Kousaku Okubo

DDBJ launches a new archive database with analytical tools for next-generation sequence data (2010)

Kaminuma, Eli, Mashima, Jun, Kodama, Yuichi, Gojobori, Takashi, Ogasawara, Osamu, Okubo, Kousaku, ...

The DNA Data Bank of Japan (DDBJ) (http://www.ddbj.nig.ac.jp) has collected and released 1 701 110 entries/1 116 138 614 bases between July 2008 and June 2009. A few highlighted data releases from...

BodyParts3D: 3D structure database for anatomical concepts (2009)

Mitsuhashi, Nobutaka, Fujieda, Kaori, Tamura, Takuro, Kawamoto, Shoko, Takagi, Toshihisa, Okubo, Kousaku

BodyParts3D is a dictionary-type database for anatomy in which anatomical concepts are represented by 3D structure data that specify corresponding segments of a 3D whole-body model for an adult human...

Integration of Diverse Knowledge and Data into Biomedical Knowledge Matrices (2007)

Yoshimasa Tsuruoka, Teruyoshi Hishiki, Osamu Ogasawara, Kousaku Okubo

After the accomplishment of human draft sequence, more and more efforts are being made in the mapping of the data-driven patterns to background knowledge, hoping to efficiently produce hypotheses out...

1 (2007)

Shinichi Morishita, Kousaku Okubo

database Teruyoshi H ishiki

1 (2007)

Shinichi Morishita, Kousaku Okubo

Genes di#erentially expressed in di#erent tissues, during development, or during specific pathologies are of foremost interest to both basic and pharmaceutical research. Digital expression profile of...

DDBJ in preparation for overview of research activities behind data submissions (2006)

Okubo, Kousaku, Sugawara, Hideaki, Gojobori, Takashi, Tateno, Yoshio

In the past year, DDBJ (http://www.ddbj.nig.ac.jp) collected and released 1 956 826 entries or 1 741 313 111 bases. The released data include ∼90 000 ESTs and cDNAs of Macaca fascicularis, and 280...

BodyMap-Xs: anatomical breakdown of 17 million animal ESTs for cross-species comparison of gene expression (2006)

Ogasawara, Osamu, Otsuji, Makiko, Watanabe, Kouji, Iizuka, Takayasu, Tamura, Takuro, Hishiki, Teruyoshi, ...

BodyMap-Xs (http://bodymap.jp) is a database for cross-species gene expression comparison. It was created by the anatomical breakdown of 17 million animal expressed sequence tag (EST) records in DDBJ...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms (2005)

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

The Human Anatomic Gene Expression Library (2004)

Motohiko Tanino, Marie-anne Debily, Takuro Tamura, Teruyoshi Hishiki, Osamu Ogasawara, Katsuji Murakawa, ...

(H-ANGEL), the H-Inv integrative display of human gene expression across disparate

BodyMap incorporated PCR-based expression profiling data and a gene ranking system (2001)

Sese, Jun, Nikaidou, Hitoshi, Kawamoto, Shoko, Minesaki, Yuichi, Morishita, Shinichi, Okubo, Kousaku

BodyMap is a human and mouse gene expression database that is based on site-directed 3′-expressed sequence tags generated at Osaka University. To date, it contains more than 300 000 tag sequences...

BodyMap: a human and mouse gene expression database (2000)

Hishiki, Teruyoshi, Kawamoto, Shoko, Morishita, Shinichi, Okubo, Kousaku

BodyMap is a human and mouse gene expression database that has been maintained since 1993. It is based on site-directed 3′-ESTs collected from non-biased cDNA libraries constructed at Osaka...

Genomic Organization and Chromosomal Localization of the Human Cathepsin L2 Gene (1999)

Itoh, Reiko, Kawamoto, Shoko, Adachi, Wakako, Kinoshita, Shigeru, Okubo, Kousaku

Cathepsin L2 is a recently described cysteine proteinase with high sequence homology to cathepsin L and other members of the papain superfamily of cysteine proteinases. Its expression is regulated in...

Eighteen Novel Human Genes Regionally Mapped on Chromosome 11 (1997)

Hori, Naohiro, Endo, Yuichi, Okubo, Kousaku, Murakawa, Katsuji, Yokoyama, Masahiro, Matoba, Ryo, ...

Expression sequence tags (EST) obtained by sequencing a randomly primed cDNA library and gene signatures (GS) obtained by sequencing a 3′-directed cDNA library can identify genes that are active in...

An Expression Profile of Active Genes in Cultured Human Keratinocytes (1996)

Kita, Hiroko, Okubo, Kousaku, Matsubara, Kenichi

An expression profile of genes active in cultured human keratinocytes was obtained by collecting 770 partial sequences froma 3′-directed cDNA library that faithfully represents the mRNA population...

Identification and Cloning of Neuroblastoma-Specific and Nerve Tissue-Specific Genes through Compiled Expression Profiles (1996)

Yokoyama, Masahiro, Nishi, Yoshisuke, Yoshii, Junji, Okubo, Kousaku, Matsubara, Kenichi

An expression profile of active genes in a human neuroblastoma cell line CHP134 was obtained by collecting 1222 partial sequences from a 3′-directed cDNA library representing a non-biased mRNA...

Chromosomal Assignments of Novel Genes Expressed in HL60 Granulocytes (1994)

Fukushima, Atsushi, Matsubara, Kenichi, Murakawa, Katsuji, Yoshii, Junji, Yokoyama, Masahiro, Okubo, Kousaku

By collecting 3′-directed cDNA sequences called gene signatures (GSs) on a large scale, it is possible to make an expression profile of genes in a particular tissue, as well as discovering a number...

Chromosomal Assignment of Short cDNA Sequences by PCR Using Overlapping and Tailed Short Primers (1994)

Chae, Keon-Sang, Murakawa, Katsuji, Okubo, Kousaku, Matsubara, Kenichi

Overlapping primers and tailed short primers are effective agents for mapping very short cDNA sequences. By using such primers, human cDNAs as short as 32 nucleotides in length can produce PCR bands....

An Expression Profile of Active Genes in Human Lung (1994)

Itoh, Kohichi, Okubo, Kousaku, Yosii, Junji, Yokouchi, Hideoki, Matsubara, Kenichi

An expression profile ofgenes active in the human lung was obtained by collecting 797 partial sequences from a 3′-directed cDNA library. Three genes were found to produce mRNA each of which...

An Expression Profile of Active Genes in Human Colonic Mucosa (1994)

Okubo, Kousaku, Yoshii, Junji, Yokouchi, Hideoki, Kameyama, Masao, Matsubara, Kenichi

An expression profile of genes active in the human colonic mucosa was obtained by collecting 959 partial sequences from a 3′-directed cDNA library. Seven genes were found to produce mRNA each of...

BodyMap incorporated PCR-based expression profiling data and a gene ranking system

Sese, Jun, Nikaidou, Hitoshi, Kawamoto, Shoko, Minesaki, Yuichi, Morishita, Shinichi, Okubo, Kousaku

BodyMap is a human and mouse gene expression database that is based on site-directed 3′-expressed sequence tags generated at Osaka University. To date, it contains more than 300 000 tag sequences...

BodyMap: a human and mouse gene expression database

Hishiki, Teruyoshi, Kawamoto, Shoko, Morishita, Shinichi, Okubo, Kousaku

BodyMap is a human and mouse gene expression database that has been maintained since 1993. It is based on site-directed 3′-ESTs collected from non-biased cDNA libraries constructed at Osaka...

BodyMap: A Collection of 3′ ESTs for Analysis of Human Gene Expression Information

Kawamoto, Shoko, Yoshii, Junji, Mizuno, Katsuya, Ito, Kouichi, Miyamoto, Yasuhide, Ohnishi, Tadashi, ...

BodyMap is a collection of site-directed 3′ expressed sequence tags (ESTs) (gene signatures, GSs) that contains the transcript compositions of various human tissues and was the first systematic...

Expression Profiling by iAFLP: A PCR-Based Method for Genome-Wide Gene Expression Profiling

Kawamoto, Shoko, Ohnishi, Tadashi, Kita, Hiroko, Chisaka, Osamu, Okubo, Kousaku

The availability of comprehensive sets of genes has prompted the researchers to carry out systematic collection of gene expression data. RT–PCR has the highest specificity and sensitivity for...

Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes

Suzuki, Yutaka, Tsunoda, Tatsuhiko, Sese, Jun, Taira, Hirotoshi, Mizushima-Sugano, Junko, Hata, Hiroko, ...

To understand the mechanism of transcriptional regulation, it is essential to identify and characterize the promoter, which is located proximal to the mRNA start site. To identify the promoters from...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites

Suzuki, Yutaka, Taira, Hirotoshi, Tsunoda, Tatsuhiko, Mizushima-Sugano, Junko, Sese, Jun, Hata, Hiroko, ...

Determination of the mRNA start site is the first step in identifying the promoter region, which is of key importance for transcriptional regulation of gene expression. The ‘oligo-capping’ method...

DDBJ in preparation for overview of research activities behind data submissions

Okubo, Kousaku, Sugawara, Hideaki, Gojobori, Takashi, Tateno, Yoshio

In the past year, DDBJ () collected and released 1 956 826 entries or 1 741 313 111 bases. The released data include ∼90 000 ESTs and cDNAs of Macaca fascicularis, and 280 million bases of mouse...

BodyMap-Xs: anatomical breakdown of 17 million animal ESTs for cross-species comparison of gene expression

Ogasawara, Osamu, Otsuji, Makiko, Watanabe, Kouji, Iizuka, Takayasu, Tamura, Takuro, Hishiki, Teruyoshi, ...

BodyMap-Xs () is a database for cross-species gene expression comparison. It was created by the anatomical breakdown of 17 million animal expressed sequence tag (EST) records in DDBJ using a sorting...

BodyMap incorporated PCR-based expression profiling data and a gene ranking system

Sese, Jun, Nikaidou, Hitoshi, Kawamoto, Shoko, Minesaki, Yuichi, Morishita, Shinichi, Okubo, Kousaku

BodyMap is a human and mouse gene expression database that is based on site-directed 3′-expressed sequence tags generated at Osaka University. To date, it contains more than 300 000 tag sequences...

BodyMap: a human and mouse gene expression database

Hishiki, Teruyoshi, Kawamoto, Shoko, Morishita, Shinichi, Okubo, Kousaku

BodyMap is a human and mouse gene expression database that has been maintained since 1993. It is based on site-directed 3′-ESTs collected from non-biased cDNA libraries constructed at Osaka...

BodyMap: A Collection of 3′ ESTs for Analysis of Human Gene Expression Information

Kawamoto, Shoko, Yoshii, Junji, Mizuno, Katsuya, Ito, Kouichi, Miyamoto, Yasuhide, Ohnishi, Tadashi, ...

BodyMap is a collection of site-directed 3′ expressed sequence tags (ESTs) (gene signatures, GSs) that contains the transcript compositions of various human tissues and was the first systematic...

Expression Profiling by iAFLP: A PCR-Based Method for Genome-Wide Gene Expression Profiling

Kawamoto, Shoko, Ohnishi, Tadashi, Kita, Hiroko, Chisaka, Osamu, Okubo, Kousaku

The availability of comprehensive sets of genes has prompted the researchers to carry out systematic collection of gene expression data. RT–PCR has the highest specificity and sensitivity for...

Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes

Suzuki, Yutaka, Tsunoda, Tatsuhiko, Sese, Jun, Taira, Hirotoshi, Mizushima-Sugano, Junko, Hata, Hiroko, ...

To understand the mechanism of transcriptional regulation, it is essential to identify and characterize the promoter, which is located proximal to the mRNA start site. To identify the promoters from...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites

Suzuki, Yutaka, Taira, Hirotoshi, Tsunoda, Tatsuhiko, Mizushima-Sugano, Junko, Sese, Jun, Hata, Hiroko, ...

Determination of the mRNA start site is the first step in identifying the promoter region, which is of key importance for transcriptional regulation of gene expression. The ‘oligo-capping’ method...

DDBJ in preparation for overview of research activities behind data submissions

Okubo, Kousaku, Sugawara, Hideaki, Gojobori, Takashi, Tateno, Yoshio

In the past year, DDBJ () collected and released 1 956 826 entries or 1 741 313 111 bases. The released data include ∼90 000 ESTs and cDNAs of Macaca fascicularis, and 280 million bases of mouse...

BodyMap-Xs: anatomical breakdown of 17 million animal ESTs for cross-species comparison of gene expression

Ogasawara, Osamu, Otsuji, Makiko, Watanabe, Kouji, Iizuka, Takayasu, Tamura, Takuro, Hishiki, Teruyoshi, ...

BodyMap-Xs () is a database for cross-species gene expression comparison. It was created by the anatomical breakdown of 17 million animal expressed sequence tag (EST) records in DDBJ using a sorting...

Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves

Hoshino, Hideharu, Uchida, Tsukasa, Otsuki, Toshiaki, Kawamoto, Shoko, Okubo, Kousaku, Takeichi, Masatoshi, ...

During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain...

Gene-L’EXPO: a Tool to Extract Knowledge From Transcriptomes and Find ‘Literature-Sparse’ Relationships Between Genes and Tissues

Hishiki, Teruyoshi, Tamada, Issei, Okubo, Kousaku

The increasing volume and diversity of transcriptome data in the public domain offer an opportunity to advance new questions and hypotheses. We anticipate that tools that can visualize the gap in the...

BodyParts3D: 3D structure database for anatomical concepts

Mitsuhashi, Nobutaka, Fujieda, Kaori, Tamura, Takuro, Kawamoto, Shoko, Takagi, Toshihisa, Okubo, Kousaku

BodyParts3D is a dictionary-type database for anatomy in which anatomical concepts are represented by 3D structure data that specify corresponding segments of a 3D whole-body model for an adult human...

DDBJ launches a new archive database with analytical tools for next-generation sequence data

Kaminuma, Eli, Mashima, Jun, Kodama, Yuichi, Gojobori, Takashi, Ogasawara, Osamu, Okubo, Kousaku, ...

The DNA Data Bank of Japan (DDBJ) (http://www.ddbj.nig.ac.jp) has collected and released 1 701 110 entries/1 116 138 614 bases between July 2008 and June 2009. A few highlighted data releases from...