LUKASZ JASKIEWICZ

Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets (2009)

Hausser, Jean, Landthaler, Markus, Jaskiewicz, Lukasz, Gaidatzis, Dimos, Zavolan, Mihaela

How miRNAs recognize their target sites is a puzzle that many experimental and computational studies aimed to solve. Several features, such as perfect pairing of the miRNA seed, additional pairing in...

ATP modulates siRNA interactions with an endogenous human Dicer complex (2005)

PELLINO, JANICE L., JASKIEWICZ, LUKASZ, FILIPOWICZ, WITOLD, SONTHEIMER, ERIK J.

Short interfering RNA (siRNA) binding by Dicer is important for RNA interference in Drosophila, but human Dicer (hDcr) has been reported to lack siRNA binding activity. We used native gel...

ATP modulates siRNA interactions with an endogenous human Dicer complex (2005)

PELLINO, JANICE L., JASKIEWICZ, LUKASZ, FILIPOWICZ, WITOLD, SONTHEIMER, ERIK J.

Short interfering RNA (siRNA) binding by Dicer is important for RNA interference in Drosophila, but human Dicer (hDcr) has been reported to lack siRNA binding activity. We used native gel...

ATP modulates siRNA interactions with an endogenous human Dicer complex

PELLINO, JANICE L., JASKIEWICZ, LUKASZ, FILIPOWICZ, WITOLD, SONTHEIMER, ERIK J.

Short interfering RNA (siRNA) binding by Dicer is important for RNA interference in Drosophila, but human Dicer (hDcr) has been reported to lack siRNA binding activity. We used native gel...

The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components

Kotaja, Noora, Bhattacharyya, Suvendra N., Jaskiewicz, Lukasz, Kimmins, Sarah, Parvinen, Martti, Filipowicz, Witold, ...

The chromatoid body is a perinuclear, cytoplasmic cloud-like structure in male germ cells whose function has remained elusive. Here we show that the chromatoid body is related to the RNA-processing...

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

Haase, Astrid D, Jaskiewicz, Lukasz, Zhang, Haidi, Lainé, Sébastien, Sack, Ragna, Gatignol, Anne, ...

Dicer is a key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also has a role in the...

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

Haase, Astrid D, Jaskiewicz, Lukasz, Zhang, Haidi, Lainé, Sébastien, Sack, Ragna, Gatignol, Anne, ...

Dicer is a key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also has a role in the...

ATP modulates siRNA interactions with an endogenous human Dicer complex

PELLINO, JANICE L., JASKIEWICZ, LUKASZ, FILIPOWICZ, WITOLD, SONTHEIMER, ERIK J.

Short interfering RNA (siRNA) binding by Dicer is important for RNA interference in Drosophila, but human Dicer (hDcr) has been reported to lack siRNA binding activity. We used native gel...

The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components

Kotaja, Noora, Bhattacharyya, Suvendra N., Jaskiewicz, Lukasz, Kimmins, Sarah, Parvinen, Martti, Filipowicz, Witold, ...

The chromatoid body is a perinuclear, cytoplasmic cloud-like structure in male germ cells whose function has remained elusive. Here we show that the chromatoid body is related to the RNA-processing...

Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System

Galgano, Alessia, Forrer, Michael, Jaskiewicz, Lukasz, Kanitz, Alexander, Zavolan, Mihaela, Gerber, André P.

Genome-wide identification of mRNAs regulated by RNA-binding proteins is crucial to uncover post-transcriptional gene regulatory systems. The conserved PUF family RNA-binding proteins repress gene...