K. Itoh

Details der Publikationsliste

Zeitraum

1979 - 2009

Anzahl

274

Co-Autoren

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents (2009)

Higgins, L. G., Kelleher, M. O., Eggleston, Ian M, Itoh, K., Yamamoto, M., Hayes, J. D.

Sulforphane can Stimulate cellular adaptation to redox stressors through transcription factor Nrf2. Using mouse embryonic fibroblasts (MEFs) as a model, we show herein that the normal homeostatic...

Isolation of Antifungal Compounds from Gardenia jasminoides (2009)

S. Tachibana, K. Itoh

Gardenia jasminoides E. (Rubiaceae) methanol extracts showed the highest level of antifungal activity against Pleurotus ostreatus, a wood-rotting fungus, compared to five other methanol plants...

1 Overview of Zonal Flow Physics (2008)

P. H. Diamond, K. Itoh, T. S. Hahm

Abstract. Zonal flows, by which we mean azimuthally symmetric band-like shear flows, are ubiquitous phenomena in nature and the laboratory. It is now widely recognized that zonal flows are a key...

Strain analysis of I-c(epsilon) characteristic of YBCO coated conductor measured by a Walters spring (2008)

Sugano, M, Choi, S, Miyazoe, A, Miyamatsu, K, Ando, T, Itoh, K, ...

lc-strain characteristic of YBCO coated conductor was measured using a Walters spring (WASP). In this technique, additional bending and thermal strains induced to the YBCO layer should be considered....

Ultra-Low Voltage Nano-Scale Embedded RAMs (2008)

K. Itoh, M. Horiguchi, T. Kawahara

Abstract—Ultra-low voltage nano-scale embedded RAMs are described, focusing on RAM cells and peripheral circuits. First, challenges and trends of low-voltage RAM cells are discussed in terms of...

Spatial Sensitivity in the Dorsal Zone (Area DZ) of Cat Auditory Cortex (2008)

John C. Middlebrooks, Li Xu, Ann Clock Eddins, David M. Green, J Neurophysiol, T. M. Woods, ...

You might find this additional information useful... This article cites 44 articles, 23 of which you can access free at:

Precision measurement of vector and tensor analyzing powers in elastic deuteron-proton scattering (2006)

Mardanpour, H., Amir-Ahmadi, H. R., Deltuva, A., Itoh, K., Kalantar-Nayestanaki, N., Kawabata, T., ...

High precision vector and tensor analyzing powers of elastic deuteron-proton d+p scattering have been measured at intermediate energies to investigate effects of three-nucleon forces (3NF). Angular...

Photo-production of neutral kaons on 12C in the threshold region (2006)

Watanabe, T., Bydžovský, P., Dobashi, K., Endo, S., Fujii, Y., Hashimoto, O., ...

Kaon photo-production process on $^{12}$C has been studied by measuring neutral kaons in a photon energy range of 0.8$-$1.1 GeV. Neutral kaons were identified by the invariant mass constructed from...

Irreversible behavior of thermal expansion in Bi2212 composite wire at low temperature. (2006)

Sugano, M., Itoh, K., Nyilas, A., Kiyoshi, T.

18th Internat.Symp.on Superconductivity (ISS 2005), Tsukuba, J, October 24-26, 2005

Resolving the Discrepancy of 135 MeV pd Elastic Scattering Cross Sections and Relativistic Effects (2005)

Sekiguchi, K., Sakai, H., Witała, H., Gloeckle, W., Golak, J., Hatanaka, K., ...

Three precise measurements for elastic pd scattering at 135 MeV/A have been performed with the three different experimental setups. The cross sections are described well by the theoretical...

Food Webs: Experts Consuming Families of Experts (2005)

Rossberg, A. G., Matsuda, H., Amemiya, T., Itoh, K.

The question what determines the structure of natural food webs has been listed among the nine most important unanswered questions in ecology. It arises naturally from many problems related to...

Exploring Vacuum Manifold of Open String Field Theory (2005)

Igarashi, Y., Itoh, K., Katsumata, F., Takahashi, T., Zeze, S.

The global symmetry generated by K_n is a subgroup of the stringy gauge symmetry. We explore the part of the vacuum manifold related by this symmetry. A strong evidence is presented that the analytic...

Some Properties of the Speciation Model for Food-Web Structure - Mechanisms for Degree Distributions and Intervality (2005)

Rossberg, A. G., Matsuda, H., Amemiya, T., Itoh, K.

We present a mathematical analysis of the speciation model for food-web structure, which had in previous work been shown to yield a good description of empirical data of food-web topology. The degree...

Classical Solutions and Order of Zeros in Open String Field Theory (2005)

Igarashi, Y., Itoh, K., Katsumata, F., Takahashi, T., Zeze, S.

Earlier an analytic approach is proposed for classical solutions describing tachyon vacuum in open string field theory. Based on the approach, we construct a certain class of classical solutions...

Overview of confinement and MHD stability in the Large Helical Device (2005)

Motojima,O., Ida,K., Watanabe,K. Y., Nagayama,Y., Komori,A., Morisaki,T., ...

This article based on the 2004 Fusion Energy Conference contributions (Vilamoura, Portugal, 1-6 November 2004)

Measurement of thermal expansion by double extensometers between 290 K and 5 K. (2005)

Sugano, M., Itoh, K., Nyilas, A., Kiyoschi, T., Matsumoto, S.

17th Internat.Symp.on Superconductivity (ISS 2004), Niigata, J, November 23-25, 2004

Staggered Fermion, its Symmetry and Ichimatsu-Patterned Lattice (2004)

Itoh, K., Kato, M., Murata, M., Sawanaka, H., So, H.

We investigate exact symmetries of a staggered fermion in D dimensions. The Dirac operator is reformulated by SO(2D) Clifford algebra. The chiral symmetry, rotational invariance and parity symmetries...

An explanatory model for food-web structure and evolution (2004)

Rossberg, A. G., Matsuda, H., Amemiya, T., Itoh, K.

Food webs are networks describing who is eating whom in an ecological community. By now it is clear that many aspects of food-web structure are reproducible across diverse habitats, yet little is...

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Inagaki, S., Yokoyama, M., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Inagaki, S., Yokoyama, M., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Idei, H., Inagaki, S., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Idei, H., Inagaki, S., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Inagaki, S., Yokoyama, M., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Idei, H., Inagaki, S., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Idei, H., Inagaki, S., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Extension and its characteristics of ECRH plasma in the LHD (2004)

Kubo, Shin, Shimozuma, T., Yoshimura, Y., Notake, T., Inagaki, S., Yokoyama, M., ...

One of the main objectives of the LHD is to extend the plasma confinement database for helical systems and to demonstrate such extended plasma confinement properties to be sustained in steady state....

Confinement characteristics of the quasi-axisymmetric stellarator CHS-qa (2004)

Okamura, S., Matsuoka, K., Nishimura, S., Isobe, M., Suzuki, C., Shimuzu, A., ...

A low aspect ratio stellarator CHS-qa with a quasi-axisymmetric configuration has been designed at NIFS, whose main objective is the experimental study of confinement improvement. The high beta...

Review on the progress of the LHD experiment (2004)

Motojima, O., Yamada, H., Komori, A., Watanabe, K. Y., Mutoh, T., Takeiri, Y., ...

Recent progress in the Large Helical Device (LHD) experiment during the last 2 yr is reviewed. The LHD has been extending its operational regime toward fusion-relevant conditions while taking...

Japanese multicenter phase II and pharmacokinetic study of rituximab in relapsed or refractory patients with aggressive B-cell lymphoma (2004)

Tobinai, K., Igarashi, T., Itoh, K., Kobayashi, Y., Taniwaki, M., Ogura, M., ...

Background: To evaluate the efficacy and feasibility of rituximab monotherapy in Japanese patients with relapsed or refractory aggressive B-cell lymphoma. Patients and methods: Sixty-eight patients...

Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts (2004)

Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., Kobata, T.

Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the...

Review of analytical treatments of barrier-type problems in plasma theory (2003)

Spineanu, F., Vlad, M., Itoh, K.

We review the analytical methods of solving the stochastic equations for barrier-type dynamical behavior in plasma systems. The path-integral approach is examined as a particularly efficient method...

Notes on a possible phenomenology of internal transport barriers in tokamak (2003)

Spineanu, F., Vlad, M., Itoh, K.

We propose a new phenomenology of the generation of internal transport barriers, based on the exact periodic solution of the Flierl-Petvishvili equation. We examine the stability of this solution and...

Pole dynamics for the Flierl-Petviashvili equation and zonal flow (2003)

Spineanu, F., Vlad, M., Itoh, K., Sanuki, H.

We use a systematic method which allows us to identify a class of exact solutions of the Flierl-Petvishvili equation. The solutions are periodic and have one dimensional geometry. We examine the...

A demonstration of magnetic field optimization in LHD (2003)

Murakami,S., Yamada,H., Wakasa,A., Sasao,M., Isobe,M., Ozaki,T., ...

The behaviors of trapped particles in helical ripples are complicated and would enhance the radial transport of energetic particles and thermal plasma (neoclassical transport) in heliotrons. Thus the...

MHD instabilities and their effects on plasma confinement in the large helical device plasmas (2003)

Toi,K., Ohdachi,S., Yamamoto,S., Nakajima,N., Sakakibara,S., Watanabe,K. Y., ...

MHD stability of NBI heated plasmas and impacts of MHD modes on plasma confinement are intensively studied in the Large Helical Device (LHD). Three characteristic MHD instabilities were observed,...

A demonstration of magnetic field optimization in LHD (2003)

Murakami, S., Yamada, H., Wakasa, A., Sasao, M., Isobe, M., Ozaki, T., ...

The behaviors of trapped particles in helical ripples are complicated and would enhance the radial transport of energetic particles and thermal plasma (neoclassical transport) in heliotrons. Thus the...

MHD instabilities and their effects on plasma confinement in the large helical device plasmas (2003)

Toi, K., Ohdachi, S., Yamamoto, S., Nakajima, N., Sakakibara, S., Watanabe, K. Y., ...

MHD stability of NBI heated plasmas and impacts of MHD modes on plasma confinement are intensively studied in the Large Helical Device (LHD). Three characteristic MHD instabilities were observed,...

Impact of heat deposition profile on global confinement of NBI heated plasmas in the LHD (2003)

Yamada, H., Murakami, S., Yamazaki, K., Kaneko, O., Miyazawa, J., Sakamoto, R., ...

Energy confinement and heat transport of net-current-free NBI heated plasmas in the large helical device (LHD) are discussed with emphasis on density and power deposition profile dependences....

Recent advances in the LHD experiment (2003)

Motojima, O., Ohyabu, N., Komori, A., Kaneko, O., Yamada, H., Kawahata, K., ...

In the first four years of the LHD experiment, several encouraging results have emerged, the most significant of which is that MHD stability and good transport are compatible in the inward shifted...

Review and future prospects of low-voltage RAM circuits (2003)

Y. Nakagome, M. Horiguchi, T. Kawahara, K. Itoh

This paper describes low-voltage random-access memory (RAM) cells and peripheral circuits for standalone and embedded RAMs, focusing on stable operation and reduced subthreshold current in standby...

Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts (2003)

Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., Kobata, T.

Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the...

Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts (2003)

Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., Kobata, T.

Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the...

Novel Approach to Super Yang-Mills Theory on Lattice - Exact fermionic symmetry and "Ichimatsu" pattern - (2002)

Itoh, K., Kato, M., Sawanaka, H., So, H., Ukita, N.

We present a lattice theory with an exact fermionic symmetry, which mixes the link and the fermionic variables. The staggered fermionic variables may be reconstructed into a Majorana fermion in the...

Fermionic Symmetry in Ichimatsu-Decomposed Lattice Models (2002)

Itoh, K., Kato, M., Sawanaka, H., So, H., Ukita, N.

We present the lattice models with exact fermionic symmetries relating fermions and link variables. The plaquettes are distributed in an Ichimatsu pattern (chequered). We explain this peculiar...

Vacuum Structure of the Ichimatsu-Decomposed Lattice Models (2002)

Itoh, K., Kato, M., Murata, M., Sawanaka, H., So, H.

We proposed an `Ichimatsu'-decomposed lattice gauge theory with fermionic symmetries. The vacuum structures of the gauge sector with two coupling constants ($\beta_p,\beta_c$) are investigated for...

Randomized phase II study of biweekly CHOP and dose-escalated CHOP with prophylactic use of lenograstim (glycosylated G-CSF) in aggressive non-Hodgkin's lymphoma: Japan Clinical Oncology Group Study 9505 (2002)

Itoh, K., Ohtsu, T., Fukuda, H., Sasaki, Y., Ogura, M., Morishima, Y., ...

Background: CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) is accepted as the best available standard treatment for first-line chemotherapy in aggressive non-Hodgkin’s lymphoma...

Super Yang-Mills Theory on Lattice and the Transformation (2001)

Itoh, K., Kato, M., Sawanaka, H., So, H., Ukita, N.

We present a new lattice super Yang-Mills theory and its SUSY transformation. After our formulation of the model in a fundamental lattice, it is extended to the whole lattice with a substructure of...

Configuration flexibility and extended regimes in Large Helical Device (2001)

Yamada, H., Komori, A., Ohyabu, N., Kaneko, O., Kawahata, K., Watanabe, K. Y., ...

Recent experimental results in the Large Helical Device have indicated that a large pressure gradient can be formed beyond the stability criterion for the Mercier (high-n) mode. While the stability...

Dose-escalation study of CHOP with or without prophylactic G-CSF in aggressive non-Hodgkin's lymphoma (2000)

Itoh, K., Ohtsu, T., Wakita, H., Igarashi, T., Ishizawa, K., Onozawa, Y., ...

Background: CHOP is accepted as the gold standard for first line chemotherapy of aggressive non-Hodgkin's lymphoma (NHL). A dose-escalation study of CHOP was conducted to determine the maximal...

Reaction mechanism and characteristics of T_{20} in d + ^3He backward elastic scattering at intermediate energies (1999)

Tanifuji, M., Ishikawa, S., Iseri, Y., Uesaka, T., Sakamoto, N., Satou, Y., ...

For backward elastic scattering of deuterons by ^3He, cross sections \sigma and tensor analyzing power T_{20} are measured at E_d=140-270 MeV. The data are analyzed by the PWIA and by the general...

AC SUSCEPTIBILITY AND MAGNETIZATION OF NB-TUBE PROCESSED NB3AL COMPOSITE WIRES. (1998)

Itoh, K., Yuyama, M., Kuroda, T.

Proceedings of the 9th International Cryogenic Materials Conference (ICMC); Held Jun 1991, Huntsville, Alabama; Edited by F. R. Fickett and R. P. Reed; Plenum Press : New York

Solvable Optimal Velocity Models and Asymptotic Trajectory (1996)

Nakanishi, K., Itoh, K., Igarashi, Y., Bando, M.

In the Optimal Velocity Model proposed as a new version of Car Following Model, it has been found that a congested flow is generated spontaneously from a homogeneous flow for a certain range of the...

The role of cardiac output response in blood flow distribution during exercise in patients with chronic heart failure (1995)

YAMABE, H., ITOH, K., YASAKA, Y., TAKATA, T., YOKOYAMA, M.

The relationship between blood flow in the working leg and cardiac output (Q) response was determined for patients with chronic heart failure. The ratio of leg blood flow (LBF) to Q (LBFIQ) at the...

CALCINOSIS AND THE ANTICENTROMERE ANTIBODY: ITS CLINICAL, RADIOLOGICAL AND IMMUNOGENETIC ASPECTS (1992)

NISHIKAI, M., ITOH, K., SATO, A.

The relationship between calcinosis and the anticentromere antibody (ACA) was studied from a clinical, radiological and immunogenetic standpoint. Ten ACA-positive scleroderma patients, 34...

HIGH PURITY ALUMINIUM-LITHIUM MASTER ALLOY BY MOLTEN SALT ELECTROLYSIS (1987)

Watanabe, Y., Toyoshima, M., Itoh, K.

The aim of this work is to develop the economical production process of the Al-Li master alloy free from metallic sodium, calcium and potassium. This master alloy can be used for aluminium-lithium...

Power supply constraints in megabit DRAMs of the future (1987)

Itoh, K., Kimura, K.

Megabit DRAM power supply is described in terms of power dissipation, reliability for small transistors, and memory cell operating margin. Such recently developed 1 Mb techniques as CMOS and...

HIGH PURITY ALUMINIUM-LITHIUM MASTER ALLOY BY MOLTEN SALT ELECTROLYSIS (1987)

Watanabe, Y., Toyoshima, M., Itoh, K.

The aim of this work is to develop the economical production process of the Al-Li master alloy free from metallic sodium, calcium and potassium. This master alloy can be used for aluminium-lithium...

Power supply constraints in megabit DRAMs of the future (1987)

Itoh, K., Kimura, K.

Megabit DRAM power supply is described in terms of power dissipation, reliability for small transistors, and memory cell operating margin. Such recently developed 1 Mb techniques as CMOS and...

HIGH PURITY ALUMINIUM-LITHIUM MASTER ALLOY BY MOLTEN SALT ELECTROLYSIS (1987)

Watanabe, Y., Toyoshima, M., Itoh, K.

The aim of this work is to develop the economical production process of the Al-Li master alloy free from metallic sodium, calcium and potassium. This master alloy can be used for aluminium-lithium...

Power supply constraints in megabit DRAMs of the future (1987)

Itoh, K., Kimura, K.

Megabit DRAM power supply is described in terms of power dissipation, reliability for small transistors, and memory cell operating margin. Such recently developed 1 Mb techniques as CMOS and...

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

Dominguez, I, Itoh, K, Sokol, S Y

The dorsoventral axis is established early in Xenopus development and may involve signaling by Wnts, a family of Wnt1-protooncogene-related proteins. The protein kinase shaggy functions in the...

Conditional expression of the ubiquitous transcription factor MafK induces erythroleukemia cell differentiation.

Igarashi, K, Itoh, K, Hayashi, N, Nishizawa, M, Yamamoto, M

Transcription factor NF-E2 activity is thought to be crucial for the transcriptional regulation of many erythroid-specific genes. The three small Maf family proteins (MafF, MafG, and MafK) that are...

Genetically engineered rice resistant to rice stripe virus, an insect-transmitted virus.

Hayakawa, T, Zhu, Y, Itoh, K, Kimura, Y, Izawa, T, Shimamoto, K, ...

The coat protein (CP) gene of rice stripe virus was introduced into two japonica varieties of rice by electroporation of protoplasts. The resultant transgenic plants expressed the CP at high levels...

Developmental and Hormonal Regulation of Rice [alpha]-Amylase(RAmy1A)-gusA Fusion Genes in Transgenic Rice Seeds.

Itoh, K., Yamaguchi, J., Huang, N., Rodriguez, R. L., Akazawa, T., Shimamoto, K.

Transgenic seeds of rice (Oryza sativa L.) were used to investigate temporal, spatial, and hormonal regulation of a rice [alpha]-amylase gene, RAmy1A. Two overlapping segments of the RAmy1A promoter...

The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CBF.

Baum, C, Itoh, K, Meyer, J, Laker, C, Ito, Y, Ostertag, W

The polycythemic strain of the spleen focus-forming virus (SFFVp) contains the most potent murine retroviral enhancer configuration known so far for gene expression in myeloerythroid hematopoietic...

Detection of alpha- and beta-hemolytic-like activity from Campylobacter jejuni.

Misawa, N, Hirayama, K, Itoh, K, Takahashi, E

Alpha-hemolytic-like activity from Campylobacter jejuni was clearly apparent when the medium pH ranged from 6.0 to 6.5, but the hemolytic zones disappeared when the pH of the medium increased....

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

Kataoka, K, Igarashi, K, Itoh, K, Fujiwara, K T, Noda, M, Yamamoto, M, ...

The maf oncogene encodes a bZip nuclear protein which recognizes sequences related to an AP-1 site either as a homodimer or as heterodimers with Fos and Jun. We describe here a novel maf-related...

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins.

Itoh, K, Igarashi, K, Hayashi, N, Nishizawa, M, Yamamoto, M

The chicken beta-globin enhancer is critical for the tissue- and developmental stage-specific expression of the beta-globin genes. This enhancer contains two indispensable cis elements, one...

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.

Oyake, T, Itoh, K, Motohashi, H, Hayashi, N, Hoshino, H, Nishizawa, M, ...

Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. The dimer compositions of their...

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen.

Yamamoto, K, Horikita, M, Tsuda, F, Itoh, K, Akahane, Y, Yotsumoto, S, ...

Hepatitis B virus (HBV) DNA was extracted from sera of six carriers with hepatitis B e antigen as well as antibody to hepatitis B surface antigen and sequenced within the pre-S regions and the S...

Serological method for identification of Vibrio parahaemolyticus from marine samples.

Shinoda, S, Nakahara, N, Ninomiya, Y, Itoh, K, Kane, H

Use of agglutination with antiserum against lateral flagella (H-agglutination) for the identification of Vibrio parahaemolyticus was studied. Sucrose-negative bacteria were isolated from seawater,...

Genetic control in the susceptibility of germfree inbred mice to infection by Escherichia coli O115a,c:K(B).

Itoh, K, Matsui, T, Tsuji, K, Mitsuoka, T, Ueda, K

We studied the susceptibility of five germfree inbred strains of mice to oral infection by murine pathogenic Escherichia coli O115a,c:K(B) (MPEC), the causative agent of mouse megaenteron. Although...

Detection and identification of Yersinia pseudotuberculosis and pathogenic Yersinia enterocolitica by an improved polymerase chain reaction method.

Nakajima, H, Inoue, M, Mori, T, Itoh, K, Arakawa, E, Watanabe, H

We developed a polymerase chain reaction method in order to detect and identify both Yersinia pseudotuberculosis and pathogenic Yersinia enterocolitica. Polymerase chain reaction was performed by...

Molecular heterogeneity of gamma delta T-cell antigen receptors expressed by CD4- CD8- T-cell clones from normal donors: both disulfide- and non-disulfide-linked receptors are delta TCS1+.

Seki, H, Nanno, M, Chen, P F, Itoh, K, Ioannides, C, Good, R A, ...

We investigated the molecular heterogeneity of gamma delta T-cell antigen receptors (TCR) expressed on T-cell clones generated from peripheral blood lymphocytes of normal donors. Extensive molecular...

Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes.

Itoh, K, Itoh, Y, Frank, M B

Two cDNA clones encoding the 52-kD form of a protein present in human Ro/SSA ribonucleoprotein complexes were cloned from a lambda gt11 human thymocyte cDNA library. These clones reacted with lupus...

Immunopathological mechanisms of human T cell lymphotropic virus type 1 (HTLV-I) uveitis. Detection of HTLV-I-infected T cells in the eye and their constitutive cytokine production.

Sagawa, K, Mochizuki, M, Masuoka, K, Katagiri, K, Katayama, T, Maeda, T, ...

The immunopathology of human T cell lymphotropic virus type 1 (HTLV-I) uveitis was addressed by using T cell clones (TCC) established from the intraocular fluid of patients with HTLV-I uveitis....

Cytosynalin: a Mr 35,000 cytoskeleton-interacting and calmodulin-binding protein.

Sobue, K, Okabe, T, Kadowaki, K, Itoh, K, Tanaka, T, Fujio, Y

A Mr 35,000 calmodulin-binding protein, which also possesses the ability to interact with a number of cytoskeletal elements, was purified from bovine synaptosomal membranes, using hydroxylapatite and...

Identification of a second T-cell antigen receptor in human and mouse by an anti-peptide gamma-chain-specific monoclonal antibody.

Ioannides, C G, Itoh, K, Fox, F E, Pahwa, R, Good, R A, Platsoucas, C D

We developed a monoclonal antibody (mAb) (9D7) against a synthetic peptide (P13K) selected from the deduced amino acid sequence of the constant region of the gamma chain of the murine T-cell antigen...

Control of Escherichia coli populations by a combination of indigenous clostridia and lactobacilli in gnotobiotic mice and continuous-flow cultures.

Itoh, K, Freter, R

The function of indigenous lactobacilli in the control of other intestinal microbial species is not clear. Still more controversial is the effect of dietary bacterial supplements containing...

Differentiation arrest and stromal cell-independent growth of murine erythroleukemia cells are associated with elevated expression of ets-related genes but not with mutation of p53.

Nibbs, R J, Itoh, K, Ostertag, W, Harrison, P R

The ELM erythroleukemia is novel in that long-term survival of leukemic cells in culture (ELM-D cells) is dependent on contact with a bone marrow-derived stromal feeder cell layer. However, a number...

Protective protein gene mutations in galactosialidosis.

Shimmoto, M, Fukuhara, Y, Itoh, K, Oshima, A, Sakuraba, H, Suzuki, Y

Four different protective protein cDNA mutations, 146A-->G (Q49R), 193T-->C (W65R), 268-269TC-->CT (S90L), and 1184A-->G (Y395C), were identified in six Japanese galactosialidosis patients with...

Induction of selective phosphorylation of a fat body protein of Sarcophaga peregrina larvae by 20-hydroxyecdysone.

Itoh, K, Ueno, K, Natori, S

20-Hydroxyecdysone was shown to induce selective phosphorylation of a fat body protein of Sarcophaga peregrina larvae with a molecular mass of 30 kDa. This phosphorylation was not associated with...

Stable expression of protective protein/cathepsin A-green fluorescent protein fusion genes in a fibroblastic cell line from a galactosialidosis patient. Model system for revealing the intracellular transport of normal and mutated lysosomal enzymes.

Naganawa, Y, Itoh, K, Shimmoto, M, Kamei, S, Takiguchi, K, Doi, H, ...

Fibroblastic cell lines derived from a galactosialidosis patient, stably expressing the chimaeric green fluorescent protein variant (EGFP) gene fused to the wild-type and mutant human lysosomal...

Carcinoembryonic antigen (CEA) in gastric juice or feces as an aid in the diagnosis of gastrointestinal cancer.

Fujimoto, S, Kitsukawa, U, Itoh, K

Carcinoembryonic antigen (CEA) levels in the feces and serum were evaluated in 22 colorectal cancer patients and 20 healthy volunteers; in CEA levels gastric juice and serum were also evaluated in 28...

Fibre type composition of the soleus muscle in hypoxia-acclimatised rats.

Hirofuji, C, Ishihara, A, Itoh, K, Itoh, M, Taguchi, S, Takeuchi-Hayashi, H

Fibre type composition in the soleus muscle was studied in second generation male and female Sprague-Dawley rats bred at 460 Torr (hypobaric hypoxia). In control male and female rats (bred at sea...

The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms.

Frank, M B, Itoh, K, Fujisaku, A, Pontarotti, P, Mattei, M G, Neas, B R

Autoantibodies to Ro/SSA occur in nearly half of the patients with systemic lupus erythematosus and are associated with lymphopenia, photosensitive dermatitis, and pulmonary and renal disease, which...

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

Dominguez, I, Itoh, K, Sokol, S Y

The dorsoventral axis is established early in Xenopus development and may involve signaling by Wnts, a family of Wnt1-protooncogene-related proteins. The protein kinase shaggy functions in the...

Conditional expression of the ubiquitous transcription factor MafK induces erythroleukemia cell differentiation.

Igarashi, K, Itoh, K, Hayashi, N, Nishizawa, M, Yamamoto, M

Transcription factor NF-E2 activity is thought to be crucial for the transcriptional regulation of many erythroid-specific genes. The three small Maf family proteins (MafF, MafG, and MafK) that are...

Genetically engineered rice resistant to rice stripe virus, an insect-transmitted virus.

Hayakawa, T, Zhu, Y, Itoh, K, Kimura, Y, Izawa, T, Shimamoto, K, ...

The coat protein (CP) gene of rice stripe virus was introduced into two japonica varieties of rice by electroporation of protoplasts. The resultant transgenic plants expressed the CP at high levels...

Developmental and Hormonal Regulation of Rice [alpha]-Amylase(RAmy1A)-gusA Fusion Genes in Transgenic Rice Seeds.

Itoh, K., Yamaguchi, J., Huang, N., Rodriguez, R. L., Akazawa, T., Shimamoto, K.

Transgenic seeds of rice (Oryza sativa L.) were used to investigate temporal, spatial, and hormonal regulation of a rice [alpha]-amylase gene, RAmy1A. Two overlapping segments of the RAmy1A promoter...

The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CBF.

Baum, C, Itoh, K, Meyer, J, Laker, C, Ito, Y, Ostertag, W

The polycythemic strain of the spleen focus-forming virus (SFFVp) contains the most potent murine retroviral enhancer configuration known so far for gene expression in myeloerythroid hematopoietic...

Detection of alpha- and beta-hemolytic-like activity from Campylobacter jejuni.

Misawa, N, Hirayama, K, Itoh, K, Takahashi, E

Alpha-hemolytic-like activity from Campylobacter jejuni was clearly apparent when the medium pH ranged from 6.0 to 6.5, but the hemolytic zones disappeared when the pH of the medium increased....

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

Kataoka, K, Igarashi, K, Itoh, K, Fujiwara, K T, Noda, M, Yamamoto, M, ...

The maf oncogene encodes a bZip nuclear protein which recognizes sequences related to an AP-1 site either as a homodimer or as heterodimers with Fos and Jun. We describe here a novel maf-related...

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins.

Itoh, K, Igarashi, K, Hayashi, N, Nishizawa, M, Yamamoto, M

The chicken beta-globin enhancer is critical for the tissue- and developmental stage-specific expression of the beta-globin genes. This enhancer contains two indispensable cis elements, one...

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.

Oyake, T, Itoh, K, Motohashi, H, Hayashi, N, Hoshino, H, Nishizawa, M, ...

Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. The dimer compositions of their...

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen.

Yamamoto, K, Horikita, M, Tsuda, F, Itoh, K, Akahane, Y, Yotsumoto, S, ...

Hepatitis B virus (HBV) DNA was extracted from sera of six carriers with hepatitis B e antigen as well as antibody to hepatitis B surface antigen and sequenced within the pre-S regions and the S...

Serological method for identification of Vibrio parahaemolyticus from marine samples.

Shinoda, S, Nakahara, N, Ninomiya, Y, Itoh, K, Kane, H

Use of agglutination with antiserum against lateral flagella (H-agglutination) for the identification of Vibrio parahaemolyticus was studied. Sucrose-negative bacteria were isolated from seawater,...

Genetic control in the susceptibility of germfree inbred mice to infection by Escherichia coli O115a,c:K(B).

Itoh, K, Matsui, T, Tsuji, K, Mitsuoka, T, Ueda, K

We studied the susceptibility of five germfree inbred strains of mice to oral infection by murine pathogenic Escherichia coli O115a,c:K(B) (MPEC), the causative agent of mouse megaenteron. Although...

Detection and identification of Yersinia pseudotuberculosis and pathogenic Yersinia enterocolitica by an improved polymerase chain reaction method.

Nakajima, H, Inoue, M, Mori, T, Itoh, K, Arakawa, E, Watanabe, H

We developed a polymerase chain reaction method in order to detect and identify both Yersinia pseudotuberculosis and pathogenic Yersinia enterocolitica. Polymerase chain reaction was performed by...

Molecular heterogeneity of gamma delta T-cell antigen receptors expressed by CD4- CD8- T-cell clones from normal donors: both disulfide- and non-disulfide-linked receptors are delta TCS1+.

Seki, H, Nanno, M, Chen, P F, Itoh, K, Ioannides, C, Good, R A, ...

We investigated the molecular heterogeneity of gamma delta T-cell antigen receptors (TCR) expressed on T-cell clones generated from peripheral blood lymphocytes of normal donors. Extensive molecular...

Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes.

Itoh, K, Itoh, Y, Frank, M B

Two cDNA clones encoding the 52-kD form of a protein present in human Ro/SSA ribonucleoprotein complexes were cloned from a lambda gt11 human thymocyte cDNA library. These clones reacted with lupus...

Immunopathological mechanisms of human T cell lymphotropic virus type 1 (HTLV-I) uveitis. Detection of HTLV-I-infected T cells in the eye and their constitutive cytokine production.

Sagawa, K, Mochizuki, M, Masuoka, K, Katagiri, K, Katayama, T, Maeda, T, ...

The immunopathology of human T cell lymphotropic virus type 1 (HTLV-I) uveitis was addressed by using T cell clones (TCC) established from the intraocular fluid of patients with HTLV-I uveitis....

Cytosynalin: a Mr 35,000 cytoskeleton-interacting and calmodulin-binding protein.

Sobue, K, Okabe, T, Kadowaki, K, Itoh, K, Tanaka, T, Fujio, Y

A Mr 35,000 calmodulin-binding protein, which also possesses the ability to interact with a number of cytoskeletal elements, was purified from bovine synaptosomal membranes, using hydroxylapatite and...

Identification of a second T-cell antigen receptor in human and mouse by an anti-peptide gamma-chain-specific monoclonal antibody.

Ioannides, C G, Itoh, K, Fox, F E, Pahwa, R, Good, R A, Platsoucas, C D

We developed a monoclonal antibody (mAb) (9D7) against a synthetic peptide (P13K) selected from the deduced amino acid sequence of the constant region of the gamma chain of the murine T-cell antigen...

Control of Escherichia coli populations by a combination of indigenous clostridia and lactobacilli in gnotobiotic mice and continuous-flow cultures.

Itoh, K, Freter, R

The function of indigenous lactobacilli in the control of other intestinal microbial species is not clear. Still more controversial is the effect of dietary bacterial supplements containing...

Differentiation arrest and stromal cell-independent growth of murine erythroleukemia cells are associated with elevated expression of ets-related genes but not with mutation of p53.

Nibbs, R J, Itoh, K, Ostertag, W, Harrison, P R

The ELM erythroleukemia is novel in that long-term survival of leukemic cells in culture (ELM-D cells) is dependent on contact with a bone marrow-derived stromal feeder cell layer. However, a number...

Protective protein gene mutations in galactosialidosis.

Shimmoto, M, Fukuhara, Y, Itoh, K, Oshima, A, Sakuraba, H, Suzuki, Y

Four different protective protein cDNA mutations, 146A-->G (Q49R), 193T-->C (W65R), 268-269TC-->CT (S90L), and 1184A-->G (Y395C), were identified in six Japanese galactosialidosis patients with...

Induction of selective phosphorylation of a fat body protein of Sarcophaga peregrina larvae by 20-hydroxyecdysone.

Itoh, K, Ueno, K, Natori, S

20-Hydroxyecdysone was shown to induce selective phosphorylation of a fat body protein of Sarcophaga peregrina larvae with a molecular mass of 30 kDa. This phosphorylation was not associated with...

Stable expression of protective protein/cathepsin A-green fluorescent protein fusion genes in a fibroblastic cell line from a galactosialidosis patient. Model system for revealing the intracellular transport of normal and mutated lysosomal enzymes.

Naganawa, Y, Itoh, K, Shimmoto, M, Kamei, S, Takiguchi, K, Doi, H, ...

Fibroblastic cell lines derived from a galactosialidosis patient, stably expressing the chimaeric green fluorescent protein variant (EGFP) gene fused to the wild-type and mutant human lysosomal...

Fibre type composition of the soleus muscle in hypoxia-acclimatised rats.

Hirofuji, C, Ishihara, A, Itoh, K, Itoh, M, Taguchi, S, Takeuchi-Hayashi, H

Fibre type composition in the soleus muscle was studied in second generation male and female Sprague-Dawley rats bred at 460 Torr (hypobaric hypoxia). In control male and female rats (bred at sea...

Carcinoembryonic antigen (CEA) in gastric juice or feces as an aid in the diagnosis of gastrointestinal cancer.

Fujimoto, S, Kitsukawa, U, Itoh, K

Carcinoembryonic antigen (CEA) levels in the feces and serum were evaluated in 22 colorectal cancer patients and 20 healthy volunteers; in CEA levels gastric juice and serum were also evaluated in 28...

The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms.

Frank, M B, Itoh, K, Fujisaku, A, Pontarotti, P, Mattei, M G, Neas, B R

Autoantibodies to Ro/SSA occur in nearly half of the patients with systemic lupus erythematosus and are associated with lymphopenia, photosensitive dermatitis, and pulmonary and renal disease, which...

Different effect of prostaglandin E2 on B-cell activation by two distinct B-cell differentiation factors, B151-TRF1/IL-5 and B151-TRF2: selective inhibition of B151-TRF2-induced antibody response through increases in intracellular cyclic AMP levels

Ishihara, K., Ono, S., Takahama, Y., Hirayama, F., Hirano, H., Itoh, K., ...

Effects of prostaglandin E2 (PGE2) on murine B-cell activation induced by two distinct B-cell differentiation factors, B151-TRF1/IL-5 and B151-TRF2, were examined. A final differentiation of unprimed...

Relative serum amyloid A (SAA) values: the influence of SAA1 genotypes and corticosteroid treatment in Japanese patients with rheumatoid arthritis

Yamada, T, Okuda, Y, Takasugi, K, Itoh, K, Igari, J

OBJECTIVES—(1) To determine whether serum concentration of serum amyloid A (SAA) protein is influenced by the SAA1 allele in Japanese patients with rheumatoid arthritis (RA) as previously shown in...

Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature.

Nishiyama, H., Danno, S., Kaneko, Y., Itoh, K., Yokoi, H., Fukumoto, M., ...

Physiological scrotal hypothermia is necessary for normal spermatogenesis and fertility in mammals. Cirp is a recently identified cold-inducible RNA-binding protein that is inducible at 32 degrees C...

Regional growth of different human melanomas as metastases in the brain of nude mice.

Schackert, G., Price, J. E., Zhang, R. D., Bucana, C. D., Itoh, K., Fidler, I. J.

Cells from eight different human melanomas and two murine melanomas were injected into the internal carotid artery of anesthetized nude mice. Although all were injected by the same route, particular...

Reduced nm 23-H1 messenger RNA expression in metastatic lymph nodes from patients with papillary carcinoma of the thyroid.

Arai, T., Watanabe, M., Onodera, M., Yamashita, T., Masunaga, A., Itoyama, S., ...

The nm 23 gene product, which possesses nucleoside diphosphate kinase activity, is a possible mediator of cancer cell invasion and metastasis. It has been divided into two distinct gene products,...

Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis

Sugita, S., Taguchi, C., Takase, H., Sagawa, K., Sueda, J., Fukushi, K., ...

AIMS—To investigate the presence of soluble Fas ligand (sFasL) and soluble Fas (sFas) in ocular fluid of patients with uveitis.
METHODS—Samples of aqueous humour (AH, n=17), vitreous fluid...

Characterization of CD4+ T helper cells in patients with Kawasaki disease (KD): preferential production of tumour necrosis factor-alpha (TNF-alpha) by V beta 2- or V beta 8- CD4+ T helper cells.

Sakaguchi, M, Kato, H, Nishiyori, A, Sagawa, K, Itoh, K

KD is an acute febrile illness in children characterized by coronary arteritis accompanied by aneurysm and thrombotic occlusion. The etiology of KD is unknown. It has been recently reported that KD...

Epitope mapping of the 52-kD Ro/SSA autoantigen.

Frank, M B, Itoh, K, McCubbin, V

Autoantibodies to Ro/SSA are commonly found in sera of patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome. The presence of these antibodies is related to lymphopenia,...

Spontaneous production of various cytokines except IL-4 from CD4+ T cells in the affected organs of sarcoidosis patients.

Hoshino, T, Itoh, K, Gouhara, R, Yamada, A, Tanaka, Y, Ichikawa, Y, ...

We investigated surface antigens and spontaneous cytokine production of T cells from bronchoalveolar lavage fluid (BALF) and aqueous humor (AH) from pulmonary sarcoidosis patients for a better...

Endotoxin stimulates monocyte–endothelial cell interactions in mouse intestinal Peyer's patches and villus mucosa

ISHII, N, TSUZUKI, Y, MATSUZAKI, K, MIYAZAKI, J, OKADA, Y, HOKARI, R, ...

Although monocyte–endothelial cell interactions represent an initial step in controlling the recruitment of monocytes in inflamed tissues, their dynamic processes in microvessels of lymphoid...

In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1

Matsuzaki, K, Tsuzuki, Y, Matsunaga, H, Inoue, T, Miyazaki, J, Hokari, R, ...

The aetiology of Crohn's disease (CD) remains unknown. Since SAMP1/Yit mice have been reported to develop CD-like spontaneous enteric inflammation, such mice have been studied as an animal model of...

Non-restricted T cell receptor (TCR)-Vα and -Vβ gene usage in patients with pulmonary sarcoidosis

HOSHINO, T, SUZUKI, R, TSURUTA, Y, MATSUTANI, T, KIKUCHI, M, KAWAMOTO, M, ...

Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by the pronounced accumulation of CD4+ T cells and macrophages in the affected organs. TCR variable (V)α and Vβ...

Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats

Hokari, R, Kato, S, Matsuzaki, K, Iwai, A, Kawaguchi, A, Nagao, S, ...

Although increased expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) has been demonstrated in inflammatory sites of various diseases, its role in colitis remains unknown. In this...

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.

Kwak, M. K., Itoh, K., Yamamoto, M., Sutter, T. R., Kensler, T. W.

BACKGROUND: The induction of phase 2 enzymes by dithiolethiones such as oltipraz is an effective means for achieving protection against environmental carcinogens in animals and humans....

Production of IL-6 by T cells from the femoral head of patients with rapidly destructive coxopathy (RDC)

TAMAI, M., SAGAWA, K., KAWABATA, R., INOUE, A., ITOH, K.

RDC is a syndrome with unknown etiology that causes rapid destruction of a hip joint. We have investigated the production of osteoclast-activating cytokines (IL-6, IL-1α and tumour necrosis...

Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation.

Kodera, Y., Isobe, K., Yamauchi, M., Satta, T., Hasegawa, T., Oikawa, S., ...

In spite of its reputation as a tumour marker, little is known about the function of carcinoembryonic antigen (CEA). We examined the mRNA expression of CEA and NCA in 26 gastric and 14 colorectal...

Retention index of thallium-201 single photon emission computerised tomography (SPECT) as an indicator of metastasis in adenocarcinoma of the lung.

Takekawa, H., Itoh, K., Abe, S., Ogura, S., Isobe, H., Sukou, N., ...

We examined the relationship between the retention of thallium-201 (201Tl) on a delayed scan and the metastatic potential of adenocarcinomas of the lung. We studied 43 patients with adenocarcinoma of...

Predicting chemotherapeutic response to small-cell lung cancer of platinum compounds by thallium-201 single-photon emission computerized tomography.

Tokuchi, Y., Isobe, H., Takekawa, H., Hanada, T., Ishida, T., Ogura, S., ...

Thallium-201 single-photon emission computerized tomography (SPECT) was used to clarify the relationship between 201Tl uptake and the response in chemotherapy to platinum compounds in 21 patients...

A phase I trial of docetaxel and 5-day continuous infusion of 5-fluorouracil in patients with advanced or recurrent breast cancer.

Ando, M., Watanabe, T., Sasaki, Y., Ying, D. F., Omuro, Y., Katsumata, N., ...

To determine the maximum-tolerated doses (MTDs), the dose-limiting toxicities (DLTs) and the recommended doses for further trials of docetaxel in combination with a 5-day continuous infusion of...

Patients in phase I trials of anti-cancer agents in Japan: motivation, comprehension and expectations.

Itoh, K., Sasaki, Y., Fujii, H., Ohtsu, T., Wakita, H., Igarashi, T., ...

We attempted to characterize the motivation, comprehension and expectations of patients who had given informed consent to participate in phase I trials of anti-cancer agents at the National Cancer...

Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles

Naito, M, Komohara, Y, Ishihara, Y, Noguchi, M, Yamashita, Y, Shirakusa, T, ...

The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte...

UFT plus gemcitabine combination chemotherapy in patients with advanced non-small-cell lung cancer: a multi-institutional phase II trial

Ichinose, Y, Seto, T, Semba, H, Itoh, K, Inoue, Y, Tanaka, F, ...

A multi-institutional phase II trial was conducted to evaluate the efficacy and toxicity of combination chemotherapy consisting of gemcitabine and UFT, which is composed of tegafur and uracil, for...

Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients

Suefuji, Y, Sasatomi, T, Shichijo, S, Nakagawa, S, Deguchi, H, Koga, T, ...

We recently reported the SART3 tumour-rejection antigen as possessing tumour epitopes capable of inducing HLA-class I-restricted cytotoxic T lymphocytes (CTLs). This study investigated expression of...

Detection of peptide-specific CTL-precursors in peripheral blood lymphocytes of cancer patients

Maeda, Y, Hida, N, Niiya, F, Katagiri, K, Harada, M, Yamana, H, ...

Development of therapeutic vaccines is one of the major areas of tumour immunotherapy today. However, clinical trials of peptide-based cancer vaccines have rarely resulted in tumour regression. This...

UDP-Gal: βGlcNAc β1, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumour antigen recognised by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumour

Tsuda, N, Nonaka, Y, Shichijo, S, Yamada, A, Ito, M, Maeda, Y, ...

Patient prognosis in the case of malignant brain tumours is generally poor, despite significant improvements in the early detection of the tumours, and thus the development of new treatment...