Lecturer Wing-kin, Sung Scribe, Cheng Weiwei, Yang Liang
Due to some evolutionary events such as recombination, horizontal gene transfer, or hybrid speciation which suggest convergence between objects, cannot be adequately described in a single tree...
Lecturer Wing-kin, Sung Scribe, Cheng Weiwei, Yang Liang
Deoxyribonucleic Acid or DNA is commonly known to be responsible for encoding the information of life. Through sexual reproduction, DNA is passed on as hereditary material to offspring. However,...
CS5238 Combinatorial Methods in Bioinformatics 2004/2005 Semester 1 (2008)
Lecturer Wing-kin, Sung Scribe, Hady Gunawan, Steven Halim, Tan Soon Heng
People believe that many widely divergent organisms are decended from a common ancestor through a process called evolution. Evolution is a process that results in inheritable changes in the...
CS5238 Combinatorial methods in bioinformatics 2004/2005 Semester 1 Lecture 10: Motif Finding (2008)
Lecturer Wing-kin, Sung Scribe, Tan Yee Fan, Neo Shi Yong, Wang Gang
One of the big challenges in molecular biology is to understand the regulation of gene expression; which is the process in which a segment of DNA is being decoded to form a protein. From the DNA...
CS5238 Combinatorial methods in bioinformatics 2006/2007 Semester 1 Lecture 10: Motif Finding (2008)
Lecturer Wing-kin, Sung Scribe, Zhang Jingbo, Shrikant Kashyap, Ag C
10.1 Regulatory element detection using correlation with expression For this part, please refer to the paper [H01]. Microarray allows us to monitor mRNA expression of many genes. These expression...
Lecturer Wing-kin, Sung Scribe, Zhong Zhi, Song Fushan
The suffix tree of a string is a fundamental data structure of combinatorial pattern matching[1]. In this lecture, we will first introduce the definition of suffix tree and then the construction of...
3.1.1 Biological Database (2008)
Lecturer Wing-kin, Sung Scribe, Chen Jinxiu, Ren Li-an
Biological database is the database of sequence. As we know,three kinds of biological sequences include protein, DNA and RNA. In recent years biological data is doubled in size every 15 or 16 months....
Lecturer Wing-kin, Sung Scribe, Hemendra S. Negi, Li Haiquan, Xu Zhou, Ip S. Wasan, ...
Deoxyribonucleic Acid or DNA is commonly known to be responsible for encoding the information of life. Through sexual reproduction, DNA is passed on as hereditary material to offspring. During the...
Lecturer Wing-kin, Sung Scribe, Zhang Zhiyong Melvin
Suffix tree is a fundamental data structure for combinatorial pattern matching[1]. In this note, we will introduce suffix tree, its construction and applications in computational biology problems. A...
CS5238 Combinatorial methods in bioinformatics 2004/2005 Semester 1 (2008)
Lecturer Wing-kin, Sung Scribe, Stanley Ng, Kwang Loong
The process of extracting DNA sequences from a given DNA sample is commonly known as sequence reconstruction or DNA sequencing. Efficient DNA sequencing of the genomes of individual species and...
CS5238 Combinatorial methods in bioinformatics 2004/2005 Semester 1 (2004)
Lecturer Wing-kin, Sung Scribe, Lee Terk Shuen, Lee Ping Alison
Proteomics is a field that is growing in importance for molecular biology research. It is defined as the systematic analysis of proteins in a cell or a tissue sample, which generally involves steps...