Ghule, Prachi N., Dominski, Zbigniew, Yang, Xiao-Cui, Marzluff, William F., Becker, Klaus A., Harper, J. Wade, ...
Human embryonic stem (hES) cells have an abbreviated G(1) phase of the cell cycle. How cells expedite G(1) events that are required for the initiation of S phase has not been resolved. One key...
Ghule, Prachi N., Becker, Klaus A., Harper, J. Wade, Lian, Jane B., Stein, Janet L., Van Wijnen, Andre J., ...
Human embryonic stem (ES) cells have an expedited cell cycle ( approximately 15 h) due to an abbreviated G1 phase ( approximately 2.5 h) relative to somatic cells. One principal regulatory event...
Becker, Klaus A., Stein, Janet L., Lian, Jane B., Van Wijnen, Andre J., Stein, Gary S.
Rapid self-renewal of human embryonic stem (ES) cells (NIH designation WA01 and WA09) is accommodated by an abbreviated cell cycle due to a reduction in the G1 phase. Thus, molecular mechanisms...
Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase (2006)
Becker, Klaus A., Ghule, Prachi N., Therrien, Jaclyn A., Lian, Jane B., Stein, Janet L., Van Wijnen, Andre J., ...
Competency for self-renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study we...
Proper regulation of the p53 protein plays a critical role in suppressing tumor formation in a variety of tissues including the mammary gland. Activity of the p53 pathway is diminished in the mammary...
Proper regulation of the p53 protein plays a critical role in suppressing tumor formation in a variety of tissues including the mammary gland. Activity of the p53 pathway is diminished in the mammary...
Hormonal control of p53 and chemoprevention (2002)
Jerry, D Joseph, Minter, Lisa M, Becker, Klaus A, Blackburn, Anneke C
Abstract Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity,...
Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice (2000)
Caroline M. Alexander, Frieda Reichsman, Michael T. Hinkes, John Lincecum, Klaus A. Becker, Susan Cumberledge, ...
Hormonal control of p53 and chemoprevention
Jerry, D Joseph, Minter, Lisa M, Becker, Klaus A, Blackburn, Anneke C
Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of...
Hormonal control of p53 and chemoprevention
Jerry, D Joseph, Minter, Lisa M, Becker, Klaus A, Blackburn, Anneke C
Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of...
Ghule, Prachi N., Dominski, Zbigniew, Yang, Xiao-cui, Marzluff, William F., Becker, Klaus A., Harper, J. Wade, ...
Human embryonic stem (hES) cells have an abbreviated G1 phase of the cell cycle. How cells expedite G1 events that are required for the initiation of S phase has not been resolved. One key regulatory...
Lu, Shaolei, Becker, Klaus A., Hagen, Mary J., Yan, Haoheng, Roberts, Amy L., Mathews, Lesley A., ...
Estrogen and progestins are essential for mammary growth and differentiation but also enhance the activity of the p53 tumor suppressor protein in the mammary epithelium. However, the pathways by...