Ebralidze, Alexander K., Guibal, Florence C., Steidl, Ulrich, Zhang, Pu, Lee, Sanghoon, Bartholdy, Boris, ...
The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and suppression of leukemia. We show here that...
Further evidence that ribavirin interacts with eIF4E (2005)
KENTSIS, ALEX, VOLPON, LAURENT, TOPISIROVIC, IVAN, SOLL, CLIFFORD E., CULJKOVIC, BILJANA, SHAO, LING, ...
This commentary discusses the recent reports in RNA by Yan and colleagues and Westman and colleagues of the apparent failure of ribavirin to bind to recombinant eIF4E and inhibit 7-methyl guanosine...
Further evidence that ribavirin interacts with eIF4E (2005)
KENTSIS, ALEX, VOLPON, LAURENT, TOPISIROVIC, IVAN, SOLL, CLIFFORD E., CULJKOVIC, BILJANA, SHAO, LING, ...
This commentary discusses the recent reports in RNA by Yan and colleagues and Westman and colleagues of the apparent failure of ribavirin to bind to recombinant eIF4E and inhibit 7-methyl guanosine...
Further evidence that ribavirin interacts with eIF4E (2005)
KENTSIS, ALEX, VOLPON, LAURENT, TOPISIROVIC, IVAN, SOLL, CLIFFORD E., CULJKOVIC, BILJANA, SHAO, LING, ...
This commentary discusses the recent reports in RNA by Yan and colleagues and Westman and colleagues of the apparent failure of ribavirin to bind to recombinant eIF4E and inhibit 7-methyl guanosine...
Borden, Katherine L. B., Campbell Dwyer, Elizabeth J., Salvato, Maria S.
The promyelocytic leukemia protein (PML) forms nuclear bodies which are altered in some disease conditions. We report that the cytoplasmic RNA virus lymphocytic choriomeningitis virus (LCMV)...
Borden, Katherine L. B., CampbellDwyer, Elizabeth J., Carlile, Graeme W., Djavani, Mahmoud, Salvato, Maria S.
The promyelocytic leukemia (PML) protein forms nuclear bodies which are relocated to the cytoplasm by the RNA virus lymphocytic choriomeningitis virus (LCMV). The viral Z protein directly binds to...
Campbell Dwyer, Elizabeth J., Lai, HuiKang, MacDonald, Rhea C., Salvato, Maria S., Borden, Katherine L. B.
Only a few host cell proteins that associate with arenaviruses have been identified. To date, the arenavirus Z protein associates with the promyelocytic leukemia protein PML and the ribosomal P...
Djavani, Mahmoud, Rodas, Juan, Lukashevich, Igor S., Horejsh, Douglas, Pandolfi, Pier Paolo, Borden, Katherine L. B., ...
Lymphocytic choriomeningitis virus (LCMV) induces type I interferon (alpha and beta interferon [IFN-α and IFN-β]) upon infection and yet is sensitive to the addition of type II interferon (gamma...
Self-assembly properties of a model RING domain
Kentsis, Alex, Gordon, Ronald E., Borden, Katherine L. B.
RING domains act in a variety of essential cellular processes but have no general function ascribed to them. Here, we observe that purified arenaviral protein Z, constituted almost entirely by its...
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA
Cohen, Natalie, Sharma, Madhulika, Kentsis, Alex, Perez, Jacqueline M., Strudwick, Stephen, Borden, Katherine L.B.
The promyelocytic leukemia protein PML is organized into nuclear bodies which mediate suppression of oncogenic transformation and of growth. The biochemical functions of PML bodies are unknown,...
Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies
Topisirovic, Ivan, Capili, Allan D., Borden, Katherine L. B.
The eukaryotic initiation factor 4E (eIF4E), when dysregulated, transforms cells. A substantial fraction of eIF4E forms nuclear bodies that colocalize with those associated with the promyelocytic...
Control of biochemical reactions through supramolecular RING domain self-assembly
Kentsis, Alex, Gordon, Ronald E., Borden, Katherine L. B.
RING domains act in a variety of unrelated biochemical reactions, with many of these domains forming key parts of supramolecular assemblies in cells. Here, we observe that purified RINGs from a...
Capili, Allan D., Schultz, David C., Rauscher, Frank J., Borden, Katherine L.B.
Plant homeodomain (PHD) domains are found in >400 eukaryotic proteins, many of which are transcriptional regulators. Naturally occurring point mutations or deletions of this domain contribute to a...
Topisirovic, Ivan, Culjkovic, Biljana, Cohen, Natalie, Perez, Jacqueline M., Skrabanek, Lucy, Borden, Katherine L.B.
The translation initiation factor eIF4E is involved in the modulation of cellular growth. In the nucleus, where eIF4E is associated with PML nuclear bodies, eIF4E mediates nucleocytoplasmic transport...
Topisirovic, Ivan, Guzman, Monica L., McConnell, Melanie J., Licht, Jonathan D., Culjkovic, Biljana, Neering, Sarah J., ...
The eukaryotic translation initiation factor 4E (eIF4E) acts as both a key translation factor and as a promoter of nucleocytoplasmic transport of specific transcripts. Traditionally, its...
Kentsis, Alex, Topisirovic, Ivan, Culjkovic, Biljana, Shao, Ling, Borden, Katherine L. B.
The eukaryotic translation initiation factor eIF4E is deregulated in many human cancers, and its overexpression in cells leads to malignant transformation. Oncogenic properties of eIF4E are directly...
Eukaryotic Translation Initiation Factor 4E Activity Is Modulated by HOXA9 at Multiple Levels
Topisirovic, Ivan, Kentsis, Alex, Perez, Jacqueline M., Guzman, Monica L., Jordan, Craig T., Borden, Katherine L. B.
The eukaryotic translation initiation factor 4E (eIF4E) alters gene expression on multiple levels. In the cytoplasm, eIF4E acts in the rate-limiting step of translation initiation. In the nucleus,...
Djavani, Mahmoud, Topisirovic, Ivan, Zapata, Juan Carlos, Sadowska, Mariola, Yang, Yida, Rodas, Juan, ...
The proline-rich homeodomain protein, PRH/HEX, participates in the early development of the brain, thyroid, and liver and in the later regenerative processes of damaged liver, vascular endothelial,...
Further evidence that ribavirin interacts with eIF4E
KENTSIS, ALEX, VOLPON, LAURENT, TOPISIROVIC, IVAN, SOLL, CLIFFORD E., CULJKOVIC, BILJANA, SHAO, LING, ...
This commentary discusses the recent reports in RNA by Yan and colleagues and Westman and colleagues of the apparent failure of ribavirin to bind to recombinant eIF4E and inhibit 7-methyl guanosine...
Borden, Katherine L. B., Campbell Dwyer, Elizabeth J., Salvato, Maria S.
The promyelocytic leukemia protein (PML) forms nuclear bodies which are altered in some disease conditions. We report that the cytoplasmic RNA virus lymphocytic choriomeningitis virus (LCMV)...
Borden, Katherine L. B., CampbellDwyer, Elizabeth J., Carlile, Graeme W., Djavani, Mahmoud, Salvato, Maria S.
The promyelocytic leukemia (PML) protein forms nuclear bodies which are relocated to the cytoplasm by the RNA virus lymphocytic choriomeningitis virus (LCMV). The viral Z protein directly binds to...
Campbell Dwyer, Elizabeth J., Lai, HuiKang, MacDonald, Rhea C., Salvato, Maria S., Borden, Katherine L. B.
Only a few host cell proteins that associate with arenaviruses have been identified. To date, the arenavirus Z protein associates with the promyelocytic leukemia protein PML and the ribosomal P...
Djavani, Mahmoud, Rodas, Juan, Lukashevich, Igor S., Horejsh, Douglas, Pandolfi, Pier Paolo, Borden, Katherine L. B., ...
Lymphocytic choriomeningitis virus (LCMV) induces type I interferon (alpha and beta interferon [IFN-α and IFN-β]) upon infection and yet is sensitive to the addition of type II interferon (gamma...
Self-assembly properties of a model RING domain
Kentsis, Alex, Gordon, Ronald E., Borden, Katherine L. B.
RING domains act in a variety of essential cellular processes but have no general function ascribed to them. Here, we observe that purified arenaviral protein Z, constituted almost entirely by its...
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA
Cohen, Natalie, Sharma, Madhulika, Kentsis, Alex, Perez, Jacqueline M., Strudwick, Stephen, Borden, Katherine L.B.
The promyelocytic leukemia protein PML is organized into nuclear bodies which mediate suppression of oncogenic transformation and of growth. The biochemical functions of PML bodies are unknown,...
Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies
Topisirovic, Ivan, Capili, Allan D., Borden, Katherine L. B.
The eukaryotic initiation factor 4E (eIF4E), when dysregulated, transforms cells. A substantial fraction of eIF4E forms nuclear bodies that colocalize with those associated with the promyelocytic...
Control of biochemical reactions through supramolecular RING domain self-assembly
Kentsis, Alex, Gordon, Ronald E., Borden, Katherine L. B.
RING domains act in a variety of unrelated biochemical reactions, with many of these domains forming key parts of supramolecular assemblies in cells. Here, we observe that purified RINGs from a...
Capili, Allan D., Schultz, David C., Rauscher, Frank J., Borden, Katherine L.B.
Plant homeodomain (PHD) domains are found in >400 eukaryotic proteins, many of which are transcriptional regulators. Naturally occurring point mutations or deletions of this domain contribute to a...
Topisirovic, Ivan, Culjkovic, Biljana, Cohen, Natalie, Perez, Jacqueline M., Skrabanek, Lucy, Borden, Katherine L.B.
The translation initiation factor eIF4E is involved in the modulation of cellular growth. In the nucleus, where eIF4E is associated with PML nuclear bodies, eIF4E mediates nucleocytoplasmic transport...
Topisirovic, Ivan, Guzman, Monica L., McConnell, Melanie J., Licht, Jonathan D., Culjkovic, Biljana, Neering, Sarah J., ...
The eukaryotic translation initiation factor 4E (eIF4E) acts as both a key translation factor and as a promoter of nucleocytoplasmic transport of specific transcripts. Traditionally, its...
Kentsis, Alex, Topisirovic, Ivan, Culjkovic, Biljana, Shao, Ling, Borden, Katherine L. B.
The eukaryotic translation initiation factor eIF4E is deregulated in many human cancers, and its overexpression in cells leads to malignant transformation. Oncogenic properties of eIF4E are directly...
Eukaryotic Translation Initiation Factor 4E Activity Is Modulated by HOXA9 at Multiple Levels
Topisirovic, Ivan, Kentsis, Alex, Perez, Jacqueline M., Guzman, Monica L., Jordan, Craig T., Borden, Katherine L. B.
The eukaryotic translation initiation factor 4E (eIF4E) alters gene expression on multiple levels. In the cytoplasm, eIF4E acts in the rate-limiting step of translation initiation. In the nucleus,...
Djavani, Mahmoud, Topisirovic, Ivan, Zapata, Juan Carlos, Sadowska, Mariola, Yang, Yida, Rodas, Juan, ...
The proline-rich homeodomain protein, PRH/HEX, participates in the early development of the brain, thyroid, and liver and in the later regenerative processes of damaged liver, vascular endothelial,...
Further evidence that ribavirin interacts with eIF4E
KENTSIS, ALEX, VOLPON, LAURENT, TOPISIROVIC, IVAN, SOLL, CLIFFORD E., CULJKOVIC, BILJANA, SHAO, LING, ...
This commentary discusses the recent reports in RNA by Yan and colleagues and Westman and colleagues of the apparent failure of ribavirin to bind to recombinant eIF4E and inhibit 7-methyl guanosine...
Regulation of p53 Localization and Activity by Ubc13▿ †
Laine, Aaron, Topisirovic, Ivan, Zhai, Dayong, Reed, John C., Borden, Katherine L. B., Ronai, Ze'ev
The abundance and activity of p53 are regulated largely by ubiquitin ligases. Here we demonstrate a previously undisclosed regulation of p53 localization and activity by Ubc13, an E2...
eIF4E is a central node of an RNA regulon that governs cellular proliferation
Culjkovic, Biljana, Topisirovic, Ivan, Skrabanek, Lucy, Ruiz-Gutierrez, Melisa, Borden, Katherine L.B.
This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical node in an RNA regulon that impacts nearly every stage of cell cycle progression. Specifically, eIF4E...
Poyurovsky, Masha V, Priest, Christina, Kentsis, Alex, Borden, Katherine L B, Pan, Zhen-Qiang, Pavletich, Nikola, ...
Mdm2, a key negative regulator of the p53 tumor suppressor, is a RING-type E3 ubiquitin ligase. The Mdm2 RING domain can be biochemically fractionated into two discrete species, one of which exists...
eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR
Culjkovic, Biljana, Topisirovic, Ivan, Skrabanek, Lucy, Ruiz-Gutierrez, Melisa, Borden, Katherine L.B.
The eukaryotic translation initiation factor eIF4E is a critical modulator of cellular growth with functions in the nucleus and cytoplasm. In the cytoplasm, recognition of the 5′ m7G cap moiety on...
The eIF4E RNA regulon promotes the Akt signaling pathway
Culjkovic, Biljana, Tan, Keith, Orolicki, Slobodanka, Amri, Abdellatif, Meloche, Sylvain, Borden, Katherine L.B.
Eukaryotic initiation factor 4E (eIF4E) promotes cellular proliferation and can rescue cells from apoptotic stimuli such as serum starvation. However, the mechanisms underlying apoptotic rescue are...
Ebralidze, Alexander K., Guibal, Florence C., Steidl, Ulrich, Zhang, Pu, Lee, Sanghoon, Bartholdy, Boris, ...
The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and suppression of leukemia. We show here that...
Djavani, Mahmoud, Topisirovic, Ivan, Zapata, Juan Carlos, Sadowska, Mariola, Yang, Yida, Rodas, Juan, ...
Topisirovic, Ivan, Siddiqui, Nadeem, Orolicki, Slobodanka, Skrabanek, Lucy A., Tremblay, Mathieu, Hoang, Trang, ...
Eukaryotic translation initiation factor 4E (eIF4E) is encoded by a potent oncogene which is highly elevated in many human cancers. Few studies have investigated how the level, and thus activity, of...
Control of p53 multimerization by Ubc13 is JNK-regulated
Topisirovic, Ivan, Gutierrez, Gustavo J., Chen, Meifan, Appella, Ettore, Borden, Katherine L. B., Ronai, Ze'ev A.
The p53 tumor suppressor protein is a key regulator of cellular proliferation and survival whose function is tightly regulated at the levels of transcription and protein stability. Here, we unveil...