Kun Ling

Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer (2010)

Sun, Yue, Turbin, Dmitry A, Ling, Kun, Thapa, Narendra, Leung, Samuel, Huntsman, David G, ...

Abstract Introduction The loss of E-cadherin based cell-cell contacts and tumor cell migration to the vasculature and lymphatic system are hallmarks of metastasis of epithelial cancers. Type I gamma...

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors

Ling, Kun, Wang, Ping, Zhao, Jian, Wu, Ya-Lan, Cheng, Zhi-Jie, Wu, Guo-Xiang, ...

The putative seven-transmembrane (TM) domains have been the structural hallmark for the superfamily of heterotrimeric G protein-coupled receptors (GPCRs) that regulate a variety of cellular functions...

Molecular Dynamics Simulations on SDF-1α: Binding with CXCR4 Receptor

Huang, Xiaoqin, Shen, Jianhua, Cui, Meng, Shen, Lingling, Luo, Xiaomin, Ling, Kun, ...

Insights into the interacting mode of CXCR4 with SDF-1α are crucial in understanding the structural and functional characteristics of CXCR4 receptor. In this paper a computational pipeline,...

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors

Ling, Kun, Wang, Ping, Zhao, Jian, Wu, Ya-Lan, Cheng, Zhi-Jie, Wu, Guo-Xiang, ...

The putative seven-transmembrane (TM) domains have been the structural hallmark for the superfamily of heterotrimeric G protein-coupled receptors (GPCRs) that regulate a variety of cellular functions...

Molecular Dynamics Simulations on SDF-1α: Binding with CXCR4 Receptor

Huang, Xiaoqin, Shen, Jianhua, Cui, Meng, Shen, Lingling, Luo, Xiaomin, Ling, Kun, ...

Insights into the interacting mode of CXCR4 with SDF-1α are crucial in understanding the structural and functional characteristics of CXCR4 receptor. In this paper a computational pipeline,...

Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin

Ling, Kun, Bairstow, Shawn F., Carbonara, Chateen, Turbin, Dmitry A., Huntsman, David G., Anderson, Richard A.

Assembly of E-cadherin–based adherens junctions (AJ) is obligatory for establishment of polarized epithelia and plays a key role in repressing the invasiveness of many carcinomas. Here we show that...

Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration

Sun, Yue, Ling, Kun, Wagoner, Matthew P., Anderson, Richard A.

Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) modulates a plethora of cytoskeletal interactions that control the dynamics of actin assembly and, ultimately, cell migration. We show that the type...

Anti-HIV Agent Trichosanthin Enhances the Capabilities of Chemokines to Stimulate Chemotaxis and G Protein Activation, and This Is Mediated through Interaction of Trichosanthin and Chemokine Receptors

Zhao, Jian, Ben, Li-Hong, Wu, Ya-Lan, Hu, Wei, Ling, Kun, Xin, Shun-Mei, ...

Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has been shown to inhibit HIV infection and has been applied in clinical...

Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin–talin switch

Ling, Kun, Doughman, Renee L., Iyer, Vidhya V., Firestone, Ari J., Bairstow, Shawn F., Mosher, Deane F., ...

Engagement of integrin receptors with the extracellular matrix induces the formation of focal adhesions (FAs). Dynamic regulation of FAs is necessary for cells to polarize and migrate. Key...