Homhuan, Atthachai, Kogure, Kentaro, Nakamura, Takashi, Shastri, Nilabh, Harashima, Hideyoshi
To improve uptake and cross-presentation of exogenous antigens (Ag) by dendritic cells (DCs), octaarginine-modified liposomes (R8-Lip) were used as a novel strategy for protein-Ag transduction....
Yamada, Yuma, Akita, Hidetaka, Kamiya, Hiroyuki, Kogure, Kentaro, Yamamoto, Takenori, Shinohara, Yasuo, ...
Mitochondria are the principal producers of energy in higher cells. Mitochondrial dysfunction is implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective...
Kogure, Kentaro, Akita, Hidetaka, Harashima, Hideyoshi
In this review, a new concept called “Programmed Packaging” is proposed for developing non-viral gene delivery systems. A Multifunctional Envelope-type Nano Device (MEND) was developed based on...
Octaarginine-modified multifunctional envelope-type nano device for siRNA (2007)
Nakamura, Yoshio, Kogure, Kentaro, Futaki, Shiroh, Harashima, Hideyoshi
The multifunctional envelope-type nano device (MEND) is a novel non-viral gene delivery system for plasmid DNA (pDNA) and oligodeoxynucleotides (ODN). We showed previously that octaarginine-modified...
Akita, Hidetaka, Ito, Rie, Kamiya, Hiroyuki, Kogure, Kentaro, Harashima, Hideyoshi
Background: Heterogeneity of transgene expression, the presence or absence (below the limit of detection) of transgene expression on a cell-by-cell basis, is a severe disadvantage in the use of...
Akita, Hidetaka, Ito, Rie, Kamiya, Hiroyuki, Kogure, Kentaro, Harashima, Hideyoshi
Background: Heterogeneity of transgene expression, the presence or absence (below the limit of detection) of transgene expression on a cell-by-cell basis, is a severe disadvantage in the use of...
Nakamura, Yoshio, Kogure, Kentaro, Yamada, Yuma, Futaki, Shiroh, Harashima, Hideyoshi, 小暮, 健太朗
A multifunctional envelope-type nano device (MEND) was developed for use as an efficient non-viral system for the delivery of plasmid DNA (pDNA) using octaarginine (R8) as an internalizing ligand....
Nakamura, Yoshio, Kogure, Kentaro, Yamada, Yuma, Futaki, Shiroh, Harashima, Hideyoshi
A multifunctional envelope-type nano device (MEND) was developed for use as an efficient non-viral system for the delivery of plasmid DNA (pDNA) using octaarginine (R8) as an internalizing ligand....
Nakamura, Yoshio, Kogure, Kentaro, Yamada, Yuma, Futaki, Shiroh, Harashima, Hideyoshi
A multifunctional envelope-type nano device (MEND) was developed for use as an efficient non-viral system for the delivery of plasmid DNA (pDNA) using octaarginine (R8) as an internalizing ligand....
Moriguchi, Rumiko, Kogure, Kentaro, Iwasa, Akitada, Akita, Hidetaka, Hideyoshi, Harashima, 原島, 秀吉
http://www.elsevier.com/wps/find/journaldescription.cws_home/502690/description
Moriguchi, Rumiko, Kogure, Kentaro, Iwasa, Akitada, Akita, Hidetaka, Hideyoshi, Harashima
A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional...
Moriguchi, Rumiko, Kogure, Kentaro, Iwasa, Akitada, Akita, Hidetaka, Hideyoshi, Harashima
A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional...
A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids (2005)
Moriguchi, Rumiko, Kogure, Kentaro, Akita, Hidetaka, Futaki, Shiroh, Miyagishi, Makoto, Taira, Kazunari, ...
A multifunctional envelope-type nano device (MEND) for use in the delivery of siRNA expression plasmids is described. The plasmid DNA encoding anti-luciferase short interfering RNA (siRNA) was...
Construction of a multifunctional envelope-type nano device by a SUV*-fusion method (2005)
Sasaki, Kentaro, Kogure, Kentaro, Chaki, Sinji, Kihira, Yoshitaka, Ueno, Masaharu, Harashima, Hideyoshi
In this review, a new concept called “Programmed Packaging” is proposed for developing non-viral gene delivery systems. A Multifunctional Envelope-type Nano Device (MEND) was developed based on...
Kogure, Kentaro, Moriguchi, Rumiko, Sasaki, Kentaro, Ueno, Masaharu, Futaki, Shiroh, Harashima, Hideyoshi
The previous termdevelopment of a multifunctional envelope-type nano devicenext term (MEND) for use in previous terma non-viralnext term gene delivery system using previous terma novel lipid film...
Tokumura, Akira, Sinomiya, Junya, Kishimoto, Seishi, Tanaka, Tamotsu, Kogure, Kentaro, Sugiura, Takayuki, ...
Lysophosphatidic acid (LPA) is a physiological agonist that is produced by lysophospholipase D, phospholipase A(1) and phospholipase A(2) in the blood of animals. It exerts diverse biological actions...
Tokumura, Akira, Sinomiya, Junya, Kishimoto, Seishi, Tanaka, Tamotsu, Kogure, Kentaro, Sugiura, Takayuki, ...
Lysophosphatidic acid (LPA) is a physiological agonist that is produced by lysophospholipase D, phospholipase A(1) and phospholipase A(2) in the blood of animals. It exerts diverse biological actions...