Eltsev, Yu., Yamada, Y., Nakao, K.
We report on transport properties of grain boundaries fabricated in YBa2Cu3O7-x thin films grown by the liquid phase epitaxy (LPE) technique on MgO asymmetrical bicrystal substrate with 45o...
Electrical transport properties of pure phase Bi-2223 single crystal (2009)
Eltsev, Yu., Lee, S., Nakao, K., Tajima, S.
We have studied electrical transport properties of pure phase Bi2Sr2Ca2Cu3O10+x single crystal below Tc. In magnetic fields B parallel c-axis just above resistance onset R(T) data are well fitted to...
Vortex glass scaling in Pb-doped Bi2223 single crystal (2009)
Eltsev, Yu., Lee, S., Nakao, K., Tajima, S.
We report on study of the vortex liquid in Pb-doped Bi-2223 single crystal using the in-plane resistivity measurements as a function of temperature and magnetic field up to 6T applied perpendicular...
Quantum circuits for solving one-dimensional Schr\"odinger equations (2009)
We construct quantum circuits for solving one-dimensional Schr\"odinger equations. Simulations of three typical examples, i.e., harmonic oscillator, square-well and Coulomb potential, show that...
A JAVA-BASED EPICS ARCHIVE VIEWER WITH SOAP INTERFACE FOR DATA RETRIEVAL (2008)
K. Furukawa, M. Satoh, I. Mejuev, K. Nakao
In advanced physics experiment systems like a large particle accelerators, it is important that physicists can easily analyze device behavior based on archived data to achieve an optimal result of...
APPLICATION TECHNOLOGY OF ALUMINUM BLOW FORMING FOR AUTOMOTIVE CLOSURE PANEL (2008)
Saito, K., Watanabe, J., Yokoyama, O., Nakao, K.
Replacement by aluminum for the closure panels is one of the common methods for lightening car body. However the application used to be limited into shallow drawing parts like hood because of its low...
APPLICATION TECHNOLOGY OF ALUMINUM BLOW FORMING FOR AUTOMOTIVE CLOSURE PANEL (2008)
Saito, K., Watanabe, J., Yokoyama, O., Nakao, K.
Replacement by aluminum for the closure panels is one of the common methods for lightening car body. However the application used to be limited into shallow drawing parts like hood because of its low...
Ando, M., Kawamura, Seiji, Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...
DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected...
The Japanese space gravitational wave antenna: DECIGO (2008)
Kawamura, Seiji, Ando, M., Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...
DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational...
The Japanese space gravitational wave antenna - DECIGO (2008)
Kawamura, Seiji, Ando, M., Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...
DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. The goal of DECIGO is to detect gravitational waves from various kinds of...
H Itoh, K Nakao, M Mukoyama, S Shiono, N Morii, A Sugawara, ...
Effects of intravenously administered beta-human atrial natriuretic polypeptide in humans
K. Nakao, S. Suenaga, K. Furumoto, M. Yoshimoto, K. Fukunaga
The effects of suspended solid particles on the hydrodynamic and mass transfer properties were experimentally studied in a wide range of the superficial gas velocity, solid particle property and...
Compensation of the Crossing Angle with Crab Cavities at KEKB (2007)
Abe, T., Akai, K., Akemoto, M., Akiyama, A., Arinaga, M., Ebihara, K., ...
Crab cavities have been installed in the KEKB B--Factory rings to compensate the crossing angle at the collision point and thus increase luminosity. The beam operation with crab crossing has been...
Upstream migration of adult chum and pink salmon in the Shibetsu River (2007)
Makiguchi, Y., Nii, H., Nakao, K., Ueda, H.
The migratory behavior and swimming patterns of anadromous upstream migratory fish have been poorly described in the Shibetsu River in eastern Hokkaido, Japan. In this 2004 study, we used...
Upstream migration of adult chum and pink salmon in the Shibetsu River (2007)
Makiguchi, Y., Nii, H., Nakao, K., Ueda, H.
The migratory behavior and swimming patterns of anadromous upstream migratory fish have been poorly described in the Shibetsu River in eastern Hokkaido, Japan. In this 2004 study, we used...
Joint LIGO and TAMA300 search for gravitational waves from inspiralling neutron star binaries (2006)
Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Agresti, J., Ajith, P., ...
We search for coincident gravitational wave signals from inspiralling neutron star binaries using LIGO and TAMA300 data taken during early 2003. Using a simple trigger exchange method, we perform an...
Physical and functional interactions between Daxx and STAT3. (2006)
Muromoto, R., Nakao, K., Watanabe, T., Sato, N., Sekine, Y., Sugiyama, K., ...
Signal transducer and activator of transcription 3 (STAT3) play key roles in the intracellular signaling pathways of the interleukin (IL)-6 family of cytokines, which exhibit a diverse set of...
Physical and functional interactions between Daxx and STAT3. (2006)
Muromoto, R., Nakao, K., Watanabe, T., Sato, N., Sekine, Y., Sugiyama, K., ...
Signal transducer and activator of transcription 3 (STAT3) play key roles in the intracellular signaling pathways of the interleukin (IL)-6 family of cytokines, which exhibit a diverse set of...
Joint LIGO and TAMA300 search for gravitational waves from inspiralling neutron star binaries (2006)
Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Agresti, Juri, Ajith, P., ...
We search for coincident gravitational wave signals from inspiralling neutron star binaries using LIGO and TAMA300 data taken during early 2003. Using a simple trigger exchange method, we perform an...
Akutsu, Tomomi, Akutsu, Tomotadu, Ando, Masaki, Arai, Koji, Araya, Akito, Asada, H., ...
We analyze the data of the TAMA300 detector to search for gravitational waves from inspiraling compact star binaries with masses of the component stars in the range 1M[sun]–3M[sun]. In this...
Upper limits from the LIGO and TAMA detectors on the rate of gravitational-wave bursts (2005)
Abbott,B., Abbott,R., Adhikari,R., Ageev,A., Agresti,J., Ajith,P., ...
Upper limits from the LIGO and TAMA detectors on the rate of gravitational-wave bursts (2005)
Abbott,B., Abbott,R., Adhikari,R., Ageev,A., Agresti,J., Ajith,P., ...
Upper limits from the LIGO and TAMA detectors on the rate of gravitational-wave bursts (2005)
Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Agresti, Juri, Ajith, P., ...
Ando, M., Arai, K., Aso, Y., Beyersdorf, P. T., Hayama, K., Iida, Y., ...
Upper limits from the LIGO and TAMA detectors on the rate of gravitational-wave bursts (2005)
Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Agresti, J., Ajith, P., ...
Nishida, T, Kubota, S, Kojima, S, Kuboki, T, Nakao, K, Kushibiki, T, ...
Nishida, T, Kubota, S, Kuboki, T, Nakao, K, Kushibiki, T, Tabata, Y, ...
Anisotropic resistivity and Hall effect in MgB2 single crystals (2002)
Eltsev, Yu., Nakao, K., Lee, S., Masui, T., Chikumoto, N., Tajima, S., ...
We report resistivity and the Hall effect measurements in the normal and superconducting states of MgB2 single crystal. The resistivity has been found to be anisotropic with slightly temperature...
Anisotropic Superconducting Properties of MgB2 Single Crystals (2002)
Eltsev, Yu., Lee, S., Nakao, K., Chikumoto, N., Tajima, S., Koshizuka, N., ...
In-plane electrical transport properties of MgB2 single crystals grown under high pressure of 4-6 GPa and temperature of 1400-1700oC in Mg-B-N system have been measured. For all specimens we found...
Eltsev, Yu., Lee, S., Nakao, K., Chikumoto, N., Tajima, S., Koshizuka, N., ...
We report on study of the electronic anisotropy of the newly discovered MgB2 superconductor using the in-plane resistivity measurements in magnetic field applied perpendicular and parallel to Mg and...
Suzuki, S., Higai, S., Nakao, K.
We study two-dimensional sigma-hole systems in boron layers by calculating the electronic structures of Mg_{1-x}Na_xB_2 and Mg_{1-x}Al_xB_2. In Mg_{1-x}Na_xB_2, it is found that the concentration of...
Newtonian Analysis of Gravitational Waves from Naked Singularity (2000)
Nakao, K., Iguchi, H., Harada, T.
Spherical dust collapse generally forms a shell focusing naked singularity at the symmetric center. This naked singularity is massless. Further the Newtonian gravitational potential and speed of the...
Sato, T, Oyake, M, Nakamura, K, Nakao, K, Fukusima, Y, Onodera, O, ...
Inoue, M., Itoh, H., Ueda, M., Naruko, T., Kojima, A., Komatsu, R., ...
Nanno, H, Sagawa, N, Itoh, H, Matsumoto, T, Terakawa, K, Mori, T, ...
Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases (1998)
Tanaka, M, Ozaki, S, Osakada, F, Mori, K, Okubo, M, Nakao, K
SPIN-FLIP TRANSITION OF Y3Fe5O12 IN ULTRA-HIGH MAGNETIC FIELDS UP TO 350 T (1988)
Nakao, K., Goto, T., Miura, N.
Faraday rotation of YIG at a wavelength of 1.15 µm was measured at low temperatures in ultra-high magnetic fields up to 350 T generated by an electromagnetic flux compression system, and the...
SPIN-FLIP TRANSITION OF Y3Fe5O12 IN ULTRA-HIGH MAGNETIC FIELDS UP TO 350 T (1988)
Nakao, K., Goto, T., Miura, N.
Faraday rotation of YIG at a wavelength of 1.15 µm was measured at low temperatures in ultra-high magnetic fields up to 350 T generated by an electromagnetic flux compression system, and the...
SPIN-FLIP TRANSITION OF Y3Fe5O12 IN ULTRA-HIGH MAGNETIC FIELDS UP TO 350 T (1988)
Nakao, K., Goto, T., Miura, N.
Faraday rotation of YIG at a wavelength of 1.15 µm was measured at low temperatures in ultra-high magnetic fields up to 350 T generated by an electromagnetic flux compression system, and the...
II. - CRYSTAL, IONIC, AND MAGNETIC STRUCTURESPHYSICAL ASPECTS OF MAGNETITE (1977)
Iida, S., Mizushima, K., Mizoguchi, M., Mada, J., Umemura, S., Yoshida, J., ...
After presenting a hystorical review of the physical studies on magnetite, our recent studies on the low temperature phase of Fe3O4 are surveyed. X-ray diffraction with superstructure lines...
II. - CRYSTAL, IONIC, AND MAGNETIC STRUCTURESPHYSICAL ASPECTS OF MAGNETITE (1977)
Iida, S., Mizushima, K., Mizoguchi, M., Mada, J., Umemura, S., Yoshida, J., ...
After presenting a hystorical review of the physical studies on magnetite, our recent studies on the low temperature phase of Fe3O4 are surveyed. X-ray diffraction with superstructure lines...
II. - CRYSTAL, IONIC, AND MAGNETIC STRUCTURESPHYSICAL ASPECTS OF MAGNETITE (1977)
Iida, S., Mizushima, K., Mizoguchi, M., Mada, J., Umemura, S., Yoshida, J., ...
After presenting a hystorical review of the physical studies on magnetite, our recent studies on the low temperature phase of Fe3O4 are surveyed. X-ray diffraction with superstructure lines...
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
Tsuzuki, T, Fujii, Y, Sakumi, K, Tominaga, Y, Nakao, K, Sekiguchi, M, ...
The mouse Rad51 gene is a mammalian homologue of the Escherichia coli recA and yeast RAD51 genes, both of which are involved in homologous recombination and DNA repair. To elucidate the physiological...
Kawamoto, T, Mitsuuchi, Y, Toda, K, Yokoyama, Y, Miyahara, K, Miura, S, ...
A gene encoding steroid 18-hydroxylase (P-450C18) was isolated from a human genomic DNA library. It was identified as CYP11B2, which was previously postulated to be a pseudogene or a less active gene...
Nakagawa, O, Ogawa, Y, Itoh, H, Suga, S, Komatsu, Y, Kishimoto, I, ...
We previously demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone mainly produced in the ventricle, while the major production site of atrial natriuretic peptide (ANP) is the...
Ogawa, Y, Itoh, H, Tamura, N, Suga, S, Yoshimasa, T, Uehira, M, ...
Brain natriuretic peptide (BNP) is a cardiac hormone that occurs predominantly in the ventricle. To study the roles of BNP in chronic cardiovascular regulation, we isolated mouse BNP cDNA and genomic...
Mukoyama, M, Nakao, K, Hosoda, K, Suga, S, Saito, Y, Ogawa, Y, ...
Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of...
Yasue, H, Obata, K, Okumura, K, Kurose, M, Ogawa, H, Matsuyama, K, ...
To examine whether atrial natriuretic polypeptide (ANP) is released from the left ventricle in patients with dilated cardiomyopathy (DCM) we measured plasma ANP level in the aortic root (Ao), the...
Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.
Saito, Y, Nakao, K, Arai, H, Nishimura, K, Okumura, K, Obata, K, ...
To elucidate the expression of the atrial natriuretic polypeptide (ANP) gene in the ventricle of the human failing heart, we have measured ANP and ANP messenger RNA (ANPmRNA) levels in left...
Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, ...
To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of...
Suga, S, Nakao, K, Itoh, H, Komatsu, Y, Ogawa, Y, Hama, N, ...
C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is thus far known to be distributed mainly in the central nervous system and is considered to act as a...
Nakao, K, Miyao, Y, Ohe, Y, Tamaoki, T
Human hepatitis B virus infection is characterized by a high degree of hepatotropism which may be due to the dependency of viral genes on specific host factors for their expression. To learn more...
c-Ha-ras down regulates the alpha-fetoprotein gene but not the albumin gene in human hepatoma cells.
Nakao, K, Lawless, D, Ohe, Y, Miyao, Y, Nakabayashi, H, Kamiya, H, ...
We studied the effects of transfection of the normal c-Ha-ras gene, rasGly-12, and its oncogenic mutant, rasVal-12, on expression of the alpha-fetoprotein (AFP) and albumin genes in a human hepatoma...
Serum leptin level is a regulator of bone mass
Elefteriou, F., Takeda, S., Ebihara, K., Magre, J., Patano, N., Ae Kim, C., ...
Leptin is a powerful inhibitor of bone formation in vivo. This antiosteogenic function involves leptin binding to its receptors on ventromedial hypothalamic neurons, the autonomous nervous system and...
Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma.
Yoshimasa, T, Nakao, K, Ohtsuki, H, Li, S, Imura, H
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these...
Nakao, K, Nakai, Y, Oki, S, Horii, K, Imura, H
To elucidate whether or not beta-endorphin exists in plasma of normal subjects, plasma extracts obtained before and after metyrapone administration were subjected to gel exclusion chromatography, and...
Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, ...
To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, 20 human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human...
Myosin heavy chain gene expression in human heart failure.
Nakao, K, Minobe, W, Roden, R, Bristow, M R, Leinwand, L A
Two isoforms of myosin heavy chain (MyHC), alpha and beta, exist in the mammalian ventricular myocardium, and their relative expression is correlated with the contractile velocity of cardiac muscle....
Watanabe, N, Madaule, P, Reid, T, Ishizaki, T, Watanabe, G, Kakizuka, A, ...
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a mammalian homolog...
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells.
Matsuda, T, Nakamura, T, Nakao, K, Arai, T, Katsuki, M, Heike, T, ...
Embryonic stem (ES) cells can be maintained in an undifferentiated state in the presence of leukemia inhibitory factor (LIF). LIF acts through a receptor complex composed of a low affinity LIF...
Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.
Miyamoto, Y, Yoshimasa, T, Arai, H, Takaya, K, Ogawa, Y, Itoh, H, ...
In order to elucidate the regulatory mechanisms of expression of the human endothelin-A receptor (hET-AR) gene, we characterized hET-AR transcripts using reverse transcriptase (RT)-PCR analysis in a...
Preservation of recurrent laryngeal nerve invaded by differentiated thyroid cancer.
Nishida, T, Nakao, K, Hamaji, M, Kamiike, W, Kurozumi, K, Matsuda, H
OBJECTIVE: This study was undertaken to determine whether the recurrent laryngeal nerve involved in differentiated thyroid carcinoma could be preserved. SUMMARY BACKGROUND DATA: Few investigations...
Influence of vitamin A on wound healing in rats with femoral fracture.
Seifter, E, Crowley, L V, Rettura, G, Nakao, K, Gruber, C, Kan, D, ...
Groups of healthy wounded rats with and without comminuted femoral fractures, and maintained on nutritionally complete commercial rat chow with and without supplemental vitamin A, were studied. The...
An appraisal of radical pancreatoduodenectomy based on glucagon secretion.
Miyata, M, Hamaji, M, Yamamoto, T, Nakao, K, Sakaguchi, H, Sakamoto, T
In an attempt to elucidate changes in endocrine functions of the pancreas associated with radical pancreatectomy for periampullary cancer, plasma levels of insulin (IRI) and pancreatic glucagon (IRG)...
Gastric inhibitory polypeptide secretion after radical pancreatoduodenectomy.
Miyata, M, Nakao, K, Tanaka, Y, Sakamoto, T, Hamaji, M, Taketani, H, ...
To elucidate the role of gastric inhibitory polypeptide (GIP) in the alteration of insulin secretion following pancreatoduodenal resection, in which the main sources of GIP are removed, plasma levels...
Levenson, S M, Kan, D, Gruber, C, Crowley, L, Jaffe, E R, Nakao, K, ...
Inoue, Y, Oike, M, Nakao, K, Kitamura, K, Kuriyama, H
1. The effects of endothelin (ET) on the Ca2+ channel current in smooth muscle cells of the guinea-pig portal vein were investigated using the patch-clamp technique with whole-cell and cell-attached...
Referral patterns to and from inpatient psychiatric services: a social network approach.
Nakao, K, Milazzo-Sayre, L J, Rosenstein, M J, Manderscheid, R W
Interorganizational linkages have assumed more import for mental health service systems during the past three decades because of increased levels of complexity in service delivery patterns. This...
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
Tsuzuki, T, Fujii, Y, Sakumi, K, Tominaga, Y, Nakao, K, Sekiguchi, M, ...
The mouse Rad51 gene is a mammalian homologue of the Escherichia coli recA and yeast RAD51 genes, both of which are involved in homologous recombination and DNA repair. To elucidate the physiological...
Kawamoto, T, Mitsuuchi, Y, Toda, K, Yokoyama, Y, Miyahara, K, Miura, S, ...
A gene encoding steroid 18-hydroxylase (P-450C18) was isolated from a human genomic DNA library. It was identified as CYP11B2, which was previously postulated to be a pseudogene or a less active gene...
Nakagawa, O, Ogawa, Y, Itoh, H, Suga, S, Komatsu, Y, Kishimoto, I, ...
We previously demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone mainly produced in the ventricle, while the major production site of atrial natriuretic peptide (ANP) is the...
Ogawa, Y, Itoh, H, Tamura, N, Suga, S, Yoshimasa, T, Uehira, M, ...
Brain natriuretic peptide (BNP) is a cardiac hormone that occurs predominantly in the ventricle. To study the roles of BNP in chronic cardiovascular regulation, we isolated mouse BNP cDNA and genomic...
Mukoyama, M, Nakao, K, Hosoda, K, Suga, S, Saito, Y, Ogawa, Y, ...
Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of...
Yasue, H, Obata, K, Okumura, K, Kurose, M, Ogawa, H, Matsuyama, K, ...
To examine whether atrial natriuretic polypeptide (ANP) is released from the left ventricle in patients with dilated cardiomyopathy (DCM) we measured plasma ANP level in the aortic root (Ao), the...
Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.
Saito, Y, Nakao, K, Arai, H, Nishimura, K, Okumura, K, Obata, K, ...
To elucidate the expression of the atrial natriuretic polypeptide (ANP) gene in the ventricle of the human failing heart, we have measured ANP and ANP messenger RNA (ANPmRNA) levels in left...
Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, ...
To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of...
Suga, S, Nakao, K, Itoh, H, Komatsu, Y, Ogawa, Y, Hama, N, ...
C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is thus far known to be distributed mainly in the central nervous system and is considered to act as a...
Nakao, K, Miyao, Y, Ohe, Y, Tamaoki, T
Human hepatitis B virus infection is characterized by a high degree of hepatotropism which may be due to the dependency of viral genes on specific host factors for their expression. To learn more...
c-Ha-ras down regulates the alpha-fetoprotein gene but not the albumin gene in human hepatoma cells.
Nakao, K, Lawless, D, Ohe, Y, Miyao, Y, Nakabayashi, H, Kamiya, H, ...
We studied the effects of transfection of the normal c-Ha-ras gene, rasGly-12, and its oncogenic mutant, rasVal-12, on expression of the alpha-fetoprotein (AFP) and albumin genes in a human hepatoma...
Serum leptin level is a regulator of bone mass
Elefteriou, F., Takeda, S., Ebihara, K., Magre, J., Patano, N., Ae Kim, C., ...
Leptin is a powerful inhibitor of bone formation in vivo. This antiosteogenic function involves leptin binding to its receptors on ventromedial hypothalamic neurons, the autonomous nervous system and...
Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma.
Yoshimasa, T, Nakao, K, Ohtsuki, H, Li, S, Imura, H
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these...
Nakao, K, Nakai, Y, Oki, S, Horii, K, Imura, H
To elucidate whether or not beta-endorphin exists in plasma of normal subjects, plasma extracts obtained before and after metyrapone administration were subjected to gel exclusion chromatography, and...
Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, ...
To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, 20 human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human...
Myosin heavy chain gene expression in human heart failure.
Nakao, K, Minobe, W, Roden, R, Bristow, M R, Leinwand, L A
Two isoforms of myosin heavy chain (MyHC), alpha and beta, exist in the mammalian ventricular myocardium, and their relative expression is correlated with the contractile velocity of cardiac muscle....
Watanabe, N, Madaule, P, Reid, T, Ishizaki, T, Watanabe, G, Kakizuka, A, ...
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a mammalian homolog...
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells.
Matsuda, T, Nakamura, T, Nakao, K, Arai, T, Katsuki, M, Heike, T, ...
Embryonic stem (ES) cells can be maintained in an undifferentiated state in the presence of leukemia inhibitory factor (LIF). LIF acts through a receptor complex composed of a low affinity LIF...
Inoue, Y, Oike, M, Nakao, K, Kitamura, K, Kuriyama, H
1. The effects of endothelin (ET) on the Ca2+ channel current in smooth muscle cells of the guinea-pig portal vein were investigated using the patch-clamp technique with whole-cell and cell-attached...
Preservation of recurrent laryngeal nerve invaded by differentiated thyroid cancer.
Nishida, T, Nakao, K, Hamaji, M, Kamiike, W, Kurozumi, K, Matsuda, H
OBJECTIVE: This study was undertaken to determine whether the recurrent laryngeal nerve involved in differentiated thyroid carcinoma could be preserved. SUMMARY BACKGROUND DATA: Few investigations...
Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.
Miyamoto, Y, Yoshimasa, T, Arai, H, Takaya, K, Ogawa, Y, Itoh, H, ...
In order to elucidate the regulatory mechanisms of expression of the human endothelin-A receptor (hET-AR) gene, we characterized hET-AR transcripts using reverse transcriptase (RT)-PCR analysis in a...
Influence of vitamin A on wound healing in rats with femoral fracture.
Seifter, E, Crowley, L V, Rettura, G, Nakao, K, Gruber, C, Kan, D, ...
Groups of healthy wounded rats with and without comminuted femoral fractures, and maintained on nutritionally complete commercial rat chow with and without supplemental vitamin A, were studied. The...
An appraisal of radical pancreatoduodenectomy based on glucagon secretion.
Miyata, M, Hamaji, M, Yamamoto, T, Nakao, K, Sakaguchi, H, Sakamoto, T
In an attempt to elucidate changes in endocrine functions of the pancreas associated with radical pancreatectomy for periampullary cancer, plasma levels of insulin (IRI) and pancreatic glucagon (IRG)...
Gastric inhibitory polypeptide secretion after radical pancreatoduodenectomy.
Miyata, M, Nakao, K, Tanaka, Y, Sakamoto, T, Hamaji, M, Taketani, H, ...
To elucidate the role of gastric inhibitory polypeptide (GIP) in the alteration of insulin secretion following pancreatoduodenal resection, in which the main sources of GIP are removed, plasma levels...
Levenson, S M, Kan, D, Gruber, C, Crowley, L, Jaffe, E R, Nakao, K, ...
Referral patterns to and from inpatient psychiatric services: a social network approach.
Nakao, K, Milazzo-Sayre, L J, Rosenstein, M J, Manderscheid, R W
Interorganizational linkages have assumed more import for mental health service systems during the past three decades because of increased levels of complexity in service delivery patterns. This...
Moon, B-G, Yoshida, T, Shiiba, M, Nakao, K, Katsuki, M, Takaki, S, ...
The interleukin-5 receptor α chain (IL-5Rα) is known to regulate the development and function of B cells and eosinophils. Although the functions of IL-5Rα cytoplasmic domain subregions have been...
Sobajima, J, Ozaki, S, Uesugi, H, Osakada, F, Inoue, M, Fukuda, Y, ...
BACKGROUND—High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 have been identified as novel antigens of perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCAs), and the...
Ishikawa, H, Nakao, K, Matsumoto, K, Nishimura, D, Ichikawa, T, Hamasaki, K, ...
Background and aim: Recent studies indicated that hepatic stem cells in the bone marrow could differentiate into mature hepatocytes, suggesting that bone marrow cells could be used for replacement of...
Hasegawa, K., Fujiwara, H., Doyama, K., Mukoyama, M., Nakao, K., Fujiwara, T., ...
Although brain natriuretic peptide is expressed in ventricles of failing hearts including dilated cardiomyopathy, its morphological localization is still unclear. In this study, we analyzed the...
Brain natriuretic peptide predicts mortality in the elderly.
Wallén, T., Landahl, S., Hedner, T., Nakao, K., Saito, Y.
OBJECTIVE: To study whether prospective measurements of circulating concentrations of brain natriuretic peptide (BNP) could predict mortality in the general elderly population. DESIGN AND SETTING:...
Yoshimura, M, Yasue, H, Tanaka, H, Kikuta, K, Sumida, H, Kato, H, ...
BACKGROUND--Plasma concentrations of A type or atrial natriuretic peptide (ANP) and B type or brain natriuretic peptide (BNP) are increased in patients with congestive heart failure (CHF)....
Seroprevalence of antibodies to HTLV-I in patients with ocular disorders.
Nakao, K, Matsumoto, M, Ohba, N
Human T-lymphotropic virus type 1 (HTLV-I) has been shown to spread worldwide and to be responsible for distinct systemic diseases, namely adult T-cell leukaemia and HTLV-I-associated myelopathy....
Clinical features of HTLV-I associated uveitis.
The prevalence of human T cell lymphoma virus type 1 (HTLV-I) was studied among patients with endogenous uveitis. Twelve (15.8%) of 76 uveitis patients with known aetiology or clinical entity were...
AIMS: To elucidate whether there exists any clinical sign characteristic of HTLV-I associated uveitis. METHODS: Fifty five patients with HTLV-I associated uveitis were reviewed. These cases had serum...
Haemorrhage in the lens: spontaneous occurrence in congenital cataract.
A 2-month-old female infant had bilateral congenital cataract. In the left eye a blood clot was situated on the subcapsular polar cataract. An uneventful lensectomy combined with anterior vitrectomy...
Ota, H, Kumagai, S, Morinobu, A, Yanagida, H, Nakao, K
Systemic sclerosis (SSc) is characterized by systemic fibrosis and microvascular lesions. As TGF-beta is suggested to be related to skin fibrosis, we examined the production of TGF-beta from...
Miyashita, T, Kawakami, A, Nakashima, T, Yamasaki, S, Tamai, M, Tanaka, F, ...
We examined the role of osteoprotegerin (OPG) on tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in rheumatoid fibroblast-like synovial cells (FLS). OPG protein...
SOBAJIMA, J, OZAKI, S, OSAKADA, F, UESUGI, H, SHIRAKAWA, H, YOSHIDA, M, ...
Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from ulcerative colitis (UC) patients have been described as reacting with proteins in the granules of human neutrophils such as cathepsin G and...
Sobajima, J, Ozaki, S, Uesugi, H, Osakada, F, Shirakawa, H, Yoshida, M, ...
In a previous study, we reported that the high mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 were novel target antigens of P-ANCA. In this study, we determined the...
Akamizu, T, Ozaki, S, Hiratani, H, Uesugi, H, Sobajima, J, Hataya, Y, ...
Although antineutrophil antibodies are thought to be involved in drug-induced neutropenia, neither the precise mechanisms nor the particular antigens on the neutrophil surface have yet been...
Leptin inhibits stress-induced apoptosis of T lymphocytes
FUJITA, Y, MURAKAMI, M, OGAWA, Y, MASUZAKI, H, TANAKA, M, OZAKI, S, ...
Leptin, which is secreted by adipocytes, the placenta and the stomach, not only controls appetite through leptin receptors in the hypothalamus but also regulates cell-mediated immunity. In this study...
Terada, K., Nakao, K., Okabe, K., Kitamura, K., Kuriyama, H.
1. The effect of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester hydrochloride (KW-3049) on the smooth muscle membrane of the...
Nakao, K., Okabe, K., Kitamura, K., Kuriyama, H., Weston, A. H.
1. The effects of cromakalim (BRL 34915) on the smooth muscle cells of guinea-pig mesenteric artery and vein were investigated with microelectrode and tension recording methods. 2. Cromakalim...
Nishiye, E., Nakao, K., Itoh, T., Kuriyama, H.
1. Factors inducing dilatation of guinea-pig basilar artery were investigated in intact and endothelium-denuded tissues by measurement of isometric tension and by electrophysiological methods. 2. The...
Ho, W. K., Nakao, K., Shibata, S.
1. Two arginine derivatives that were developed as thrombin inhibitors (TI-189 and TI-233) selectively inhibited the 5-hydroxytryptamine (5-HT)-induced contraction of rabbit aortic strips in a...
Beech, D. J., Zhang, H., Nakao, K., Bolton, T. B.
1. Single channel and whole-cell current recordings were made from single smooth muscle cells isolated from the rabbit portal vein. 2. Application of 10 microM levcromakalim ((-)-Ckm) to single cells...
Beech, D. J., Zhang, H., Nakao, K., Bolton, T. B.
1. Whole-cell and inside-out patch recordings were made from single smooth muscle cells that had been isolated enzymatically and mechanically from the rabbit portal vein. 2. In whole-cells the...
A vascular smooth muscle-specific CD4+ T cell line that induces pulmonary vasculitis in MRL-+/+ mice
SUMITA, S, OZAKI, S, OKAZAKI, T, SOBAJIMA, J, NAKAO, K
We established a T cell line, MV1, specific for rat vascular smooth muscle antigen from the regional lymph nodes of immunized MRL/Mp-+/+ mice. Adoptive transfer of MV1 T cells induced vasculitis...
SOBAJIMA, J, OZAKI, S, OKAZAKI, T, OSAKADA, F, SUMITA, S, MORI, K, ...
We analysed the clinical significance of ANCA in patients with ulcerative colitis. On either an indirect immunofluorescence assay or an ELISA with fixed neutrophils, 71% (25/35) of the patients were...
Shimizu, K, Chin, K, Nakamura, T, Masuzaki, H, Ogawa, Y, Hosokawa, R, ...
Background: The control of body weight and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) are important because both factors have significant...
Ito, Y, Matsuura, N, Sakon, M, Takeda, T, Umeshita, K, Nagano, H, ...
In this study, we investigated the proliferating cell index by the percentage of Ki-67 expressing cells (Ki-67 LI) and the apoptotic index (AI) by the number of morphologically apoptotic cells per...
The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma
Ito, Y, Monden, M, Takeda, T, Eguchi, H, Umeshita, K, Nagano, H, ...
The status of Fas and Fas ligand (Fas L) expression was investigated in this study for 103 hepatocellular carcinomas (HCC). We studied the expression of the following three factors, Fas and Fas L...