Kelvin Cain

Caspase-9 cleavage: do you need it (2007)

Twiddy, Davina, Cain, Kelvin

This is the authors' final draft of the commentary published as Biochemical Journal, 2007, 405(1), e1-2, and available from http://www.biochemj.org/bj/405/e001/bj405e001.htm

Five members of the CEBP transcription factor family are targeted by recurrent IGH-translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) (2007)

Akasaka, Takashi, Balasas, Theodore, Russell, Lisa J., Sugimoto, Kei-ji, Majid, Aneela, Walewska, Renata, ...

CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid leukemogenesis. Mutations of CEBPA are found in a...

Involvement of the CEBP gene family in four IGH@ chromosomal translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) (2005)

Dyer, Martin J.S., Akasaka, Takashi, Balasas, Theodore, Russell, Lisa, Sugimoto, Kei-Ji, Majid, Aneela, ...

Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are rare in BCP-ALL (comprising ~3% of cases) and involve different breakpoints from those found in lymphoma and...

Diarylurea Compounds Inhibit Caspase Activation by Preventing the Formation of the Active 700-Kilodalton Apoptosome Complex

Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja

The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...

Dibutylchloromethyltin chloride, a covalent inhibitor of the adenosine triphosphate synthase complex

Cain, Kelvin, Partis, Michael D., Griffiths, David E.

1. The synthesis of dibutylchloromethyltin chloride, a new covalent inhibitor of the mitochondrial ATP synthase [oligomycin-sensitive ATPase (adenosine triphosphatase)] complex is described, together...

Diarylurea Compounds Inhibit Caspase Activation by Preventing the Formation of the Active 700-Kilodalton Apoptosome Complex

Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja

The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...

Dibutylchloromethyltin chloride, a covalent inhibitor of the adenosine triphosphate synthase complex

Cain, Kelvin, Partis, Michael D., Griffiths, David E.

1. The synthesis of dibutylchloromethyltin chloride, a new covalent inhibitor of the mitochondrial ATP synthase [oligomycin-sensitive ATPase (adenosine triphosphatase)] complex is described, together...

Caspase-9 cleavage, do you need it?

Twiddy, Davina, Cain, Kelvin

Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby...

Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells

MacFarlane, Marion, Cain, Kelvin, Sun, Xiao-Ming, Alnemri, Emad S., Cohen, Gerald M.

Identification of the processing/activation of multiple interleukin-1β converting enzyme (ICE)–like proteases and their target substrates in the intact cell is critical to our understanding of the...