Fujii, Y., Fodde, Enrico, Watanabe, K., Murakami, K.
Ajina Tepa is one of the most important archaeological sites in central Asia and it was fully excavated in the 1960s using modern documentation techniques. The UNESCO/Japan Trust Fund project...
DEVELOPMENT OF AN INTERFACE FOR USING EGS4 PHYSICS PROCESS IN GEANT4 (2009)
As simulation system, the variety of physics processes implemented is one of the most important functionalities. In that sense, Geant4 is one of the most powerful simulation toolkits. Its flexibility...
Murakami, K., Matsubara, N., Ichikawa, S., Kisa, T., Nakayama, T., Takamoto, K., ...
Pt pillars with a waist size of 20 nm and a length of 300 nm were fabricated by electron-beam-induced deposition and characterized by transmission electron microscopy before and after annealing or...
The FANTOM Consortium And Riken Omics Science Centre, Forrest, ARR, Van Nimwegen, E, Daub, CO, Balwierz, PJ, Irvine, KM, ...
Takagi, N., Murakami, K., Fujimaki, A., Yoshikawa, N., Inoue K., Honda, H., ...
We propose a desk-side supercomputer with large-scale reconfigurable data-paths (LSRDPs) using superconducting rapid singleflux-quantum (RSFQ) circuits. It has several sets of computing unit which...
8, M.Nagano 1, H.Ohoka
Hayashida Honda, N. Hayashida, S. Imaizumi, N. Inoue, K. Kadota, F. Kakimoto, ...
A very energetic cosmic ray of energy about (1.7¸2.6)\Theta10 20 eV was observed by the Akeno Giant Air Shower Array (AGASA) on December 3, 1993 from the direction of galactic longitude l=131 ffi...
H Okubo, S Sasaki, K Murakami, M K Kim, Y Takahashi, Y Hosoi, ...
Toshito, T., Kodama, K., Sihver, L., Yusa, K., Ozaki, M., Amako, K., ...
We have studied charged nuclear fragments produced by 200 - 400 MeV/nucleon carbon ions, interacting with water and polycarbonate, using a newly developed emulsion detector. Total and partial...
Geant4 and its validation (2006)
Amako, K., Guatelli, S., Ivanchencko, V., Maire, M., Mascialino, B., Murakami, K., ...
Geant4 is an object-oriented toolkit for simulating the passage of particles through matter. At the very heart of Geant4 there is a wide set of complementary, and sometimes alternative, physics...
Geant4 and its validation (2006)
Amako, K., Guatelli, S., Ivanchencko, V., Maire, M., Mascialino, B., Murakami, K., ...
Geant4 is an object-oriented toolkit for simulating the passage of particles through matter. At the very heart of Geant4 there is a wide set of complementary, and sometimes alternative, physics...
Geant4 Developments and Applications (2006)
Allison, J., Amako, K., Apostolakis, J., Araujo, H., Dubois, P.A., Asai, M., ...
Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including...
Maybauer, MO, Maybauer, DM, Fraser, JF, Traber, LD, Westphal, M, Enkhbaatar, P, ...
Objective: To investigate the effects of recombinant human activated protein C (rhAPC) on pulmonary function in acute lung injury (ALI) resulting from smoke inhalation in association with a bacterial...
The importance of antibiotics in animal models of sepsis (2005)
Maybauer, MO, Maybauer, DM, Fraser, JF, Traber, LD, Murakami, K, Mizutani, A, ...
No abstract available.
Comparison of Geant4 electromagnetic physics models against the NIST reference data (2005)
Amako, K., Guatelli, S., Ivanchenko, V.N., Maire, M., Mascialino, B., Murakami, K., ...
The Geant4 Simulation Toolkit provides an ample set of physics models describing electromagnetic interactions of particles with matter. This paper presents the results of a series of comparisons for...
Comparison of Geant4 electromagnetic physics models against the NIST reference data (2005)
Amako, K., Guatelli, S., Ivanchenko, V.N., Maire, M., Mascialino, B., Murakami, K., ...
The Geant4 Simulation Toolkit provides an ample set of physics models describing electromagnetic interactions of particles with matter. This paper presents the results of a series of comparisons for...
Sensitization of Nanocrystalline SnO2 Films with Indoline Dyes (2005)
Agyeman , B. O., Kaneko , S., Kumara , G. R. A, Okuya, M., Murakami , K., Konno, A., ...
Using newly synthesized indoline dyes as sensitizers for photoelectrochemical solar cells based on SnO2 nanocrystalline films, an energy conversion efficiency of 2.8% is achieved, compared with 1.2%...
Matrix Quantum Mechanics for Supermembrane on AdS_{7} x S^{4} (2004)
We explore the light-cone gauge formulation of a closed supermembrane on AdS_{7} x S^{4}. We obtain the action of matrix quantum mechanics with large N U(N) gauge symmetry for the light-cone...
Smoke inhalation injury and tissue dysoxia: what is the link? (2004)
Westphal, M, Morita, N, Murakami, K, Enkhbaatar, P, Traber, L, Traber, D
No abstract available.
Development of an Interface for Using EGS4 Physics Processes in Geant4 (2003)
Murakami, K., Amako, K., Hirayama, H., Namito, Y., Sasaki, T., Asai, M., ...
As simulation system, the variety of physics processes implemented is one of the most important functionalities. In that sense, Geant4 is one of the most powerful simulation toolkits. Its flexibility...
Solar Neutron Event in Association with a Large Solar Flare on November 24, 2000 (2003)
Watanabe, K., Muraki, Y., Matsubara, Y., Murakami, K., Sako, T., Tsuchiya, H., ...
Solar neutrons have been detected using the neutron monitor located at Mt. Chacaltaya, Bolivia, in association with a large solar flare on November 24, 2000. This is the first detection of solar...
GEANT4: A Simulation toolkit (2003)
Agostinelli, S, Allison, J, Amako, K, Apostolakis, John, Araújo, H M, Arce, P, ...
Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes...
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Effect of silane-coupling agent on natural rubber filled with silica generated in situ (2003)
Murakami, K, Iio, S, Ikeda, Y, Ito, H, Tosaka, M, Kohjiya, S
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Geant4 - A simulation toolkit (2003)
Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., ...
Open Wilson Lines as States of Closed String (2002)
System of a D-brane in bosonic string theory on a constant $B$ field background is studied in order to obtain further insight into the bulk-boundary duality. Boundary states which describe arbitrary...
p-p' System with B Field and Projection Operator Noncommutative Solitons (2001)
We study the system of the Dp'-brane with Dp-brane (p
Heparin nebulization attenuates acute lung injury with sepsis after smoke inhalation in sheep (2001)
Murakami, K, Katahira, J, McGuire, R, Cox, R, Hawkins, H, Herndon, D, ...
No abstract available.
Chen, B., Itoyama, H., Matsuo, T., Murakami, K.
The gaussian damping factor (g.d.f.) and the new interaction vertex with the symplectic tensor are the characteristic properties of the N-point scalar-vector scattering amplitudes of the p-p' (p <...
Worldsheet and Spacetime Properties of p-p' System with B Field and Noncommutative Geometry (2000)
Chen, B., Itoyama, H., Matsuo, T., Murakami, K.
We study worldsheet and spacetime properties of the p-p' (p < p') open string system with constant B_{ij} field viewed from the Dp' brane. The description of this system in terms of the CFT with spin...
p-p' System with B-field, Branes at Angles and Noncommutative Geometry (1999)
Chen, B., Itoyama, H., Matsuo, T., Murakami, K.
We study the generic $p-p^\prime$ system in the presence of constant NS 2-form $B_{ij}$ field. We derive properties concerning with the noncommutativity of D-brane worldvolume, the Green functions...
Experimental search for the decay mode K_L -> pi^0 gamma e^+ e^- (1999)
Murakami, K., Hemmi, Y., Kurashige, H., Matono, Y., Nomura, T., Sakamoto, H., ...
We report on results of a search for the decay mode K_L -> pi^0 gamma e^+ e^- conducted by the E162 experiment at KEK. We observed no events and set a 90% confidence level upper limit of Br(K_L ->...
The Anisotropy of Cosmic Ray Arrival Direction around 10^18eV (1999)
Hayashida, N., Honda, K., Inoue, N., Kadota, K., Kakimoto, F., Kakizawa, S., ...
Anisotropy in the arrival directions of cosmic rays around 10^{18}eV is studied using data from the Akeno 20 km^2 array and the Akeno Giant Air Shower Array (AGASA), using a total of about 216,000...
Takeda, M., Hayashida, N., Honda, K., Inoue, N., Kadota, K., Kakimoto, F., ...
With the Akeno Giant Air Shower Array (AGASA), 581 cosmic rays above 10^19eV, 47 above 4 x 10^19eV, and 7 above 10^20eV are observed until August 1998. Arrival direction distribution of these...
Takeuchi, Y., Hemmi, Y., Kurashige, H., Matono, Y., Murakami, K., Nomura, T., ...
In order to study photomultiplier's short-term gain stability at high counting rate, we constructed an LED pulsed light source and its output monitor system. For the monitor system, we employed a...
Molecular Weight Distribution by Stress Relaxation. (1998)
Tobolsky,A. V., Mercurio,A., Murakami,K.
Supersedes AD-208 490.
Observation of the decay mode K_L -> pi^+ pi^- e^+ e^- (1998)
Takeuchi, Y., Hemmi, Y., Kurashige, H., Matono, Y., Murakami, K., Nomura, T., ...
We report on results of an experimental search for the K_L -> pi^+ pi^- e^+ e^- decay mode. We found 13.5 +- 4.0 events and determined its branching ratio to be (4.4 +- 1.3(stat) +-...
Takeda, M., Hayashida, N., Honda, K., Inoue, N., Kadota, K., Kakimoto, F., ...
The cosmic-ray energy spectrum above 10^{18.5} eV is reported using the updated data set of the Akeno Giant Air Shower Array (AGASA) from February 1990 to October 1997. The energy spectrum extends...
The Anisotropy of Cosmic Ray Arrival Directions around 10$^{18}$eV (1998)
Hayashida, AGASA Collaboration: N., Honda, K., Inoue, N., Kadota, K., Kakimoto, F., Kamata, K., ...
Anisotropy in the arrival directions of cosmic rays with energies above 10$^{17}$eV is studied using data from the Akeno 20 km$^2$ array and the Akeno Giant Air Shower Array (AGASA), using a total of...
E140: Step-down therapy in celiprolol treated hypertensive patients (1998)
T. Iwata, K. Kohara, K. Murakami, H. Azechi, T. Jo, K. Watanabe, ...
Matrix Model for Dirichlet Open String (1998)
Ezawa, K., Matsuo, Y., Murakami, K.
We discuss the open string ending on D $p$-branes in IKKT framework. First we determine the boundary conditions of Green-Schwarz superstring which are consistent with supersymmetry and...
Ezawa, K., Matsuo, Y., Murakami, K.
We study open supermembranes in 11 dimensional rigid superspace with 6 dimensional topological defects (M-theory five-branes). After rederiving in the Green-Schwarz formalism the boundary conditions...
BPS Configuration of Supermembrane With Winding in M-direction (1997)
Ezawa, K., Matsuo, Y., Murakami, K.
We study de Wit-Hoppe-Nicolai supermembrane with emphasis on the winding in M-direction. We propose a SUSY algebra of the supermembrane in the Lorentz invariant form. We analyze the BPS conditions...
Inhibition of transcription by the TAR RNA of HIV-1 in a nuclear extract of HeLa cells (1997)
Yamamoto, R, Koseki, S, Ohkawa, J, Murakami, K, Nishikawa, S, Taira, K, ...
Hayashida, N, Honda, K, Honda, M, Inoue, N, Kadota, K, Kakimoto, F, ...
The cosmic ray energy spectrum above 10$^{19}$ eV determined by AGASA (1996)
Doi, T, Hayashida, N, Honda, K, Honda, M, Inoue, N, Kadota, K, ...
Characteristics of Giant air showers of energies around 50 EeV observed by AGASA (1996)
Doi, T, Hayashida, N, Honda, K, Honda, M, Inoue, N, Kadota, K, ...
Composition of cosmic rays between 10$^{16.5}$ eV and 10$^{19.0}$ eV observed at Akeno (1996)
Doi, T, Hayashida, N, Honda, K, Honda, M, Imaizumi, S, Inoue, N, ...
Point source search for cosmic rays above 3 x 10$^{17}$ eV by AGASA (1996)
Doi, T, Hayashida, N, Honda, K, Honda, M, Inoue, N, Kadota, K, ...
Inclined giant air showers with energies above 10$^{19.5}$ eV observed by AGASA (1996)
Doi, T, Hayashida, N, Honda, K, Honda, M, Inoue, N, Kadota, K, ...
Tang, Y, Murakami, K, Ishihama, A, DeHaseth, P L
The rightward regulatory region of bacteriophage lambda contains two promoters, pRM and pR, which direct the synthesis of nonoverlapping divergent transcripts from start sites 82 bp apart. Each of...
Hayashida, N, Honda, K, Honda, M, Imaizumi, S, Inoue, N, Kadota, K, ...
Hayashida, N, Honda, K, Honda, M, Imaizumi, S, Inoue, N, Kadota, K, ...
Yoshida, S, Hayashida, N, Honda, K, Honda, M, Imaizumi, S, Inoue, N, ...
Matsuki, H., Miyazawa, H., Yamaguchi, M., Watanabe, T., Murakami, K., Yamamoto, T.
Amorphous magnetic fiber of 10 µm in diameter was developed, which shows high value and desirable frequency characteristic of the permeability. The cloth transformer of thickness less than 1 mm...
Matsuki, H., Miyazawa, H., Yamaguchi, M., Watanabe, T., Murakami, K., Yamamoto, T.
Amorphous magnetic fiber of 10 µm in diameter was developed, which shows high value and desirable frequency characteristic of the permeability. The cloth transformer of thickness less than 1 mm...
Matsuki, H., Miyazawa, H., Yamaguchi, M., Watanabe, T., Murakami, K., Yamamoto, T.
Amorphous magnetic fiber of 10 µm in diameter was developed, which shows high value and desirable frequency characteristic of the permeability. The cloth transformer of thickness less than 1 mm...
Matsuki, H., Miyazawa, H., Yamaguchi, M., Watanabe, T., Murakami, K., Yamamoto, T.
Amorphous magnetic fiber of 10 µm in diameter was developed, which shows high value and desirable frequency characteristic of the permeability. The cloth transformer of thickness less than 1 mm...
Van Brug, H., Bijkerk, F., Gerritsen, H., Murakami, K., Van Der Wiel, M.J.
We present time resolved x-ray absorption measurements (90-300eV) on amorphous silicon foils, that are pulsed laser irradiated. These results are compared with absorption measurements on silicon...
Van Brug, H., Bijkerk, F., Gerritsen, H., Murakami, K., Van Der Wiel, M.J.
We present time resolved x-ray absorption measurements (90-300eV) on amorphous silicon foils, that are pulsed laser irradiated. These results are compared with absorption measurements on silicon...
Van Brug, H., Bijkerk, F., Gerritsen, H., Murakami, K., Van Der Wiel, M.J.
We present time resolved x-ray absorption measurements (90-300eV) on amorphous silicon foils, that are pulsed laser irradiated. These results are compared with absorption measurements on silicon...
Van Brug, H., Bijkerk, F., Gerritsen, H., Murakami, K., Van Der Wiel, M.J.
We present time resolved x-ray absorption measurements (90-300eV) on amorphous silicon foils, that are pulsed laser irradiated. These results are compared with absorption measurements on silicon...
STABILITY OF THE SHAPE MEMORY EFFECT - EFFECT OF GRAIN SIZE REFINEMENT (1982)
Ikai, Y., Murakami, K., Mishima, K.
Resistivity to thermal degradation in repeated martensitic transformation is evaluated through optical reflectivity measurements. Any thermal ageing treatment before thermal loading does not improve...
STABILITY OF THE SHAPE MEMORY EFFECT - EFFECT OF GRAIN SIZE REFINEMENT (1982)
Ikai, Y., Murakami, K., Mishima, K.
Resistivity to thermal degradation in repeated martensitic transformation is evaluated through optical reflectivity measurements. Any thermal ageing treatment before thermal loading does not improve...
STABILITY OF THE SHAPE MEMORY EFFECT - EFFECT OF GRAIN SIZE REFINEMENT (1982)
Ikai, Y., Murakami, K., Mishima, K.
Resistivity to thermal degradation in repeated martensitic transformation is evaluated through optical reflectivity measurements. Any thermal ageing treatment before thermal loading does not improve...
Suzuki, A, Thies, R S, Yamaji, N, Song, J J, Wozney, J M, Murakami, K, ...
Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta (TGF-beta) superfamily, have been implicated in bone formation and the regulation of early development. To...
Shirasaka, T, Murakami, K, Ford, H, Kelley, J A, Yoshioka, H, Kojima, E, ...
Four 2-amino-6-halo- and four 6-halo-2',3'-dideoxypurine ribofuranosides (ddPs) were synthesized and tested for in vitro activity to suppress the infectivity, cytopathic effect, Gag protein...
Inhibition of transcription by the TAR RNA of HIV-1 in a nuclear extract of HeLa cells.
Yamamoto, R, Koseki, S, Ohkawa, J, Murakami, K, Nishikawa, S, Taira, K, ...
Regulation of transcription of human immunodeficiency virus type-1 (HIV-1) requires specific interaction of Tat protein with the trans-activation response region (TAR). Inhibition of replication of...
Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, ...
The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF)...
Murakami, K, Nomura, K, Doi, M, Yoshida, T
Methicillin- and cephem-resistant Staphylococcus aureus (137 strains) for which the cefazolin MICs are at least 25 micrograms/ml could be classified into low-resistance (83% of strains) and...
Murakami, K, Nomura, K, Doi, M, Yoshida, T
A methicillin-resistant strain of Staphylococcus aureus which produced low-affinity penicillin-binding protein 2' (PBP 2') spontaneously lost PBP 2 when the strain was cultivated at 43 degrees C...
Bactericidal activity of M14659 enhanced in low-iron environments.
Mochizuki, H, Yamada, H, Oikawa, Y, Murakami, K, Ishiguro, J, Kosuzume, H, ...
The bactericidal activity of M14659 against Escherichia coli in low-iron environments was investigated and compared with that of ceftriaxone and ceftazidime. The bactericidal activity of M14659...
Tang, Y, Murakami, K, Ishihama, A, DeHaseth, P L
The rightward regulatory region of bacteriophage lambda contains two promoters, pRM and pR, which direct the synthesis of nonoverlapping divergent transcripts from start sites 82 bp apart. Each of...
Boucher, P E, Murakami, K, Ishihama, A, Stibitz, S
The expression of virulence factor genes in Bordetella pertussis is mediated by the BvgA-BvgS two-component signal transduction system. The response regulator, BvgA, acts directly as a...
Chugani, S A, Parsek, M R, Hershberger, C D, Murakami, K, Ishihama, A, Chakrabarty, A M
The soil bacterium Pseudomonas putida is capable of degrading many aromatic compounds, including benzoate, through catechol as an intermediate. The catabolism of catechol is mediated by the catBCA...
Yang, J, Murakami, K, Camakaris, H, Fujita, N, Ishihama, A, Pittard, A J
To examine the role of the amino acid residues (between positions 258 and 275 and positions 297 and 298) of the alpha-subunit of RNA polymerase in TyrR-mediated activation of the mtr promoter, we...
A spontaneous high-level methicillin-resistant mutant, SRM1648, for which the MIC of methicillin is 1,600 microg/ml, was isolated on a plate containing 400 microg of the antibiotic/ml on which had...
From high-level methicillin-resistant Staphylococcus aureus SRM551, the low-level heterogeneously resistant mutant, SRM563, was isolated by transposon mutagenesis. The transposon insertion occurred...
Covalent binding of moxalactam to cephalosporinase of Citrobacter freundii.
The inhibition of Citrobacter freundii cephalosporinase activity by moxalactam is shown to be due to the formation of a transiently stable covalent complex, probably acyl enzyme. The covalent complex...
7 alpha-formylamino substituent confers beta-lactamase-inactivating potency on 1-oxacephalosporins.
Murakami, K, Doi, M, Yoshida, T
7 alpha-Formylamino-1-oxacephalosporins 7 alpha-formylamino-7 beta-[2- (methylaminocarbonyl)amino-2-(2-thienyl)acetamido]-3-[(1-methyl-1H -tetra zol-5-yl)thiomethyl]-1-oxa-3-cephem-4-carboxylic acid...
The effects of the alpha-carboxyl of the phenylmalonyl side chain and the 7 alpha-methoxy group in moxalactam (6059-S) (7 beta-[2-carboxy-2-(4-hydroxyphenyl) acetamido]-7...
Komatsu, Y, Murakami, K, Nishikawa, T
An eschericia coli K-12 mutant highly resistant to moxalactam but only slightly resistant to other beta-lactam antibiotics was obtained by mutagen treatment. The affinity of moxalactam for its target...
1-Oxacephalosporins had a higher ability to penetrate through the outer layer of the envelope of gram-negative bacteria than the corresponding cephalosporins. In spite of the liability of 1-oxa...
In vitro and in vivo antifungal activities of D0870, a new triazole agent.
Yamada, H, Tsuda, T, Watanabe, T, Ohashi, M, Murakami, K, Mochizuki, H
In vitro and in vivo antifungal activities of D0870 were evaluated in comparison with those of fluconazole. D0870, which is the R-enantiomer of ICI195,739, was found to be the mycologically active...
Maki, H, Yamaguchi, T, Murakami, K
Tn918 mutagenesis of a high-level methicillin-resistant Staphylococcus aureus (methicillin MIC, 800 micrograms/ml) led to the isolation of a low-resistance mutant. The Tn918 insert was transferred...
Murakami, K, Hashimoto, Y, Murooka, Y
The gene from Propionibacterium freudenreichii that encodes glutamate 1-semialdehyde 2,1-aminomutase (EC 5.4.3.8), which is involved in the C5 pathway for synthesis of delta-aminolevulinic acid...
A Mucor pusillus mutant defective in asparagine-linked glycosylation.
Murakami, K, Aikawa, J, Wada, M, Horinouchi, S, Beppu, T
A Mucor pusillus mutant defective in asparagine-linked glycosylation was found in our stock cultures. This mutant, designated 1116, secreted aspartic proteinase (MPP) in a less-glycosylated form than...
A methicillin-susceptible, novobiocin-resistant strain of Staphylococcus aureus (RN2677; methicillin MIC, 0.8 micrograms/ml) was transformed with DNA prepared from highly and homogeneously...
Morgan, M E, Chi, S C, Murakami, K, Mitsuya, H, Anderson, B D
AIDS dementia complex is a neurologic disorder, characterized by increasingly severe cognitive, behavioral, and motor impairment, which is associated with human immunodeficiency virus (HIV) infection...
Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction.
Murakami, K, Minamide, W, Wada, K, Nakamura, E, Teraoka, H, Watanabe, S
A simple and reliable method using a polymerase chain reaction (PCR) was devised to identify methicillin-resistant staphylococci. By using lysates of the strain to be tested as templates and 22-mer...
Kobayashi, Y, Okazaki, K, Murakami, K
Of 35 strains of Helicobacter pylori tested, 5 were found to adhere well to HEp-2 cells. We selected three of these adhesive strains and four from the remaining strains to examine their ability to...
Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter.
Tamura, K, Umemura, S, Ishii, M, Tanimoto, K, Murakami, K, Fukamizu, A
Angiotensinogen is shown to be produced by the liver and the hepatoma cell line HepG2. As a first step for understanding the molecular relationship between the transcriptional regulation of the...
Mechanism of cAMP regulation of renin gene transcription by proximal promoter.
Tamura, K, Umemura, S, Yamaguchi, S, Iwamoto, T, Kobayashi, S, Fukamizu, A, ...
Renin is produced mainly by the kidney, and cAMP is a main positive regulator of its synthesis. This study was undertaken to analyze the molecular mechanism of cAMP-mediated regulation of Ren-1C gene...
Murakami, K, Gotschlich, E C, Seiff, M E
The class 2 protein of Neisseria meningitidis is the major outer membrane protein and a porin. A lambda gt11 bank of meningococcal chromosomal DNA was screened with monoclonal antibodies against...
Matsumoto, K, Murakami, K, Okada, N
When salmon total DNA was transcribed in a HeLa cell extract, a discrete 6S RNA was found to be synthesized by RNA polymerase III. We isolated several phage clones containing the 6S RNA gene from a...
Tamura, K, Tanimoto, K, Murakami, K, Fukamizu, A
Renin, a key enzyme controlling blood pressure, is produced mainly in the kidney. To identify the transcriptional regulatory elements of the mouse Ren-1c gene, the promoter regions were fused to the...
Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease.
An endogenous inhibitor of high molecular weight protease was purified from human erythrocytes and partially characterized. The inhibitor was isolated by DEAE-Sephacel ion-exchange chromatography...
Cloning and sequence analysis of cDNA for human renin precursor.
Imai, T, Miyazaki, H, Hirose, S, Hori, H, Hayashi, T, Kageyama, R, ...
The primary structure of human renin precursor has been deduced from its cDNA sequence. A library of cDNA clones was constructed from human kidney poly(A)+ RNA by applying the vector/primer method of...
Structure of the human renin gene.
Miyazaki, H, Fukamizu, A, Hirose, S, Hayashi, T, Hori, H, Ohkubo, H, ...
The human renin gene was isolated from a Charon 4A human genomic library and characterized. The gene spans about 11.7 kilobases and consists of 10 exons and 9 introns that map at points that could be...
Murakami, K, Fujita, N, Ishihama, A
The carboxy-terminal one-third of Escherichia coli RNA polymerase alpha subunit plays a key role in transcription regulation by a group of protein transcription factors and DNA enhancer (UP)...
In vitro mitochondrial import of the purified precursor form (pOTC) of rat ornithine carbamoyltransferase (OTC) is stimulated by a cytosolic factor(s) contained in rabbit reticulocyte lysate. A...
Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol.
Micromolar concentrations of cis-fatty acid synergistically activate type III protein kinase C with diacylglycerol. This synergistic effect occurs at low concentrations of cis-fatty acid and...
Biochemical properties of amphibian bone morphogenetic protein-4 expressed in CHO cells.
Suzuki, A, Nishimatsu, S, Shoda, A, Takebayashi, K, Murakami, K, Ueno, N
The biochemical properties of recombinant amphibian bone morphogenetic protein-4 (BMP-4), the cDNA of which has been cloned recently by screening of a Xenopus cDNA library, was characterized. The...
Chen, S G, Kulju, D, Halt, S, Murakami, K
A long-chain neutral phospholipid, dioleoylphosphatidylcholine, was found to support protein kinase C activation by cis-fatty acid and diacylglycerol (DAG). This effect of phosphatidylcholine (PC) is...
Autoinduction of activin genes in early Xenopus embryos.
Suzuki, A, Nagai, T, Nishimatsu, S, Sugino, H, Eto, Y, Shibai, H, ...
Activin exhibits a potent mesoderm inducing activity towards the ectodermal tissue (animal cap) of Xenopus laevis blastulae. Thus in order to investigate the role of activin in morphogenesis of early...
Similarity between physicochemical properties of recombinant rat prorenin and native inactive renin.
Hosoi, M, Kim, S, Yamauchi, T, Watanabe, T, Murakami, K, Suzuki, F, ...
Rat prorenin was synthesized by Chinese-hamster ovary cells transfected with an expression vector containing rat preprorenin cDNA sequences, then purified by concanavalin A-Sepharose chromatography...
Kamikashi, T., Kizaki, H., Murakami, K., Ishibashi, S.
Hexokinase isoenzyme type I was purified from various rat tissues, and was subjected to kinetic studies in the presence or the absence of p-chloromercuribenzenesulphonate. The mode of the inhibition...
N-Terminal amino acid sequence of the -subunit of human pituitary luteinizing hormone.
Inagami, T, Murakami, K, Puett, D, Hartree, A S, Nureddin, A
Eshete, F, Chung, H, Gannon-Murakami, L, Murakami, K
The C2 domain in protein kinase C (PKC) is homologous to equivalent domains in a number of important cytoplasmic proteins. Except for its implied function in Ca2+ and phospholipid binding, the...
Shiota, N, Fukamizu, A, Okunishi, H, Takai, S, Murakami, K, Miyazaki, M
Chymase is responsible for the formation of angiotensin II, which plays crucial roles in the pathogenesis of cardiovascular diseases. In the present study we determined the gene organization of a...
Murakami, K, Ide, T, Nakazawa, T, Okazaki, T, Mochizuki, T, Kadowaki, T
Peroxisome-proliferator-activated receptors (PPARs) alpha and gamma are ligand-dependent transcription factors that are key regulators of lipid and carbohydrate homoeostasis. Fatty acids bind to the...
Single-molecule imaging of RNA polymerase-DNA interactions in real time.
Harada, Y, Funatsu, T, Murakami, K, Nonoyama, Y, Ishihama, A, Yanagida, T
Using total internal reflection fluorescence microscopy, we have directly observed individual interactions of single RNA polymerase molecules with a single molecule of lambda-phage DNA suspended in...
Human renin in transgenic mouse kidney is localized to juxtaglomerular cells.
Fukamizu, A, Hatae, T, Kon, Y, Sugimura, M, Hasegawa, T, Yokoyama, M, ...
To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the...
Myxoedema coma induced by beta-adrenoreceptor-blocking agent.
Murakami, K, Kasama, T, Hayashi, R, Tsushima, M, Nishioheda, Y, Koh, H, ...
Comparative study of renin expression in the coagulating glands of C57BL/6 and Balb/c mice.
Kon, Y, Endoh, D, Fukamizu, A, Murakami, K, Hashimoto, Y, Sugimura, M
The comparative localisation of renin in the genital organs, especially in the coagulating glands of male mice of the strains C57BL/6 and Balb/c, was investigated using immunocytochemical,...
Kon, Y, Hashimoto, Y, Kitagawa, H, Sugimura, M, Murakami, K
Renin-containing cells in fetal adrenal glands of the mouse were investigated with the protein A-gold immunocytochemical technique. On Day 14 of gestation, a small number of specific granules were...
Suzuki, A, Thies, R S, Yamaji, N, Song, J J, Wozney, J M, Murakami, K, ...
Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta (TGF-beta) superfamily, have been implicated in bone formation and the regulation of early development. To...
Shirasaka, T, Murakami, K, Ford, H, Kelley, J A, Yoshioka, H, Kojima, E, ...
Four 2-amino-6-halo- and four 6-halo-2',3'-dideoxypurine ribofuranosides (ddPs) were synthesized and tested for in vitro activity to suppress the infectivity, cytopathic effect, Gag protein...
Inhibition of transcription by the TAR RNA of HIV-1 in a nuclear extract of HeLa cells.
Yamamoto, R, Koseki, S, Ohkawa, J, Murakami, K, Nishikawa, S, Taira, K, ...
Regulation of transcription of human immunodeficiency virus type-1 (HIV-1) requires specific interaction of Tat protein with the trans-activation response region (TAR). Inhibition of replication of...
Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, ...
The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF)...
Murakami, K, Nomura, K, Doi, M, Yoshida, T
Methicillin- and cephem-resistant Staphylococcus aureus (137 strains) for which the cefazolin MICs are at least 25 micrograms/ml could be classified into low-resistance (83% of strains) and...
Murakami, K, Nomura, K, Doi, M, Yoshida, T
A methicillin-resistant strain of Staphylococcus aureus which produced low-affinity penicillin-binding protein 2' (PBP 2') spontaneously lost PBP 2 when the strain was cultivated at 43 degrees C...
Bactericidal activity of M14659 enhanced in low-iron environments.
Mochizuki, H, Yamada, H, Oikawa, Y, Murakami, K, Ishiguro, J, Kosuzume, H, ...
The bactericidal activity of M14659 against Escherichia coli in low-iron environments was investigated and compared with that of ceftriaxone and ceftazidime. The bactericidal activity of M14659...
Tang, Y, Murakami, K, Ishihama, A, DeHaseth, P L
The rightward regulatory region of bacteriophage lambda contains two promoters, pRM and pR, which direct the synthesis of nonoverlapping divergent transcripts from start sites 82 bp apart. Each of...
Boucher, P E, Murakami, K, Ishihama, A, Stibitz, S
The expression of virulence factor genes in Bordetella pertussis is mediated by the BvgA-BvgS two-component signal transduction system. The response regulator, BvgA, acts directly as a...
Chugani, S A, Parsek, M R, Hershberger, C D, Murakami, K, Ishihama, A, Chakrabarty, A M
The soil bacterium Pseudomonas putida is capable of degrading many aromatic compounds, including benzoate, through catechol as an intermediate. The catabolism of catechol is mediated by the catBCA...
Yang, J, Murakami, K, Camakaris, H, Fujita, N, Ishihama, A, Pittard, A J
To examine the role of the amino acid residues (between positions 258 and 275 and positions 297 and 298) of the alpha-subunit of RNA polymerase in TyrR-mediated activation of the mtr promoter, we...
A spontaneous high-level methicillin-resistant mutant, SRM1648, for which the MIC of methicillin is 1,600 microg/ml, was isolated on a plate containing 400 microg of the antibiotic/ml on which had...
From high-level methicillin-resistant Staphylococcus aureus SRM551, the low-level heterogeneously resistant mutant, SRM563, was isolated by transposon mutagenesis. The transposon insertion occurred...
Covalent binding of moxalactam to cephalosporinase of Citrobacter freundii.
The inhibition of Citrobacter freundii cephalosporinase activity by moxalactam is shown to be due to the formation of a transiently stable covalent complex, probably acyl enzyme. The covalent complex...
7 alpha-formylamino substituent confers beta-lactamase-inactivating potency on 1-oxacephalosporins.
Murakami, K, Doi, M, Yoshida, T
7 alpha-Formylamino-1-oxacephalosporins 7 alpha-formylamino-7 beta-[2- (methylaminocarbonyl)amino-2-(2-thienyl)acetamido]-3-[(1-methyl-1H -tetra zol-5-yl)thiomethyl]-1-oxa-3-cephem-4-carboxylic acid...
The effects of the alpha-carboxyl of the phenylmalonyl side chain and the 7 alpha-methoxy group in moxalactam (6059-S) (7 beta-[2-carboxy-2-(4-hydroxyphenyl) acetamido]-7...
Komatsu, Y, Murakami, K, Nishikawa, T
An eschericia coli K-12 mutant highly resistant to moxalactam but only slightly resistant to other beta-lactam antibiotics was obtained by mutagen treatment. The affinity of moxalactam for its target...
1-Oxacephalosporins had a higher ability to penetrate through the outer layer of the envelope of gram-negative bacteria than the corresponding cephalosporins. In spite of the liability of 1-oxa...
In vitro and in vivo antifungal activities of D0870, a new triazole agent.
Yamada, H, Tsuda, T, Watanabe, T, Ohashi, M, Murakami, K, Mochizuki, H
In vitro and in vivo antifungal activities of D0870 were evaluated in comparison with those of fluconazole. D0870, which is the R-enantiomer of ICI195,739, was found to be the mycologically active...
Maki, H, Yamaguchi, T, Murakami, K
Tn918 mutagenesis of a high-level methicillin-resistant Staphylococcus aureus (methicillin MIC, 800 micrograms/ml) led to the isolation of a low-resistance mutant. The Tn918 insert was transferred...
Murakami, K, Hashimoto, Y, Murooka, Y
The gene from Propionibacterium freudenreichii that encodes glutamate 1-semialdehyde 2,1-aminomutase (EC 5.4.3.8), which is involved in the C5 pathway for synthesis of delta-aminolevulinic acid...
A Mucor pusillus mutant defective in asparagine-linked glycosylation.
Murakami, K, Aikawa, J, Wada, M, Horinouchi, S, Beppu, T
A Mucor pusillus mutant defective in asparagine-linked glycosylation was found in our stock cultures. This mutant, designated 1116, secreted aspartic proteinase (MPP) in a less-glycosylated form than...
A methicillin-susceptible, novobiocin-resistant strain of Staphylococcus aureus (RN2677; methicillin MIC, 0.8 micrograms/ml) was transformed with DNA prepared from highly and homogeneously...
Morgan, M E, Chi, S C, Murakami, K, Mitsuya, H, Anderson, B D
AIDS dementia complex is a neurologic disorder, characterized by increasingly severe cognitive, behavioral, and motor impairment, which is associated with human immunodeficiency virus (HIV) infection...
Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction.
Murakami, K, Minamide, W, Wada, K, Nakamura, E, Teraoka, H, Watanabe, S
A simple and reliable method using a polymerase chain reaction (PCR) was devised to identify methicillin-resistant staphylococci. By using lysates of the strain to be tested as templates and 22-mer...
Kobayashi, Y, Okazaki, K, Murakami, K
Of 35 strains of Helicobacter pylori tested, 5 were found to adhere well to HEp-2 cells. We selected three of these adhesive strains and four from the remaining strains to examine their ability to...
Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter.
Tamura, K, Umemura, S, Ishii, M, Tanimoto, K, Murakami, K, Fukamizu, A
Angiotensinogen is shown to be produced by the liver and the hepatoma cell line HepG2. As a first step for understanding the molecular relationship between the transcriptional regulation of the...
Mechanism of cAMP regulation of renin gene transcription by proximal promoter.
Tamura, K, Umemura, S, Yamaguchi, S, Iwamoto, T, Kobayashi, S, Fukamizu, A, ...
Renin is produced mainly by the kidney, and cAMP is a main positive regulator of its synthesis. This study was undertaken to analyze the molecular mechanism of cAMP-mediated regulation of Ren-1C gene...
Murakami, K, Gotschlich, E C, Seiff, M E
The class 2 protein of Neisseria meningitidis is the major outer membrane protein and a porin. A lambda gt11 bank of meningococcal chromosomal DNA was screened with monoclonal antibodies against...
Matsumoto, K, Murakami, K, Okada, N
When salmon total DNA was transcribed in a HeLa cell extract, a discrete 6S RNA was found to be synthesized by RNA polymerase III. We isolated several phage clones containing the 6S RNA gene from a...
Tamura, K, Tanimoto, K, Murakami, K, Fukamizu, A
Renin, a key enzyme controlling blood pressure, is produced mainly in the kidney. To identify the transcriptional regulatory elements of the mouse Ren-1c gene, the promoter regions were fused to the...
Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease.
An endogenous inhibitor of high molecular weight protease was purified from human erythrocytes and partially characterized. The inhibitor was isolated by DEAE-Sephacel ion-exchange chromatography...
Cloning and sequence analysis of cDNA for human renin precursor.
Imai, T, Miyazaki, H, Hirose, S, Hori, H, Hayashi, T, Kageyama, R, ...
The primary structure of human renin precursor has been deduced from its cDNA sequence. A library of cDNA clones was constructed from human kidney poly(A)+ RNA by applying the vector/primer method of...
Structure of the human renin gene.
Miyazaki, H, Fukamizu, A, Hirose, S, Hayashi, T, Hori, H, Ohkubo, H, ...
The human renin gene was isolated from a Charon 4A human genomic library and characterized. The gene spans about 11.7 kilobases and consists of 10 exons and 9 introns that map at points that could be...
Murakami, K, Fujita, N, Ishihama, A
The carboxy-terminal one-third of Escherichia coli RNA polymerase alpha subunit plays a key role in transcription regulation by a group of protein transcription factors and DNA enhancer (UP)...
In vitro mitochondrial import of the purified precursor form (pOTC) of rat ornithine carbamoyltransferase (OTC) is stimulated by a cytosolic factor(s) contained in rabbit reticulocyte lysate. A...
Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol.
Micromolar concentrations of cis-fatty acid synergistically activate type III protein kinase C with diacylglycerol. This synergistic effect occurs at low concentrations of cis-fatty acid and...
Biochemical properties of amphibian bone morphogenetic protein-4 expressed in CHO cells.
Suzuki, A, Nishimatsu, S, Shoda, A, Takebayashi, K, Murakami, K, Ueno, N
The biochemical properties of recombinant amphibian bone morphogenetic protein-4 (BMP-4), the cDNA of which has been cloned recently by screening of a Xenopus cDNA library, was characterized. The...
Chen, S G, Kulju, D, Halt, S, Murakami, K
A long-chain neutral phospholipid, dioleoylphosphatidylcholine, was found to support protein kinase C activation by cis-fatty acid and diacylglycerol (DAG). This effect of phosphatidylcholine (PC) is...
Autoinduction of activin genes in early Xenopus embryos.
Suzuki, A, Nagai, T, Nishimatsu, S, Sugino, H, Eto, Y, Shibai, H, ...
Activin exhibits a potent mesoderm inducing activity towards the ectodermal tissue (animal cap) of Xenopus laevis blastulae. Thus in order to investigate the role of activin in morphogenesis of early...
Similarity between physicochemical properties of recombinant rat prorenin and native inactive renin.
Hosoi, M, Kim, S, Yamauchi, T, Watanabe, T, Murakami, K, Suzuki, F, ...
Rat prorenin was synthesized by Chinese-hamster ovary cells transfected with an expression vector containing rat preprorenin cDNA sequences, then purified by concanavalin A-Sepharose chromatography...
Human renin in transgenic mouse kidney is localized to juxtaglomerular cells.
Fukamizu, A, Hatae, T, Kon, Y, Sugimura, M, Hasegawa, T, Yokoyama, M, ...
To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the...
Kamikashi, T., Kizaki, H., Murakami, K., Ishibashi, S.
Hexokinase isoenzyme type I was purified from various rat tissues, and was subjected to kinetic studies in the presence or the absence of p-chloromercuribenzenesulphonate. The mode of the inhibition...
N-Terminal amino acid sequence of the -subunit of human pituitary luteinizing hormone.
Inagami, T, Murakami, K, Puett, D, Hartree, A S, Nureddin, A
Eshete, F, Chung, H, Gannon-Murakami, L, Murakami, K
The C2 domain in protein kinase C (PKC) is homologous to equivalent domains in a number of important cytoplasmic proteins. Except for its implied function in Ca2+ and phospholipid binding, the...
Shiota, N, Fukamizu, A, Okunishi, H, Takai, S, Murakami, K, Miyazaki, M
Chymase is responsible for the formation of angiotensin II, which plays crucial roles in the pathogenesis of cardiovascular diseases. In the present study we determined the gene organization of a...
Murakami, K, Ide, T, Nakazawa, T, Okazaki, T, Mochizuki, T, Kadowaki, T
Peroxisome-proliferator-activated receptors (PPARs) alpha and gamma are ligand-dependent transcription factors that are key regulators of lipid and carbohydrate homoeostasis. Fatty acids bind to the...
Comparative study of renin expression in the coagulating glands of C57BL/6 and Balb/c mice.
Kon, Y, Endoh, D, Fukamizu, A, Murakami, K, Hashimoto, Y, Sugimura, M
The comparative localisation of renin in the genital organs, especially in the coagulating glands of male mice of the strains C57BL/6 and Balb/c, was investigated using immunocytochemical,...
Kon, Y, Hashimoto, Y, Kitagawa, H, Sugimura, M, Murakami, K
Renin-containing cells in fetal adrenal glands of the mouse were investigated with the protein A-gold immunocytochemical technique. On Day 14 of gestation, a small number of specific granules were...
Single-molecule imaging of RNA polymerase-DNA interactions in real time.
Harada, Y, Funatsu, T, Murakami, K, Nonoyama, Y, Ishihama, A, Yanagida, T
Using total internal reflection fluorescence microscopy, we have directly observed individual interactions of single RNA polymerase molecules with a single molecule of lambda-phage DNA suspended in...
Myxoedema coma induced by beta-adrenoreceptor-blocking agent.
Murakami, K, Kasama, T, Hayashi, R, Tsushima, M, Nishioheda, Y, Koh, H, ...
Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells.
Ueno, A, Murakami, K, Yamanouchi, K, Watanabe, M, Kondo, T
Interleukin-8 (IL-8) is regarded as an important mediator of inflammation because of its potent and specific chemotactic activity on neutrophils. In the present investigation, human umbilical vein...
Mechanism of haematuria in lupus nephritis.
Makino, H, Kawasaki, H, Murakami, K, Hironaka, K, Amano, T, Ota, Z
Troglitazone decreases collagen accumulation in prediabetic stage of a type II diabetic rat model
YAO, L, MIZUSHIGE, K, NOMA, T, MURAKAMI, K, OHMORI, K, MATSUO, H, ...
Mori, Y, Hosono, M, Murakami, K, Katoh, H, Yoshikawa, Y, Kuribayashi, K, ...
Thymectomy on day 3 after birth induced autoimmune gastritis (AIG) at the age of 2 months in 51-73% of BALB/c mice, and in only 3-5% of DBA/2 mice. AIG was detected by histological and serological...
Murakami, K., Hosono, M., Maruyama, H., Mori, Y., Nishio, A., Fukumoto, M., ...
We examined the role of Mls antigens in the induction of autoimmune gastritis (AIG) in BALB/c and DBA/2 mice subjected to thymectomy. The prevalence of AIG in Mls-1b mice which underwent thymectomy...
CTLA-4 blockade inhibits induction of Helicobacter pylori-associated gastritis in mice
WATANABE, K, MURAKAMI, K, SATO, R, OKIMOTO, T, MAEDA, K, NASU, M, ...
The balance between Th1 and Th2 response determines the outcome of Helicobacter pylori infection. Interferon (IFN)-γ plays an inductive role in gastric inflammation, whereas interleukin (IL)-4...
CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease
Hosokawa, Y, Hosokawa, I, Ozaki, K, Nakae, H, Murakami, K, Miyake, Y, ...
CXCL12 is a CXC chemokine that is related to lymphocyte infiltration and angiogenesis in inflammatory sites such as arthritis. However, the expression and roles of CXCL12 in periodontal disease are...
Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus.
Murakami, K, Nambu, S, Koh, H, Kobayashi, M, Shigeta, Y
Glucose-lowering mechanism by clofibrate was studied in non-insulin dependent diabetics managed with dietary therapy alone. Clofibrate 1500 mg was administered for 1 month to 15 patients, and 75 g...
Ito, K., Nakashima, T., Murakami, K., Murakami, T.
1. Based on the findings in the preceding paper we investigated the ability of pulmonary endothelial cells to metabolize prostaglandin F2 alpha (PGF2 alpha) and angiotensin I (AI), and to produce...
Nitroglycerine-induced biphasic relaxation in vascular smooth muscle of rat aorta.
Karaki, H., Murakami, K., Nakagawa, H., Urakawa, N.
Nitroglycerine induced biphasic relaxation in the rat aorta, previously contracted by noradrenaline; a rapid decrease in tension was followed by a gradual increase reaching a steady level below the...
Karaki, H., Murakami, K., Nakagawa, H., Ozaki, H., Urakawa, N.
1 Several putative calmodulin antagonists have been examined for their inhibitory action on muscle tension and cellular Ca content in the K-depolarized vascular and intestinal smooth muscles. 2 The...
Karaki, H., Murakami, K., Nakagawa, H., Urakawa, N.
Effects of N2-dansyl-L-arginine-4-t-butylpiperidine amide (TI233) on the contractions in vascular and intestinal smooth muscles were examined. High K-induced sustained contractions in the smooth...
Urinary laminin fragments as a tumour marker potentially reflecting basement membrane destruction.
Katayama, M., Kamihagi, K., Hirai, S., Kurome, T., Murakami, K., Hino, F., ...
The presence of soluble laminin fragments in urine of healthy subjects, patients with diabetes, and patients with tumours was studied using sandwich immunoenzymometric assay technique. The form of...
Doki, Y, Murakami, K, Yamaura, T, Sugiyama, S, Misaki, T, Saiki, I
This study is designed to establish a pulmonary tumour model to investigate the biology and therapy of lung cancer in mice. Current methods for forming a solitary intrapulmonary nodule and subsequent...