories (1993)
Breysem, Y, Van Besien, B, Geboes, K, ...
Anorectal ulceration eventually leading to rectal stenosis was observed in 10 patients who abused analgetic suppositories containing acetylsalicylic acid, acetaminophen, and codeine. Most patients...
Geboes, K, Meulemans, A, Schuurkes, J
The influence of rhein anthrone on the peristaltic reflex was studied with a modified Trendelenburg technique in the range from 10(-8) to 4 x 10(-5) mol/l, using a normal and reversed guinea pig...
Ashkenazi, A, Belli, D, Boige, N, Bouquet, J, Cadranel, S, ...
In this paper, a Working Group on Gastro-Oesophageal Reflux discusses recommendations for the first line diagnostic and therapeutic approach of gastro-oesophageal reflux disease in infants and...
This study shows that rhein anthrone has no laxative potency in germ-free rats because after intracaecal administration of a dose of 50 mg/kg the large intestine transit exceeded 240 min. The time...
Valvular colonic sphincter substitutes. An experimental study in dogs (1993)
Three types of colonic sphincter substitutes were placed at an abdominal colostomy in dogs. Simple valve construction (8) was based on orthograde intussusception of the colon over 3.5 cm. In...
Crohn's disease and pre-aphthoid lesions (1993)
Department of Gastroenterology, University Hospital, Leuven, Belgium.
Animal models for Helicobacter pylori (1993)
Ectors, Nadine; U0016969, Henneresse, P E, Geboes, K, Eyssen, Hendrik; U0018158, Janssens, J, Vantrappen, Gaston; U0017164
Glycosaminoglycans and the gut (1993)
Department of Medicine, University of Leuven, Belgium.
Microscopic lesions of the duodenum in Crohn's disease (1993)
Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, D'Haens, G, Geboes, K, Vantrappen, Gaston; U0017164
Endoskopie bei entzündlichen Darmerkrankungen (1993)
Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, Geboes, K
Demonstration of nitric oxide positive neurons in Crohn's disease (1993)
Geboes, K, Mebis, Joseph; U0009630, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969, Vantrappen, Gaston; U0017164
Microscopic spectrum of duodenitis in Crohn's disease (1993)
Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, D'Haens, G, Geboes, K, Vantrappen, Gaston; U0017164
Ileocolonoscopy and Spondarthritis (1988)
DEQUEKER, J., GRILLET, B., DE CLERCK, L., RUTGEERTS, P., GEBOES, K.
CT diagnosis of primary torsion of greater omentum (1987)
Baert, A L, Kerremans, R, Geboes, K
The etiology of primary volvulus of the omentum in the absence of other intraabdominal pathology remains obscure. Abdominal pain and tenderness are always present. Computed tomography demonstrates an...
SYSTEMATIC ILEOCOLONOSCOPY AND BOWEL BIOPSY STUDY IN SPONDYLARTHROPATHY (1987)
GRILLET, B., DE CLERCK, L., DEQUEKER, J., RUTGEERTS, P., GEBOES, K.
In order to evaluate the frequency of ileitis in a population of patients with spondylarthropathy, an ileocolonoscopy with biopsies was performed in 88 consecutive patients with back pain and/or...
Familial deficiency of granulocyte bactericidal capacity associated with growth retardation (1978)
Weening, R S, Roos, D, Stadsbaeder, S, Geboes, K, Standaert, L, ...
GASTROINTESTINAL DISORDERS IN OLD AGE (1977)
399 elderly patients were studied in order to establish the frequency of different gastrointestinal diseases and to see to what extent gastrointestinal problems influenced the clinical picture and...