Long-Term Maintenance of Human Keratinocytes In Vitro (2005)
Jens Hasskarl, Palanivel Velupillai, Siribang-on Piboonniyom, Miranda Grace, Karl Münger
Duensing, Stefan, Lee, Benjamin H, Cin, Paola, Münger, Karl
Abstract Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and...
Expression of the synthetic gene of an artificial DDT-binding polypeptide in Escherichia coli (1987)
Moser, Rudolf, Frey, Stefan, Münger, Karl, Hehlgans, Thomas, Klauser, Stephan, Langen, Hanno, ...
This paper reports the expression of an artificial functional polypeptide in bacteria. The gene of a designed 24-residue DDT-binding polypeptide (DBP) was inserted between the BamHI and PstI cleavage...
Syken, Josh, De-Medina, Tali, Münger, Karl
Mitochondria have emerged as central regulators of apoptosis. Here, we show that TID1, a human homolog of the Drosophila tumor suppressor lethal (2) tumorous imaginal discs, l(2)tid, encodes two...
Immortalization of primary human keratinocytes by the helix–loop–helix protein, Id-1
Alani, Rhoda M., Hasskarl, Jens, Grace, Miranda, Hernandez, Maria-Clementia, Israel, Mark A., Münger, Karl
Basic helix–loop–helix (bHLH) DNA-binding proteins have been demonstrated to regulate tissue-specific transcription within multiple cell lineages. The Id family of helix–loop–helix proteins...
Duensing, Stefan, Lee, Lily Y., Duensing, Anette, Basile, John, Piboonniyom, Siribang-on, Gonzalez, Sonia, ...
Loss of genomic integrity is a defining feature of many human malignancies, including human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions. Here we show that...
Gonzalez, Sonia L., Stremlau, Matt, He, Xi, Basile, John R., Münger, Karl
The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that...
Duensing, Stefan, Duensing, Anette, Flores, Elsa R., Do, Anh, Lambert, Paul F., Münger, Karl
Primary human keratinocytes with ectopic expression of high-risk human papillomavirus (HPV) E6 and E7 oncoproteins display abnormal centrosome numbers, multipolar mitoses, and aneusomy. However, it...
Genther, Sybil M., Sterling, Stephanie, Duensing, Stefan, Münger, Karl, Sattler, Carol, Lambert, Paul F.
Human papillomaviruses (HPVs) are small circular DNA viruses that cause warts. Infection with high-risk anogenital HPVs, such as HPV type 16 (HPV16), is associated with human cancers, specifically...
Duensing, Stefan, Lee, Benjamin H, Cin, Paola Dal, Münger, Karl
Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and...
Duensing, Stefan, Münger, Karl
The human papillomavirus type 16 (HPV-16) E7 oncoprotein rapidly induces centrosome duplication errors in primary human cells, thereby increasing the propensity for multipolar mitoses, which can lead...
Balsitis, Scott J., Sage, Julien, Duensing, Stefan, Münger, Karl, Jacks, Tyler, Lambert, Paul F.
Although the human papillomavirus (HPV) E7 oncogene is known to contribute to the development of human cervical cancer, the mechanisms of its carcinogenesis are poorly understood. The first...
Jones, D. Leanne, Alani, Rhoda M., Münger, Karl
The high risk human papillomaviruses (HPVs) are associated etiologically with the majority of human cervical carcinomas. These HPVs encode two viral oncoproteins, E6 and E7, which are expressed...
Mechanisms of Human Papillomavirus-Induced Oncogenesis
Münger, Karl, Baldwin, Amy, Edwards, Kirsten M., Hayakawa, Hiroyuki, Nguyen, Christine L., Owens, Michael, ...
Huh, Kyung-Won, DeMasi, Joseph, Ogawa, Hidesato, Nakatani, Yoshihiro, Howley, Peter M., Münger, Karl
The human papillomavirus type 16 (HPV-16) E7 gene encodes a multifunctional oncoprotein that can subvert multiple cellular regulatory pathways. The best-known cellular targets of the HPV-16 E7...
Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding
DeMasi, Joseph, Huh, Kyung-Won, Nakatani, Yoshihiro, Münger, Karl, Howley, Peter M.
The E7 oncoprotein of bovine papillomavirus type 1 (BPV-1) is required for the full transformation activity of the virus. However, the mechanism by which E7 contributes to cellular transformation is...
Wise-Draper, Trisha M., Allen, Hillary V., Thobe, Megan N., Jones, Elizabeth E., Habash, Kristen B., Münger, Karl, ...
The human DEK proto-oncogene is a nucleic acid binding protein with suspected roles in human carcinogenesis, autoimmune disease, and viral infection. Intracellular DEK functions, however, are poorly...
Baldwin, Amy, Huh, Kyung-Won, Münger, Karl
High-risk human papillomaviruses (HPVs) are present in virtually all cervical carcinomas. However, the majority of women infected with high-risk HPVs do not develop cervical cancer. Therefore,...
Syken, Josh, De-Medina, Tali, Münger, Karl
Mitochondria have emerged as central regulators of apoptosis. Here, we show that TID1, a human homolog of the Drosophila tumor suppressor lethal (2) tumorous imaginal discs, l(2)tid, encodes two...
Immortalization of primary human keratinocytes by the helix–loop–helix protein, Id-1
Alani, Rhoda M., Hasskarl, Jens, Grace, Miranda, Hernandez, Maria-Clementia, Israel, Mark A., Münger, Karl
Basic helix–loop–helix (bHLH) DNA-binding proteins have been demonstrated to regulate tissue-specific transcription within multiple cell lineages. The Id family of helix–loop–helix proteins...
Duensing, Stefan, Lee, Lily Y., Duensing, Anette, Basile, John, Piboonniyom, Siribang-on, Gonzalez, Sonia, ...
Loss of genomic integrity is a defining feature of many human malignancies, including human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions. Here we show that...
Gonzalez, Sonia L., Stremlau, Matt, He, Xi, Basile, John R., Münger, Karl
The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that...
Duensing, Stefan, Duensing, Anette, Flores, Elsa R., Do, Anh, Lambert, Paul F., Münger, Karl
Primary human keratinocytes with ectopic expression of high-risk human papillomavirus (HPV) E6 and E7 oncoproteins display abnormal centrosome numbers, multipolar mitoses, and aneusomy. However, it...
Genther, Sybil M., Sterling, Stephanie, Duensing, Stefan, Münger, Karl, Sattler, Carol, Lambert, Paul F.
Human papillomaviruses (HPVs) are small circular DNA viruses that cause warts. Infection with high-risk anogenital HPVs, such as HPV type 16 (HPV16), is associated with human cancers, specifically...
Duensing, Stefan, Lee, Benjamin H, Cin, Paola Dal, Münger, Karl
Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and...
Duensing, Stefan, Münger, Karl
The human papillomavirus type 16 (HPV-16) E7 oncoprotein rapidly induces centrosome duplication errors in primary human cells, thereby increasing the propensity for multipolar mitoses, which can lead...
Balsitis, Scott J., Sage, Julien, Duensing, Stefan, Münger, Karl, Jacks, Tyler, Lambert, Paul F.
Although the human papillomavirus (HPV) E7 oncogene is known to contribute to the development of human cervical cancer, the mechanisms of its carcinogenesis are poorly understood. The first...
Jones, D. Leanne, Alani, Rhoda M., Münger, Karl
The high risk human papillomaviruses (HPVs) are associated etiologically with the majority of human cervical carcinomas. These HPVs encode two viral oncoproteins, E6 and E7, which are expressed...
Mechanisms of Human Papillomavirus-Induced Oncogenesis
Münger, Karl, Baldwin, Amy, Edwards, Kirsten M., Hayakawa, Hiroyuki, Nguyen, Christine L., Owens, Michael, ...
Huh, Kyung-Won, DeMasi, Joseph, Ogawa, Hidesato, Nakatani, Yoshihiro, Howley, Peter M., Münger, Karl
The human papillomavirus type 16 (HPV-16) E7 gene encodes a multifunctional oncoprotein that can subvert multiple cellular regulatory pathways. The best-known cellular targets of the HPV-16 E7...
Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding
DeMasi, Joseph, Huh, Kyung-Won, Nakatani, Yoshihiro, Münger, Karl, Howley, Peter M.
The E7 oncoprotein of bovine papillomavirus type 1 (BPV-1) is required for the full transformation activity of the virus. However, the mechanism by which E7 contributes to cellular transformation is...
Wise-Draper, Trisha M., Allen, Hillary V., Thobe, Megan N., Jones, Elizabeth E., Habash, Kristen B., Münger, Karl, ...
The human DEK proto-oncogene is a nucleic acid binding protein with suspected roles in human carcinogenesis, autoimmune disease, and viral infection. Intracellular DEK functions, however, are poorly...
Baldwin, Amy, Huh, Kyung-Won, Münger, Karl
High-risk human papillomaviruses (HPVs) are present in virtually all cervical carcinomas. However, the majority of women infected with high-risk HPVs do not develop cervical cancer. Therefore,...
Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component γ-Tubulin▿
Nguyen, Christine L., Eichwald, Catherine, Nibert, Max L., Münger, Karl
Expression of a high-risk human papillomavirus (HPV) E7 oncoprotein is sufficient to induce aberrant centrosome duplication in primary human cells. The resulting centrosome-associated mitotic...
Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6▿
McLaughlin-Drubin, Margaret E., Huh, Kyung-Won, Münger, Karl
The papillomavirus life cycle is intimately coupled to the differentiation state of the infected epithelium. Since papillomaviruses lack most of the rate-limiting enzymes required for genome...
Baldwin, Amy, Li, Wenliang, Grace, Miranda, Pearlberg, Joseph, Harlow, Ed, Münger, Karl, ...
Human papillomavirus (HPV) oncoproteins subvert cellular signaling pathways, including kinase pathways, during the carcinogenic process. To identify kinases targeted by the HPV16 E7 oncoprotein,...
Nguyen, Christine L., Münger, Karl
We previously observed that high-risk human papillomavirus type 16 (HPV16) E7 expression leads to the delocalization of dynein from mitotic spindles (C. L. Nguyen, M. E. McLaughlin-Drubin, and K....