The not-for-profit form and translational research: Kerr revisited? (2005)
Abstract Translational research conducted in academic health centers is confounded by the organizational structure in which the work is performed. Investigators must obtain research funding and...
Jared A. Silverman, Mary Lou Hayes, Benjamin J. Luft, Keith A. Joiner
The immunosuppressive agent cyclosporin A (CsA) also possesses broad-spectrum antimicrobial activity. Previous investigators have reported that the obligate intracellular protozoan Toxoplasma gondii...
Host but Not Parasite Cholesterol Controls Toxoplasma Cell Entry by Modulating Organelle Discharge
Coppens, Isabelle, Joiner, Keith A.
Host cell cholesterol is implicated in the entry and replication of an increasing number of intracellular microbial pathogens. Although uptake of viral particles via cholesterol-enriched caveolae is...
Activation of the Alternative Complement Pathway by Blood Culture Isolates of Bacteroides fragilis
Joiner, Keith A., Hawiger, Alexandra, Gelfand, Jeffrey A.
Blood culture isolates of Bacteroides caused depletion of alternative complement pathway hemolytic activity, but no fall in C4 titers, when incubated in vitro with normal serum or serum containing...
Toxopain-1 Is Critical for Infection in a Novel Chicken Embryo Model of Congenital Toxoplasmosis
Que, Xuchu, Wunderlich, Annette, Joiner, Keith A., Reed, Sharon L.
We tested the hypothesis that cathepsins and specifically toxopain-1, a cathepsin B, play a critical role in the pathogenesis of toxoplasmosis. We found that inhibiting the expression of...
The not-for-profit form and translational research: Kerr revisited?
Translational research conducted in academic health centers is confounded by the organizational structure in which the work is performed. Investigators must obtain research funding and appropriate...
Host but Not Parasite Cholesterol Controls Toxoplasma Cell Entry by Modulating Organelle Discharge
Coppens, Isabelle, Joiner, Keith A.
Host cell cholesterol is implicated in the entry and replication of an increasing number of intracellular microbial pathogens. Although uptake of viral particles via cholesterol-enriched caveolae is...
Activation of the Alternative Complement Pathway by Blood Culture Isolates of Bacteroides fragilis
Joiner, Keith A., Hawiger, Alexandra, Gelfand, Jeffrey A.
Blood culture isolates of Bacteroides caused depletion of alternative complement pathway hemolytic activity, but no fall in C4 titers, when incubated in vitro with normal serum or serum containing...
Toxopain-1 Is Critical for Infection in a Novel Chicken Embryo Model of Congenital Toxoplasmosis
Que, Xuchu, Wunderlich, Annette, Joiner, Keith A., Reed, Sharon L.
We tested the hypothesis that cathepsins and specifically toxopain-1, a cathepsin B, play a critical role in the pathogenesis of toxoplasmosis. We found that inhibiting the expression of...
The not-for-profit form and translational research: Kerr revisited?
Translational research conducted in academic health centers is confounded by the organizational structure in which the work is performed. Investigators must obtain research funding and appropriate...
Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum†
Massimine, Kristen M., McIntosh, Michael T., Doan, Lanxuan T., Atreya, Chloé E., Gromer, Stephan, Sirawaraporn, Worachart, ...
4′,5′-Dibromo-2′,7′-dinitrofluorescein, a red dye commonly referred to as eosin B, inhibits Toxoplasma gondii in both enzymatic and cell culture studies with a 50% inhibitory concentration...
Karsten, Verena, Qi, Huilin, Beckers, Con J.M., Reddy, Anita, Dubremetz, Jean-Francois, Webster, Paul, ...
All known proteins that accumulate in the vacuolar space surrounding the obligate intracellular protozoan parasite Toxoplasma gondii are derived from parasite dense granules. To determine if...
Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more
Joiner, Keith A., Roos, David S.
Name a single-celled eukaryote that boasts a small genome size, is easily cultivated in haploid form, for which a wide variety of molecular genetic tools are available, and that exhibits a simple,...
Coppens, Isabelle, Sinai, Anthony P., Joiner, Keith A.
The obligate intracellular protozoan Toxoplasma gondii resides within a specialized parasitophorous vacuole (PV), isolated from host vesicular traffic. In this study, the origin of parasite...
Sinai, Anthony P., Joiner, Keith A.
Toxoplasma gondii replicates within a specialized vacuole surrounded by the parasitophorous vacuole membrane (PVM). The PVM forms intimate interactions with host mitochondria and endoplasmic...
Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum
Elliott, David A., McIntosh, Michael T., Hosgood, H. Dean, Chen, Shuo, Zhang, Gina, Baevova, Pavlina, ...
During the bloodstage of malaria infection, the parasite internalizes and degrades massive amounts of hemoglobin from the host red blood cell. Using serial thin-section electron microscopy and...
Differential Effects of Quinoline Antimalarials on Endocytosis in Plasmodium falciparum▿
Roberts, Lindi, Egan, Timothy J., Joiner, Keith A., Hoppe, Heinrich C.
The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine,...