Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling (2007)
Beeram, M, Tan, Q-TN, Tekmal, RR, Russell, D, Middleton, A, DeGraffenried, LA
Background: Resistance to endocrine therapy is a major impediment in breast cancer therapeutics. The Phosphatidylinositol-3-OH kinase (PI3K)/Protein kinase B (Akt/PKB) kinase signaling pathway has...